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Matthew 16:12

“Warning Against the Leaven of the Leaders”· Matthew 16:5–12Read in context
King James Version
Then understood they how that he bade them not beware of the leaven of bread, but of the doctrine of the Pharisees and of the Sadducees.
KJV (with Strong's)
Then G5119 understood they G4920 how that G3754 he bade G2036 them not G3756 beware G4337 of G575 the leaven G2219 of bread G740, but G235 of G575 the doctrine G1322 of the Pharisees G5330 and G2532 of the Sadducees G4523.
Complete Jewish Bible
Then they understood -- they were to guard themselves not from yeast for bread but from the teaching of the P'rushim and Tz'dukim.
Berean Standard Bible
Then they understood that He was not telling them to beware of the leaven used in bread, but of the teaching of the Pharisees and Sadducees.
American Standard Version
Then understood they that he bade them not beware of the leaven of bread, but of the teaching of the Pharisees and Sadducees.
World English Bible Messianic
Then they understood that he didn’t tell them to beware of the yeast of bread, but of the teaching of the Pharisees and Sadducees.
Geneva Bible (1599)
Then vnderstood they that he had not said that they should beware of the leauen of bread, but of the doctrine of the Pharises, and Sadduces.
Young's Literal Translation
Then they understood that he did not say to take heed of the leaven of the bread, but of the teaching, of the Pharisees and Sadducees.
हिन्दी · HCV
तब उन्हें यह विषय समझ में आया कि येशु रोटी के खमीर का नहीं परंतु फ़रीसियों और सदूकियों की गलत शिक्षा का वर्णन कर रहे थे.
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Summary

Matthew 16:12 marks a pivotal moment in the disciples' spiritual development, as they finally grasp the profound metaphorical nature of Jesus' warning concerning "leaven." Initially misinterpreting His words as a literal admonition about physical bread, this verse signifies their breakthrough in understanding that Jesus was cautioning them against the insidious, corrupting influence of the false doctrines propagated by the religious leaders of their day, the Pharisees and the Sadducees. It underscores the critical importance of spiritual discernment over mere literal comprehension.

Context

Literary Context

This verse concludes a significant teaching episode that begins with Jesus' initial warning to "beware of the leaven of the Pharisees and of the Sadducees" in Matthew 16:6. The disciples, having forgotten to bring bread for their journey, immediately misinterpret this as a rebuke for their oversight regarding physical food, as indicated in Matthew 16:7-8. Jesus then patiently reminds them of the two miraculous feedings—the five thousand and the four thousand—to highlight their lack of spiritual insight despite witnessing His power and provision (Matthew 16:9-10). The disciples' silence in Matthew 16:11 suggests their continued confusion, making Matthew 16:12 the crucial turning point where their minds are finally opened to the deeper, spiritual meaning of Jesus' metaphor. This progression emphasizes the often-slow process of spiritual understanding, even for those closest to Jesus.

Historical & Cultural Context

The warning about "leaven" would have resonated deeply within Jewish culture. Leaven (yeast) was commonly understood as a fermenting agent that permeated an entire batch of dough, often symbolizing corruption, impurity, or evil, particularly in Old Testament sacrificial laws where it was forbidden in offerings (Exodus 12:15). The Pharisees were a prominent Jewish sect known for their strict adherence to the Mosaic Law and their extensive oral traditions, which often overshadowed the spirit of the law, leading to legalism and hypocrisy (Matthew 23). The Sadducees, on the other hand, were a priestly aristocratic sect, politically influential but theologically conservative, rejecting the resurrection, angels, and the oral tradition of the Pharisees (Matthew 22:23; Acts 23:8). Jesus' warning thus targeted the core errors of both groups: the Pharisees' externalism and man-made traditions, and the Sadducees' skepticism and denial of supernatural truth.

Key Themes

This verse is central to several key themes within Matthew's Gospel and the broader biblical narrative. It powerfully illustrates the theme of spiritual discernment, urging believers to look beyond superficial interpretations and grasp the deeper spiritual truths that Jesus conveys. It highlights the pervasive danger of false doctrine, using the metaphor of leaven to show how erroneous teachings, even seemingly small, can subtly corrupt an individual's faith or an entire community. This concept is echoed elsewhere in the New Testament, such as Paul's warning in Galatians 5:9. Furthermore, the passage underscores the nature of true discipleship, which requires not only intellectual understanding but also a spiritual openness to receive and apply divine truth. The disciples' initial struggle and eventual understanding serve as a model for all who seek to follow Christ, emphasizing the need for humility and a willingness to be taught by the Master.

Exposition and Analysis

Key Word Analysis

understood syníēmi' G4920

Meaning "to put together, i.e. (mentally) to comprehend; by implication, to act piously." This indicates a cognitive breakthrough, a mental assembling of previously disparate pieces of information, leading to a comprehensive grasp of Jesus' meaning. It implies not just hearing but truly internalizing the message.

leaven zýmē' G2219

Meaning "ferment (as if boiling up)." This term, derived from the concept of boiling or bubbling, vividly portrays the active, pervasive nature of yeast. In biblical metaphor, it consistently symbolizes a corrupting or permeating influence, often negative, due to its ability to spread throughout a mass.

doctrine didachḗ' G1322

Meaning "instruction (the act or the matter)." This word refers to the content of teaching or the act of teaching itself. Here, it specifically denotes the body of beliefs, principles, and practices taught by the Pharisees and Sadducees, which Jesus identifies as spiritually harmful.

Verse Breakdown

"Then understood they"

This phrase marks a crucial turning point. After Jesus' repeated questions and their initial confusion, the disciples finally achieve clarity. Their understanding shifts from a literal, material interpretation to a spiritual, metaphorical one, indicating a significant step forward in their spiritual maturity and discernment.

"how that he bade [them] not beware of the leaven of bread"

This clarifies their previous misapprehension. They realize Jesus' warning was not about the physical absence of bread or the literal yeast used in baking. The emphasis is on the fact that His command was not concerning a mundane, physical matter, but something far more profound and spiritual.

"but of the doctrine of the Pharisees and of the Sadducees"

This clause reveals the true object of Jesus' warning. The "leaven" is explicitly identified as the "doctrine" (teaching) of these two prominent Jewish sects. This highlights that the danger lies in their theological and ethical errors, which, like leaven, could subtly permeate and corrupt the spiritual lives of those who embraced them.

Literary Devices

The verse primarily employs Metaphor and Didacticism. The central metaphor is "leaven" representing "doctrine." This powerful image effectively conveys the insidious, pervasive, and corrupting nature of false teaching. Just as a small amount of yeast can affect an entire batch of dough, so too can erroneous beliefs subtly permeate and alter one's entire spiritual understanding and practice. The passage also functions as a moment of Didacticism, as Jesus uses the disciples' misunderstanding to teach them a deeper spiritual truth about discernment. Their journey from literal misinterpretation to spiritual comprehension serves as a pedagogical tool for readers, emphasizing the importance of looking beyond the surface to grasp the true meaning of spiritual warnings. The Irony is also present in the disciples' initial focus on physical bread while missing the profound spiritual bread of life that Jesus offered.

Theological and Thematic Connections

Matthew 16:12 serves as a timeless warning against the pervasive danger of false teaching, emphasizing that spiritual discernment is paramount for true faith. The "leaven" metaphor highlights how erroneous doctrines, even subtle ones, can corrupt the entire body of belief and practice, much like yeast permeates dough. This passage underscores the importance of grounding one's faith in the authentic teachings of Christ and the Scriptures, rather than in human traditions or skeptical philosophies. It calls believers to critical engagement with all teachings, testing them against the revealed truth of God's Word.

Reflection and Application

Matthew 16:12 challenges us to cultivate a profound spiritual discernment, moving beyond superficial understanding to grasp the deeper truths of God's Word. In an age saturated with diverse voices and competing ideologies, the "leaven" of false doctrine remains a potent threat. This verse calls us to vigilance, urging us to scrutinize teachings not by their popularity or the charisma of their proponents, but by their fidelity to the unchanging truth of Scripture. Just as the disciples needed to understand Jesus' true meaning, we must diligently study the Bible, allowing the Holy Spirit to illuminate our understanding and equip us to identify and reject any teaching that subtly undermines the gospel, promotes legalism, or denies core biblical truths. Our spiritual health and the purity of the church depend on our commitment to discerning truth from error.

Questions for Reflection

  1. What "leaven" or subtle false doctrines might be present in contemporary society or even within Christian circles today?
  2. How can I cultivate greater spiritual discernment in my own life to recognize and resist teachings that subtly contradict biblical truth?
  3. In what ways might I, like the disciples, be prone to focusing on the literal or superficial, missing deeper spiritual realities?

FAQ

What exactly was the "doctrine" of the Pharisees and Sadducees that Jesus warned against?

The "doctrine" (Greek: didachḗ) of the Pharisees and Sadducees represented distinct but equally dangerous spiritual errors. The Pharisees' "leaven" primarily consisted of legalism, hypocrisy, and the elevation of man-made traditions over God's written law. They meticulously observed external rituals and rules, often neglecting the internal transformation of the heart and true righteousness (Matthew 23:23-28). Their emphasis on outward appearance and self-righteousness choked genuine faith. The Sadducees' "leaven," conversely, was characterized by skepticism, materialism, and a denial of core supernatural truths. They rejected the resurrection of the dead, the existence of angels, and the spiritual realm, adhering only to the Pentateuch and dismissing oral traditions (Matthew 22:23; Acts 23:8). Their error was a rationalistic approach that stripped faith of its divine power and hope. Jesus warned against both, as each, in its own way, distorted God's truth and hindered true relationship with Him.

Christ-Centered Fulfillment

Matthew 16:12, while a warning against false doctrine, ultimately points to Christ as the sole source of true doctrine and the ultimate antidote to spiritual corruption. Jesus, as the incarnate Word of God, embodies the truth that the Pharisees and Sadducees distorted and denied. Unlike their "leaven" of legalism, hypocrisy, and skepticism, Jesus offers the pure "bread of life" (John 6:35), providing spiritual nourishment and eternal truth that truly satisfies. He is the one who not only exposes false teachings but also provides the spiritual discernment necessary to recognize them, through the indwelling Holy Spirit who guides believers into all truth (John 16:13). The disciples' eventual understanding in this verse foreshadows the greater clarity and spiritual insight available to all who fix their eyes on Jesus, the author and perfecter of our faith (Hebrews 12:2). He is the standard by which all doctrine is measured, and only by adhering to His teachings can believers avoid the corrupting influence of the world's "leaven" and walk in genuine righteousness.

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Public-domain commentary

Matthew Henry

From his Commentary on the Whole Bible. Henry comments on passages, not single verses — this entry covers Matthew 16:5–12. His three-level outline is real structure in the source text, so it is rendered as structure.

1662–1714 · 8 verses
Passage under commentMatthew 16:5–12
I. II. Main points1. 2. Sub-points(1.) (2.) Details

We have here Christ's discourse with his disciples concerning bread, in which, as in many other discourses, he speaks to them of spiritual things under a similitude, and they misunderstand him of carnal things. The occasion of it was, their forgetting to victual their ship, and to take along with them provisions for their family on the other side of the water; usually they carried bread along with them, because they were sometimes in desert places; and when they were not, yet they would not be burthensome. But now they forgot; we will hope it was because their minds and memories were filled with better things. Note, Christ's disciples are often such as have no great forecast for the world.

I.Here is the caution Christ gave them, to beware of the leaven of the Pharisees.

He had now been discoursing with the Pharisees and Sadducees, and saw them to be men of such a spirit, that it was necessary to caution his disciples to have nothing to do with them. Disciples are in most danger from hypocrites; against those that are openly vicious they stand upon their guard, but against Pharisees, who are great pretenders to devotion, and Sadducees, who pretend to a free and impartial search after truth, they commonly lie unguarded: and therefore the caution is doubted, Take heed, and beware.

The corrupt principles and practices of the Pharisees and Sadducees are compared to leaven; they were souring, and swelling, and spreading, like leaven; they fermented wherever they came.

II.Their mistake concerning this caution, Mat 16:7.

They thought Christ hereby upbraided them with their improvidence and forgetfulness, that they were so busy attending to his discourse with the Pharisees, that therefore they forgot their private concerns. Or, because having no bread of their own with them, they must be beholden to their friends for supply, he would not have them to ask it of the Pharisees and Sadducees, nor to receive of their alms, because he would not so far countenance them; or, for fear, lest, under pretence of feeding them, they should do them a mischief. Or, they took it for a caution, not to be familiar with the Pharisees and Sadducees, not to eat with them (Pro 23:6), whereas the danger was not in their bread (Christ himself did eat with them, Luk 7:36; Luk 11:37; Luk 14:1), but in their principles.

III.The reproof Christ gave them for this.

1.He reproves their distrust of his ability and readiness to supply them in this strait (Mat 16:8); "O ye of little faith, why are ye in such perplexity because ye have taken no bread, that ye can mind nothing else, that ye think your Master is as full of it as you, and apply every thing he saith to that?" He does not chide them for their little forecast, as they expected he would. Note, Parents and masters must not be angry at the forgetfulness of their children and servants, more than is necessary to make them take more heed another time; we are all apt to be forgetful of our duty. This should serve to excuse a fault, Peradventure it was an oversight. See how easily Christ forgave his disciples' carelessness, though it was in such a material point as taking bread; and do likewise. But that which he chides them for is their little faith.

(1.)He would have them to depend upon him for supply, though it were in a wilderness, and not to disquiet themselves with anxious thoughts about it. Note, Though Christ's disciples be brought into wants and straits, through their own carelessness and incogitancy, yet he encourages them to trust in him for relief. We must not therefore use this as an excuse for our want of charity to those who are really poor, that they should have minded their own affairs better, and then they would not have been in need. It may be so, but they must not therefore be left to starve when they are in need.

(2.)He is displeased at their solicitude in this matter. The weakness and shiftlessness of good people in their worldly affairs is that for which men are apt to condemn them; but it is not such an offence to Christ as their inordinate care and anxiety about those things. We must endeavour to keep the mean between the extremes of carelessness and carefulness; but of the two, the excess of thoughtfulness about the world worst becomes Christ's disciples. "O ye of little faith, why are ye disquieted for want of bread?" Note, To distrust Christ, and to disturb ourselves when we are in straits and difficulties, is an evidence of the weakness of our faith, which, if it were in exercise as it should be, would ease us of the burthen of care, by casting it on the Lord, who careth for us.

(3.)The aggravation of their distrust was the experience they had so lately had of the power and goodness of Christ in providing for them, Mat 16:9, Mat 16:10. Though they had no bread with them, they had him with them who could provide bread for them. If they had not the cistern, they had the Fountain. Do ye not yet understand, neither remember? Note, Christ's disciples are often to be blamed for the shallowness of their understandings, and the slipperiness of their memories. "Have ye forgot those repeated instances of merciful and miraculous supplies; five thousand fed with five loaves, and four thousand with seven loaves, and yet they had enough and to spare? Remember how many baskets ye took up." These baskets were intended for memorials, by which to keep the mercy in remembrance, as the pot of manna which was preserved in the ark, Exo 16:32. The fragments of those meals would be a feast now; and he that could furnish them with such an overplus then, surely could furnish them with what was necessary now. That meat for their bodies was intended to be meat or their faith (Psa 74:14), which therefore they should have lived upon, now that they had forgotten to take bread. Note, We are therefore perplexed with present cares and distrusts, because we do not duly remember our former experiences of divine power and goodness.

2.He reproves their misunderstanding of the caution he gave them (Mat 16:11); How is it that you do not understand? Note, Christ's disciples may well be ashamed of the slowness and dulness of their apprehensions in divine things; especially when they have long enjoyed the means of grace; I spake it not unto you concerning bread. He took it ill,

(1.)That they should think him as thoughtful about bread as they were; whereas his meat and drink were to do his Father's will.

(2.)That they should be so little acquainted with his way of preaching, as to take that literally which he spoke by way of parable; and should thus make themselves like the multitude, who, when Christ spoke to them in parables, seeing, saw not, and hearing, heard not, Mat 13:13.

IV.The rectifying of the mistake by this reproof (Mat 16:12); Then understood they what he meant.

Note, Christ therefore shows us our folly and weakness, that we may stir up ourselves to take things right. He did not tell them expressly what he meant, but repeated what he had said, that they should beware of the leaven; and so obliged them, by comparing this with his other discourses, to arrive at the sense of it in their own thoughts. Thus Christ teaches by the Spirit of wisdom in the heart, opening the understanding to the Spirit of revelation in the word. And those truths are most precious, which we have thus digged for, and have found out after some mistakes. Though Christ did not tell them plainly, yet now they were aware that by the leaven of the Pharisees and Sadducees, he meant their doctrine and way, which were corrupt and vicious, but, as they managed them, very apt to insinuate themselves into the minds of men like leaven, and to eat like a canker. They were leading men, and were had in reputation, which made the danger of infection by their errors the greater. In our age, we may reckon atheism and deism to be the leaven of the Sadducees, and popery to be the leaven of the Pharisees, against both which it concerns all Christians to stand upon their guard.

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Historical interpretation

Nine Centuries of Reception

10 surviving comments on this verse. Each one is dated, so this reads as a timeline rather than a list.

10 quotes · AD 367–1274
Ante-NicenePost-NiceneEarly MedievalMedieval
4005006007008009001000110012001300

Select a marker to jump to its quote. Markers stagger vertically where authors wrote within a few decades of each other.

AD 367Hilary of Poitiersas quoted by Aquinas, AD 1274Post-NiceneSourceCatena Aurea by Aquinas
Observe, we do not read here as in other places, that He sent the multitudes away and departed; but because the error of unbelief held the minds of the presumptuous, it is said that He left them.

Herein the Apostles are admonished not to be partakers in the doctrine of the Jews; for the works of the Law were established to produce faith, and to prefigure the things that were to follow; and they on whose times truth itself had chanced should look for no further types of truth; lest the teaching of the Pharisees, which knew not of Christ, should stay the effect of Gospel truth.
AD 407John Chrysostomas quoted by Aquinas, AD 1274Post-NiceneSourceCatena Aurea by Aquinas
But that you may learn what force Christ's reproof had upon His disciples, and how it roused their sluggish spirit, hear what says the Evangelist; Then they understood how that he bade them not beware of the leaven of bread, but of the doctrine of the Pharisees and the Sadducees; yet He had not interpreted this to them. This instruction of the Lord them drew them away from Jewish observances, and made them attentive instead of careless, and raised them out of their little faith, that whenever they should seem to have but little provision of bread they should have no fear about food, but should despise all those things.
"And when His disciples," so it is said, "were come to the other side, they forgot to take bread. Then Jesus said unto them, Take heed and beware of the leaven of the Pharisees and of the Sadducees."

And why said He not plainly, Beware of their teaching? His will is to remind them of what had been done, for He knew they had forgotten. But for accusing them at once there seemed to be no reasonable ground, but to take the occasion from themselves, and so to reprove them, would make the charge admissible. "And why did He not then reprove them, when they said, 'Whence should we have so many loaves in the wilderness?' for it seemed a good time then to say what He says here." That He might not seem to rush hastily on the miracle. And besides, He would not blame them before the multitude, nor seek honor in their presence. And now too the accusation had greater reason, for that after repetition of the miracle they were so minded.

Wherefore also He works another miracle, and then and not till then He reproves; I mean, He brings forward what they were reasoning in their hearts. But what were their reasonings? "Because," so it is said, "we have taken no bread." For as yet they were full of trepidation about the purifications of the Jews, and the observances of meats.

Wherefore on all accounts He attacks them even with severity, saying, "Why reason ye in yourselves, O ye of little faith, because ye have brought no bread? Perceive ye not yet, neither understand? Have ye your heart hardened? Having eyes, see ye not? Having ears, hear ye not? Do ye not remember the five loaves of the five thousand, and how many baskets ye took up? neither the seven loaves of the four thousand, and how many baskets ye took up?"

Seest thou intense displeasure? For nowhere else doth He appear to have so rebuked them. Wherefore then doth He so? In order again to cast out their prejudice about the meats. I mean that with this view, whereas then He had only said, "Perceive ye not, neither understand?" in this place, and with a strong rebuke, He saith, "O ye of little faith."

For not everywhere is lenity a good thing. And as He used to allow them freedom of speech, so doth He also reprove, by this variety providing for their salvation. And mark thou at once His reproof, how strong, and His mildness. For all but excusing Himself to them for His severe reproofs to them, He saith, "Do ye not yet consider the five loaves, and how many baskets ye took up; and the seven loaves, and how many baskets ye took up?" And to this end He sets down also the numbers, as well of the persons fed as of the fragments, at once both bringing them to recollection of the past, and making them more attentive to the future.

And to teach thee how great the power of His reproof, and how it roused up their slumbering mind, hear what saith the evangelist. For Jesus having said no more, but having reproved them, and added this only, "How is it that ye do not understand, that I spake it not to you concerning bread that ye should beware, but of the leaven of the Pharisees and Sadducees;" He subjoined, saying, "Then understood they that He bade them not beware of the leaven of bread, but of the doctrine of the Pharisees and Sadducees," although He had not uttered that interpretation.

See how much good His reproof wrought. For it both led them away from the Jewish observances, and when they were remiss, made them more heedful, and delivered them from want of faith; so that they were not afraid nor in alarm, if at any time they seemed to have few loaves; nor were they careful about famine, but despised all these things.
AD 407John Chrysostomas quoted by Aquinas, AD 1274Post-NiceneSourceCatena Aurea by Aquinas
Why did He not say plainly, Take heed of the doctrine of the Pharisees? Because He would remind them of those things that had been done in the multiplication of the loaves, knowing them to be forgetful. To have given them this charge at once bluntly would have seemed unreasonable; but to find fault with them on occasion furnished by themselves prepared the way for the charge; therefore it is that the Evangelist brings forward their thoughts; But they thought within themselves, saying, It is because we have taken no bread.

Because the disciples still grovelled about Jewish observances, the Lord sharply rebukes them for the benefit of all; whence it follows, But Jesus knowing their thoughts said unto them, O ye of little faith, why consider ye among yourselves because ye have no bread?

This He does that He may put away from them all care for food. But why did He not reprove them, when they said, Whence should we have so much bread in the wilderness? for that seemed a more fitting occasion. He did not blame them at that time that He might not seem to be by that urged on to do miracles, and He was unwilling to find fault with them before the people. Also there was more reason in the charge, when after two miracles of multiplication of loaves, they had anxiety about food. Observe with what mildness He rebukes them; He makes an excuse in answer Himself, saying, Do ye not yet understand, nor remember the five loaves?

By this calling to mind what was past, and rousing their attention to what was to come.

But that you may learn what force Christ's reproof had upon His disciples, and how it roused their sluggish spirit, hear what says the Evangelist; Then they understood how that he bade them not beware of the leaven of bread, but of the doctrine of the Pharisees and the Sadducees; yet He had not interpreted this to them. This instruction of the Lord them drew them away from Jewish observances, and made them attentive instead of careless, and raised them out of their little faith, that whenever they should seem to have but little provision of bread they should have no fear about food, but should despise all those things.
AD 420JeromePost-NiceneSourceCOMMENTARY ON MATTHEW 2.16.6-12
This was a favorable opportunity for instruction which was ordered by the Savior. He said, “Beware the leaven of the Pharisees and the Sadducees.” He taught them what the five loaves and seven that had nourished five thousand and four thousand men in the desert signified. He showed that there is a spiritual understanding underlying these events, even if the import of the sign is clear. For if the leaven of the Pharisees and the Sadducees indicated not physical bread but twisted narratives and heretical teaching, then might not also the food by which the people of God were nourished signify the true and complete doctrine?Someone might inquire, “How is it that they do not have the loaves? For they immediately boarded the boat after the seven baskets had been filled.” But the Scripture testifies to the fact that they had forgotten to take food with them.
Remember the leaven about which even the apostle speaks when he writes, “A little leaven spoils the whole dough.” The sort of leaven of which he speaks is something like the kind that Marcion and Valentinus and all heretics exhibited. It is to be avoided by all means.
Leaven has this power, that, if mixed with flour, that which seemed small would grow into something larger and draw to its own essence the whole loaf. So too with heretical doctrine, if it tosses even a tiny spark into your heart, in a short time a huge flame grows beneath and draws to itself a person’s entire substance. It was then that they finally understood that he had not meant them to beware simply of the leaven of bread but of the teaching of the Pharisees and Sadducees.
AD 420Jeromeas quoted by Aquinas, AD 1274Post-NiceneSourceCatena Aurea by Aquinas
For he that takes heed of the leaven of the Pharisees and the Sadducees, does not observe the precepts of the Law and of the letter, and neglects the traditions of men that he may do the commandments of God. This is the leaven of which the Apostle speaks, A little leaven leaveneth the whole lump. (1 Cor. 5:6.) By every means also we should avoid that leaven which Marcion, Valentinus, and all the heretics had. For the nature of leaven is such, that when mixed with flour, that which seemed a little increases to a large quantity, and brings the whole mixture to its own flavour. Thus heretical doctrine if it have cast but a small spark into your breast, in a short time a mighty flame is raised, and drives the whole temper of the man along with it.

How had they no bread, seeing that as soon as they had filled seven baskets they entered into the boat, and came into the parts of Magedan? There they hear that they ought to take heed of the leaven of the Pharisees and Sadducees. But the Scripture is witness that they had forgotten to take the baskets with them.

Thus He takes this occasion to instruct them what is meant by the five loaves and the seven loaves, the five thousand and the four thousand, who were fed in the desert. For if the leaven of the Pharisees and Sadducees signified not earthly food, but corrupt traditions and heretical dogmas, why should not the food with which the people of God is nourished signify the true and uncorrupt doctrine?
AD 420JeromePost-NiceneSourceCommentary on Matthew
(Verses 8 and following.) But Jesus, being aware of this, said to them: Why are you discussing among yourselves, O you of little faith, that you have no bread? Do you still not understand or remember the five loaves for the five thousand men, and how many baskets you took up? Nor the seven loaves for the four thousand men, and how many baskets you took up? How is it that you do not understand that I did not speak to you about bread? Beware of the leaven of the Pharisees and Sadducees. Then they understood that he did not tell them to beware of the leaven of bread, but of the teaching of the Pharisees and Sadducees. By occasion of the precept, which the Savior had commanded, saying: Beware of the leaven of the Pharisees and Sadducees, He teaches them what the five loaves and the seven signify: the five thousand men, and the four thousand, who were fed in the wilderness. Although the greatness of the miracles is clear, yet something else is shown in spiritual understanding. For if the leaven of the Pharisees and Sadducees signifies not bodily bread, but perverse traditions and heretical doctrines, why do the foods, with which the people of God are nourished, not signify the true and complete teaching? Let someone ask and say: How is it that they did not have bread, who, when seven baskets were filled immediately, they got into the boat and came to the region of Magadan; and there the sailors hear that they should beware of the leaven of the Pharisees and Sadducees? But the Scripture testifies that they forgot to take bread with them. This is the leaven that the Apostle speaks of; A little leaven leavens the whole lump (I Cor. V, 6). Marcion and Valentinus and all heretics had this kind of leaven, which is to be avoided in every way. This fermentation has the power that if it is mixed with flour, which seemed small, it grows into something greater, and attracts the entire mixture to its flavor ((or conversion)) : and so also heretical doctrine, if it has thrown even a small spark into your heart, in a short time it grows into a great flame, and draws the entire possession of the person to itself. Finally, it follows: Then they understood that he did not say to beware of leavened bread, but of the doctrine of the Pharisees and Sadducees.
AD 533Remigius of Rheimsas quoted by Aquinas, AD 1274Post-NiceneSourceCatena Aurea by Aquinas
They were bound to their Master with so great affection, that they were unwilling to part from Him for even a moment of time. And herein it should be observed how far they were from any longing for delicacies, when they took so small care for necessaries, that they had even forgotten to take bread, without which human weakness cannot support itself. He said unto them, Take heed and beware of the leaven of the Pharisees; and of the Sadducees.
AD 1107Theophylact of OhridMedieval
Then understood they how that He bade them not beware of the leaven of bread, but of the doctrine of the Pharisees and of the Sadducees. They thought that He was telling them to guard themselves against the stain of Jewish food, which is why they discussed among themselves that they had not brought any bread. He upbraids them for being mindless and of little faith. They were mindless by not remembering how many He had fed with how many loaves; they showed little faith by not believing that Christ Himself could provide bread even if they had not bought any bread from the Jews. As He rebuked them rather sharply — for meekness is not good on every occasion — they immediately understood that by "leaven" He meant "teaching"; such is the effect of a judicious rebuke on any occasion.
AD 1274Glossa Ordinariaas quoted by Aquinas, AD 1274MedievalSourceCatena Aurea by Aquinas
(non occ.) As the Lord had left the Pharisees on account of their unbelief, so now He teaches His disciples to be on their guard against their doctrine; whence it follows, And when His disciples were come to the other side, they had forgotten to take bread.

(ord.) As much as to say; Why do ye think that I spake of earthly bread, for which ye ought not to have a thought, having beheld Me of so little make such abundant overplus?

(interlin.) As much as to say, Do ye not understand the mystery, nor remember the miracle?
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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