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King James Version
And ye shall be betrayed both by parents, and brethren, and kinsfolks, and friends; and some of you shall they cause to be put to death.
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KJV (with Strong's)
And G1161 ye shall be betrayed G3860 both G2532 by G5259 parents G1118, and G2532 brethren G80, and G2532 kinsfolks G4773, and G2532 friends G5384; and G2532 some of G1537 you G5216 shall they cause to be put to death G2289.
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Complete Jewish Bible
You will be betrayed even by parents, brothers, relatives and friends; some of you they will have put to death;
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Berean Standard Bible
You will be betrayed even by parents and brothers and relatives and friends, and some of you will be put to death.
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American Standard Version
But ye shall be delivered up even by parents, and brethren, and kinsfolk, and friends; and some of you shall they cause to be put to death.
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World English Bible Messianic
You will be handed over even by parents, brothers, relatives, and friends. They will cause some of you to be put to death.
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Geneva Bible (1599)
Yea, ye shalbe betrayed also of your parents, and of your brethren, and kinsmen, and friendes, and some of you shall they put to death.
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Young's Literal Translation
`And ye shall be delivered up also by parents, and brothers, and kindred, and friends, and they shall put of you to death;
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In the KJVVerse 25,843 of 31,102

Study This Verse

SUMMARY

Luke 21:16 presents a stark and sobering prophecy from Jesus, delivered as part of His Olivet Discourse, foretelling the intense persecution His followers would face. This particular verse highlights the uniquely painful dimension of this opposition: betrayal not merely by external enemies but by those bound by the closest ties of family and friendship, leading even to martyrdom for some. It underscores the radical cost of discipleship and the profound loyalty demanded by allegiance to Christ.

CONTEXT

  • Literary Context: This verse is deeply embedded within Jesus' extensive eschatological discourse, commonly known as the Olivet Discourse, recorded in Luke 21. Following His pronouncements about the imminent destruction of the Temple in Luke 21:5-6 and the broader signs preceding the end of the age in Luke 21:7-11, Jesus shifts His focus to the personal trials His disciples would endure. He warns them they will be arrested, brought before rulers, and hated by all for His name's sake, yet promises divine assistance in their testimony (Luke 21:12-15). Verse 16 intensifies this warning by specifying the intimate sources of betrayal, a theme powerfully echoed in parallel accounts in Matthew 10:21 and Mark 13:12.
  • Historical & Cultural Context: In the ancient world, and particularly within Jewish society, family bonds were paramount. The extended family (including "kinsfolks" or relatives) and close friends formed the bedrock of social, economic, and religious life. Betrayal from within this intimate circle was not merely a personal slight but a profound rupture of the social fabric, carrying immense shame and often leading to destitution or death for the accused. Jesus' prophecy here would have been particularly shocking and terrifying to His disciples, as it directly challenged the foundational security provided by their most trusted relationships. The Roman Empire, which would soon become the primary persecutor of Christians, often demanded loyalty to the state and emperor above all else, making refusal a capital offense. This context highlights the radical nature of Christian commitment, which, by prioritizing allegiance to Christ, could lead to the severing of even the most sacred human ties.
  • Key Themes: This verse powerfully contributes to several overarching themes within Luke's Gospel and broader New Testament theology. Firstly, it underscores the radical cost of discipleship, making it clear that following Jesus might demand the ultimate sacrifice, including life itself, and the painful severance of cherished human relationships. This aligns with Jesus' earlier teachings about taking up one's cross daily (Luke 9:23) and prioritizing Him above family (Luke 14:26). Secondly, it emphasizes the theme of divine foreknowledge and sovereignty. Jesus' precise and unflinching predictions demonstrate His divine authority and His comprehensive understanding of future events, preparing His disciples for hardships so they would not be surprised or lose faith. Lastly, it highlights the nature of persecution, revealing its insidious ability to infiltrate even the most intimate spheres of life, testing the depth and sincerity of one's faith in the face of ultimate pressure.

EXPOSITION AND ANALYSIS

Key Word Analysis

  • betrayed (Greek, paradídōmi', G3860): Meaning "to surrender, i.e., yield up, intrust, transmit." This word carries the strong connotation of handing someone over, often to an authority for judgment or punishment. It is the same powerful term used to describe Judas's handing over of Jesus to the authorities, implying a deliberate act of treachery that leads to dire consequences.
  • parents (Greek, goneús', G1118): Meaning "a parent." This specific mention underscores the shocking and unnatural nature of the betrayal. In ancient societies, parents were expected to protect and nurture their children; their betrayal would represent a complete inversion of natural order and a profound emotional wound.
  • cause to be put to death (Greek, thanatóō', G2289): Meaning "to kill (literally or figuratively)." This term signifies actual execution or martyrdom. The phrase "some of you shall they cause to be put to death" indicates that while not all disciples would suffer martyrdom, a significant number would, highlighting the extreme stakes of their commitment.

Verse Breakdown

  • "And ye shall be betrayed both by parents, and brethren, and kinsfolks, and friends;": This clause vividly describes the intimate and deeply painful nature of the coming persecution. The list of betrayers—parents, siblings, relatives, and friends—systematically dismantles the most fundamental and trusted relationships in a person's life. This betrayal is not from external enemies, but from those within one's own household and social circle, emphasizing the profound isolation and emotional devastation that would accompany such opposition to Christ. It speaks to a loyalty to the world or to self-preservation that transcends even the strongest familial and social bonds.
  • "and [some] of you shall they cause to be put to death.": This second clause reveals the ultimate consequence of such betrayal and persecution for a portion of Jesus' followers: martyrdom. It is a stark and unvarnished prediction that death awaits some who remain faithful. This is not a generalized threat but a specific warning of lethal intent, underscoring the extreme cost of discipleship and the severity of the trials to come. The phrase "some of you" indicates that while not universal, it would be a real and tragic outcome for many.

Literary Devices

Luke 21:16 employs several potent literary devices to convey its message. Foreshadowing is prominent, as Jesus explicitly predicts future events, preparing His disciples for the severe trials ahead. This prophetic element serves to validate His divine authority and to fortify His followers against surprise and despair. The specific listing of "parents, and brethren, and kinsfolks, and friends" is an example of climax or gradation, moving from the most intimate familial bonds to broader social ties, thereby intensifying the shock and emotional impact of the betrayal. This enumeration also functions as synecdoche, where a part (these specific relationships) stands for the whole (all human relationships), implying that no bond, however sacred, would be immune to the divisive power of allegiance to Christ. Finally, the stark contrast between the expected loyalty of family and friends and their predicted betrayal creates a powerful irony, highlighting the radical and counter-cultural nature of true discipleship.

THEOLOGICAL AND THEMATIC CONNECTIONS

Luke 21:16 profoundly underscores the radical demands of allegiance to Christ, revealing that following Him may necessitate a loyalty that transcends even the most fundamental human bonds. This verse challenges any notion of a cost-free discipleship, emphasizing that commitment to the Kingdom of God can lead to profound personal sacrifice, including the severing of family ties and even martyrdom. Theologically, it aligns with the New Testament's consistent teaching that suffering is an expected part of the Christian life, serving as a refining fire that tests and proves genuine faith, ultimately leading to a deeper reliance on God's sustaining grace. It also highlights the divisive nature of truth in a fallen world, where fidelity to Christ inevitably brings conflict with those who reject Him, even within one's own household.

REFLECTION AND APPLICATION

Luke 21:16, though a prophecy of severe persecution, offers profound insights for believers today. While overt martyrdom by family members may be rare in many contemporary contexts, the principle of betrayal and opposition from unexpected sources remains deeply relevant. Following Christ can still lead to social ostracization, professional setbacks, or intense familial tension when one's commitment to biblical truth clashes with prevailing cultural norms or personal expectations. This verse calls us to examine the depth of our commitment: are we prepared to prioritize Christ above all earthly relationships, even the most cherished ones? It challenges us to cultivate a faith so rooted in Christ that it can withstand the pain of rejection from those we love, reminding us that our ultimate allegiance is to Him alone. In such trials, our steadfastness becomes a powerful testimony to the surpassing worth of knowing Christ.

Questions for Reflection

  • In what ways might loyalty to Christ create tension or division within my own family or closest relationships today?
  • How does Jesus' foreknowledge of these betrayals strengthen my resolve to remain faithful amidst opposition?
  • What does this verse teach me about the true cost of discipleship, and how does it challenge my understanding of commitment to Christ?
  • How can I prepare my heart to respond with grace and truth if I face betrayal or opposition from those closest to me because of my faith?

FAQ

Does Luke 21:16 mean that all Christians will be betrayed by their families and put to death?

Answer: No, Luke 21:16 is a prophetic warning given to Jesus' disciples about the severe persecution they would face, particularly in the early church era and in future periods of intense tribulation. The phrase "some of you" clearly indicates that not all believers would suffer martyrdom, though many would. The primary emphasis is on the nature of the opposition—that it would be deeply personal and come from unexpected sources, including family and friends. While not every Christian will experience literal betrayal leading to death, the principle of facing opposition and the potential for strained relationships due to one's faith in Christ remains relevant for believers across all generations. The New Testament consistently teaches that suffering is a normal part of the Christian life (2 Timothy 3:12).

CHRIST-CENTERED FULFILLMENT

Luke 21:16, while a prophecy of the disciples' suffering, finds its ultimate and most profound fulfillment in the person and experience of Jesus Christ Himself. He is the quintessential example of one "betrayed" by those closest to Him, most notably by Judas, one of His own chosen disciples (Luke 22:47-48). Jesus' entire earthly ministry was marked by rejection and opposition, culminating in His unjust trial and crucifixion, a clear instance of being "put to death" by the authorities, spurred on by His own people (Luke 23:20-25). Furthermore, Jesus had already taught that His coming would bring division, even within families, stating, "Do not think that I have come to bring peace to the earth. I have not come to bring peace, but a sword" (Matthew 10:34-36). Thus, the suffering foretold for His disciples is a direct participation in the pattern of His own life, death, and resurrection. Through His suffering, death, and triumphant resurrection, Christ has overcome the world and its opposition (John 16:33), enabling His followers to endure betrayal and even death with the promise of eternal life and vindication in Him (Revelation 2:10).

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Commentary on Luke 21 verses 5–19

I. II. Main points1. 2. Sub-points(1.) (2.) Details[1.] [2.] Fine details

See here, I. With what admiration some spoke of the external pomp and magnificence of the temple, and they were some of Christ's own disciples too; and they took notice of it to him how it was adorned with goodly stones and gifts, Luk 21:5. The outside was built up with goodly stones, and within it was beautified and enriched with the presents that were offered up for that purpose, and were hung up in it. They thought their Master should be as much affected with those things as they were, and should as much regret the destruction of them as they did. When we speak of the temple, it should be of the presence of God in it, and of the ordinances of God administered in it, and the communion which his people there have with him. It is a poor thing, when we speak of the church, to let our discourse dwell upon its pomps and revenues, and the dignities and powers of its officers and rulers; for the king's daughter is all glorious within.

II. With what contempt Christ spoke of them, and with what assurance of their being all made desolate very shortly (Luk 21:6): "As for those things which you behold, those dear things which you are so much in love with, behold, the days will come, and some now living may live to see them, in which there shall not be left one stone upon another. This building, which seems so beautiful that one would think none could, for pity, pull it down, and which seems so strong that one would think none would be able to pull it down, shall yet be utterly ruined; and this shall be done as soon as ever the spiritual temple of the gospel church (the substance of that shadow) begins to flourish in the world." Did we by faith foresee the blasting and withering of all external glory, we should not set our hearts upon it as those do that cannot see, or will not look, so far before them.

III. With what curiosity those about him enquire concerning the time when this great desolation should be: Master, when shall these things be? Luk 21:7. It is natural to us to covet to know future things and the time of them, which it is not for us to know, when we are more concerned to ask what is our duty in the prospect of these things, and how we may prepare for them, which it is for us to know. They enquire what sign there shall be when these things shall come to pass. They ask not for a present sign, to confirm the prediction itself, and to induce them to believe it (Christ's word was enough for that), but what the future signs will be of the approaching accomplishment of the prediction, by which they may be put in mind of it. These signs of the times Christ had taught them to observe.

IV. With what clearness and fulness Christ answers their enquiries, as far as was necessary to direct them in their duty; for all knowledge is desirable as far as it is in order to practice.

1.They must expect to hear of false Christs and false prophets appearing, and false prophecies given out (Luk 21:8): Many shall come in my name; he does not mean in the name of Jesus, though there were some deceivers who pretended commissions from him (as Act 19:13), but usurping the title and character of the Messiah. Many pretended to be the deliverers of the Jewish church and nation from the Romans, and to fix the time when the deliverance should be wrought, by which multitudes were drawn into a snare, to their ruin. They shall say, hoti egō eimi - I am he, or I am, as if they would assume that incommunicable name of God, by which he made himself known when he came to deliver Israel out of Egypt, I am; and, to encourage people to follow them, they added, "The time draws near when the kingdom shall be restored to Israel, and all who will follow me shall share in it." Now as to this, he gives them a needful caution (1.) "Take heed that you be not deceived; do not imagine that I shall myself come again in external glory, to take possession of the throne of kingdoms. No, you must not expect any such thing, for my kingdom is not of this world." When they asked solicitously and eagerly, Master, when shall these things be? the first word Christ said was, Take heed that you be not deceived. Note, Those that are most inquisitive in the things of God (though it is very good to be so) are in most danger of being imposed upon, and have most need to be upon their guard. (2.) "Go you not after them. You know the Messiah is come, and you are not to look for any other; and therefore do not so much as hearken to them, nor have any thing to do with them." If we are sure that Jesus is the Christ, and his doctrine is the gospel, of God, we must be deaf to all intimations of another Christ and another gospel.

2.They must expect to hear of great commotions in the nations, and many terrible judgments inflicted upon the Jews and their neighbours. (1.) There shall be bloody wars (Luk 21:10): Nation shall rise against nation, one part of the Jewish nation against another, or rather the whole against the Romans. Encouraged by the false Christs, they shall wickedly endeavour to throw off the Roman yoke, by taking up arms against the Roman powers; when they had rejected the liberty with which Christ would have made them free they were left to themselves, to grasp at their civil liberty in ways that were sinful, and therefore could not be successful. (2.) There shall be earthquakes, great earthquakes, in divers places, which shall not only frighten people, but destroy towns and houses, and bury many in the ruins of them. (3.) There shall be famines and pestilences, the common effects of war, which destroys the fruits of the earth, and, by exposing men to ill weather and reducing them to ill diet, occasions infectious diseases. God has various ways of punishing a provoking people. The four sorts of judgments which the Old Testament prophets so often speak of are threatened by the New Testament prophets too; for, though spiritual judgments are more commonly inflicted in gospel times, yet God makes use of temporal judgments also. (4.) There shall be fearful sights and great signs from heaven, uncommon appearances in the clouds, comets and blazing stars, which frighten the ordinary sort of beholders, and have always been looked upon as ominous, and portending something bad. Now, as to these, the caution he gives them is, "Be not terrified. Others will be frightened at them, but be not you frightened, Luk 21:2. As to the fearful sights, let them not be fearful to you, who look above the visible heavens to the throne of God's government in the highest heavens. Be not dismayed at the signs of heaven, for the heathen are dismayed at them, Jer 10:2. And, as to the famines and pestilences, you fall into the hands of God, who has promised to those who are his that in the days of famine they shall be satisfied, and that he will keep them from the noisome pestilence; trust therefore in him, and be not afraid. Nay, when you hear of wars, when without are fightings and within are fears, yet then be not you terrified; you know the worst that any of these judgments can do to you, and therefore be not afraid of them; for," [1.] "It is your interest to make the best of that which is, for all your fears cannot alter it: these things must first come to pass; there is no remedy; it will be your wisdom to make yourselves easy by accommodating yourselves to them." [2.] "There is worse behind; flatter not yourselves with a fancy that you will soon see an end of these troubles, no, not so soon as you think of: the end is not by and by, not suddenly. Be not terrified, for, if you begin so quickly to be discouraged, how will you bear up under what is yet before you?"

3.They must expect to be themselves for signs and wonders in Israel; their being persecuted would be a prognostic of the destruction of the city and temple, which he had now foretold. Nay, this would be the first sign of their ruin coming: "Before all these, they shall lay their hands on you. The judgment shall begin at the house of God; you must smart first, for warning to them, that, if they have any consideration, they may consider, If this be done to the green tree, what shall be done to the dry? See Pe1 4:17, Pe1 4:18. But this is not all; this must be considered not only as the suffering of the persecuted, but as the sin of the persecutors. Before God's judgments are brought upon them, they shall fill up the measure of their iniquity by laying their hands on you." Note, The ruin of a people is always introduced by their sin; and nothing introduces a surer or sorer ruin than the sin of persecution. This is a sign that God's wrath is coming upon a people to the uttermost when their wrath against the servants of God comes to the uttermost. Now as to this,

(1.)Christ tells them what hard things they should suffer for his name's sake, much to the same purport with what he had told them when he first called them to follow him, Mt. 10: They should know the wages of it, that they might sit down and count the cost. St. Paul, who was the greatest labourer and sufferer of them all, not being now among them, was told by Christ himself what great things he should suffer for his name's sake (Act 9:16), so necessary is it that all who will live godly in Christ Jesus should count upon persecution. The Christians, having themselves been originally Jews, and still retaining an equal veneration with them for the Old Testament and all the essentials of their religion, and differing only in ceremony, might expect fair quarter with them; but Christ bids them not expect it: "No, they shall be the most forward to persecute you." [1.] "They shall use their own church-power against you: They shall deliver you up to the synagogues to be scourged there, and stigmatized with their anathemas." [2.] "They shall incense the magistrates against you: they shall deliver you into prisons, that you may be brought before kings and rulers for my name's sake, and be punished by them." [2.] "Your own relations will betray you (Luk 21:16), your parents, brethren, and kinsfolks, and friends; so that you will not know whom to put a confidence in, or where to be safe." [4.] "Your religion will be made a capital crime, and you will be called to resist unto blood. Some of you shall they cause to be put to death; so far must you be from expecting honour and wealth that you must expect nothing but death in its most frightful shapes, death in all its dreadful pomp. Nay." [5.] "You shall be hated of all men for my name's sake." This is worse than death itself, and was fulfilled when the apostles were not only appointed to death, but made a spectacle to the world, and counted as the filth of the world, and the offscouring of all things, which every body loathes, Co1 4:9, Co1 4:13. They were hated of all men, that is, of all bad men, who could not bear the light of the gospel (because it discovered their evil deeds), and therefore hated those who brought in that light, flew in their faces, and would have pulled them to pieces. The wicked world, which hated to be reformed, hated Christ the great Reformer, and all that were his, for his sake. The rulers of the Jewish church, knowing very well that if the gospel obtained among the Jews their usurped abused power was at an end, raised all their forces against it, put it into an ill name, filled people's minds with prejudices against it, and so made the preachers and professors of it odious to the mob.

(2.)He encourages them to bear up under their trials, and to go on in their work, notwithstanding the opposition they would meet with.

[1.]God will bring glory both to himself and them out of their sufferings: "It shall turn to you for a testimony, Luk 21:13. Your being set up thus for a mark, and publicly persecuted, will make you the more taken notice of and your doctrine and miracles the more enquired into; your being brought before kings and rulers will give you an opportunity of preaching the gospel to them, who otherwise would never have come within hearing of it; your suffering such severe things, and being so hated by the worst of men, men of the most vicious lives, will be a testimony that you are good, else you would not have such bad men for your enemies; your courage, and cheerfulness, and constancy under your sufferings will be a testimony for you, that you believe what you preach, that you are supported by a divine power, and that the Spirit of God and glory rests upon you."

[2.]"God will stand by you, and own you, and assist you, in your trials; you are his advocates, and you shall be well furnished with instructions, Luk 21:14, Luk 21:15. Instead of setting your hearts on work to contrive an answer to informations, indictments, articles, accusations, and interrogatories, that will be exhibited against you in the ecclesiastical and civil courts, on the contrary, settle it in your hearts, impress it upon them, take pains with them to persuade them not to meditate before what you shall answer; do not depend upon your own wit and ingenuity, your own prudence and policy, and do not distrust or despair of the immediate and extraordinary aids of the divine grace. Think not to bring yourselves off in the cause of Christ as you would in a cause of your own, by your own parts and application, with the common assistance of divine Providence, but promise yourselves, for I promise you, the special assistance of divine grace: I will give you a mouth and wisdom." This proves Christ to be God; for it is God's prerogative to give wisdom, and he it is that made man's mouth. Note, First, A mouth and wisdom together completely fit a man both for services and sufferings; wisdom to know what to say, and a mouth wherewith to say it as it should be said. It is a great happiness to have both matter and words wherewith to honour God and do good; to have in the mind a storehouse well furnished with things new and old, and a door of utterance by which to bring them forth. Secondly, Those that plead Christ's cause may depend upon him to give them a mouth and wisdom, which way soever they are called to plead it, especially when they are brought before magistrates for his name's sake. It is not said that he will send an angel from heaven to answer for them, though he could do this, but that he will give them a mouth and wisdom to enable them to answer for themselves, which puts a greater honour upon them, which requires them to use the gifts and graces Christ furnishes them with, and redounds the more to the glory of God, who stills the enemy and the avenger out of the mouths of babes and sucklings. Thirdly, When Christ gives to his witnesses a mouth and wisdom, they are enabled to say that both for him and themselves which all their adversaries are not able to gainsay or resist, so that they are silenced, and put to confusion. This was remarkably fulfilled presently after the pouring out of the Spirit, by whom Christ gave his disciples this mouth and wisdom, when the apostles were brought before the priest sand rulers, and answered them so as to make them ashamed, Acts 4, 5, and Act 6:1-15.

[3.]"You shall suffer no real damage by all the hardships they shall put upon you (Luk 21:18): There shall not a hair of your head perish." Shall some of them lose their heads, and yet not lose a hair? It is a proverbial expression, denoting the greatest indemnity and security imaginable; it is frequently used both in the Old Testament and New, in that sense. Some think that it refers to the preservation of the lives of all the Christians that were among the Jews when they were cut off by the Romans; historians tell us that not one Christian perished in that desolation. Others reconcile it with the deaths of multitudes in the cause of Christ, and take it figuratively in the same sense that Christ saith, He that loseth his life for my sake shall find it. "Not a hair of your head shall perish but," First, "I will take cognizance of it." To this end he had said (Mat 10:30), The hairs of your head are all numbered; and an account is kept of them, so that none of them shall perish but he will miss it. Secondly, "It shall be upon a valuable consideration." We do not reckon that lost or perishing which is laid out for good purposes, and will turn to a good account. If we drop the body itself for Christ's name's sake, it does not perish, but is well bestowed. Thirdly, "It shall be abundantly recompensed; when you come to balance profit and loss, you will find that nothing has perished, but, on the contrary, that you have great gain in present comforts, especially in the joys of a life eternal;" so that though we may be losers for Christ we shall not, we cannot, be losers by him in the end.

[4.]"It is therefore your duty and interest, in the midst of your own sufferings and those of the nation, to maintain a holy sincerity and serenity of mind, which will keep you always easy (Luk 21:19): In your patience possess ye your souls; get and keep possession of your souls." Some read it as a promise, "You may or shall possess your souls." It comes all to one. Note, First, It is our duty and interest at all times, especially in perilous trying times, to secure the possession of our own souls; not only that they be not destroyed and lost for ever, but that they be not distempered now, nor our possession of them disturbed and interrupted. "Possess your souls, be your own men, keep up the authority and dominion of reason, and keep under the tumults of passion, that neither grief nor fear may tyrannize over you, nor turn you out of the possession and enjoyment of yourselves." In difficult times, when we can keep possession of nothing else, then let us make that sure which may be made sure, and keep possession of our souls. Secondly, It is by patience, Christian patience, that we keep possession of our own souls. "In suffering times, set patience upon the guard for the preserving of your souls; by it keep your souls composed and in a good frame, and keep out all those impressions which would ruffle you and put you out of temper."

Matthew Henry (1662–1714) — Commentary on the Whole Bible. This section covers verses 5–19. Public domain.
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TertullianAD 220
Against Marcion Book IV
Now, what plea is wiser and more irresistible than the simple and open" confession made in a martyr's cause, who "prevails with God"-which is what "Israel" means? Now, one cannot wonder that He forbade "premeditation," who actually Himself received from the Father the ability of uttering words in season: "The Lord hath given to me the tongue of the learned, that I should know how to speak a word in season (to him that is weary); " except that Marcion introduces to us a Christ who is not subject to the Father. That persecutions from one's nearest friends are predicted, and calumny out of hatred to His name, I need not again refer to.
Gregory of Nyssa (as quoted by Aquinas, AD 1274)AD 395
Catena Aurea by Aquinas
But let us consider the state of things at that time. While all men were suspected, kinsfolk were divided against one another, each differing from the other in religion; the gentile son stood up the betrayer of his believing parents, and of his believing son the unbelieving father became the determined accuser; no age was spared in the persecution of the faith; women were unprotected even by the natural weakness of their sex.
Ambrose of Milan (as quoted by Aquinas, AD 1274)AD 397
Catena Aurea by Aquinas
There are also other wars which the Christian wages, the struggles of different lusts, and the conflicts of the will; and domestic foes are far more dangerous than foreign.

Now in one place Christ speaks in His disciples, as here; in another, the Father; (Mat. 16:17) in another the Spirit of the Father speaketh. (Mat. 10:20.) These do not differ but agree together, In that one speaketh, three speak, for the voice of the Trinity is one.
Cyril of AlexandriaAD 444
COMMENTARY ON LUKE, HOMILY 139
Jesus gives them clear and evident signs of the time when the consummation of the world draws near. He says that there will be wars, turmoil, famines and epidemics everywhere. There will be terrors from heaven and great signs. As another Evangelist says, “All the stars shall fall, and the heaven be rolled up like a scroll, and its powers will be shaken.”In the middle of this, the Savior places what refers to the capture of Jerusalem. He mixes the accounts together in both parts of the narrative. Before all these things, he says, “They will lay their hands on you and persecute you, delivering you up to synagogues and to prisons and bringing you before kings and rulers for my name’s sake. This will be a witness to you.” Before the times of consummation, the land of the Jews was taken captive, and the Roman armies overran it. They burned the temple, overthrew their national government, and stopped the means for legal worship. They no longer had sacrifices, now that the temple was destroyed. The country of the Jews together with Jerusalem itself was totally laid waste. Before these things happened, they persecuted the blessed disciples. They imprisoned them and had a part in unendurable trials. They brought the disciples before judges and sent them to kings. Paul was sent to Rome to Caesar.…
Christ promises, however, that he will deliver them certainly and completely. He says that a hair of your head will not perish.
Cyril of Alexandria (as quoted by Aquinas, AD 1274)AD 444
Catena Aurea by Aquinas
Or He says this, because before that Jerusalem should be taken by the Romans, the disciples, having suffered persecution from the Jews, were imprisoned and brought before rulers; Paul was sent to Rome to Cæsar, and stood before Festus and Agrippa.
It follows, And it shall turn to you for a testimony. In the Greek it is εἰς μαρτύριον, that is, for the glory of martyrdom.
Gregory the Dialogist (as quoted by Aquinas, AD 1274)AD 604
Catena Aurea by Aquinas
(Hom. 35. in Evang.) Because the things which have been prophesied of arise not from the injustice of the inflictor of them, but from the deserts of the world which suffers them, the deeds or wicked men are foretold; as it is said, But before all these things, they shall lay their hands upon you: as if He says, First the hearts of men, afterwards the elements, shall be disturbed, that when the order of things is thrown into confusion, it may be plain from what retribution it arises. For although the end of the world depends upon its own appointed course, yet finding some more corrupt than others who shall rightly be overwhelmed in its fall, our Lord makes them known.

(ut sup.) Or, for a testimony, that is, against those who by persecuting you bring death upon themselves, or living do not imitate you, or themselves becoming hardened perish without excuse, from whom the elect take example that they may live. But as hearing so many terrible things the hearts of men may be troubled, He therefore adds for their consolation, Settle it therefore in your hearts, &c.

(ut sup.) As if the Lord said to His disciples, "Be not afraid, go forward to the battle, it is I that fight; you utter the words, I am He that speaketh."

(ut sup.) We are the more galled by the persecutions we suffer from those of whose dispositions we made sure, because together with the bodily pain, we are tormented by the bitter pangs of lost affection.

(ut sup.) But because of the hard things foretold concerning the affliction of death, there immediately follows a consolation, concerning the joy of the resurrection, when it is said, But there shall not an hair of your head perish. As though He said to the martyrs, Why fear ye for the perishing of that which when cut, pains, when that can not perish in you, which when cut gives no pain?

(Mor. 5. c. 16.) He who preserves patience in adversity, is thereby rendered proof against all affliction, and so by conquering himself, he gains the government of himself; as it follows, In your patience shall ye possess your souls. For what is it to possess your souls, but to live perfectly in all things, and sitting as it were upon the citadel of virtue to hold in subjection every motion of the mind?

(Hom. 35. in Ev.) By patience then we possess our souls, because when we are said to govern ourselves, we begin to possess that very thing which we are. But for this reason, the possession of the soul is laid in the virtue of patience, because patience is the root and guardian of all virtues. Now patience is to endure calmly the evils which are inflicted by others, and also to have no feeling of indignation against him who inflicts them.
Gregory the DialogistAD 604
Forty Gospel Homilies, Homily 35
It follows: "But you will be betrayed by parents and brothers, and relatives and friends, and they will put some of you to death." Evils inflicted by strangers cause lesser pain. But those torments rage more fiercely within us which we suffer from those in whose minds we had confidence, because along with bodily harm, the evils of lost love torment us. Hence it is that the Lord says through the Psalmist concerning Judas His betrayer: "Indeed if my enemy had cursed me, I would have borne it; and if he who hated me had spoken great things against me, I would certainly have hidden myself from him. But you, a man of one mind with me, my guide and my acquaintance, who took sweet food together with me, we walked in the house of God with agreement." And again: "The man of my peace in whom I trusted, and who ate my bread, has greatly plotted treachery against me." As if He says in plain words about His betrayer: I bore his transgression all the more gravely because I perceived it from one who seemed to be mine. All the elect, therefore, because they are members of the supreme Head, also follow their Head in sufferings, so that they feel those very people as adversaries in their death from whose life they had confidence, and their reward of labor increases all the more as the gain of their virtue profits from another's loss of love.
Bede (as quoted by Aquinas, AD 1274)AD 735
Catena Aurea by Aquinas
Or else, There shall not perish a hair of the head of our Lord's Apostles, because not only the noble deeds and words of the Saints, but even the slightest thought shall meet with its deserving reward.
BedeAD 735
On the Gospel of Luke
But you will be betrayed by parents and brothers and relatives and friends, and they will put some of you to death, and you will be hated by everyone because of my name. Lesser pain is caused by evils inflicted by strangers; indeed, the torments rage more within us that we suffer from those minds of whom we had confidence because with the loss of body, the evils torment us of lost charity. But because hard things are predicted about the affliction of death, immediately consolation is added about the joy of resurrection, when it is said:
Theophylact of Ohrid (as quoted by Aquinas, AD 1274)AD 1107
Catena Aurea by Aquinas
For because they were foolish and inexperienced, the Lord tells them this, that they might not be confounded when about to give account to the wise. And He adds the cause, For I will give you a mouth and wisdom, which all your adversaries shall not be able to gainsay or resist. As if He said, Ye shall forthwith receive of me eloquence and wisdom, so that all your adversaries, were they gathered together in one, shall not be able to resist you, neither in wisdom, that is, the power of the understanding, nor in eloquence, that is, excellence of speech, for many men have often wisdom in their mind, but being easily provoked to their great disturbance, mar the whole when their time of speaking comes, But not such were the Apostles, for in both these gifts they were highly favoured.

Having in what has gone before dispelled the fear of inexperience, He goes on to warn them of another very certain event, which might agitate their minds, lest falling suddenly upon them, it should dismay them; for it follows, And ye shall be betrayed both by parents, and brethren, and kinsfolk, and some of you shall they cause to be put to death.

To all this He adds the hatred which they shall meet with from all men.
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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