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Revelation 17:1

“The Judgment of the Great Harlot”Revelation 17:1–6

King James Version
And there came one of the seven angels which had the seven vials, and talked with me, saying unto me, Come hither; I will shew unto thee the judgment of the great whore that sitteth upon many waters:

Bible text: King James Version (1769 Blayney text) · Public domain

KJV (with Strong's)
And G2532 there came G2064 one G1520 of G1537 the seven G2033 angels G32 which G3588 had G2192 the seven G2033 vials G5357, and G2532 talked G2980 with G3326 me G1700, saying G3004 unto me G3427, Come hither G1204; I will shew G1166 unto thee G4671 the judgment G2917 of the great G3173 whore G4204 that sitteth G2521 upon G1909 many G4183 waters G5204:

Bible text: King James Version with Strong's numbers · Public domain

Berean Standard Bible
Then one of the seven angels with the seven bowls came and said to me, “Come, I will show you the punishment of the great prostitute, who sits on many waters.

Bible text: Berean Standard Bible · Public domain

American Standard Version
And there came one of the seven angels that had the seven bowls, and spake with me, saying, Come hither, I will show thee the judgment of the great harlot that sitteth upon many waters;

Bible text: American Standard Version (1901) · Public domain

World English Bible Messianic
One of the seven angels who had the seven bowls came and spoke with me, saying, “Come here. I will show you the judgment of the great prostitute who sits on many waters,

Bible text: World English Bible, Messianic edition · Public domain

Geneva Bible (1599)
Then there came one of the seuen Angels, which had the seuen vials, and talked with me, saying vnto me, Come: I will shewe thee the damnation of the great whore that sitteth vpon many waters,

Bible text: Geneva Bible (1599) · Public domain

Young's Literal Translation
And there came one of the seven messengers, who were having the seven vials, and he spake with me, saying to me, `Come, I will shew to thee the judgment of the great whore, who is sitting upon the many waters,

Bible text: Young's Literal Translation · Public domain

King James Version — Interlinear
34 Greek words
  1. ΚαὶKaiAndG2532CONJConjunction
  2. ἦλθενēlthencameG2064V-2AAI-3SVerb 2nd Aorist Active Indicative 3rd Singular
  3. εἷςheisoneG1520A-NSMAdjective Nominative Singular Masculine
  4. ἐκekofG1537PREPPreposition
  5. τῶνtōntheG3588T-GPMDefinite article Genitive Plural Masculine
  6. ἑπτὰheptasevenG2033A-NUIAdjective
  7. ἀγγέλωνangelōnangelsG32N-GPMNoun Genitive Plural Masculine
  8. τῶνtōnthoseG3588T-GPMDefinite article Genitive Plural Masculine
  9. ἐχόντωνechontōnhavingG2192V-PAP-GPMVerb Present Active Participle Genitive Plural Masculine
  10. τὰςtastheG3588T-APFDefinite article Accusative Plural Feminine
  11. ἑπτὰheptasevenG2033A-NUIAdjective
  12. φιάλαςphialasbowlsG5357N-APFNoun Accusative Plural Feminine
  13. καὶkaiandG2532CONJConjunction
  14. ἐλάλησενelalēsenspokeG2980V-AAI-3SVerb Aorist Active Indicative 3rd Singular
  15. μετ᾽met᾽withG3326PREPPreposition
  16. ἐμοῦemoumeG1473S-1SGSNPossessive pronoun Genitive 1st Person Singular Neuter
  17. λέγωνlegōnsayingG3004V-PAP-NSMVerb Present Active Participle Nominative Singular Masculine
  18. μοι·moito meG3165P-1DSPersonal pronoun Dative 1st Singular
  19. δεῦροdeuroCome hereG1204INJInterjection
  20. δείξωdeixōI will showG1166V-FAI-1SVerb Future Active Indicative 1st Singular
  21. σοιsoiyouG4771P-2DSPersonal pronoun Dative 2nd Singular
  22. τὸtotheG3588T-ASNDefinite article Accusative Singular Neuter
  23. κρίμαkrimapunishmentG2917N-ASNNoun Accusative Singular Neuter
  24. τῆςtēsof theG3588T-GSFDefinite article Genitive Singular Feminine
  25. πόρνηςpornēsprostituteG4204N-GSFNoun Genitive Singular Feminine
  26. τῆςtēs[the]G3588T-GSFDefinite article Genitive Singular Feminine
  27. μεγάληςmegalēsgreatG3173A-GSFAdjective Genitive Singular Feminine
  28. τῆςtēswhoG3588T-GSFDefinite article Genitive Singular Feminine
  29. καθημένηςkathēmenēsis sittingG2521V-PNP-GSFVerb Present Middle Or Passive Deponent Participle Genitive Singular Feminine
  30. ἐπὶepiuponG1909PREPPreposition
  31. τῶνtōn[the]G3588T-GPNDefinite article Genitive Plural Neuter
  32. ὑδάτωνhudatōnwatersG5204N-GPNNoun Genitive Plural Neuter
  33. τῶνtōn[the]G3588T-GPNDefinite article Genitive Plural Neuter
  34. πολλῶνpollōnmanyG4183A-GPNAdjective Genitive Plural Neuter
English is a literal word-by-word gloss of the Greek, not the KJV's wording. Why?

This is the original text the KJV's translators worked from — each Greek word with its own literal English meaning in this verse, prepared by scholars at Tyndale House, Cambridge. The KJV translates whole sentences, not word by word, so its wording differs: one Greek word can become several English words, and the KJV may choose “charity” where the gloss reads “love”. Both are faithful — they answer different questions. For the KJV's own rendering, switch to the KJV text.

Words in [ ] are added by the English.

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This verse

One of the angels who poured out the bowls of God’s wrath calls John to come and see God’s sentence on the great whore who sits as ruler over many peoples.

“And there came one of the seven angels which had the seven vials,”

One of the angels who poured out the last plagues in chapter 16, so this vision explains the judgments just finished and names their target.

“and talked with me, saying unto me, Come hither;”

A personal summons, deûro, calling John to a closer place from which to see.

“I will shew unto thee the judgment of the great whore”

The angel promises to show her kríma, the verdict God has given. Her judgment is the subject of the whole vision, and chapter 18 tells of her fall.

“that sitteth upon many waters:”

Jeremiah’s words to Babylon on the Euphrates. Verse 15 explains the waters as peoples, multitudes, nations and tongues, and sitting over them means ruling them.

Passage studyRevelation 17:1–6

The Judgment of the Great Whore

1And there came one of the seven angels which had the seven vials, and talked with me, saying unto me, Come hither; I will shew unto thee the judgment of the great whore that sitteth upon many waters: 2With whom the kings of the earth have committed fornication, and the inhabitants of the earth have been made drunk with the wine of her fornication. 3So he carried me away in the spirit into the wilderness: and I saw a woman sit upon a scarlet coloured beast, full of names of blasphemy, having seven heads and ten horns. 4And the woman was arrayed in purple and scarlet colour, and decked with gold and precious stones and pearls, having a golden cup in her hand full of abominations and filthiness of her fornication: 5And upon her forehead was a name written, MYSTERY, BABYLON THE GREAT, THE MOTHER OF HARLOTS AND ABOMINATIONS OF THE EARTH. 6And I saw the woman drunken with the blood of the saints, and with the blood of the martyrs of Jesus: and when I saw her, I wondered with great admiration.

Summary

One of the seven angels who poured out the vials of God’s wrath takes John aside to show him the judgment of the great whore who sits upon many waters. In the wilderness John sees a woman riding a scarlet beast that is covered with names of blasphemy and has seven heads and ten horns. She is dressed in purple and scarlet and decked with gold, precious stones and pearls, and in her hand is a golden cup full of abominations. The name on her forehead is MYSTERY, BABYLON THE GREAT, THE MOTHER OF HARLOTS AND ABOMINATIONS OF THE EARTH, and she is drunk with the blood of the saints and the martyrs of Jesus. God lets John see the world’s great seducer as she truly is, splendid on the outside, filthy within and murderous toward his people, and he shows her already under his sentence.

Who shows John the great whore, and why

The messenger is “one of the seven angels which had the seven vials”, the angels who have just poured out the last plagues of God’s wrath in Revelation 16. That chapter ends with great Babylon remembered before God (Revelation 16:19), and now one of the same angels comes to explain who she is and why she is judged. This vision belongs with those judgments as their explanation, and it leads on into the fall of Babylon in Revelation 18.

The angel speaks to John directly. “Come hither” translates deûro, a command to come, and it calls John to a nearer place from which to see. “I will shew” is deiknýō, to show. What he will show is the kríma of the great whore, a word that means a decision, verdict or sentence. Here it is the sentence God has passed on her, and the rest of this chapter and all of the next set out what it is.

Why she is called a whore

The word pórnē means a prostitute, and mégas, “great”, marks her as great in size and reach. The prophets often pictured a city or nation that had turned from God to idols and to proud alliances as a harlot. Isaiah mourned over Jerusalem, “How is the faithful city become an harlot!” (Isaiah 1:21), and Ezekiel gave a whole chapter to Jerusalem’s harlotry (Ezekiel 16). The same picture was used of foreign cities, of Nineveh in Nahum 3:4 and of Tyre in Isaiah 23:17. So in “the great whore” John’s first readers would hear of a power that draws people away from the true God and sells itself for gain.

What the many waters are

“Sitteth upon many waters” recalls the words Jeremiah spoke to Babylon, “O thou that dwellest upon many waters” (Jeremiah 51:13), for ancient Babylon stood on the Euphrates and ruled many peoples. The word hýdōr is the ordinary word for water, and the angel himself explains it later in the chapter: “The waters which thou sawest, where the whore sitteth, are peoples, and multitudes, and nations, and tongues” (Revelation 17:15). She sits as ruler over the nations of the world.

What her fornication with the kings means

The verb porneúō means to act the harlot, and figuratively to practise idolatry, and the noun porneía means harlotry, which in the prophets above all means idolatry. The fornication of verse 2 is first of all spiritual unfaithfulness, where people who owe their worship and loyalty to God give them to other gods, to worldly powers and to gain. The prophets charged Israel with this very sin. Jeremiah speaks of Israel’s adulteries (Jeremiah 3:8–9), Hosea’s own marriage became a picture of Israel’s unfaithfulness (Hosea 1–3), Hosea says that “the spirit of whoredoms hath caused them to err” (Hosea 4:12), and Ezekiel says punishment comes because Israel went whoring after the nations (Ezekiel 23:30). James uses the same language for believers who love the world: “Ye adulterers and adulteresses, know ye not that the friendship of the world is enmity with God?” (James 4:4).

“The kings of the earth” are the rulers of the world. In John’s day they would have included the Roman emperors with the client kings and governors under them. They join themselves to her and profit from her, giving her their allegiance and resources in return for power, wealth and influence. The word for earth, gē, means the earth or the land, and it can take in the people who live on it, so “the kings of the earth” and “the inhabitants of the earth” together reach from the throne to the common people.

The wine that makes the nations drunk

The inhabitants of the earth “have been made drunk with the wine of her fornication”. The verb methýō means to drink to intoxication, to get drunk. Her wine is everything she offers to draw people away from God: pleasure, prosperity, false promises and false teaching. Like strong drink it clouds judgment, so that people lose the power to tell truth from error and join in her idolatry willingly. Jeremiah used the same picture of a cup for ancient Babylon, as verse 4 shows.

The woman on the scarlet beast

The angel carries John away “in the spirit”, en pneumati. The word pneûma means breath or wind and, by analogy, a spirit, and here it means that God’s Spirit took hold of John and enabled him to see spiritual realities beyond ordinary sight. Ezekiel tells of the Spirit lifting him up and taking him away in the same way (Ezekiel 3:12–14). The place is the wilderness, eremos, which in Scripture is a place of desolation and judgment and also a place where God meets his people and speaks to them, as he did with Israel on its journey and with Elijah. There, away from the noise of her cities, John sees her plainly.

He sees “a woman”, gynḗ, the ordinary word for a woman or wife. The prophets used a woman as a picture of a city or a people, faithful or unfaithful, and this woman is soon named as Babylon the Great. She sits on “a scarlet coloured beast”. The word thēríon means a wild beast or animal, and in Daniel’s visions beasts stand for kingdoms and empires (Daniel 7). Her sitting on the beast shows a close alliance between them. She rides it, so she directs it, and she is carried along by its power. Its scarlet colour, kokkinos, speaks of luxury and royalty, and also of sin and bloodshed.

The beast is “full of names of blasphemy”. It openly defies God, speaks against him, claims for itself what belongs to God alone and demands the worship that is his. Paul describes the man of sin in similar terms, as one who exalts himself above all that is called God (2 Thessalonians 2:3–4).

The seven heads and ten horns

The angel interprets these himself. The seven heads are seven mountains and seven kings (Revelation 17:9–10), and the ten horns are ten kings who receive power with the beast (Revelation 17:12). The same marks appear on the great red dragon (Revelation 12:3) and on the beast that rises out of the sea (Revelation 13:1–2), and the ten horns go back to the fourth beast of Daniel’s vision (Daniel 7:7–8). So this beast belongs with the powers opposed to God that run through Daniel and through Revelation 12 and 13, one continuing line of oppression that reaches its height at the end. Believers differ on the details. Many take the seven mountains to point to Rome, some take the seven heads as a succession of world empires and others as a complete system of rule, and many look for the ten kings in a coalition of rulers still to come.

Splendour outside and filth inside

The woman is “arrayed in purple and scarlet colour”. These were the colours of royalty and wealth, made with costly dyes and worn by the rich and powerful. She is “decked”, gilded or adorned with gold, chrysóō, “with gold and precious stones and pearls”. By the world’s measure she is glorious and desirable, and she appeals to every human longing for wealth and status. Ezekiel’s account of Jerusalem’s harlotry belongs beside this verse (Ezekiel 16:15–19).

In her hand is “a golden cup … full of abominations and filthiness of her fornication”. The cup is gold, and what it holds is repulsive. The word for full, gémō, means to be full or filled. “Abominations” is bdélygma, something detestable, an object of disgust, and in the Greek Old Testament and the New Testament it is often used of idols and idolatrous worship. “Fornication” here is porneía again, the unfaithfulness of verse 2, and its “filthiness” is the defilement it leaves behind. A golden cup in the hand also calls to mind the drink offerings poured out in pagan worship.

Jeremiah used this picture of ancient Babylon: “Babylon hath been a golden cup in the LORD’s hand, that made all the earth drunken” (Jeremiah 51:7). The wine she gives the nations in verse 2 comes from this cup, and its gold is the bait. What the world admires and desires can be detestable to God, which is why John writes elsewhere, “Love not the world, neither the things that are in the world” (1 John 2:15). All her splendour comes to its end when the cry goes up, “Babylon the great is fallen, is fallen” (Revelation 18:2).

The name on her forehead

“And upon her forehead was a name written.” In John’s day a mark on the forehead could show that a slave belonged to a master, that a priest was dedicated, or that a criminal or prostitute stood in public shame. This woman’s name is written where everyone can read it, so the mark that identifies her also declares her disgrace.

The first word of the name is “MYSTERY”, mystḗrion, a secret once hidden and now made known by God to those he shows it to. Human reason alone could never discern her true nature, and here God reveals it. Paul speaks in a similar way of “the mystery of iniquity” already at work in the world, which the Lord will reveal and destroy (2 Thessalonians 2:7).

“BABYLON THE GREAT”. Babylṓn comes from the Hebrew Babel, which carries the sense of confusion. Ancient Babylon was the empire that conquered Judah, destroyed Jerusalem and carried God’s people into exile (2 Kings 25), and its name stood for pride, idolatry and oppression. The prophets announced God’s judgment against it (Isaiah 13:1). In Revelation the name becomes the title of the whole world power that takes that city’s place against God, and “the great” marks the reach of her influence and the size of her wickedness.

“THE MOTHER OF HARLOTS AND ABOMINATIONS OF THE EARTH” makes her the source of all the spiritual unfaithfulness the prophets condemned, the harlotry of Hosea 1 and of Ezekiel 23. She brings it to birth and nurtures it, and from her come the idolatry, injustice, violence and moral corruption that defile the earth.

Who is Babylon the Great?

The angel gives his own answer at the end of the chapter: “And the woman which thou sawest is that great city, which reigneth over the kings of the earth” (Revelation 17:18). Believers differ on how to name that city. For John’s first readers, who were suffering under Rome, the name pointed to Rome, the great power of their day, and “Babylon” was used then as a veiled name for it. Some believers see in her chiefly a false religious system, others a world economic power or political empire, and others a union of all three. Many hold that she stands for every power in history that opposes God and leads the world into idolatry, and that she comes to a final, full form before Christ returns, in the city whose fall is described in Revelation 18. On every reading she is the enemy of God and of his people, and God judges her.

Drunk with the blood of the saints

John sees “the woman drunken with the blood of the saints, and with the blood of the martyrs of Jesus”. The verb is methýō again. She made the nations drunk with the wine of her fornication in verse 2, and now she herself is drunk with blood. The picture is of someone who has drunk deeply and kept on drinking, utterly given over to the killing of God’s people. The word haîma, blood, stands for life violently taken, and it is said twice.

The saints are God’s people, set apart for him. The martyrs of Jesus are named alongside them. The word mártys means a witness and, by analogy, a martyr, so these are the people who bore witness to Jesus and paid for it with their lives, singled out because of their testimony. For John’s first readers this was close at hand, since testimony to Jesus could bring prison, torture and death under emperors such as Nero and Domitian. Jesus told his disciples, “ye shall be hated of all nations for my name’s sake” (Matthew 24:9), and Paul wrote, “all that will live godly in Christ Jesus shall suffer persecution” (2 Timothy 3:12).

God has counted this blood. The souls under the altar, slain for the word of God, cry out for him to judge and avenge them (Revelation 6:9–11), and when Babylon falls, “in her was found the blood of prophets, and of saints” (Revelation 18:24). To persecute God’s people is to attack God himself, and the sentence of verse 1 is his answer.

Did John admire the woman?

John was astonished at her. In the English of the KJV, “admiration” means wonder and amazement, and the Greek word is thaûma, wonder. John is bewildered by the depth of her wickedness and by the suffering she has brought on God’s people, and his wonder is what leads the angel to explain the woman and the beast (Revelation 17:7–18).

The Lamb who overcomes her

Over against the whore stand the Lamb and his bride. The beast is full of names of blasphemy, and Christ bears “a name which is above every name” (Philippians 2:9–11). The beast and its kings make war with the Lamb, and the Lamb overcomes them (Revelation 17:14), for he is “KING OF KINGS, AND LORD OF LORDS” (Revelation 19:16) and comes as the rider on the white horse to judge and make war (Revelation 19:11–16). He has already triumphed over principalities and powers at the cross (Colossians 2:15), and his victory ends in the great voices of heaven: “The kingdoms of this world are become the kingdoms of our Lord, and of his Christ” (Revelation 11:15).

The kings of the earth sell their loyalty to the woman, and Christ remained faithful to his Father, obedient unto death (Philippians 2:8). The woman is dressed in purple and gold, and he came in humility, “not to be ministered unto, but to minister, and to give his life a ransom for many” (Mark 10:45). His kingdom is “not of this world” (John 18:36). She offers a cup of filth, and he offers living water that satisfies thirst for ever (John 4:10–14). Her deceptions keep the world in darkness, and he came as the light that exposes it (John 3:19).

The blood in verse 6 has its answer in his blood. Babylon is drunk with the blood of the innocent, and Christ’s blood was shed “for the remission of sins” (Matthew 26:28) when he “suffered without the gate” (Hebrews 13:12). He is “the Lamb of God, which taketh away the sin of the world” (John 1:29), and he cleanses people from the very abominations her cup holds. The martyrs who die for him share in the fellowship of his sufferings (Philippians 3:10), and the slain Lamb, who alone is worthy to open the scroll (Revelation 5:6–10), will see that every drop of their blood is avenged.

The woman also has a counterpart. Christ loves the church and gives himself for her, to present her “not having spot, or wrinkle, or any such thing” (Ephesians 5:25–27). The marriage of the Lamb follows the fall of Babylon (Revelation 19:7–9), and John later sees the holy city, new Jerusalem, “prepared as a bride adorned for her husband” (Revelation 21:2–3). The harlot’s jewels are paid for with unfaithfulness and blood, and the bride’s beauty is her husband’s gift. In that city “God shall wipe away all tears from their eyes” (Revelation 21:4).

Keeping faith while Babylon glitters

These verses teach us to see as God sees. Babylon still dresses in purple and gold, and her cup still looks precious, whether it holds wealth, power, comfort, the world’s approval or even a good cause that has become our ultimate concern. The angel shows us what is in the cup, so that we can recognise her offers and refuse them. Whatever asks for the loyalty that belongs to Christ is her wine, however good it looks, and Scripture calls us to be sober and vigilant (1 Peter 5:8) and to keep our devotion to him whole.

Her wine reaches kings and ordinary people alike, so each of us can ask where we have made peace with what God hates. The voice from heaven is plain: “Come out of her, my people, that ye be not partakers of her sins” (Revelation 18:4).

For believers who suffer for Jesus, verse 6 is a word of comfort. God sees every drop of his people’s blood, and he has already passed sentence on those who shed it. Babylon looks great, yet she rides a beast destined for destruction, and the Lamb shall overcome. Those who belong to him can stand firm and stay faithful, waiting for the kingdom that is surely coming.

Last revised

Public-domain commentary

Matthew Henry

From his Commentary on the Whole Bible. Henry wrote on whole passages, and this entry covers Revelation 17:1–6.

1662–1714 · 6 verses
Passage under commentRevelation 17:1–6

Here we have a new vision, not as to the matter of it, for that is contemporary with what came under the three last vials; but as to the manner of description, etc. Observe, 1. The invitation given to the apostle to take a view of what was here to be represented: Come hither, and I will show thee the judgment of the great whore, etc., Revelation 17:1. This is a name of great infamy. A whore [in this passage] is one that is married, and has been false to her husband's bed, has forsaken the guide of her youth, and broken the covenant of God. She had been a prostitute to the kings of the earth, whom she had intoxicated with the wine of her fornication. 2. The appearance she made: it was gay and gaudy, like such sort of creatures: She was arrayed in purple, and scarlet colour, and decked with gold, and precious stones, and pearls, Revelation 17:4. Here were all the allurements of worldly honour and riches, pomp and pride, suited to sensual and worldly minds. 3. Her principal seat and residence - upon the beast that had seven heads and ten horns; that is to say, Rome, the city on seven hills, infamous for idolatry, tyranny, and blasphemy. 4. Her name, which was written on her forehead. It was the custom of impudent harlots to hang out signs, with their names, that all might know what they were. Now in this observe, (1.) She is named from her place of residence - Babylon the great. But, that we might not take it for the old Babylon literally so called, we are told there is a mystery in the name; it is some other great city resembling the old Babylon. (2.) She is named from her infamous way and practice; not only a harlot, but a mother of harlots, breeding up harlots, and nursing and training them up to idolatry, and all sorts of lewdness and wickedness - the parent and nurse of all false religion and filthy conversation. 5. Her diet: she satiated herself with the blood of the saints and martyrs of Jesus. She drank their blood with such greediness that she intoxicated herself with it; it was so pleasant to her that she could not tell when she had had enough of it: she was satiated, but never satisfied.

Historical interpretation

Five Centuries of Reception

6 surviving comments on this verse. Each one is dated, so this reads as a timeline rather than a list.

6 quotes · AD 258–735
Ante-NicenePost-NiceneEarly Medieval
300400500600700

Select a marker to jump to its quote. Markers stagger vertically where authors wrote within a few decades of each other.

That a woman ought not to be adorned in a worldly fashion. In the Apocalypse: "And there came one of the seven angels having vials, and approached me, saying, Come, I will show thee the condemnation of the great whore, who sitteth upon many waters, with whom the kings of the earth have committed fornication. And I saw a woman who sate upon a beast. And that woman was clothed with a purple and scarlet robe; and she was adorned with gold, and precious stones, and pearls, holding a golden cup in her hand full of curses, and impurity, and fornication of the whole earth." Also to Timothy: "Let your women be such as adorn themselves with shamefacedness and modesty, not with twisted hair, nor with gold, nor with pearls, or precious garments, but as becometh women professing chastity, with a good conversation." Of this same thing in the Epistle of Peter to the people at Pontus: "Let there be in a woman not the outward adorning of ornament, or of gold, or of apparel, but the adorning of the heart." Also in Genesis: "Thamar covered herself with a cloak, and adorned herself; and when Judah beheld her, she appeared to him to be a harlot."
"There came one of the seven angels, which have the seven bowls, and spake with me, saying, Come, I will show thee the judgment of that great whore who sitteth upon many waters. And I saw the woman drunk with the blood of the saints, and with the blood of the martyrs." The decrees of that senate are always accomplished against all, contrary to the preaching of the true faith; and now already mercy being cast aside, itself here gave the decree among all nations.
d. AD 550OecumeniusPost-NiceneSourceCommentary on Revelation
Having fulfilled the matters concerning the end of the present age, the vision turns to another thing, wishing to show the evangelist the matters concerning Rome. And he says, "Come, I will show you the judgment of the great prostitute who sits on many waters" speaking of "judgment", meaning her conduct and her society, in which she has been judged to be and how she pursues it.

And he calls her a "prostitute", as one prostituting herself and apostatizing from God; for this too is called prostitution in divine Scripture according to what was said by the prophet to the God of all: "You have destroyed everyone that commits fornication against you.." (Ps. 72:27)

And he says there are "many waters", over which she rules and which are governed, as he himself says.
d. AD 560Primasius of HadrumetumPost-NiceneSourceCOMMENTARY ON THE APOCALYPSE 17:1
Isaiah speaks of the devil in a similar manner when he foretells the fall [of the devil] under the figure of the leader of Babylon. “How you are fallen from heaven, O Lucifer, who has risen in the morning.” Speaking of the body of all the lost, which he often calls by various yet suitable names, the Holy Spirit considers that it always moves to a greater variety of excesses and is corrupted by its wickedness and is hooked on its errors and is made mad by such a level of impiety that it is opposed by the gentle. And so [the Holy Spirit] depicts this body which is perishing with a suitable description, calling it a “harlot.” For being forsaken by the Creator, she has given herself over to prostitution, allowing herself to be ravished by demons. She is called “great” because of the enormity of her transgressions through which she has offended the saints for a long time. She sits upon many waters, that is, upon many nations.
d. AD 614Andreas of CaesareaEarly MedievalSourceCOMMENTARY ON THE APOCALYPSE 17:1-3
Some consider this harlot to be old Rome, since she sits on seven hills, and the seven heads of the beast that carries [the harlot] to be the more ungodly kings from Domitian to Diocletian who persecuted the church. However, we are guided as much as possible by the sequence of events and think that she is either the earthly kingdom generally, depicted as in one body, or that city that is ruled until the arrival of the antichrist. For old Rome lost the power of dominion a long time ago, and we do not suppose that the ancient status will again return to it. But should we grant this, the power that governs today will have been destroyed beforehand. For the Revelation says, “The woman that you saw is the great city that has dominion over the kings of the earth.”
d. AD 735BedeEarly MedievalSourceCommentary on Revelation
Come, I will show you the condemnation of the great harlot, etc. The multitude of the lost, who, forsaking the Creator, surrendered themselves to demons to be defiled, is remembered as sitting on the waters, that is, in the discord of the peoples. Conversely, the multitude of believers was of one heart and one soul. Whom the Apostle betrothed to one man to present a chaste virgin to Christ.
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.

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