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King James Version
And he stretched forth his hand toward his disciples, and said, Behold my mother and my brethren!
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KJV (with Strong's)
And G2532 he stretched forth G1614 his G846 hand G5495 toward G1909 his G846 disciples G3101, and said G2036, Behold G2400 my G3450 mother G3384 and G2532 my G3450 brethren G80!
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Complete Jewish Bible
Pointing to his talmidim, he said, "Look! Here are my mother and my brothers!
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Berean Standard Bible
Pointing to His disciples, He said, “Here are My mother and My brothers.
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American Standard Version
And he stretched forth his hand towards his disciples, and said, Behold, my mother and my brethren!
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World English Bible Messianic
He stretched out his hand towards his disciples, and said, “Behold, my mother and my brothers!
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Geneva Bible (1599)
And he stretched foorth his hand toward his disciples, and said, Beholde my mother and my brethren.
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Young's Literal Translation
And having stretched forth his hand toward his disciples, he said, `Lo, my mother and my brethren!
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In the KJVVerse 23,539 of 31,102

Study This Verse

SUMMARY

Matthew 12:49 captures a pivotal moment in Jesus' ministry where He redefines the concept of family, shifting the emphasis from biological lineage to spiritual kinship. In response to being told His mother and brothers were seeking Him, Jesus gestures towards His disciples, declaring them to be His true family, thereby establishing a new paradigm where obedience to God's will takes precedence over earthly ties. This declaration profoundly impacts the understanding of discipleship and the nature of God's household.

CONTEXT

  • Literary Context: This verse immediately follows a brief narrative in Matthew 12:46-48 where Jesus' mother and brothers arrive, seeking to speak with Him while He is teaching a crowd. The interruption serves as a literary device to prompt Jesus' profound teaching on spiritual family. Prior to this, Jesus has been engaged in a series of confrontations with the Pharisees, culminating in their accusation that He casts out demons by the power of Beelzebul (Matthew 12:24). His subsequent teaching on the unforgivable sin and the tree known by its fruit (Matthew 12:31-37) sets the stage for His redefinition of identity and belonging, moving from external appearances or earthly relationships to internal spiritual alignment. The passage concludes with Jesus' explicit statement in Matthew 12:50 that "whosoever shall do the will of my Father which is in heaven, the same is my brother, and sister, and mother."
  • Historical & Cultural Context: In ancient Jewish society, family (the mishpachah) was the foundational unit of identity, security, and social structure. Lineage and blood ties were paramount, carrying significant social and religious weight, particularly in a patriarchal system. To be part of a family meant belonging, protection, and a share in the family's honor and inheritance. Jesus' statement would have been startling, even revolutionary, to His audience. It challenged the deeply ingrained cultural norms that prioritized biological family above all else. His disciples, typically men who had left their families and livelihoods to follow Him, represented a new kind of social unit, a spiritual family formed around His teachings and mission, rather than traditional kinship. This reorientation was not meant to negate the importance of biological family but to elevate the spiritual bond with God and fellow believers to a position of ultimate priority.
  • Key Themes: Matthew 12:49 contributes significantly to several key themes within the Gospel of Matthew and broader biblical theology. The most prominent is the Redefinition of Family, where Jesus asserts that spiritual obedience and discipleship create a bond stronger and more enduring than biological ties. This theme is further explored in Matthew 10:37 where Jesus states, "He that loveth father or mother more than me is not worthy of me." Another critical theme is Obedience to God's Will, which is explicitly stated in the subsequent verse (Matthew 12:50) as the defining characteristic of this new spiritual family. This highlights that true relationship with God and Christ is not merely intellectual assent but active submission to divine purpose. Finally, the verse underscores the Primacy of Discipleship, elevating the status of those who actively follow and learn from Jesus. By identifying His disciples as His "mother and brethren," Jesus validates their commitment and inclusion in His most intimate circle, emphasizing that the kingdom of God is built upon those who hear and obey His word, as seen in the parable of the sower in Matthew 13:1-23.

EXPOSITION AND ANALYSIS

Key Word Analysis

  • Behold (Greek, idoú', G2400): This interjection, often translated as "look!" or "see!", is a direct command used to draw immediate attention to what follows. In this context, it functions as a dramatic pointer, signaling a profound and significant declaration from Jesus. It demands the audience's focus on the new reality Jesus is about to unveil, emphasizing the importance of His redefinition of family.
  • disciples (Greek, mathētḗs', G3101): Derived from a root meaning "to learn," a mathētḗs is a learner or pupil. In the New Testament, it refers specifically to those who follow Jesus, committing to His teachings and way of life. By stretching His hand towards them and identifying them as His family, Jesus elevates their status beyond mere students to intimate spiritual kin, highlighting the deep relational aspect of true discipleship.
  • brethren (Greek, adelphós', G80): This term, meaning "brother" (literally or figuratively), extends beyond biological siblings to include fellow members of a community, kin, or even humanity at large. Here, Jesus uses it in parallel with "mother" to refer to His biological family, but then applies it spiritually to His disciples. This dual usage underscores the radical shift in definition, where spiritual unity transcends even the most fundamental human relationships.

Verse Breakdown

  • "And he stretched forth his hand toward his disciples,": This action is a deliberate, public, and symbolic gesture. Stretching forth the hand often signifies an act of blessing, inclusion, or authority. In this instance, it is an overt act of identification and embrace. Jesus is not merely speaking words; He is performing a physical act that visually aligns Himself with His followers, signaling their immediate and profound importance to Him. This gesture underscores the intentionality of His subsequent declaration, making it a visible and tangible statement of affiliation.
  • "and said, Behold my mother and my brethren!": This declaration is the crux of the verse. By saying "Behold," Jesus draws attention to a new reality. He points not to His biological family, who are waiting outside, but to His disciples, effectively stating that these individuals, united by their commitment to Him and the Father's will, constitute His true family. This statement is revolutionary, challenging the deeply entrenched cultural and societal norms that prioritized blood relations. It establishes a spiritual kinship that transcends earthly ties, laying the groundwork for the concept of the church as the family of God.

Literary Devices

The verse employs several powerful literary devices. Symbolism is evident in Jesus' act of "stretching forth his hand," which is a symbolic gesture of inclusion, affirmation, and ownership. It visually represents His embrace of the disciples as His true kin. The use of Contrast is central to the verse's meaning; Jesus contrasts His biological family (who are mentioned just prior) with His spiritual family (His disciples). This stark juxtaposition highlights the radical nature of His redefinition of family. Furthermore, the exclamation "Behold!" serves as an Interjection that immediately grabs the audience's attention, signaling the profound and unexpected nature of Jesus' declaration. This rhetorical device emphasizes the significance and authority of His words, ensuring that the audience grasps the gravity of His teaching.

THEOLOGICAL AND THEMATIC CONNECTIONS

Matthew 12:49 is a profound theological statement that reorients our understanding of identity and belonging within God's kingdom. It asserts that true kinship with Christ is not a matter of biological descent or social status, but of spiritual alignment and active obedience to the will of God. This teaching elevates the spiritual family—the community of believers—to a place of supreme importance, demonstrating that the bonds forged through faith and discipleship are more enduring and significant in God's eyes than even the most fundamental human relationships. It challenges believers to prioritize their relationship with God and their fellow spiritual kin, recognizing that their ultimate identity is found in being children of God and co-heirs with Christ. This concept forms the very foundation of the Church as the household of God, united by faith in Jesus Christ and obedience to the heavenly Father.

REFLECTION AND APPLICATION

Matthew 12:49 challenges us to deeply examine where our primary allegiance lies and how we define "family." In a world that often prioritizes blood ties, social networks, or self-interest, Jesus' declaration calls us to a radical reorientation: our deepest and most significant family bond is with God through Christ, and with those who share this spiritual kinship. This means actively pursuing God's will, nurturing relationships within the body of Christ, and understanding that our identity is rooted in our spiritual adoption, not merely our earthly lineage. It encourages us to live out our faith in practical ways, demonstrating love and commitment to our spiritual brothers and sisters, just as we would to our closest biological relatives. This passage invites us to consider if our priorities and actions truly reflect the values of God's kingdom, where obedience and spiritual connection are paramount.

Questions for Reflection

  • How does Jesus' redefinition of family challenge my own understanding of loyalty and belonging?
  • In what ways do my actions demonstrate my commitment to my spiritual family (the church) as much as, or more than, my biological family?
  • What practical steps can I take to prioritize "doing the will of my Father which is in heaven" in my daily life, thereby strengthening my bond with Christ and His true family?

FAQ

Did Jesus disown His biological family by making this statement?

Answer: No, Jesus did not disown His biological family. Rather, He expanded and redefined the concept of family to include a spiritual dimension that transcends biological ties. His statement in Matthew 12:49-50 emphasizes that while earthly family is important, the ultimate bond is formed through obedience to God's will. This redefinition elevates the spiritual relationship to a position of supreme importance, indicating that those who follow God's will are as intimately connected to Him as His closest kin. Jesus continued to interact with His mother, even entrusting her care to John at the cross (John 19:26-27). His teaching here is not a rejection of biological family, but an assertion that spiritual kinship is of eternal significance and takes precedence in the kingdom of God.

CHRIST-CENTERED FULFILLMENT

Matthew 12:49 finds its Christ-centered fulfillment in Jesus' establishment of a new covenant community, a spiritual family united not by bloodline but by faith in Him and obedience to the Father's will. Jesus, as the Son of God, inaugurates this new household, inviting all who believe to be adopted into it. He is the elder brother, the firstborn among many brethren (Romans 8:29), who makes it possible for humanity to become children of God (John 1:12). Through His atoning work on the cross, Jesus breaks down the dividing wall of hostility, creating one new humanity, one family, out of Jew and Gentile (Ephesians 2:14-19). This spiritual family, the Church, is the body of Christ, with Him as the head, united by the Holy Spirit and bound by a shared commitment to the Father's purposes. Thus, Jesus' declaration in Matthew 12:49 foreshadows the inclusive, global family of God, redeemed by His blood and called to live in obedient fellowship, reflecting the very nature of God's love and unity.

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Commentary on Matthew 12 verses 46–50

I. II. Main points1. 2. Sub-points(1.) (2.) Details

Many excellent, useful sayings came from the mouth of our Lord Jesus upon particular occasions; even his digressions were instructive, as well as his set discourses: as here,

Observe, I. How Christ was interrupted in his preaching by his mother and his brethren, that stood without, desiring to speak with him (Mat 12:40, Mat 12:47); which desire of theirs was conveyed to him through the crowd. It is needless to enquire which of his brethren they were that came along with his mother (perhaps they were those who did not believe in him, Joh 7:5); or what their business was; perhaps it was only designed to oblige him to break off, for fear he should fatigue himself, or to caution him to take heed of giving offence by his discourse to the Pharisees, and or involving himself in a difficulty; as if they could teach him wisdom.

1.He was as yet talking to the people. Note, Christ's preaching was talking; it was plain, easy, and familiar, and suited to their capacity and case. What Christ had delivered had been cavilled at, and yet he went on. Note, The opposition we meet with in our work, must not drive us from it. He left off talking with the Pharisees, for he saw he could do no good with them; but continued to talk to the common people, who, not having such a conceit of their knowledge as the Pharisees had, were willing to learn.

2.His mother and brethren stood without, desiring to speak with him, when they should have been standing within, desiring to hear him. They had the advantage of his daily converse in private, and therefore were less mindful to attend upon his public preaching. Note, Frequently those who are nearest to the means of knowledge and grace, are most negligent. Familiarity and easiness of access breed some degree of contempt. We are apt to neglect that this day, which we think we may have any day, forgetting that it is only the present time we can be sure of; tomorrow is none of ours. There is too much truth in that common proverb, "The nearer the church, the further from God;" it is pity it should be so.

3.They not only would not hear him themselves, but they interrupted others that heard him gladly. The devil was a sworn enemy to our Saviour's preaching. He had sought to baffle his discourse by the unreasonable cavils of the scribes and Pharisees, and when he could not gain his point that way, he endeavoured to break it off by the unseasonable visits of relations. Note, We often meet with hindrances and obstructions in our work, by our friends that are about us, and are taken off by civil respects from our spiritual concerns. Those who really wish well to us and to our work, may sometimes, by their indiscretion, prove our back-friends, and impediments to us in our duty; as Peter was offensive to Christ, with his, "Master, spare thyself," when he thought himself very officious. The mother of our Lord desired to speak with him; it seemed she had not then learned to command her Son, as the iniquity and idolatry of the church of Rome has since pretended to teach her: nor was she so free from fault and folly as they would make her. It was Christ's prerogative, and not his mother's, to do every thing wisely, and well, and in its season. Christ once said to his mother, How is it that ye sought me? Wist he not, that I must be about my Father's business? And it was then said, she laid up that saying in her heart (Luk 2:49); but if she had remembered it now, she would not have given him this interruption when he was about his Father's business. Note, There is many a good truth that we thought was well laid up when we heard it, which yet is out of the way when we have occasion to use it.

II. How he resented this interruption, Mat 12:48-50.

1.He would not hearken to it; he was so intent upon his work, that no natural or civil respects should take him off from it. Who is my mother and who are my brethren? Not that natural affection is to be put off, or that, under pretence of religion, we may be disrespectful to parents, or unkind to other relations; but every thing is beautiful in its season, and the less duty must stand by, while the greater is done. When our regard to our relations comes in competition with the service of God, and the improving of an opportunity to do good, in such a case, we must say to our Father, I have not seen him, as Levi did, Deu 33:9. The nearest relations must be comparatively hated, that is, we must love them less than Christ (Luk 14:26), and our duty to God must have the preference. This Christ has here given us an example of; the zeal of God's house did so far eat him up, that it made him not only forget himself, but forget his dearest relations. And we must not take it ill of our friends, nor put it upon the score of their wickedness, if they prefer the pleasing of God before the pleasing of us; but we must readily forgive those neglects which may be easily imputed to a pious zeal for God's glory and others' good. Nay, we must deny ourselves and our own satisfaction, rather than do that which may any way divert our friends fRom. or distract them in, their duty to God.

2.He took that occasion to prefer his disciples, who were his spiritual kindred, before his natural relations as such: which was a good reason why he would not leave preaching to speak with his brethren. He would rather be profiting his disciples, than pleasing his relations. Observe,

(1.)The description of Christ's disciples. They are such as do the will of his Father; not only hear it, and know it, and talk of it, but do it; for doing the will of God is the best preparative for discipleship (Joh 7:17), and the best proof of it (Mat 7:21); that denominates us his disciples indeed. Christ does not say, "Whosoever shall do my will," for he came not to seek or do his own will distinct from his Father's: his will and his Father's are the same; but he refers us to his Father's will, because now in his present state and work he referred himself to it, Joh 6:38.

(2.)The dignity of Christ's disciples: The same is my brother, and sister, and mother. His disciples, that had left all to follow him, and embraced his doctrine, were dearer to him than any that were akin to him according to the flesh. They had preferred Christ before their relations; they left their father (Mat 4:22; Mat 10:37); and now to make them amends, and to show that there was no love lost, he preferred them before his relations. Did not they hereby receive, in point of honour, a hundred fold? Mat 19:29. It was very endearing and very encouraging for Christ to say, Behold my mother and my brethren; yet it was not their privilege alone, this honour have all the saints. Note, All obedient believers are near akin to Jesus Christ. They wear his name, bear his image, have his nature, are of his family. He loves them, converses freely with them as his relations. He bids them welcome to his table, takes care of them, provides for them, sees that they want nothing that is fit for them: when he died he left them rich legacies, now he is in heaven he keeps up a correspondence with them, and will have them all with him at last, and will in nothing fail to do the kinsman's part (Rut 3:13), nor will ever be ashamed of his poor relations, but will confess them before men, before the angels, and before his Father.

Matthew Henry (1662–1714) — Commentary on the Whole Bible. This section covers verses 46–50. Public domain.
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Hilary of Poitiers (as quoted by Aquinas, AD 1274)AD 367
Catena Aurea by Aquinas
Because He had spoken all the aforesaid things in the power of His Father's majesty, therefore the Evangelist proceeds to tell what answer He made to one that told Him that His mother and His brethren waited for Him without; While he yet spake unto the people, his mother and his brethren stood without desiring to see him.

And He cannot be held to have thought meanly of His mother, seeing that in His passion He evinced the most extreme carefulness for her.

Although they had like the rest power to come in, yet they abstain from all approach to Him, for he came unto his own, and his own received him not. (John 1:11.)
Ambrose of Milan (as quoted by Aquinas, AD 1274)AD 397
Catena Aurea by Aquinas
(in Luc. 8:21.) Nor does He overthrow the duty of filial submission, which is conveyed in the command, Honour thy father and thy mother, (Ex. 20:12.) but shows that He owes more to the mysteries and relationship of His Father, than of His mother; as it follows, And stretching out his hand to his disciples, he said, Behold my mother and my brethren.
John Chrysostom (as quoted by Aquinas, AD 1274)AD 407
Catena Aurea by Aquinas
(Hom. xliv.) But mart the loftiness of His brethrena; when they should have come in and heartened with the crowd, or if they would not this, to have waited the end of His speech, and then to have approached Him—they on the contrary call Him out to them, and do this before the multitude, therein showing their superabundant love of honour, and also, that with all authority they lay their commands upon Christ. This the Evangelist covertly hints when he says, While he yet spake; as much as to say, Was there no other time? But what did they seek to say? Was it aught of the dogmas of truth? then should they have brought it forth before all, that all might profit thereby. But if of other things that concerned themselves alone, they should not have called Him in such haste, whence it is plain that they did this out of vain glory.

For He said not, Go and say unto her, She is not My mother, but continues His discourse to him that had brought Him word; as it follows; But he answered and said unto him that told him, Who is my mother? and who are my brethren?

But had He desired to disown His mother, He would have done it at the time when the Jews cast His birth in His teeth.

And besides what has been said, He taught also somewhat more, namely, that we should not neglect virtue relying on any kindred. For if it profited His mother nothing that she was such, if she had not had virtue, who is there that shall be saved by his kindred? For there is one only nobility, to do the will of God, and therefore it follows, Whoso shall do the will of my Father which is in heaven, the same is my brother, and sister, and mother. Many women have blessed that holy Virgin and her womb, and have desired to be made such mothers. What is it then that hinders? Behold, He hath set before you a broad way, and not women only, but men likewise, may become the mother of God.
John ChrysostomAD 407
Homily on the Gospel of Matthew 44
That which I was lately saying, that when virtue is wanting all things are vain, this is now also pointed out very abundantly. For I indeed was saying, that age and nature, and to dwell in the wilderness, and all such things, are alike unprofitable, where there is not a good mind; but to-day we learn in addition another thing, that even to have borne Christ in the womb, and to have brought forth that marvellous birth, hath no profit, if there be not virtue.

And this is hence especially manifest. "For while He yet talked to the people," it is said, "one told Him, Thy mother and Thy brethren seek Thee. But He saith, who is my mother, and who are my brethren?" And this He said, not as being ashamed of His mother, nor denying her that bare Him; for if He had been ashamed of her, He would not have passed through that womb; but as declaring that she hath no advantage from this, unless she do all that is required to be done. For in fact that which she had essayed to do, was of superfluous vanity; in that she wanted to show the people that she hath power and authority over her Son, imagining not as yet anything great concerning Him; whence also her unseasonable approach. See at all events both her self-confidence and theirs. Since when they ought to have gone in, and listened with the multitude; or if they were not so minded, to have waited for His bringing His discourse to an end, and then to have come near; they call Him out, and do this before all, evincing a superfluous vanity, and wishing to make it appear, that with much authority they enjoin Him. And this too the evangelist shows that he is blaming, for with this very allusion did he thus express himself, "While He yet talked to the people;" as if he should say, What? was there no other opportunity? Why, was it not possible to speak with Him in private?

And what was it they wished to say? For if it were touching the doctrines of the truth, they ought to have propounded these things publicly, and stated them before all, that the rest also might have the benefit: but if about other matters that concerned themselves, they ought not to have been so urgent. For if He suffered not the burial of a father, lest the attendance on Him should be interrupted, much less ought they to have stopped His discourse to the people, for things that were of no importance. Whence it is clear, that nothing but vainglory led them to do this; which John too declares, by saying, "Neither did His brethren believe on Him;" and some sayings too of theirs he reports, full of great folly; telling us that they were for dragging Him to Jerusalem, for no other purpose, but that they themselves might reap glory from His miracles. "For if thou do these things," it is said, "show Thyself to the world. For there is no man that doeth anything in secret, and seeketh himself to be manifest;" when also He Himself rebuked them, attributing it to their carnal mind. That is, because the Jews were reproaching Him, and saying, "Is not this the carpenter's son, whose father and mother we know? and His brethren, are not they with us?" they, willing to throw off the disparagement caused by His birth, were calling Him to the display of His miracles.

For this cause He quite repels them, being minded to heal their infirmity; since surely, had it been His will to deny His mother, He would have denied her then, when the Jews were reproaching Him. But as it is, we see that He takes so great care of her, as even at the very cross to commit her to the disciple whom He loved most of all, and to give him a great charge concerning her.

But now He doth not so, out of care for her, and for His brethren. I mean, because their regard for Him was as towards a mere man, and they were vainglorious, He casts out the disease, not insulting, but correcting them.

But do thou, I pray, examine not the words only, which contain a moderate reproof, but also the unbecoming conduct of His brethren, and the boldness wherewith they had been bold and who was the person reproving it, no mere man, but the only-begotten Son of God; and with what purpose He reproved; that it was not with intent to drive them to perplexity, but to deliver them from the most tyrannical passion and to lead them on by little and little to the right idea concerning Himself, and to convince her that He was not her Son only, but also her Lord: so wilt thou perceive that the reproof is in the highest degree both becoming Him and profitable to her, and withal having in it much gentleness. For He said not, "Go thy way, tell my mother, thou art not my mother," but He addresses Himself to the person that told Him; saying, "Who is my mother?" together with the things that have been mentioned providing for another object also. What then is that? That neither they nor others confiding in their kindred, should neglect virtue. For if she is nothing profited by being His mother, were it not for that quality in her, hardly will any one else be saved by his kindred. For there is one only nobleness, to do the will of God. This kind of noble birth is better than the other, and more real.
Jerome (as quoted by Aquinas, AD 1274)AD 420
Catena Aurea by Aquinas
(cont. Helvid. 14, et seq.) From this is taken one of Helvidius's propositions, on the ground that mention is made in the Gospel of the brethren of the Lord. How, says he, are they called brethren of the Lord, if they were not his brethren? But now it should be known that in divine Scripture men are said to be brethren in four different ways, by nature, by nation, by kindred, and by affection. By nature, as Esau and Jacob. By nation, as all Jews are called brethren, as in Deuteronomy, Thou shalt not set over thee a foreigner who is not thy brother. (Deut. 17:15) They are called brethren by kindred who are of one family, as in Genesis, Abraham said unto Lot, Let there not be strife between thee and me, for we are brethren. (Gen. 13:8) Also men are called brethren by affection, which is of two kinds, special and general. Special, as all Christians are called brethren, as the Saviour says, Go tell my brethren. General, inasmuch as all men are born of one father, we are bound together by a tie of consanguinity, as in that, Say unto them that hate you, Ye are our brethren. (Is. 66:5 sec. LXX.) I ask then, after which manner these are called the Lord's brethren in the Gospel? According to nature? But Scripture saith not, neither calling them sons of Mary nor of Joseph. By nation? But it is absurd that some few out of all the Jews should be called brethren, seeing that all the Jews who were there might have thus been called brethren. By affection, either of a human sort, or of the Spirit? If that be true, yet how were they more His brethren than the Apostles, whom He instructed in the inmost mysteries. Or if because they were men, and all men are brethren, it was foolish to say of them in particular, Behold, thy brethren seek thee. It only remains then that they should be His brethren by kindred, not by affection, not by privilege of nation, not by nature.

(in loc.) But some suspect the brethren of the Lord to be sons of Joseph by another wife, following the idle fancies of apocryphal writers, who have coined a certain woman called E sea. But we understand by the brethren of the Lord, not the sons of Joseph, but cousins of the Saviour, sons of a sister of Mary, an aunt of Our Lord, who is said to be the mother of James the Less, and Joseph, and Jude, whom in another place of the Gospel we find called the brethren of the Lord. (Mark 6:3) And that cousins are called brethren, appears from every part of Scripture.

He that delivers this message, seems to me not to do it casually and without meaning, but as setting a snare for Him, whether He would prefer flesh and blood to the spiritual work; and thus the Lord refused to go out, not because He disowned His mother and His brethren, but that He might confound him that had laid this snare for Him.

He did not then, as Marcion and Manichæus say, disown His mother, so as to be thought to be born of a phantasm, but He preferred His Apostles to His kindred, that we also in a comparison of our affections should set the spirit before the flesh.

Let us also expound in another way. The Saviour is speaking to the multitude—that is, He teaches the Gentiles the inward mysteries; His mother and His brethren, that is the synagogue and the Jewish people, stand without.

And when they shall have asked and enquired, and sent a messenger, they shall receive for answer, that their will is free, and that they can enter in, if they will believe.
JeromeAD 420
Commentary on Matthew
(Verses 49, 50.) Behold my mother and my brothers. For whoever does the will of my Father who is in heaven, he is my brother and sister and mother. These are my mother, who daily begets me in the souls of believers. These are my brothers, who do the works of my Father. Therefore, he did not deny his mother, as Marcion and Manichaeus believed, that he was born from a phantom; but he preferred the apostles to kinship, so that we may also prefer the spirit to the flesh in comparison of love. Behold, your mother and brothers are standing outside, seeking you. Some of the Lord's brothers suspect that Joseph had children by another wife, following the delusions of the apocryphal writings and inventing a certain Melcha or Escha as a little woman. But as it is contained in the book that we wrote against Helvidius, by the brothers of the Lord, we understand the children of Mary's sister, who is said to be the mother of James the Lesser and Joseph and Judas, whom we read are called the brothers of the Lord in another place in the Gospel. But Scripture demonstrates that brothers are called consobrinos. Let us also say differently: The Savior speaks to the crowds, teaching the nations from within. His mother and brothers, that is, the synagogue and the Jewish people, stand outside and desire to enter, but they become unworthy of his word. And when they ask, inquire, and send a message, they receive the answer that they are free to enter and believe if they wish, but they cannot enter unless they ask someone else.
Augustine of HippoAD 430
Is it not true that the Virgin Mary did the Father’s will, she who believed in faith, conceived in faith and was chosen so that, through her, salvation could be born for us among humans and was begotten by Christ before Christ was begotten in her? Holy Mary carried out, plainly and clearly, the Father’s will. Therefore it is greater for Mary to have been a disciple of Christ than the mother of Christ. Indeed, it is greater and better to have been the disciple of Christ than the mother of Christ. Mary was therefore blessed because, even before she gave birth, she bore the Master in her womb. … Mary is holy and Mary is blessed, but the church is greater than the Virgin Mary. And why? Because Mary is a part of the church, a holy limb, an extraordinary limb, an outstanding limb, but she is only a limb of the whole body. If she is but a part of the whole body, greater indeed is the body than a limb. Christ is the head, and Christ is the entire head and body. What shall I say? We have a divine head. We have God as our head...
Gregory the Dialogist (as quoted by Aquinas, AD 1274)AD 604
Catena Aurea by Aquinas
(Mor. vii. 17.) For it often happens that the soul in the commencement of its progress is lifted up, and prides itself on its virtues, that it opens an entrance to the adversary who is raging against it, and who shows himself the more violent in breaking into it, by how much he was grieved at being cast out, though but for a short space.

(Hom. in Ev. iii. 2.) The Lord deigned to call faithful disciples His brethren, saying, Go, tell my brethren. Since then a man may be made a brother of the Lord by coming to the faith, it should be enquired how one may become also His mother. Be it known by us then, that he that by believing is made brother or sister of Christ, becomes His mother by preaching; for in pouring Him into the heart of the hearer, he may be said to beget the Lord; and he is made the Lord's mother, when by his word love of the Lord is begotten in the mind of his neighbour.

(ubi sup.) Thus also His mother is declared to stand without, as though she was not acknowledged, because the synagogue is therefore not acknowledged by its Author, because it held to the observance of the Law, and having lost the spiritual discernment thereof, kept itself without to guard the letter.
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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