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Translation
King James Version
Whosoever shall seek to save his life shall lose it; and whosoever shall lose his life shall preserve it.
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KJV (with Strong's)
Whosoever G3739 G1437 shall seek G2212 to save G4982 his G846 life G5590 shall lose G622 it G846; and G2532 whosoever G3739 G1437 shall lose G622 his G846 life shall preserve G2225 it G846.
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Complete Jewish Bible
Whoever aims at preserving his own life will lose it, but whoever loses his life will stay alive.
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Berean Standard Bible
Whoever tries to save his life will lose it, but whoever loses his life will preserve it.
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American Standard Version
Whosoever shall seek to gain his life shall lose it: but whosoever shall lose his life shall preserve it.
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World English Bible Messianic
Whoever seeks to save his life loses it, but whoever loses his life preserves it.
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Geneva Bible (1599)
Whosoeuer will seeke to saue his soule, shall loose it: and whosoeuer shall loose it, shall get it life.
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Young's Literal Translation
Whoever may seek to save his life, shall lose it; and whoever may lose it, shall preserve it.
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In the KJVVerse 25,685 of 31,102

Study This Verse

SUMMARY

Luke 17:33 encapsulates a profound and counter-intuitive teaching from Jesus, presenting a spiritual paradox that is foundational to Christian discipleship. It asserts that genuine life and eternal preservation are not found in self-preservation or clinging to earthly existence, but rather in a radical willingness to surrender one's life, identity, and worldly aspirations for the sake of Christ and His Kingdom. This statement challenges conventional human wisdom, inviting believers to embrace a path of self-denial that ultimately leads to true spiritual flourishing and eternal gain.

CONTEXT

  • Literary Context: This verse is situated within a larger discourse by Jesus concerning the coming of the Kingdom of God and the Son of Man, recorded in Luke 17:20-37. Jesus has just warned His disciples about the sudden, unexpected, and decisive nature of His return, drawing vivid parallels to the catastrophic judgments in the days of Noah and Lot, where people were consumed by mundane activities, oblivious to impending divine intervention (Luke 17:26-32). The preceding verses emphasize the urgency of detachment from earthly possessions and concerns, particularly the warning in Luke 17:31-32 for those on the housetop not to go back for their goods, and to "remember Lot's wife," who looked back and was lost. Luke 17:33 serves as a climactic summary of this call to radical, unreserved commitment in light of eschatological realities, underscoring that clinging to the temporal will result in eternal loss, while surrendering the temporal will secure the eternal.
  • Historical & Cultural Context: In the 1st-century Jewish context, life was deeply intertwined with family, land, and community. Self-preservation, securing one's lineage, and maintaining one's social standing were paramount. The Roman occupation also added a layer of political tension, where loyalty to one's people or to the occupying power could have life-or-death consequences. Jesus' teaching on "losing one's life" would have been profoundly counter-cultural. It directly challenged the prevailing human instinct for survival and the societal values that prioritized earthly security and prosperity. This was not merely a philosophical statement but a radical call to reorient one's entire existence, potentially risking social ostracism, economic hardship, or even martyrdom, for allegiance to a kingdom "not of this world" (John 18:36).
  • Key Themes: Luke 17:33 contributes significantly to several major themes found throughout Jesus' teaching and the broader New Testament. Firstly, it articulates a profound Paradoxical Truth, where what seems like loss from a worldly perspective is, in God's economy, the only path to true gain. Secondly, it underscores the theme of Self-Denial and Sacrifice, calling for a willingness to prioritize God's will and the values of His Kingdom above one's own safety, comfort, or even physical existence. This resonates with other calls to radical commitment, such as Luke 9:23 where Jesus commands His followers to "take up their cross daily." Thirdly, the verse highlights the critical distinction between an Eternal vs. Temporal Focus, urging disciples to invest in what is eternal rather than clinging to what is fleeting. Finally, it defines a core aspect of the Cost of Discipleship, emphasizing that true allegiance to Christ often requires a "death to self" (Galatians 2:20), a willingness to forsake all for the sake of following Him.

EXPOSITION AND ANALYSIS

Key Word Analysis

  • life (Greek, psychḗ', G5590): From ψύχω (psychō), meaning "to breathe," this term refers broadly to the soul, one's self, or one's personal identity and aspirations. While it can denote physical life, in this context, it carries a deeper meaning encompassing one's inner being, desires, and the very essence of selfhood that seeks self-preservation and worldly fulfillment. It is distinguished from zoē (ζωή), which refers to mere biological vitality, and pneuma (πνεῦμα), which is the rational and immortal spirit. Here, psychē represents the individual's temporal existence and self-centered drive.
  • lose (Greek, apóllymi', G622): Derived from ἀπό (apo, "from") and the base of ὄλεθρος (olethros, "destruction"), this verb means to destroy fully, to perish, or to lose. In the context of "life," it signifies not merely physical death but a profound and ultimate spiritual ruin or forfeiture. It implies a complete failure to attain true existence or salvation, a state of being utterly undone or wasted.
  • preserve (Greek, zōogonéō', G2225): From the same root as ζῶον (zōon, "living creature") and a derivative of γίνομαι (ginomai, "to become"), this verb literally means "to engender alive" or "to keep alive." By analogy, it signifies to rescue, to save from death, or to cause to live. In this verse, it denotes the act of truly saving, making whole, or giving genuine, enduring life—implying not just survival, but true flourishing and eternal salvation in God's eyes.

Verse Breakdown

  • "Whosoever shall seek to save his life shall lose it": This clause presents the first part of the paradox. The individual who actively strives to secure, protect, and preserve their earthly existence, their personal comfort, their worldly ambitions, or their self-centered identity (their psychē) will ultimately experience a profound loss. This loss is not merely physical death but a spiritual forfeiture, a failure to attain the true, eternal life that God offers. It speaks to the futility of self-reliance and the danger of prioritizing temporal security over spiritual reality.
  • "and whosoever shall lose his life shall preserve it": This second clause offers the counter-intuitive solution and promise. The one who willingly surrenders their earthly life, their self-centered desires, their worldly ambitions, or even their physical existence for the sake of Christ and His Kingdom (i.e., "loses" their psychē) will, in turn, truly "preserve" it. This preservation signifies not just survival, but the attainment of genuine, eternal life, wholeness, and salvation in God's economy. It is a promise that radical self-denial for Christ's sake leads to ultimate and everlasting gain.

Literary Devices

Luke 17:33 is a masterclass in concise and impactful communication, employing several literary devices. The most prominent is Paradox, where two seemingly contradictory statements are presented as true. The idea that one must lose life to save it directly challenges conventional logic, forcing the listener to consider a deeper, spiritual reality. This paradox is further emphasized by Antithesis, the direct opposition of ideas—"seek to save" versus "lose," and "lose" versus "preserve." This stark contrast highlights the mutually exclusive outcomes of two different approaches to life. The structure of the verse also exhibits a form of Chiasmus (ABBA structure), where the concepts are presented in a mirrored order: "save life (A) / lose it (B)" followed by "lose life (B') / preserve it (A')." This chiastic structure adds emphasis and memorability to the profound truth being conveyed, drawing attention to the central, transformative action of "losing."

THEOLOGICAL AND THEMATIC CONNECTIONS

This paradoxical statement from Jesus is a cornerstone of New Testament theology, revealing a fundamental principle of God's Kingdom that stands in stark contrast to worldly wisdom. It teaches that true life is not found in accumulation, self-preservation, or earthly security, but in radical surrender and self-giving. This principle is deeply rooted in the very nature of God, who gave His Son, and in the pattern of Christ's own life and redemptive work. The "losing" of one's life is not an act of nihilism but an act of profound faith, trusting that God's economy operates on principles of resurrection and new creation, where death to self leads to life in Christ. It underscores the spiritual reality that clinging to the temporal ultimately results in eternal emptiness, while releasing the temporal for God's purposes secures an eternal inheritance. This teaching calls believers to a radical reorientation of their values, prioritizing God's will and Kingdom above all else, even life itself.

REFLECTION AND APPLICATION

Luke 17:33 serves as an enduring call to radical discipleship, challenging us to continually examine where our ultimate allegiance lies. In a world that constantly urges us to secure our own comfort, reputation, and material well-being, Jesus' words invite us to a counter-cultural path. This "losing" of life can manifest in various ways: letting go of personal ambitions that conflict with God's call, sacrificing financial security for missional living, forgiving those who have wronged us even when it feels like a loss of justice, or prioritizing the needs of others above our own convenience. It demands a daily surrender of our self-will, our perceived control, and our desire for worldly affirmation, trusting that God's plan for our lives is infinitely better than our own. This verse encourages us to live with an eternal perspective, understanding that true gain is measured not by what we accumulate on earth, but by what we invest in God's Kingdom through self-giving love and obedience.

Questions for Reflection

  • In what specific areas of my life am I currently "seeking to save" my life (e.g., comfort, reputation, control, material possessions)?
  • What might it look like for me to "lose" my life for Christ's sake in my daily routines, relationships, or career?
  • How does my understanding of eternal life influence my willingness to surrender temporal desires or comforts?
  • What fears or insecurities prevent me from fully embracing the paradoxical truth of Luke 17:33?

FAQ

Does "lose his life" mean I have to literally die as a martyr?

Answer: While Luke 17:33 certainly includes the willingness to suffer martyrdom for Christ, its primary meaning extends beyond literal physical death. The Greek word psychē (life/soul) encompasses one's self, identity, desires, and worldly ambitions. Therefore, "losing one's life" means a radical surrender of one's self-centered agenda, desires, and control to God. It implies a daily "death to self" in favor of living for Christ and His Kingdom. This can manifest as sacrificing personal comfort, reputation, financial security, or worldly success for the sake of the Gospel, as seen in passages like Philippians 3:7-8, where Paul counts everything as loss for the sake of Christ.

How can I practically "lose my life" in my everyday Christian walk?

Answer: "Losing your life" daily involves prioritizing God's will above your own, even when it's difficult or costly. Practically, this can mean choosing to forgive someone who has wronged you, even if it feels like a loss of your right to anger; giving generously of your time, talents, or finances even when it means personal sacrifice; speaking truth in love even when it's unpopular; or choosing obedience to Christ's commands over personal comfort or worldly success. It's about surrendering your agenda for God's, your desires for His, and your control for His sovereignty, trusting that true life is found in Him (Romans 12:1-2).

CHRIST-CENTERED FULFILLMENT

Luke 17:33 finds its ultimate and most profound fulfillment in the person and work of Jesus Christ Himself. He is the quintessential example of one who "lost His life" to "preserve it" for the salvation of humanity. Though divine, He did not cling to His heavenly prerogatives but "emptied himself, by taking the form of a servant, being born in the likeness of men" (Philippians 2:7). Jesus willingly laid down His life, not only by facing the agony of the cross but by consistently prioritizing the Father's will over His own comfort, safety, and earthly desires throughout His ministry. He declared, "I am the good shepherd. The good shepherd lays down his life for the sheep" (John 10:11). His death was the ultimate act of "losing" His physical life, yet through His resurrection, He "preserved" it, securing eternal life not only for Himself but for all who believe (Romans 6:9-10). Thus, Jesus perfectly embodies the paradox: His self-giving sacrifice on the cross, the ultimate act of losing His life, became the means by which He gained victory over death and secured eternal life for all who follow Him, becoming "the author of eternal salvation to all who obey him" (Hebrews 5:9). He calls us to follow His pattern, knowing that in Him, our "death" to self leads to true, abundant, and everlasting life.

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Commentary on Luke 17 verses 20–37

I. II. Main points1. 2. Sub-points(1.) (2.) Details

We have here a discourse of Christ's concerning the kingdom of God, that is, the kingdom of the Messiah, which was now shortly to be set up, and of which there was great expectation.

I. Here is the demand of the Pharisees concerning it, which occasioned this discourse. They asked when the kingdom of God should come, forming a notion of it as a temporal kingdom, which should advance the Jewish nation above the nations of the earth. They were impatient to hear some tidings of its approach; they understood, perhaps, that Christ had taught his disciples to pray for the coming of it, and they had long preached that it was at hand. "Now," say the Pharisees, "when will that glorious view open? When shall we see this long-looked-for kingdom?"

II. Christ's reply to this demand, directed to the Pharisees first, and afterwards to his own disciples, who knew better how to understand it (Luk 17:22); what he said to both, he saith to us.

1.That the kingdom of the Messiah was to be a spiritual kingdom, and not temporal and external. They asked when it would come. "You know not what you ask," saith Christ; "it may come, and you not be aware of it." For it has not an external show, as other kingdoms have, the advancements and revolutions of which are taken notice of by the nations of the earth, and fill the newspapers; so they expected this kingdom of God would do. "No," saith Christ, (1.) "It will have a silent entrance, without pomp, without noise; it cometh not with observation," meta paratērēseōs - with outward show. They desired to have their curiosity satisfied concerning the time of it, to which Christ does not give them any answer, but will have their mistakes rectified concerning the nature of it: "It is not for you to know the times of this kingdom, these are secret things, which belong not to you; but the great intentions of this kingdom, these are things revealed." When Messiah the Prince comes to set up his kingdom, they shall not say, Lo here, or Lo there, as when a prince goes in progress to visit his territories it is in every body's mouth, he is here, or he is there; for where the king is there is the court. Christ will not come with all this talk; it will not be set up in this or that particular place; nor will the court of that kingdom be here or there; nor will it be here or there as it respects the country men are of, or the place they dwell in, as if that would place them nearer to, or further fRom. that kingdom. Those who confine Christianity and the church to this place or that party, cry, Lo here, or Lo there, than which nothing is more contrary to the designs of catholic Christianity; so do they who make prosperity and external pomp a mark of the true church. (2.) "It has a spiritual influence: The kingdom of God is within you." It is not of this world, Joh 18:36. Its glory does not strike men's fancies, but affects their spirits, and its power is over their souls and consciences; from them it receives homage, and not from their bodies only. The kingdom of God will not change men's outward condition, but their hearts and lives. Then it comes when it makes those humble, and serious, and heavenly, that were proud, and vain, and carnal, - when it weans those from the world that were wedded to the world; and therefore look for the kingdom of God in the revolutions of the heart, not of the civil government. The kingdom of God is among you; so some read it. "You enquire when it will come, and are not aware that it is already begun to be set up in the midst of you. The gospel is preached, it is confirmed by miracles, it is embraced by multitudes, so that it is in your nation, though not in your hearts." Note, It is the folly of many curious enquirers concerning the times to come that they look for that before them which is already among them.

2.That the setting up of this kingdom was a work that would meet with a great deal of opposition and interruption, Luk 17:22. The disciples thought they should carry all before them, and expected a constant series of success in their work; but Christ tells them it would be otherwise: "The days will come, before you have finished your testimony and done your work, when you shall desire to see one of the days of the Son of man" (one such a day as we now have), "of the prosperity and progress of the gospel, and shall not see it. At first, indeed, you will have wonderful success" (so they had, when thousands were added to the church in a day); "but do not think it will be always so; no, you will be persecuted and scattered, silenced and imprisoned, so that you will not have opportunities of preaching the gospel without fear, as you now have; people will grow cool to it, when they have enjoyed it awhile, so that you will not see such harvests of souls gathered in to Christ afterwards as at first, nor such multitudes flocking to him as doves to their windows." This looks forward to his disciples in after-ages; they must expect much disappointment; the gospel will not be always preached with equal liberty and success. Ministers and churches will sometimes be under outward restraints. Teachers will be removed into corners, and solemn assemblies scattered. Then they will wish to see such days of opportunity as they have formerly enjoyed, sabbath days, sacrament days, preaching days, praying days; these are days of the Son of man, in which we hear from him, and converse with him. The time may come when we may in vain wish for such days. God teaches us to know the worth of such mercies by the want of them. It concerns us, while they are continued, to improve them, and in the years of plenty to lay up in store for the years of famine. Sometimes they will be under inward restraints, will not have such tokens of the presence of the Son of man with them as they have had. The Spirit is withdrawn from them; they see not their signs; the angel comes not down to stir the waters; there is a great stupidity among the children of men, and a great lukewarmness among the children of God; then they shall wish to see such victorious triumphant days of the Son of man as they have sometimes seen, when he has ridden forth with his bow and his crown, conquering and to conquer, but they will not see them. Note, We must not think that Christ's church and cause are lost because not always alike visible and prevailing.

3.That Christ and his kingdom are not to be looked for in this or that particular place, but his appearance will be general in all places at once (Luk 17:23, Luk 17:24): "They will say to you, See here, or, See there; here is one that will deliver the Jews out of the hands of the oppressing Romans, or there is one that will deliver the Christians out of the hands of the oppressing Jews; here is the Messiah, and there is his prophet; here in this mountain, or there at Jerusalem, you will find the true church. Go not after them, nor follow them; do not heed such suggestions. The kingdom of God was not designed to be the glory of one people only, but to give light to the Gentiles; for as the lightning that lightens out of one part under heaven, and shines all on a sudden irresistibly to the other part under heaven, so shall also the Son of man be in his day." (1.) "The judgments that are to destroy the Jewish nation, to lay them waste, and to deliver the Christians from them, shall fly like lightning through the land, shall lay all waste from one end of it to another; and those that are marked for this destruction can no more avoid it, nor oppose it, than they can a flash of lightning." (2.) "The gospel that is to set up Christ's kingdom in the world shall fly like lightning through the nations. The kingdom of the Messiah is not to be a local thing, but is to be dispersed far and wide over the face of the whole earth; it shall shine from Jerusalem to all parts about, and that in a moment. The kingdoms of the earth shall be leavened by the gospel ere they are aware of it." The trophies of Christ's victories shall be erected on the ruins of the devil's kingdom, even in those countries that could never be subdued to the Roman yoke. The design of the setting up of Christ's kingdom was not to make one nation great, but to make all nations good - some, at least, of all nations; and this point shall be gained, though the nations rage, and the kings of the earth set themselves with all their might against it.

4.That the Messiah must suffer before he must reign (Luk 17:25): "First must he suffer many things, many hard things, and be rejected of this generation; and, if he be thus treated, his disciples must expect no other than to suffer and be rejected too for his sake." They thought of having the kingdom of the Messiah set up in external splendour: "No," saith Christ, "we must go by the cross to the crown. The Son of man must suffer many things. Pain, and shame, and death, are those many things. He must be rejected by this generation of unbelieving Jews, before he be embraced by another generation of believing Gentiles, that his gospel may have the honour of triumphing over the greatest opposition from those who ought to have given it the greatest assistance; and thus the excellency of the power will appear to be of God, and not of man; for, though Israel be not gathered, yet he will be glorious to the ends of the earth."

5.That the setting up of the kingdom of the Messiah would introduce the destruction of the Jewish nation, whom it would find in a deep sleep of security, and drowned in sensuality, as the old world was in the days of Noah, and Sodom in the days of Lot, Luk 17:26, etc. Observe,

(1.)How it had been with sinners formerly, and in what posture the judgments of God, of which they had been fairly warned, did at length find them. Look as far back as the old world, when all flesh had corrupted their way, and the earth was filled with violence. Come a little lower, and think how it was with the men of Sodom, who were wicked, and sinners before the Lord exceedingly. Now observe concerning both these, [1.] That they had fair warning given them of the ruin that was coming upon them for their sins. Noah was a preacher of righteousness to the old world; so was Lot to the Sodomites. They gave them timely notice of what would be in the end of their wicked ways, and that it was not far off. [2.] That they did not regard the warning given them, and gave no credit, no heed to it. They were very secure, went on in their business as unconcerned as you could imagine; they did eat, they drank, indulged themselves in their pleasures, and took no care of any thing else, but to make provision for the flesh, counted upon the perpetuity of their present flourishing state, and therefore married wives, and were given in marriage, that their families might be built up. They were all very merry; so were the men of Sodom, and yet very busy too: they bought, they sold, they planted, they builded. These were lawful things, but the fault was that they minded these inordinately, and their hearts were entirely set upon them, as that they had no heart at all to prepare against the threatened judgments. When they should have been, as the men of Nineveh, fasting and praying, repenting and reforming, upon warning given them of an approaching judgment, they were going on securely, eating flesh, and drinking wine, when God called to weeping and to mourning, Isa 22:12, Isa 22:13. [3.] That they continued in their security and sensuality, till the threatened judgment came. Until the day that Noah entered into the ark, and Lot went out of Sodom, nothing said or done to them served to alarm or awaken them. Note, Though the stupidity of sinners in a sinful way is as strange as it is without excuse, yet we are not to think it strange, for it is not without example. It is the old way that wicked men have trodden, that have gone slumbering to hell, as if their damnation slumbered while they did. [4.] That God took care for the preservation of those that were his, who believed and feared, and took the warning themselves which they gave to others. Noah entered into the ark, and there he was safe; Lot went out of Sodom, and so went out of harm's way. If some run on heedless and headlong into destruction, that shall be no prejudice to the salvation of those that believe. [5.] That they were surprised with the ruin which they would not fear, and were swallowed up in it, to their unspeakable horror and amazement. The flood came, and destroyed all the sinners of the old world; fire and brimstone came, and destroyed all the sinners of Sodom. God has many arrows in his quiver, and uses which he will in making war upon his rebellious subjects, for he can make which he will effectual. But that which is especially intended here is to show what a dreadful surprise destruction will be to those who are secure and sensual.

(2.)How it will be with sinners still (Luk 17:30): Thus shall it be in the day when the Son of man is revealed. When Christ comes to destroy the Jewish nation, by the Roman armies, the generality of that nation will be found under such a reigning security and stupidity as this. They have warning given by Christ now, and will have it repeated to them by the apostles after him, as they had by Noah and Lot; but it will be all in vain. They will continue secure, will go on in their neglect and opposition of Christ and his gospel, till all the Christians are withdrawn from among them and gone to the place of refuge. God will provide for them on the other side Jordan, and then a deluge of judgments shall flow in upon them, which will destroy all the unbelieving Jews. One would have thought that this discourse of our Saviour's, which was public, and not long after published to the world, should have awakened them; but it did not, for the hearts of that people were hardened, to their destruction. In like manner, when Jesus Christ shall come to judge the world, at the end of time, sinners will be found in the same secure and careless posture, altogether regardless of the judgment approaching, which will therefore come upon them as a snare; and in like manner the sinners of every age go on securely in their evil ways, and remember not their latter end, nor the account that they must give. Woe to them that are thus at ease in Zion.

6.That it ought to be the care of his disciples and followers to distinguish themselves from the unbelieving Jews in that day, and, leaving them, their city and country, to themselves, to flee at the signal given, according to the direction that should be given. Let them retire, as Noah to his ark, and Lot to his Zoar. You would have healed Jerusalem, as of old Babylon, but she is not healed, and therefore forsake her, flee out of the midst of her, and deliver every man his soul, Jer 51:6, Jer 51:9. This flight of theirs from Jerusalem must be expeditious, and must not be retarded by any concern about their worldly affairs (Luk 17:31): "He that shall be on the house-top, when the alarm is given, let him not come down, to take his stuff away, both because he cannot spare so much time, and because the carrying away of his effects will but encumber him and retard his flight." Let him not regard his stuff at such a time, when it will be next to a miracle of mercy if he have his life given him for a prey. It will be better to leave his stuff behind him than to stay to look after it, and perish with them that believe not. It will be their concern to do as Lot and his family were charged to do: Escape for thy life. Save yourselves from this untoward generation. (2.) When they have made their escape, they must not think of returning (Luk 17:32): "Remember Lot's wife; and take warning by her not only to flee from this Sodom (for so Jerusalem is become, Isa 1:10), but to persevere in your flight, and do not look back, as she did; be not loth to leave a place marked for destruction, whomsoever or whatsoever you leave behind you, that is ever so dear to you." Those who have left the Sodom of a natural state, let them go forward, and not so much as look a kind look towards it again. Let them not look back, lest they should be tempted to go back; nay, lest that be construed a going back in heart, or an evidence that the heart was left behind. Lot's wife was turned into a pillar of salt, that she might remain a lasting monument of God's displeasure against apostates, who begin in the spirit and end in the flesh. (3.) There would be no other way of saving their lives than by quitting the Jews, and, if they thought to save themselves by a coalition with them, they would find themselves mistaken (Luk 17:33): "Whosoever shall seek to save his life, by declining from his Christianity and complying with the Jews, he shall lose it with them and perish in the common calamity; but whosoever is willing to venture his life with the Christians, upon the same bottom on which they venture, to take his lot with them in life and in death, he shall preserve his life, for he shall make sure of eternal life, and is in a likelier way at that time to save his life than those who embark in a Jewish bottom, or ensure upon their securities." Note, Those do best themselves that trust God in the way of duty.

7.That all good Christians should certainly escape, but many of them very narrowly, from that destruction, Luk 17:34-36. When God's judgments are laying all waste, he will take an effectual course to preserve those that are his, by remarkable providences distinguishing between them and others that were nearest to them: two in a bed, one taken and the other left; one snatched out of the burning and taken into a place of safety, while the other is left to perish in the common ruin. Note, Though the sword devours one as well as another, and all things seem to come alike to all, yet sooner or later it shall be made to appear that the Lord knows them that are his and them that are not, and how to take out the precious from the vile. We are sure that the Judge of all the earth will do right; and therefore, when he sends a judgment on purpose to avenge the death of his Son upon those that crucified him, he will take care that none of those who glorified him, and gloried in his cross, shall be taken away by that judgment.

8.That this distinguishing, dividing, discriminating work shall be done in all places, as far as the kingdom of God shall extend, Luk 17:37. Where, Lord? They had enquired concerning the time, and he would not gratify their curiosity with any information concerning that; they therefore tried him with another question: "Where, Lord? Where shall those be safe that are taken? Where shall those perish that are left?" The answer is proverbial, and may be explained so as to answer each side of the question: Wheresoever the body is, thither will the eagles be gathered together. (1.) Wherever the wicked are, who are marked for perdition, they shall be found out by the judgments of God; as wherever a dead carcase is, the birds of prey will smell it out, and make a prey of it. The Jews having made themselves a dead and putrefied carcase, odious to God's holiness and obnoxious to his justice, wherever any of that unbelieving generation is, the judgments of God shall fasten upon them, as the eagles do upon the prey: Thine hand shall find out all thine enemies (Psa 21:8), though they set their nests among the stars, Oba 1:4. The Roman soldiers will hunt the Jews out of all their recesses and fastnesses, and none shall escape. (2.) Wherever the godly are, who are marked for preservation, they shall be found happy in the enjoyment of Christ. As the dissolution of the Jewish church shall be extended to all parts, so shall the constitution of the Christian church. Wherever Christ is, believers will flock to him, and meet in him, as eagles about the prey, without being directed or shown the way, by the instinct of the new nature. Now Christ is where his gospel, and his ordinances, and his church are: For where two or three are gathered in his name there is he in the midst of them, and thither therefore others will be gathered to him. The kingdom of the Messiah is not to have one particular place for its metropolis, such as Jerusalem was to the Jewish church, to which all Jews were to resort; but, wherever the body is, wherever the gospel is preached and ordinances are ministered, thither will pious souls resort, there they will find Christ, and by faith feast upon him. Wherever Christ records his name he will meet his people, and bless them, Joh 4:21, etc.; Ti1 2:8. Many good interpreters understand it of the gathering of the saints together to Christ in the kingdom of glory: "Ask not where the carcase will be, and how they shall find the way to it, for they shall be under infallible direction; to him who is their living, quickening Head, and the centre of their unity, to him shall the gathering of the people be."

Matthew Henry (1662–1714) — Commentary on the Whole Bible. This section covers verses 20–37. Public domain.
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Eusebius of Caesarea (as quoted by Aquinas, AD 1274)AD 339
Catena Aurea by Aquinas
He hereby implies that a persecution will come from the son of perdition upon Christ's faithful. By that day then He means the time previous to the end of the world, in which let not him who is flying return, nor care to lose his goods, lest he imitate Lot's wife, who when she fled out of the city of Sodom, turning back, died, and became a pillar of salt.
Ambrose of MilanAD 397
Commentary on Luke
“He that will be on the housetop, do not let him go down. He that will be in the field, do not let him turn back.” How may I understand what is the field unless Jesus himself teaches me? He says, “No one putting his hand to the plough and looking back is fit for the kingdom of God.” The lazy person sits in the farmhouse, but the industrious person plants in the field. The weak are at the fireplace, but the strong are at the plough. The smell of a field is good, because the smell of Jacob is the smell of a full field. A field is full of flowers. It is full of different fruits. Plough your field if you want to be sent to the kingdom of God. Let your field flower, fruitful with good rewards. Let there be a fruitful vine on the sides of your house and young olive plants around your table. Already aware of its fertility, let your soul, sown with the Word of God and tilled by spiritual farming, say to Christ, “Come, my brother, let us go out into the field.” Let him reply, “I have come into my garden, my sister, my bride. I have gathered my vintage of myrrh.” What is better than the vintage of faith, by which the fruit of the resurrection is stored and the spring of eternal rejoicing is watered?
Ambrose of MilanAD 397
Commentary on Luke
For this reason, the Lord says, “Remember Lot’s wife,” who because she looked back, lost the function of her own nature. Satan and Sodom are behind. Flee excess and shun extravagance. Know that not everyone can flee to the mountain. Remember that the one who did not return to his old pursuits, as if to Sodom, escaped because he came to the mountain. She, who was weaker since she looked back, could not come to the mountain. She remained, although her husband’s help supported her.
Cyril of AlexandriaAD 444
COMMENTARY ON LUKE, HOMILY 118
Whoever loses his life shall certainty save it. This is what the blessed martyrs did, enduring conflicts even to loss of blood and life and placing on their heads as their crown their true love for Christ. Those who, from weakness of resolution and mind, denied the faith and fled from the present death of the body, became their own murderers. They will go down to hell to suffer the penalties of their wicked cowardice. The judge will descend from heaven. He will call those who with all their heart have loved him and earnestly practiced a completely virtuous life, saying, "Come, you blessed of my Father, inherit the kingdom prepared for you from the foundations of the world." He will pass a severe and overwhelming sentence on those who have led careless and unrestrained lives or have not maintained the glory of faith in him, saying to them, "Depart, you cursed, into everlasting fire."
Cyril of Alexandria (as quoted by Aquinas, AD 1274)AD 444
Catena Aurea by Aquinas
How a man may lose his own life to save it, St. Paul explains when he speaks of some who crucified their flesh with the affections and lusts, (Gal. 5:24.) that is, with perseverance and devotion engaging in the conflict.
BedeAD 735
On the Gospel of Luke
Whoever seeks to save his life will lose it. This sentence can be correctly understood in two ways, but both meanings refer to one single end, namely, to suffer adversities for Christ, indeed not to fear to endure death itself. For he who, with death threatening from a persecutor, if he does not deny Christ, prefers rather to save his life for a time by denying, undoubtedly prepares it for eternal perdition. Likewise, he who seeks the eternal salvation of his soul, does not doubt to lose it temporally into the hands of persecutors, that is, to give it into death. But to both meanings, what follows fits aptly:
Bede (as quoted by Aquinas, AD 1274)AD 735
Catena Aurea by Aquinas
Now mystically, Lot, which is interpreted 'turning aside,' is the people of the elect, who, while in Sodom, i. e. among the wicked, live as strangers, to the utmost of their power turning aside from all their wicked ways. But when Lot went out, Sodom is destroyed, for at the end of the world, the angels shall go forth and sever the wicked from among the just, and cast them into a furnace of fire. (Matt. 13:49.) The fire and brimstone, however, which He relates to have rained from heaven, does not signify the flame itself of everlasting punishment, but the sudden coming of that day.
BedeAD 735
On the Gospel of Luke
And whoever loses it will save it. That is, whoever loses it here, will save it there, he who has delivered it to death for Christ, considering it all day as a sheep to be slaughtered (Romans 8), then with Christ rising and helping, will find it free for the sake of the name of Christ.
Theophylact of Ohrid (as quoted by Aquinas, AD 1274)AD 1107
Catena Aurea by Aquinas
Matthew relates all these things to have been said by our Lord, with reference to the destruction of Jerusalem, that when the Romans came upon them, they who were on the housetop should not come down to take any thing, but fly at once, nor they that were in the field return home. And surely so it was at the taking of Jerusalem, and again will be at the coming of Antichrist, but much more at the completion of all things, when that intolerable destruction shall come.

Next follows the promise, Whosoever shall seek, &c. as if he said, Let no man in the persecutions of Antichrist seek to secure his life, for he shall lose it, but whoso shall expose himself to trials and death shall be safe, never submitting himself to the tyrant from his love of life.
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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