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Translation
King James Version
Or what shall a man give in exchange for his soul?
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KJV (with Strong's)
Or G2228 what G5101 shall G1325 a man G444 give G1325 in exchange G465 for his G846 soul G5590?
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Complete Jewish Bible
What could a person give in exchange for his life?
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Berean Standard Bible
Or what can a man give in exchange for his soul?
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American Standard Version
For what should a man give in exchange for his life?
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World English Bible Messianic
For what will a man give in exchange for his life?
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Geneva Bible (1599)
Or what exchange shall a man giue for his soule?
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Young's Literal Translation
Or what shall a man give as an exchange for his life?
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Mark 8:27-30, Mark 8:31-9:0
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In the KJVVerse 24,538 of 31,102

Study This Verse

SUMMARY

Mark 8:37 concludes a profound rhetorical inquiry from Jesus, underscoring the immeasurable and irreplaceable value of the human soul. This powerful question serves as the climax of His teaching on the radical demands of true discipleship, challenging His listeners to critically evaluate their ultimate priorities and recognize that no earthly gain, wealth, or success can ever compensate for the eternal loss of one's very being.

CONTEXT

  • Literary Context: This verse is strategically placed within a pivotal section of Mark's Gospel, immediately following Peter's momentous confession of Jesus as the Christ at Caesarea Philippi. This confession marks a turning point, as Jesus then begins to openly disclose His true mission, which involves His impending suffering, death, and resurrection. In response to Peter's rebuke of this prediction, Jesus then issues a universal call to costly discipleship, instructing His followers to "deny himself, and take up his cross, and follow me." The immediate preceding verse, Mark 8:36, poses the parallel question, "For what shall it profit a man, if he shall gain the whole world, and lose his own soul?" Mark 8:37 then logically extends this thought, emphasizing the absolute impossibility of recovering a lost soul once it has been forfeited, thereby reinforcing the gravity of the choices presented in the call to discipleship.
  • Historical & Cultural Context: Jesus' audience lived in a world where material wealth, social status, and political power were highly prized, particularly under the Roman Empire. The concept of "soul" (Greek: psychē) held various meanings in antiquity. While Greek philosophy often conceived of the soul as an immortal, immaterial essence distinct from the body, the Hebrew understanding (Hebrew: nephesh) was more holistic, referring to the entire living being, the person themselves, including their vitality, emotions, and consciousness. Jesus' use of psychē here encompasses both the vital principle of life and the eternal essence of the person, highlighting its ultimate, enduring value beyond any temporary earthly possessions. The cultural pursuit of worldly gain, as opposed to spiritual or eternal realities, was a temptation then, just as it is now, making Jesus' question profoundly counter-cultural.
  • Key Themes: This verse powerfully contributes to several overarching themes in Mark's Gospel and the broader biblical narrative. Firstly, it underscores The Inestimable Value of the Human Soul, asserting that one's eternal life and very being are of supreme worth, far surpassing any earthly possession, wealth, or power. No temporal commodity can serve as an adequate exchange or ransom for it. Secondly, it highlights The Futility of Material Gain when pursued at the expense of spiritual well-being. Gaining the "whole world" (a hyperbolic expression for ultimate earthly success) is utterly meaningless if it leads to the loss of one's eternal self. This theme resonates with Jesus' teaching to seek first the kingdom of God. Finally, the rhetorical question emphasizes the Eternal Consequences of Present Choices, forcing listeners to confront the long-term implications of their decisions regarding allegiance to Christ versus worldly desires. The choices made in this life have everlasting repercussions for one's ultimate destiny.

EXPOSITION AND ANALYSIS

Key Word Analysis

  • Or (Greek, ḗ', G2228): This primary particle serves as a disjunctive, introducing an alternative or second part of a question, often implying a comparative "than." In Mark 8:37, it links directly to the preceding verse, "For what shall it profit a man, if he shall gain the whole world, and lose his own soul?" The "or" then presents the follow-up, equally impossible, scenario: "Or what shall a man give in exchange for his soul?" It highlights the stark choice and the utter lack of viable alternatives.
  • man (Greek, ánthrōpos', G444): Derived from words meaning "man-faced" or "human being," this term refers to humanity in general, encompassing any individual. By using ánthrōpos, Jesus universalizes the question, making it applicable to every person, regardless of their status, wealth, or background. It underscores that the dilemma of the soul's value is a fundamental human concern.
  • give (Greek, dídōmi', G1325): This verb, meaning "to give" or "to grant," is used broadly to describe the act of bestowing or offering something. In this context, it refers to the act of offering a payment or compensation. The rhetorical question posits the impossibility of any human being giving anything of sufficient value to reclaim a lost soul, emphasizing that such a transaction is beyond human capacity.
  • exchange (Greek, antállagma', G465): This noun, derived from a compound meaning "in return for" or "in place of," specifically denotes an equivalent, a counter-price, or a ransom. It signifies something given as compensation for another thing. Jesus' use of antállagma here powerfully conveys that absolutely no such counter-price or equivalent exists in the human realm for the soul once it is forfeited. The soul is beyond any earthly valuation or transactional recovery.
  • soul (Greek, psychḗ', G5590): As discussed in the context, psychē refers to the breath, the vital principle, the inner being, and the entire person, including their eternal essence. It is distinct from pneuma (rational, immortal spirit) and zoē (mere biological life). In Mark 8:37, psychē encompasses the totality of one's life, identity, and eternal destiny. The loss of this psychē is not merely physical death but an eternal spiritual forfeiture, making its value inestimable.

Verse Breakdown

  • "Or what shall a man give": This opening phrase immediately signals a rhetorical question, implying that the answer is "nothing." The use of "man" (ánthrōpos) makes the question universal, applying to any human being. It challenges the listener to consider what resources, power, or influence they might possess that could possibly serve as a means of recovery. The implied answer is a stark realization of human inadequacy in the face of eternal consequence.
  • "in exchange for his soul?": This clause specifies the object of the impossible transaction – "his soul" (psychē) – and the nature of the transaction – "in exchange" (antállagma). The word "exchange" highlights the commercial metaphor, where something is given to redeem or compensate for something lost. Jesus' question powerfully asserts that the soul's value is so immense that no earthly commodity, no amount of wealth, no worldly achievement, and no self-effort can ever be sufficient to buy it back once it has been forfeited. The question forces a confrontation with the ultimate, eternal stakes of one's life choices.

Literary Devices

The verse primarily employs a Rhetorical Question, which is a question posed for effect rather than to elicit an answer. Jesus uses this device to emphasize the self-evident truth that nothing in the world can equal the value of a human soul. The question forces the audience to internalize this profound reality and confront their priorities. There is also an element of Hyperbole in the preceding verse (Mark 8:36), "if he shall gain the whole world," which sets up the impossibility of the exchange in Mark 8:37. This exaggerated scenario highlights the vast disparity between finite, earthly possessions and the infinite, eternal value of the soul. Furthermore, a strong Contrast is drawn between the transient, material world and the eternal, spiritual essence of a person. This stark juxtaposition underscores the folly of prioritizing the former over the latter.

THEOLOGICAL AND THEMATIC CONNECTIONS

Mark 8:37 stands as a profound theological statement on the inherent dignity and eternal value of human life, made in the image of God. It highlights humanity's fallen state, where the "soul" (the whole person, including their eternal destiny) is in jeopardy, and no human effort or earthly possession can redeem it. This verse implicitly points to the necessity of a divine ransom, a truth that pervades biblical theology. It underscores that salvation is not something that can be earned or purchased by human means, but is a gift that addresses the ultimate and eternal need of the human spirit. The question compels a recognition of our utter dependence on a power greater than ourselves for the redemption of our souls.

REFLECTION AND APPLICATION

Mark 8:37 remains profoundly relevant for every individual today, challenging us to soberly assess our lives and priorities. In a world that often measures success by material accumulation, social status, and fleeting pleasures, Jesus' question cuts through the noise, demanding that we consider what truly holds eternal value. It calls us to a radical re-evaluation: are we investing our limited time, energy, and resources in things that will ultimately perish, or in the eternal realities of our soul and God's kingdom? This verse reinforces the call to authentic discipleship, where following Christ may mean denying self and embracing a path that runs counter to worldly wisdom, understanding that true life is found not in clinging to earthly comforts but in surrendering to God's will. It prompts us to consider the urgency of our spiritual condition and the ultimate destiny of our souls, reminding us that the most precious possession we have cannot be bought or sold.

Questions for Reflection

  • What pursuits or possessions in my life might I be prioritizing over the eternal well-being of my soul?
  • How does the immeasurable value of my soul impact my daily decisions and long-term goals?
  • In what ways am I being challenged to "lose my life" for Christ's sake, in order to truly "save it" (as per Mark 8:35)?

FAQ

What does "soul" mean in this context, and how can it be "lost"?

Answer: In Mark 8:37, "soul" (Greek: psychē) refers not merely to physical life or a disembodied spirit, but to the entire person—their inner being, vital essence, identity, and eternal destiny. It encompasses the totality of who one is, including their relationship with God. To "lose" one's soul in this context means to forfeit one's eternal well-being and destiny, to suffer eternal separation from God. This loss is not a temporary setback but an ultimate, irreversible spiritual ruin, often depicted as a consequence of prioritizing worldly gain and self-preservation over following Christ and embracing His call to self-denial (as seen in Mark 8:34-35).

Is Jesus implying that salvation can be bought or sold, or that it can be lost once gained?

Answer: Jesus is not implying that salvation can be bought or sold by human means; quite the opposite. His rhetorical question emphasizes that no earthly currency or human effort is sufficient to buy back a soul once it is lost. The question highlights the impossibility of a human-initiated transaction for eternal life. Regarding losing salvation, this passage speaks to the consequence of not choosing the path of Christ and His kingdom, or of choosing the world over Christ. It addresses the ultimate outcome for those who prioritize temporary worldly gain over eternal spiritual reality. For those who have genuinely committed their lives to Christ, the New Testament offers strong assurances of God's preserving power and faithfulness (e.g., John 10:28-29, Romans 8:38-39). The warning here is against the initial choice that leads to eternal forfeiture.

CHRIST-CENTERED FULFILLMENT

Mark 8:37, with its stark question about the irreplaceable value of the soul, powerfully sets the stage for the ultimate Christ-centered fulfillment of humanity's deepest need. While no man can give anything in exchange for his soul, God Himself, in His infinite love, provided the ultimate and only sufficient "exchange" or "ransom" for our souls: His Son, Jesus Christ. Jesus, the Good Shepherd, lays down His life for the sheep, demonstrating that the true price for our eternal well-being was not silver or gold, but His own precious blood (as affirmed in 1 Peter 1:18-19). He came "not to be ministered unto, but to minister, and to give his life a ransom for many" (Matthew 20:28). Thus, the very "soul" that is priceless and irredeemable by human means finds its redemption in the person and work of Christ. He is the divine "exchange" that secures eternal life for all who believe, fulfilling the profound truth that what is impossible for man is possible with God (Luke 18:27).

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Commentary on Mark 8 verses 27–38

I. II. Main points1. 2. Sub-points(1.) (2.) Details

We have read a great deal of the doctrine Christ preached, and the miracles he wrought, which were many, and strange, and well-attested, of various kinds, and wrought in several places, to the astonishment of the multitudes that were eye-witnesses of them. It is now time for us to pause a little, and to consider what these things mean; the wondrous works which Christ then forbade the publishing of, being recorded in these sacred writings, are thereby published to all the world, to us, to all ages; now what shall we think of them? Is the record of those things designed only for an amusement, or to furnish us with matter for discourse? No, certainly these things are written, that we may believe that Jesus is the Christ the Son of God (Joh 20:31); and this discourse which Christ had with his disciples, will assist us in making the necessary reflections upon the miracles of Christ, and a right use of them. Three things we are here taught to infer from the miracles Christ wrought.

I. They prove that he is the true Messiah, the Son of God, and Saviour of the world: this the works he did witnessed concerning him; and this his disciples, who were the eye-witnesses of those works, here profess their belief of; which cannot but be a satisfaction to us in making the same inference from them.

1.Christ enquired of them what the sentiments of the people were concerning him; Who did men say that I am? Mar 8:27. Note, Though it is a small thing for us to be judged of men, yet it may sometimes do us good to know what people say of us, not that we may seek our own glory, but that we may hear our faults. Christ asked them, not that he might be informed, but that they might observe it themselves, and inform one another.

2.The account they gave him, was such as plainly intimated the high opinion the people had of him. Though they came short of the truth, yet they were convinced by his miracles that he was an extraordinary person, sent from the invisible world with a divine commission. It is probable that they would have acknowledged him to be the Messiah, if they had not been possessed by their teachers with a notion that the Messiah must be a temporal Prince, appearing in external pomp and power, which the figure Christ made, would not comport with; yet (whatever the Pharisees said, whose copyhold was touched by the strictness and spirituality of his doctrine) none of the people said that he was a Deceiver, but some said that he was John Baptist, others Elias, others one of the prophets, Mar 8:28. All agreed that he was one risen from the dead.

3.The account they gave him of their own sentiments concerning him, intimated their abundant satisfaction in him, and in their having left all to follow him, which now, after some time of trial, they see no reason to repent; But whom say ye that I am? To this they have an answer ready, Thou art the Christ, the Messiah often promised, and long expected, Mar 8:29. To be a Christian indeed, is, sincerely to believe that Jesus is the Christ, and to act accordingly; and that he is so, plainly appears by his wondrous works. This they knew, and must shortly publish and maintain; but for the present they must keep it secret (Mar 8:30), till the proof of it was completed, and they were completely qualified to maintain it, by the pouring out of the Holy Ghost; and then let all the house of Israel know assuredly that God has made this same Jesus, whom ye crucified, both Lord and Christ, Act 2:36.

II. These miracles of Christ take off the offence of the cross, and assure us that Christ was, in it, not conquered, but a Conqueror. Now that the disciples are convinced that Jesus is the Christ, they may bear to hear of his sufferings, which Christ now begins to give them notice of, Mar 8:31.

1.Christ taught his disciples that he must suffer many things, Though they had got over the vulgar error of the Messiah's being a temporal Prince, so far as to believe their Master to be the Messiah, notwithstanding his present meanness, yet still they retained it, so far as to expect that he would shortly appear in outward pomp and grandeur, and restore the kingdom to Israel; and therefore, to rectify that mistake, Christ here gives them a prospect of the contrary, that he must be rejected of the elders, and the chief priests, and the scribes, who, they expected, should be brought to own and prefer him; that, instead of being crowned, he must be killed, he must be crucified, and after three days he must rise again to a heavenly life, and to be no more in this world. This he spoke openly (Mar 8:32), parrēsia. He said it freely and plainly, and did not wrap it up in ambiguous expressions. The disciples might easily understand it, if they had not been very much under the power of prejudice: or, it intimates that he spoke it cheerfully and without any terror, and would have them to hear it so: he spoke that saying boldly, as one that not only knew he must suffer and die, but was resolved he would, and made it his own act and deed.

2.Peter opposed it; He took him, and began to rebuke him. Here Peter showed more love than discretion, a zeal for Christ and his safety, but not according to knowledge. He took him - proslabomenos. He took hold of him, as it were to stop and hinder him, took him in his arms, and embraced him (so some understand it); he fell on his neck, as impatient to hear that his dear Master should suffer such hard things; or he took him aside privately, and began to rebuke him. This was not the language of the least authority, but of the greatest affection, of that jealousy for the welfare of those we love, which is strong as death. Our Lord Jesus allowed his disciples to be free with him, but Peter here took too great a liberty.

3.Christ checked him for his opposition (Mar 8:33); He turned about, as one offended, and looked on his disciples, to see if the rest of them were of the same mind, and concurred with Peter in this, that, if they did, they might take the reproof to themselves, which he was now about to give to Peter; and he said, Get thee behind me, Satan. Peter little thought to have had such a sharp rebuke for such a kind dissuasive, but perhaps expected as much commendation now for his love as he had lately for his faith. Note, Christ sees that amiss in what we say and do, which we ourselves are not aware of, and knows what manner of spirit we are of, when we ourselves do not. (1.) Peter spoke as one that did not rightly understand, nor had duly considered, the purposes and counsels of God. When he saw such proofs as he every day saw of the power of Christ, he might conclude that he could not be compelled to suffer; the most potent enemies could not overpower him whom diseases and deaths, whom winds and waves and devils themselves, were forced to obey and yield to: and when he saw so much of the wisdom of Christ every day, he might conclude that he would not choose to suffer but for some very great and glorious purposes; and therefore he ought not thus to have contradicted him, but to have acquiesced. He looked upon his death only as a martyrdom, like that of the prophets, which he thought might be prevented, if either he would take a little care not to provoke the chief priests, or to keep out of the way; but he knew not that the thing was necessary for the glory of God, the destruction of Satan, and the salvation of man, that the Captain of our salvation must be made perfect through sufferings, and so must bring many sons to glory. Note, The wisdom of man is perfect folly, when it pretends to give measures to the divine counsels. The cross of Christ, the great instance of God's power and wisdom, was to some a stumbling-block, and to others foolishness. (2.) Peter spoke as one that did not rightly understand, nor had duly considered, the nature of Christ's kingdom; he took it to be temporal and human, whereas it is spiritual and divine. Thou savourest not the things that are of God, but those that are of men; ou phroneis - thou mindest not; so the word is rendered, Rom 8:5. Peter seemed to mind more the things that relate to the lower world, and the life that now is, than those which relate to the upper world, and the life to come. Minding the things of men more than the things of God, our own credit, ease, and safety, more than the things of God, and his glory and kingdom, is a very great sin, and the root of much sin, and very common among Christ's disciples; and it will appear in suffering times, those times of temptation, when those in whom the things of men have the ascendant, are in danger of falling off. Non sapis - Thou art not wise (so it may be read) in the things of God, but in the things of men. It is important to consider what generation we appear wise in, Luk 16:8. It seems policy to shun trouble, but if with that we shun duty, it is fleshly wisdom (Co2 1:12), and it will be folly in the end.

III. These miracles of Christ should engage us all to follow him, whatever it cost us, not only as they were confirmations of his mission, but as they were explications of his design, and the tendency of that grace which he came to bring; plainly intimating that by his Spirit he would do that for our blind, deaf, lame, leprous, diseased, possessed souls, which he did for the bodies of those many who in those distresses applied themselves to him. Frequent notice had been taken of the great flocking that there was to him for help in various cases: now this is written, that we may believe that he is the great Physician of souls, and may become his patients, and submit to his regimen; and here he tells us upon what terms we may be admitted; and he called all the people to him, to hear this, who modestly stood at some distance when he was in private conversation with his disciples. This is that which all are concerned to know, and consider, if they expect Christ should heal their souls.

1.They must not be indulgent of the ease of the body; for (Mar 8:34), "Whosoever will come after me for spiritual cures, as these people do for bodily cures, let him deny himself, and live a life of self-denial, mortification, and contempt of the world; let him not pretend to be his own physician, but renounce all confidence in himself and his own righteousness and strength, and let him take up his cross, conforming himself to the pattern of a crucified Jesus, and accommodating himself to the will of God in all the afflictions he lies under; and thus let him continue to follow me;" as many of those did, whom Christ healed. Those that will be Christ's patients must attend on him, converse with him, receive instruction and reproof from him, as those did that followed him, and must resolve they will never forsake him.

2.They must not be solicitous, no, not for the life of the body, when they cannot keep it without quitting Christ, Mar 8:35. Are we invited by the words and works of Christ to follow him? Let us sit down, and count the cost, whether we can prefer our advantages by Christ before life itself, whether we can bear to think of losing our life for Christ's sake and the gospel's. When the devil is drawing away disciples and servants after him, he conceals the worst of it, tells them only of the pleasure, but nothing of the peril, of his service; Ye shall not surely die; but what there is of trouble and danger in the service of Christ, he tells us of it before, tells us we shall suffer, perhaps we shall die, in the cause; and represents the discouragements not less, but greater, than commonly they prove, that it may appear he deals fairly with us, and is not afraid that we should know the worst; because the advantages of his service abundantly suffice to balance the discouragements, if we will but impartially set the one over against the other. In short,

(1.)We must not dread the loss of our lives, provided it be in the cause of Christ (Mar 8:35); Whosoever will save his life, by declining Christ, and refusing to come to him, or by disowning and denying him after he has in profession come to Christ, he shall lose it, shall lose the comfort of his natural life, the root and fountain of his spiritual life, and all his hopes of eternal life; such a bad bargain will he make for himself. But whosoever shall lose his life, shall be truly willing to lose it, shall venture it, shall lay it down when he cannot keep it without denying Christ, he shall save it, he shall be an unspeakable gainer; for the loss of his life shall be made up to him in a better life. It is looked upon to be some kind of recompence to those who lose their lives in the service of their prince and country, to have their memories honoured and their families provided for; but what is that to the recompence which Christ makes in eternal life to all that die for him?

(2.)We must dread the loss of our souls, yea, though we should gain the whole world by it (Mar 8:36, Mar 8:37); For what shall it profit a man, if he should gain the whole world, and all the wealth, honour, and pleasure, in it, by denying Christ, and lose his own soul? "True it is," said Bishop Hooper, the night before he suffered martyrdom, "that life is sweet, and death is bitter, but eternal death is more bitter, and eternal life is more sweet." As the happiness of heaven with Christ, is enough to countervail the loss of life itself for Christ, so the gain of all the world in sin, is not sufficient to countervail the ruin of the soul by sin.

What that is that men do, to save their lives, and gain the world, he tells us (Mar 8:38), and of what fatal consequence it will be to them; Whosoever therefore shall be ashamed of me, and of my words, in this adulterous and sinful generation, of him shall the Son of man be ashamed. Something like this we had, Mat 10:33. But it is here expressed more fully. Note, [1.] The disadvantage that the cause of Christ labours under this world, is, that it is to be owned and professed in an adulterous and sinful generation; such the generation of mankind is, gone a whoring from God, in the impure embraces of the world and the flesh, lying in wickedness; some ages, some places, are more especially adulterous and sinful, as that was in which Christ lived; in such a generation the cause of Christ is opposed and run down, and those that own it, are exposed to reproach and contempt, and every where ridiculed and spoken against. [2.] There are many, who, though they cannot but own that the cause of Christ is a righteous cause, are ashamed of it, because of the reproach that attends the professing of it; they are ashamed of their relation to Christ, and ashamed of the credit they cannot but give to his words; they cannot bear to be frowned upon and despised, and therefore throw off their profession, and go down the stream of a prevailing apostasy. [3.] There is a day coming, when the cause of Christ will appear as bright and illustrious as now it appears mean and contemptible; when the Son of man comes in the glory of his Father with his holy angels, as the true Shechinah, the brightness of his Father's glory, and the Lord of angels. [4.] Those that are ashamed of Christ in this world where he is despised, he will be ashamed of in that world where he is eternally adored. They shall not share with him in his glory then, that were not willing to share with him in his disgrace now.

Matthew Henry (1662–1714) — Commentary on the Whole Bible. This section covers verses 27–38. Public domain.
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Pseudo-Jerome (as quoted by Aquinas, AD 1274)
Catena Aurea by Aquinas
Or else, as a skilful pilot, foreseeing a storm in a calm, wishes his sailors to be prepared; so also the Lord says, If any one will follow me, &c.
John Chrysostom (as quoted by Aquinas, AD 1274)AD 407
Catena Aurea by Aquinas
(Hom. in Matt. 55) As if He would say to Peter, Thou indeed dost rebuke Me, who am willing to undergo My passion, but I tell thee, that not only is it wrong to prevent Me from suffering, but neither canst thou be saved unless thou thyself diest. Again He says, Whosoever wishes to come after me; as if He said, I call you to those good things which a man should wish for, I do not force you to evil and burdensome things; for he who does violence to his hearer, often stands in his way; but he who leaves him free, rather draws him to himself. And a man denies himself when he cares not for his body, so that whether it be scourged, or whatever of like nature it may suffer, he bears it patiently.

(ubi sup.) But He says not, a man should not spare himself, but what is more, that he should deny himself, as if he had nothing in common with himself, but face danger, and look upon such things as if another were suffering; and this is really to spare himself; for parents then most truly act kindly to their children, when they give them up to their masters, with an injunction not to spare them. Again, He shows the degree to which a man should deny himself, when He says, And take up his cross, by which He means, even to the most shameful death.

(ubi sup.) And this He says, because it may happen that a man may suffer and yet not follow Christ, that is, when he does not suffer for Christ's sake; for he follows Christ, who walks after Him, and conforms himself to His death, despising those principalities and powers under whose power, before the coming of Christ, he committed sin. Then there follows, For whosoever will save his life shall lose it; but whosoever shall lose his life for my sake and the Gospel's, the same shall save it. I give you these commands, as it were to spare you; for whosoever spares his son, brings him to destruction, but whosoever does not spare him, saves him. It is therefore right to be always prepared for death; for if in the battles of this world, he who is prepared for death fights better than others, though none can restore him to life after death, much more is this the case in spiritual battle, when so great a hope of resurrection is set before him, since he who gives up his soul unto death saves it.

(ubi sup.) As therefore He had said, For who so ever will save his life shall lose it, lest any one should suppose this loss to be equivalent to that salvation, He adds, For what shall it profit a man, if he shall gain the whole world, and lose his own soul, &c. As if He said, Think not that he has saved his soul, who has shunned the perils of the cross; for when a man, at the cost of his soul, that is, his life, gains the whole world, what has he besides, now that his soul is perishing? Has he another soul to give for his soul? For a man can give the price of his house in exchange for the house, but in losing his soul, he has not another soul to give. And it is with a purpose that He says, Or what shall a man give in exchange for his soul? for God, in exchange for our salvation, has given the precious blood of Jesus Christ.

(Hom. in Matt. 56) And He did not declare the names of those who were about to go up, lest the other disciples should feel some touch of human frailty, and He tells it to them beforehand, that they might come with minds better prepared to be taught all that concerned that vision.
Pseudo-Chrysostom (as quoted by Aquinas, AD 1274)AD 500
Catena Aurea by Aquinas
(Vict. Ant. e Cat. in Marc.) He then who has learned this, is bound zealously to confess Christ without shame. And this generation is called adulterous, because it has left God the true Bridegroom of the soul, and has refused to follow the doctrine of Christ, but has prostrated itself to the devil and taken up the seeds of impiety, for which reason also it is called sinful. Whosoever therefore amongst them has denied the kingdom of Christ, and the words of God revealed in the Gospel, shall receive a reward befitting His impiety, when He hears in the second advent, I know you not. (Matt. 7:23)

(Orig. in Matt. tom. xii. 33, 35) But in a mystical sense, Christ is life, and the devil is death, and he tastes of death, who dwells in sin; even now every one, according as he has good or evil doctrines, tastes the bread either of life or of death. And indeed, it is a less evil to see death, a greater to taste of it, still worse to follow it, worst of all to be subject to it.
Remigius of Rheims (as quoted by Aquinas, AD 1274)AD 533
Catena Aurea by Aquinas
And life is to be taken in this place for the present life, and not for the substance itself of the soul.
Gregory the Dialogist (as quoted by Aquinas, AD 1274)AD 604
Catena Aurea by Aquinas
(Hom. 32. in Evang.) There are however some, who confess Christ, because they see that all men are Christians; for if the name of Christ were not at this day in such great glory, the Holy Church would not have so many professors. The voice of profession therefore is not sufficient for a trial of faith whilst the profession of the generality defends it from shame. In the time of peace therefore there is another way, by which we may be known to ourselves. We are ever fearful of being despised by our neighbours, we think it shame to bear injurious words; if perchance we have quarrelled with our neighbour, we blush to be the first to give satisfaction; for our carnal heart, in seeking the glory of this life, disdains humility.
Bede (as quoted by Aquinas, AD 1274)AD 735
Catena Aurea by Aquinas
After showing to His disciples the mystery of His passion and resurrection, He exhorts them, as well as the multitude, to follow the example of His passion. Wherefore it goes on; And when he had called the people unto him with his disciples also, he said unto them, Whosoever wishes to come after me, let him deny himself.

(ubi sup.) For we deny ourselves, when we avoid what we were of old, and strive to reach that point, whither we are newly called. And the cross is taken up by us, when either our body is pained by abstinence, or our soul afflicted by fellow-feeling for our neighbour.

(in Marc. 2, 36) Or else He says this, because in time of persecution, our life is to be laid aside, but in time of peace, our earthly desires are to be broken, which He implies when He says, For what shall it profit a man, &c. But we are often hindered by a habit of shamefacedness, from expressing with our voice the rectitude which we preserve in our hearts; and therefore it is added, For whosoever shall confess me and my words in this adulterous and sinful generation, him also shall the Son of man confess, when he cometh in the glory of his Father with the holy angels.

(in Marc. 3. 36) Truly it was done with a loving foresight, in order that they, having tasted for a brief moment the contemplation of everlasting joy, might with the greater strength bear up under adversity.

(ubi sup.) Or else the present Church is called the kingdom of God; and some of the disciples were to live in the body until they should see the Church built up, and raised against the glory of the world; for it was right to make some promises concerning this life to the disciples who were uninstructed, that they might be built up with greater strength for the time to come.
Theophylact of Ohrid (as quoted by Aquinas, AD 1274)AD 1107
Catena Aurea by Aquinas
He says that Peter savours the things which be of men, in that he in some way savoured carnal affections, for Peter wished that Christ should spare Himself and not be crucified.

For a man who denies another, be it brother or father, does not sympathize with him, nor grieve at his fate, though he be wounded and die; thus we ought to despise our body, so that if it should be wounded or hurt in any way, we should not mind its suffering.

For at that time the cross appeared shameful, because malefactors were fixed to it.

But because after the cross we must have a new strength, He adds, and follow me.

For that faith which only remains in the mind is not sufficient, but the Lord requires also the confession of the mouth; for when the soul is sanctified by faith, the body ought also to be sanctified by confession.

Him then who shall have confessed that his God was crucified, Christ Himself also shall confess, not here, where He is esteemed poor and wretched, but in His glory and with a multitude of Angels.

But because He had spoken of His glory, in order to show that His promises were not vain, He subjoins, Verily I say unto you, That there be some of them that stand here who shall not taste of death, till they have seen the kingdom of God come with power. As if He said, Some, that is, Peter, James, and John, shall not taste of death, until I show them, in my transfiguration, with what glory I am to come in my second advent; for the transfiguration was nothing else, but an announcement of the second coming of Christ, in which also Christ Himself and the Saints will shine.
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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