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Translation
King James Version
All we like sheep have gone astray; we have turned every one to his own way; and the LORD hath laid on him the iniquity of us all.
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KJV (with Strong's)
All we like sheep H6629 have gone astray H8582; we have turned H6437 every one H376 to his own way H1870; and the LORD H3068 hath laid H6293 on him the iniquity H5771 of us all.
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Complete Jewish Bible
We all, like sheep, went astray; we turned, each one, to his own way; yet ADONAI laid on him the guilt of all of us. Or: and in fellowship with him
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Berean Standard Bible
We all like sheep have gone astray, each one has turned to his own way; and the LORD has laid upon Him the iniquity of us all.
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American Standard Version
All we like sheep have gone astray; we have turned every one to his own way; and Jehovah hath laid on him the iniquity of us all.
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World English Bible Messianic
All we like sheep have gone astray. Everyone has turned to his own way; and the LORD has laid on him the iniquity of us all.
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Geneva Bible (1599)
All we like sheepe haue gone astraye: wee haue turned euery one to his owne way, and the Lord hath layed vpon him the iniquitie of vs all.
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Young's Literal Translation
All of us like sheep have wandered, Each to his own way we have turned, And Jehovah hath caused to meet on him, The punishment of us all.
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Study This Verse

SUMMARY

Isaiah 53:6 stands as a profound declaration of humanity's universal estrangement from God and the divine provision for reconciliation. This pivotal verse, nestled within the prophetic "Suffering Servant" passage, starkly portrays the collective and individual rebellion of mankind, likening it to sheep wandering aimlessly from their shepherd. It then unveils the astonishing truth of God's sovereign act: the transfer of the accumulated guilt and penalty of all human iniquity onto the innocent Servant, thereby establishing the foundational concept of substitutionary atonement.

CONTEXT

  • Literary Context: Isaiah 53:6 is an integral part of the fourth and most detailed "Servant Song" (Isaiah 52:13-53:12), which forms the climax of the book's prophetic description of the Messiah. This poetic section shifts from earlier depictions of the Servant as Israel or a prophetic figure to a singular individual whose suffering is vicarious and redemptive. The preceding verses (Isaiah 53:1-5) describe the Servant's humble appearance, rejection, and profound suffering, emphasizing that His pain was for the transgressions of others. This sets the stage for verse 6 to explain why He suffered—namely, for the universal sin of humanity. The subsequent verses (Isaiah 53:7-12) then detail the Servant's silent endurance, unjust death, and ultimate vindication through resurrection, emphasizing the profound theological implications of His atoning work. The entire passage is a theological masterpiece, weaving together themes of sin, judgment, sacrifice, and salvation, culminating in a vision of divine justice satisfied through selfless suffering.
  • Historical & Cultural Context: The imagery of "sheep" and "shepherd" was deeply embedded in ancient Israelite culture, where pastoralism was a primary way of life. Sheep were known for their tendency to wander, get lost, and be vulnerable without a shepherd's guidance, making them a powerful and relatable metaphor for humanity's spiritual condition: prone to straying from God's path, self-reliant, and ultimately lost without divine intervention. Furthermore, the concept of "iniquity" and its expiation was central to the Mosaic Law and the sacrificial system, where animal sacrifices were offered to atone for sin, providing a temporary covering. This verse, however, points beyond these temporary measures to a definitive, once-for-all sacrifice. The idea of corporate responsibility and the transfer of guilt, though distinct from individual culpability, was also present in ancient Near Eastern thought, providing a conceptual framework for understanding how one could bear the iniquity of others.
  • Key Themes: This verse powerfully articulates several core themes within Isaiah and the broader biblical narrative. Firstly, it underscores the theme of Universal Sinfulness, declaring that "all we like sheep have gone astray," echoing later New Testament affirmations that all have sinned and fall short of the glory of God. Secondly, it introduces the profound concept of Substitutionary Atonement, where "the LORD hath laid on him the iniquity of us all," signifying a divine transfer of guilt and punishment from humanity to the innocent Servant. This theme is foundational to Christian theology, finding its ultimate fulfillment in Christ's work on the cross. Thirdly, the verse highlights Divine Initiative in salvation, emphasizing that it is "the LORD" who orchestrates this redemptive act, not humanity's effort. This aligns with the overarching biblical narrative that salvation is a gift of God's grace, as seen in passages like Ephesians 2:8-9. Finally, it reinforces the Messianic Prophecy of a suffering servant, a theme that pervades the book of Isaiah and anticipates the coming of Jesus Christ.

EXPOSITION AND ANALYSIS

Key Word Analysis

  • gone astray (Hebrew, tâʻâh', H8582): This verb signifies to vacillate, reel, or stray, both literally and figuratively. It implies a deviation from the correct path, an error, or a wandering. Here, it underscores humanity's collective and individual tendency to deviate from God's righteous ways, not merely by accident but through a deliberate, albeit often unconscious, turning away from divine guidance and truth.
  • iniquity (Hebrew, ʻâvôn', H5771): This term denotes perversity, moral evil, fault, or sin, and notably, the punishment or guilt associated with it. It encompasses not just the act of sin but its corrupting nature and its deserved consequences. The use of this word highlights the comprehensive nature of what was laid upon the Servant—the full weight of humanity's moral rebellion and its due recompense, including both the offense and its penalty.
  • laid (Hebrew, pâgaʻ', H6293): This primitive root means to impinge, strike, fall upon, or cause to meet. It conveys a strong, decisive, and intentional act. In this context, it describes God's deliberate and sovereign action of causing the full burden and penalty of humanity's sin to "fall upon" or "strike" the Suffering Servant, emphasizing the purposeful and decisive nature of the atonement, where the full impact of sin was directed to Him.

Verse Breakdown

  • "All we like sheep have gone astray": This clause establishes the universal nature of human sinfulness. The vivid simile "like sheep" powerfully illustrates humanity's innate tendency to wander from God's protective and guiding presence, emphasizing a collective spiritual lostness, vulnerability, and a lack of self-direction. The verb "gone astray" implies a deviation from the right path, a wandering off course from God's intended design for humanity, highlighting a fundamental spiritual disorientation.
  • "we have turned every one to his own way": This second clause reinforces the first, adding the crucial dimension of individual volition and self-direction in sin. It highlights that the "straying" is not merely passive aimlessness but an active, deliberate choice by "every one" to pursue their own desires, wisdom, and paths, rather than submitting to God's will and wisdom. This underscores the personal responsibility inherent in human rebellion against divine authority and the self-centered nature of sin.
  • "and the LORD hath laid on him the iniquity of us all." This climactic clause introduces the divine solution to humanity's universal sin. It is "the LORD" (Yahweh), the sovereign God, who takes the initiative in this redemptive act. The phrase "hath laid on him" signifies a purposeful transfer or imposition of the full burden of "the iniquity of us all"—encompassing all guilt, moral perversity, and deserved punishment—onto the singular, innocent "him," the Suffering Servant. This is the profound essence of substitutionary atonement, where the innocent bears the penalty for the guilty, orchestrated by God Himself.

Literary Devices

Isaiah 53:6 is rich with Literary Devices that amplify its profound message. The most prominent is the Simile "All we like sheep have gone astray," which powerfully likens humanity's collective and individual tendency to wander from God to the inherent nature of sheep to stray from their shepherd. This simile is extended into a broader Metaphor, where humanity is implicitly portrayed as a lost flock, vulnerable and self-destructive without divine guidance. The phrase "every one to his own way" employs Emphasis through repetition and individualization, underscoring the pervasive and personal nature of sin, highlighting that each person is culpable. Furthermore, there is a stark Contrast presented: humanity's self-chosen "own way" versus God's divine intervention and provision. The entire verse functions as a profound Prophecy, foretelling a future act of divine redemption. The final clause, "the LORD hath laid on him the iniquity of us all," uses Transference or Substitutionary Language, describing the imputation of sin from many to one, a central theological concept conveyed through precise and impactful phrasing that underscores God's sovereign and redemptive action.

THEOLOGICAL AND THEMATIC CONNECTIONS

Isaiah 53:6 is a theological bedrock, articulating the twin truths of universal human sinfulness and God's radical provision for atonement. It reveals that the human condition is one of inherent rebellion, where every individual chooses a path divergent from God's righteous design. This collective and individual straying results in "iniquity," a state of moral perversity that demands divine justice. Yet, in a breathtaking display of grace, the sovereign LORD takes the initiative to "lay" this immense burden of sin and its consequences upon an innocent substitute. This concept of substitutionary atonement is not merely a legal transaction but a profound expression of divine love and justice converging to redeem a lost humanity. It prefigures the New Covenant, where the ultimate sacrifice would be made, satisfying God's righteous demands and opening the way for reconciliation.

REFLECTION AND APPLICATION

Isaiah 53:6 compels us to a profound self-examination and an overflowing gratitude. It strips away any illusion of self-sufficiency or inherent goodness, forcing us to confront the uncomfortable truth that "all we like sheep have gone astray." This recognition of our universal tendency to choose "our own way" over God's perfect path is the essential first step towards genuine repentance and a deep appreciation for grace. The verse then pivots to God's incredible solution, reminding us that our iniquity was not ignored but divinely dealt with. This truth should humble us, knowing the immense cost of our redemption, and simultaneously fill us with immense hope and peace. It calls us to abandon our "own ways" and wholeheartedly embrace the Shepherd who bore our burden, living lives of grateful obedience and surrender to His guidance. This passage fosters a profound sense of worship for a God who, in His infinite love, provided the ultimate sacrifice for our reconciliation, inviting us to find our true path and purpose in Him.

Questions for Reflection

  • In what specific ways do I, like a sheep, tend to "go astray" or turn to "my own way" rather than God's?
  • How does the truth that "the LORD hath laid on him the iniquity of us all" personally impact my understanding of God's love, justice, and the depth of my salvation?
  • What practical steps can I take to more consistently follow the Shepherd's voice and resist the temptation to pursue my "own way," aligning my life with His will?

FAQ

Who is the "him" that the LORD laid the iniquity upon?

Answer: From a Christian theological perspective, the "him" in Isaiah 53:6 is unequivocally understood to be Jesus Christ, the Messiah. The entire "Suffering Servant" passage (Isaiah 52:13-53:12) is seen as a prophetic foretelling of Jesus' life, suffering, death, and resurrection. New Testament authors frequently quote or allude to this chapter when explaining Christ's atoning work, such as when John the Baptist identifies Jesus as "the Lamb of God, who takes away the sin of the world!", or when Peter states that Christ "himself bore our sins in his body on the tree".

What does it mean that "the LORD hath laid on him the iniquity of us all"?

Answer: This phrase signifies the theological concept of substitutionary atonement. It means that God, in His divine plan, supernaturally transferred or imputed the guilt, penalty, and consequences of all humanity's sin onto the innocent Suffering Servant. The Servant bore the full weight of the punishment that humanity deserved, thereby satisfying God's righteous demands for justice. This act was not merely a symbolic gesture but a real, decisive divine action where the Servant became the sin-bearer, allowing for the possibility of forgiveness and reconciliation for those who trust in Him. This is echoed in 2 Corinthians 5:21, which states that God "made him who knew no sin to be sin for us, so that in him we might become the righteousness of God."

Is sin truly universal, as implied by "All we like sheep have gone astray"?

Answer: Yes, the Bible consistently teaches the universality of sin. Isaiah 53:6 clearly states "All we like sheep have gone astray" and "every one to his own way," indicating that sin is a pervasive condition affecting all humanity, not just a select few. This Old Testament declaration is powerfully affirmed in the New Testament, most notably by the Apostle Paul in Romans 3:23, where he writes, "for all have sinned and fall short of the glory of God." This universal fallenness underscores the universal need for a Savior and the profound grace of God's provision in the Suffering Servant.

CHRIST-CENTERED FULFILLMENT

Isaiah 53:6 finds its profound and ultimate fulfillment in the person and work of Jesus Christ. He is the Suffering Servant, prophesied centuries earlier, upon whom the "LORD hath laid... the iniquity of us all." Jesus, the sinless Lamb of God, perfectly embodied the innocent substitute. His life was one of complete obedience, never once turning to "His own way" but always to the Father's will, even unto death. Thus, when He went to the cross, He did so not for His own transgressions but as the perfect sacrifice for a wandering humanity. The full weight of our collective and individual rebellion, our "iniquity," was divinely imputed to Him. On the cross, Jesus bore the curse and penalty for sin, becoming "sin for us" as 2 Corinthians 5:21 declares, so that "in him we might become the righteousness of God." His suffering was vicarious, meaning He suffered in our place, bearing the judgment we deserved. This divine exchange, where our sin was laid upon Him and His righteousness is offered to us, is the very heart of the Gospel and the glorious truth that sets us free from the bondage of our "own way" to walk in His. As 1 Peter 3:18 beautifully summarizes, "For Christ also suffered once for sins, the righteous for the unrighteous, to bring you to God."

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Commentary on Isaiah 53 verses 4–9

I. II. Main points1. 2. Sub-points(1.) (2.) Details

In these verses we have,

I. A further account of the sufferings of Christ. Much was said before, but more is said here, of the very low condition to which he abased and humbled himself, to which he became obedient even to the death of the cross. 1. He had griefs and sorrows; being acquainted with them, he kept up the acquaintance, and did not grow shy, no, not of such melancholy acquaintance. Were griefs and sorrows allotted him? He bore them, and blamed not his lot; he carried them, and did neither shrink from them, nor sink under them. The load was heavy and the way long, and yet he did not tire, but persevered to the end, till he said, It is finished. 2. He had blows and bruises; he was stricken, smitten, and afflicted. His sorrows bruised him; he felt pain and smart from them; they touched him in the most tender part, especially when God was dishonoured, and when he forsook him upon the cross. All along he was smitten with the tongue, when he was cavilled at and contradicted, put under the worst of characters, and had all manner of evil said against him. At last he was smitten with the hand, with blow after blow. 3. He had wounds and stripes. He was scourged, not under the merciful restriction of the Jewish law, which allowed not above forty stripes to be given to the worst of male factors, but according to the usage of the Romans. And his scourging, doubtless, was the more severe because Pilate intended it as an equivalent for his crucifixion, and yet it proved a preface to it. He was wounded in his hands, and feet, and side. Though it was so ordered that not a bone of him should be broken, yet he had scarcely in any part a whole skin (how fond soever we are to sleep in one, even when we are called out to suffer for him), but from the crown of his head, which was crowned with thorns, to the soles of his feet, which were nailed to the cross, nothing appeared but wounds and bruises. 4. He was wronged and abused (Isa 53:7): He was oppressed, injuriously treated and hardly dealt with. That was laid to his charge which he was perfectly innocent of, that laid upon him which he did not deserve, and in both he was oppressed and injured. He was afflicted both in mind and body; being oppressed, he laid it to heart, and, though, he was patient, was not stupid under it, but mingled his tears with those of the oppressed, that have no comforter, because on the side of the oppressors there is power, Ecc 4:1. Oppression is a sore affliction; it has made many a wise man mad (Ecc 7:7); but our Lord Jesus, though, when he was oppressed, he was afflicted, kept possession of his own soul. 5. he was judged and imprisoned, as is implied in his being taken from prison and judgment, Isa 53:8. God having made him sin for us, he was proceeded against as a malefactor; he was apprehended and taken into custody, and made a prisoner; he was judge, accused, tried, and condemned, according to the usual forms of law: God filed a process against him, judged him in pursuance of that process, and confined him in the prison of the grave, at the door of which a stone was rolled and sealed. 6. He was cut off by an untimely death from the land of the living, though he lived a most useful life, did so many good works, and they were all such that one would be apt to think it was for some of them that they stoned him. He was stricken to death, to the grave which he made with the wicked (for he was crucified between two thieves, as if he had been the worst of the three) and yet with the rich, for he was buried in a sepulchre that belonged to Joseph, an honourable counsellor. Though he died with the wicked, and according to the common course of dealing with criminals should have been buried with them in the place where he was crucified, yet God here foretold, and Providence so ordered it, that he should make his grave with the innocent, with the rich, as a mark of distinction put between him and those that really deserved to die, even in his sufferings.

II. A full account of the meaning of his sufferings. It was a very great mystery that so excellent a person should suffer such hard things; and it is natural to ask with amazement, "How came it about? What evil had he done?" His enemies indeed looked upon him as suffering justly for his crimes; and, though they could lay nothing to his charge, they esteemed him stricken, smitten of God, and afflicted, Isa 53:4. Because they hated him, and persecuted him, they thought that God did, that he was his enemy and fought against him; and therefore they were the more enraged against him, saying, God has forsaken him; persecute and take him, Psa 71:11. Those that are justly smitten are smitten of God, for by him princes decree justice; and so they looked upon him to be smitten, justly put to death as a blasphemer, a deceiver, and an enemy to Caesar. Those that saw him hanging on the cross enquired not into the merits of his cause, but took it for granted that he was guilty of every thing laid to his charge and that therefore vengeance suffered him not to live. Thus Job's friends esteemed him smitten of God, because there was something uncommon in his sufferings. It is true he was smitten of God, Isa 53:10 (or, as some read it, he was God's smitten and afflicted, the Son of God, though smitten and afflicted), but not in the sense in which they meant it; for, though he suffered all these things,

1.He never did any thing in the least to deserve this hard usage. Whereas he was charged with perverting the nation, and sowing sedition, it was utterly false; he had done no violence, but went about doing good. And, whereas he was called that deceiver, he never deserved that character; for there was no deceit in his mouth (Isa 53:9), to which the apostle refers, Pe1 2:22. He did no sin, neither was guile found in his mouth. He never offended either in word or deed, nor could any of his enemies take up that challenge of his, Which of you convinceth me of sin? The judge that condemned owned he found no fault in him, and the centurion that executed him professed that certainly he was a righteous man.

2.He conducted himself under his sufferings so as to make it appear that he did not suffer as an evil-doer; for, though he was oppressed and afflicted, yet he opened not his mouth (Isa 53:7), no, not so much as to plead his own innocency, but freely offered himself to suffer and die for us, and objected nothing against it. This takes away the scandal of the cross, that he voluntarily submitted to it, for great and holy ends. By his wisdom he could have evaded the sentence, and by his power have resisted the execution; but thus it was written, and thus it behoved him to suffer. This commandment he received from his Father, and therefore he was led as a lamb to the slaughter, without any difficulty or reluctance (he is the Lamb of God); and as a sheep is dumb before the shearers, nay, before the butchers, so he opened not his mouth, which denotes not only his exemplary patience under affliction (Psa 39:9), and his meekness under reproach (Psa 38:13), but his cheerful compliance with his Father's will. Not my will, but thine be done. Lo, I come. By this will we are sanctified, his making his own soul, his own life, an offering for our sin.

3.It was for our good, and in our stead, that Jesus Christ suffered. This is asserted here plainly and fully, and in a very great variety of emphatical expressions.

(1.)It is certain that we are all guilty before God. We have all sinned, and have come short of the glory of God (Isa 53:6): All we like sheep have gone astray, one as well as another. The whole race of mankind lies under the stain of original corruption, and every particular person stands charged with many actual transgressions. We have all gone astray from God our rightful owner, alienated ourselves from him, from the ends he designed us to move towards and the way he appointed us to move in. We have gone astray like sheep, which are apt to wander, and are unapt, when they have gone astray, to find the way home again. That is our true character; we are bent to backslide from God, but altogether unable of ourselves to return to him. This is mentioned not only as our infelicity (that we go astray from the green pastures and expose ourselves to the beasts of prey), but as our iniquity. We affront God in going astray from him, for we turn aside every one to his own way, and thereby set up ourselves, and our own will, in competition with God and his will, which is the malignity of sin. Instead of walking obediently in God's way, we have turned wilfully and stubbornly to our own way, the way of our own heart, the way that our own corrupt appetites and passions lead us to. We have set up for ourselves, to be our own masters, our own carvers, to do what we will and have what we will. Some think it intimates our own evil way, in distinction from the evil way of others. Sinners have their own iniquity, their beloved sin, which does most easily beset them, their own evil way, that they are particularly fond of and bless themselves in.

(2.)Our sins are our sorrows and our griefs (Isa 53:4), or, as it may be read, our sicknesses and our wounds: the Septuagint reads it, our sins; and so the apostle, Pe1 2:24. Our original corruptions are the sickness and disease of the soul, an habitual indisposition; our actual transgressions are the wounds of the soul, which put conscience to pain, if it be not seared and senseless. Or our sins are called our griefs and sorrows because all our griefs and sorrows are owing to our sins and our sins deserve all our griefs and sorrows, even those that are most extreme and everlasting.

(3.)Our Lord Jesus was appointed and did undertake to make satisfaction for our sins and so to save us from the penal consequences of them. [1.] He was appointed to do it, by the will of his Father; for the Lord has laid on him the iniquity of us all. God chose him to be the Saviour of poor sinners and would have him to save them in this way, by bearing their sins and the punishment of them; not the idem - the same that we should have suffered, but the tantundem - that which was more than equivalent for the maintaining of the honour of the holiness and justice of God in the government of the world. Observe here, First, In what way we are saved from the ruin to which by sin we had become liable - by laying our sins on Christ, as the sins of the offerer were laid upon the sacrifice and those of all Israel upon the head of the scape-goat. Our sins were made to meet upon him (so the margin reads it); the sins of all that he was to save, from every place and every age, met upon him, and he was met with for them. They were made to fall upon him (so some read it) as those rushed upon him that came with swords and staves to take him. The laying of our sins upon Christ implies the taking of them off from us; we shall not fall under the curse of the law if we submit to the grace of the gospel. They were laid upon Christ when he was made sin (that is, a sin-offering) for us, and redeemed us from the curse of the law by being made a curse for us; thus he put himself into a capacity to make those easy that come to him heavily laden under the burden of sin. See Psa 40:6-12. Secondly, By whom this was appointed. It was the Lord that laid our iniquities on Christ; he contrived this way of reconciliation and salvation, and he accepted of the vicarious satisfaction Christ was to make. Christ was delivered to death by the determinate counsel and foreknowledge of God. None but God had power to lay our sins upon Christ, both because the sin was committed against him and to him the satisfaction was to be made, and because Christ, on whom the iniquity was to be laid, was his own Son, the Son of his love, and his holy child Jesus, who himself knew no sin. Thirdly, For whom this atonement was to be made. It was the iniquity of us all that was laid on Christ; for in Christ there is a sufficiency of merit for the salvation of all, and a serious offer made of that salvation to all, which excludes none that do not exclude themselves. It intimates that this is the one only way of salvation. All that are justified are justified by having their sins laid on Jesus Christ, and, though they were ever so many, he is able to bear the weight of them all. [2.] He undertook to do it. God laid upon him our iniquity; but did he consent to it? Yes, he did; for some think that the true reading of the next words (Isa 53:7) is, It was exacted, and he answered; divine justice demanded satisfaction for our sins, and he engaged to make the satisfaction. He became our surety, not as originally bound with us, but as bail to the action: "Upon me be the curse, my Father." And therefore, when he was seized, he stipulated with those into whose hands he surrendered himself that that should be his disciples' discharge: If you seek me, let these go their way, Joh 18:8. By his own voluntary undertaking he made himself responsible for our debt, and it is well for us that he was responsible. Thus he restored that which he took not away.

(4.)Having undertaken our debt, he underwent the penalty. Solomon says: He that is surety for a stranger shall smart for it. Christ, being surety for us, did smart for it. [1.] He bore our griefs and carried our sorrows, Isa 53:4. He not only submitted to the common infirmities of human nature, and the common calamities of human life, which sin had introduced, but he underwent the extremities of grief, when he said, My soul is exceedingly sorrowful. He made the sorrows of this present time heavy to himself, that he might make them light and easy for us. Sin is the wormwood and the fall in the affliction and the misery. Christ bore our sins, and so bore our griefs, bore them off us, that we should never be pressed above measure. This is quoted (Mat 8:17) with application to the compassion Christ had for the sick that came to him to be cured and the power he put forth to cure them. [2.] He did this by suffering for our sins (Isa 53:5): He was wounded for our transgressions, to make atonement for them and to purchase for us the pardon of them. Our sins were the thorns in his head, the nails in his hands and feet, the spear in his side. Wounds and bruises were the consequences of sin, what we deserved and what we had brought upon ourselves, Isa 1:6. That these wounds and bruises, though they are painful, may not be mortal, Christ was wounded for our transgressions, was tormented or pained (the word is used for the pains of a woman in travail) for our revolts and rebellions. He was bruised, or crushed, for our iniquities; they were the procuring cause of his death. To the same purport is Isa 53:8, for the transgression of my people was he smitten, the stroke was upon him that should have been upon us; and so some read it, He was cut off for the iniquity of my people, unto whom the stroke belonged, or was due. He was delivered to death for our offences, Rom 4:25. Hence it is said to be according to the scriptures, according to this scripture, that Christ died for our sins, Co1 15:3. Some read this, by the transgressions of my people; that is, by the wicked hands of the Jews, who were, in profession, God's people, he was stricken, was crucified and slain, Act 2:23. But, doubtless, we are to take it in the former sense, which is abundantly confirmed by the angel's prediction of the Messiah's undertaking, solemnly delivered to Daniel, that he shall finish transgression, make an end of sin, and make reconciliation for iniquity, Dan 9:24.

(5.)The consequence of this to us is our peace and healing, Isa 53:5. [1.] Hereby we have peace: The chastisement of our peace was upon him; he, by submitting to these chastisements, slew the enmity, and settled an amity, between God and man; he made peace by the blood of his cross. Whereas by sin we had become odious to God's holiness and obnoxious to his justice, through Christ God is reconciled to us, and not only forgives our sins and saves us from ruin, but takes us into friendship and fellowship with himself, and thereby peace (that is, all good) comes unto us, Col 1:20. He is our peace, Eph 2:14. Christ was in pain that we might be at ease; he gave satisfaction to the justice of God that we might have satisfaction in our own minds, might be of good cheer, knowing that through him our sins are forgiven us. [2.] Hereby we have healing; for by his stripes we are healed. Sin is not only a crime, for which we were condemned to die and which Christ purchased for us the pardon of, but it is a disease, which tends directly to the death of our souls and which Christ provided for the cure of. By his stripes (that is, the sufferings he underwent) he purchased for us the Spirit and grace of God to mortify our corruptions, which are the distempers of our souls, and to put our souls in a good state of health, that they may be fit to serve God and prepared to enjoy him. And by the doctrine of Christ's cross, and the powerful arguments it furnishes us with against sin, the dominion of sin is broken in us and we are fortified against that which feeds the disease.

(6.)The consequence of this to Christ was his resurrection and advancement to perpetual honour. This makes the offence of the cross perfectly to cease; he yielded himself to die as a sacrifice, as a lamb, and, to make it evident that the sacrifice he offered of himself was accepted, we are told here, Isa 53:8, [1.] That he was discharged: He was taken from prison and from judgment; whereas he was imprisoned in the grave under a judicial process, lay there under an arrest for our debt, and judgment seemed to be given against him, he was by an express order from heaven taken out of the prison of the grave, an angel was sent on purpose to roll away the stone and set him at liberty, by which the judgment given against him was reversed and taken off; this redounds not only to his honour, but to our comfort; for, being delivered for our offences, he was raised again for our justification. That discharge of the bail amounted to a release of the debt. [2.] That he was preferred: Who shall declare his generation? his age, or continuance (so the word signifies), the time of his life? He rose to die no more; death had no more dominion over him. He that was dead is alive, and lives for evermore; and who can describe that immortality to which he rose, or number the years and ages of it? And he is advanced to this eternal life because for the transgression of his people he became obedient to death. We may take it as denoting the time of his usefulness, as David is said to serve his generation, and so to answer the end of living. Who can declare how great a blessing Christ by his death and resurrection will be to the world? Some by his generation understand his spiritual seed: Who can count the vast numbers of converts that shall by the gospel be begotten to him, like the dew of the morning?

When thus exalted he shall live to see

A numberless believing progeny

Of his adopted sons; the godlike race

Exceed the stars that heav'n's high arches grace.

- Sir R. Blackmore

Of this generation of his let us pray, as Moses did for Israel, The Lord God of our fathers make them a thousand times so many more as they are, and bless them as he has promised them, Deu 1:11.

Matthew Henry (1662–1714) — Commentary on the Whole Bible. This section covers verses 4–9. Public domain.
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Clement of RomeAD 99
Clement's First Letter to the Corinthians, Chapter 16
For Christ is of those who are humble-minded, and not of those who exalt themselves over His flock. Our Lord Jesus Christ, the Sceptre of the majesty of God, did not come in the pomp of pride or arrogance, although He might have done so, but in a lowly condition, as the Holy Spirit had declared regarding Him. For He says, "Lord, who has believed our report, and to whom is the arm of the Lord revealed? We have declared [our message] in His presence: He is, as it were, a child, and like a root in thirsty ground; He has no form nor glory, yea, we saw Him, and He had no form nor comeliness; but His form was without eminence, yea, deficient in comparison with the [ordinary] form of men. He is a man exposed to stripes and suffering, and acquainted with the endurance of grief: for His countenance was turned away; He was despised, and not esteemed. He bears our iniquities, and is in sorrow for our sakes; yet we supposed that [on His own account] He was exposed to labour, and stripes, and affliction. But He was wounded for our transgressions, and bruised for our iniquities. The chastisement of our peace was upon Him, and by His stripes we were healed. All we, like sheep, have gone astray; [every] man has wandered in his own way; and the Lord has delivered Him up for our sins, while He in the midst of His sufferings opens not His mouth. He was brought as a sheep to the slaughter, and as a lamb before her shearer is dumb, so He opens not His mouth. In His humiliation His judgment was taken away; who shall declare His generation? For His life is taken from the earth. For the transgressions of my people was He brought down to death. And I will give the wicked for His sepulchre, and the rich for His death, because He did no iniquity, neither was guile found in His mouth. And the Lord is pleased to purify him by stripes. If you make an offering for sin, your soul shall see a long-lived seed. And the Lord is pleased to relieve Him of the affliction of His soul, to show Him light, and to form Him with understanding, to justify the Just One who ministers well to many; and He Himself shall carry their sins. On this account He shall inherit many, and shall divide the spoil of the strong; because His soul was delivered to death, and He was reckoned among the transgressors, and He bare the sins of many, and for their sins was He delivered." [Isaiah 53:1-12] And again He says, "I am a worm, and no man; a reproach of men, and despised of the people. All that see me have derided me; they have spoken with their lips; they have wagged their head, [saying] He hoped in God, let Him deliver Him, let Him save Him, since He delights in Him." [Psalm 22:6-8] You see, beloved, what is the example which has been given us; for if the Lord thus humbled Himself, what shall we do who have through Him come under the yoke of His grace?
Clement of AlexandriaAD 215
The Instructor Book 1
Isaiah says [about Christ], “The Lord has laid on him the iniquity of us all,” that is, to correct our iniquities and set them right. For that reason, he alone is able to forgive our sins, he who has been appointed by the Father of all as our educator, for he alone is able to separate obedience from disobedience.
Theodore StratelatesAD 319
FRAGMENTS ON ISAIAH
He bore the sum of human evils and every form of transgression, as well as their recompense and punishment. And as if he were our debtor, the only-begotten Word of God, coming into the world alongside us, fulfilled every law and all righteousness and did not stumble over sin but received it willingly so as to change our punishment into peace and harmony. For undergoing temptation he carried our rebukes and punishments, and by faith we make our own his sufferings, and dying together with him we are saved by grace. He was not delivered by force but as an act of obedience.
JeromeAD 420
Commentary on Isaiah
But he was wounded for our transgressions, he was bruised for our iniquities: the chastisement of our peace was upon him, and with his stripes we are healed. All we like sheep have gone astray; we have turned every one to his own way; and the Lord hath laid on him the iniquity of us all. He was oppressed, and he was afflicted, yet he opened not his mouth. LXX: But he was wounded for our sins, and he was weakened for our iniquities. He was wounded for our iniquities, saying in the psalm: They have dug my hands and my feet (Ps. XXI, 18), so that with his wound he might heal our wounds, and he was crushed, or afflicted because of our sins, so that he became a curse for us, to deliver us from the curse. For every man who hangs on a tree is cursed (Deut. XXI, Galat. III). Therefore, our discipline of peace is upon him. For what we should have endured for our own sins, He suffered for us, making peace through the blood of His cross, whether those on earth or those in heaven. For He Himself is our peace, who made both one, and broke down the middle wall of partition, abolishing in His flesh the enmity, that is, the law of commandments contained in ordinances, that He might create in Himself one new man, making peace. From which it is clear, that just as the bruised and lacerated body bears signs of injury in bruises and discoloration: so too the soul truly suffered for us, lest it be believed in Christ partly as truth and partly as falsehood (Rom. III). All, as it is said, have gone astray like sheep, and we are in need of God's mercy, saying in the psalm: I have strayed like a lost sheep (Ps. CXVIII, 176); which in the parable of the Good Shepherd in the Gospel was carried on his concerned shoulders (Matth. XV). But the following verse shows who these sheep are. Man has wandered in his way; or rather, each one has turned aside in his own way, in order to follow his own error, abandoning the right path, and thinking differently about the Crucified. However, the Lord placed on him the iniquity of all of us, or he handed him over for our sins; so that what we could not bear on account of our weakness, he would bear for us, who was offered, because he himself willed it. For He endured the cross not out of necessity, but out of His own will, saying in the Gospel: 'The cup which My Father has given Me, shall I not drink it?' (John XVIII, 11). And to Peter, who was scandalized by the name of the cross because he did not know the mystery and was trembling with human fear, He said: 'Get behind me, Satan, you are a stumbling block to me; for you are not setting your mind on the things of God, but on the things of men' (Matthew XVI, 23). Otherwise, if He had not been willingly offered, He who could indicate and foretell the traitor and was speaking to the Apostles, 'You will all fall away because of Me this night,' could have caused those who were sent to him to turn away, but he boldly came to meet them and offered Himself saying, 'Whom do you seek?' (John XVIII, 4, 6). Those who immediately fell backward; for they could not bear the voice of the present God. And beautifully he added: And he did not open his mouth. When Pilate said to him: Don't you speak to me? he refused to answer. Or according to the Septuagint: He did not open his mouth in affliction. Or according to Symmachus and Theodotion, he did not open his mouth when he heard.
Theodoret of CyrusAD 458
COMMENTARY ON ISAIAH 17:53.6
The offenses of all were not equal, and there was not only one way of being impious; for the idols of the Egyptians and those of the Phoenicians were not the same, those of the Greeks were different, and those of the Scythians were something else. Nevertheless, although the forms of error were different, we had all in a common manner abandoned the true God, and by this we resembled sheep who have gone astray and are exposed to the wolves.
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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