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“The Last Supper”· Luke 22:14–20
Translation
King James Version
Likewise also the cup after supper, saying, This cup is the new testament in my blood, which is shed for you.
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KJV (with Strong's)
Likewise G5615 also G2532 the cup G4221 after G3326 supper G1172, saying G3004, This G5124 cup G4221 is the new G2537 testament G1242 in G1722 my G3450 blood G129, which G3588 is shed G1632 for G5228 you G5216.
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Complete Jewish Bible
He did the same with the cup after the meal, saying, “This cup is the New Covenant, ratified by my blood, which is being poured out for you.
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Berean Standard Bible
In the same way, after supper He took the cup, saying, “This cup is the new covenant in My blood, which is poured out for you.
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American Standard Version
And the cup in like manner after supper, saying, This cup is the new covenant in my blood, even that which is poured out for you.
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World English Bible Messianic
Likewise, he took the cup after supper, saying, “This cup is the new covenant in my blood, which is poured out for you.
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Geneva Bible (1599)
Likewise also after supper he tooke the cup, saying, This cup is that newe Testament in my blood, which is shed for you.
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Young's Literal Translation
In like manner, also, the cup after the supping, saying, `This cup is the new covenant in my blood, that for you is being poured forth.
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Study This Verse

Summary

Luke 22:20 captures Jesus' profound declaration during the Last Supper, instituting the New Covenant through the symbol of the cup. Following the breaking of bread, Jesus presents the wine as His blood, signifying the establishment of a new, grace-based relationship between God and humanity, sealed by His impending sacrificial death. This pivotal moment reinterprets the Passover meal, transforming it into a forward-looking sacrament that anticipates Christ's atoning work on the cross and its personal, redemptive implications for all believers.

Context

Literary Context

This verse is embedded within Luke's account of the Last Supper, specifically after Jesus has broken bread and declared it to be His body given for the disciples (Luke 22:19). The action with the cup follows immediately, completing the institution of the Lord's Supper. This entire scene is framed by Jesus' deep desire to share this Passover meal with His disciples before His suffering (Luke 22:15). It stands in stark contrast to the preceding narrative of Judas's betrayal (Luke 22:3-6) and the disciples' argument about greatness that follows (Luke 22:24-30), highlighting the solemn, redemptive purpose of Jesus' actions amidst human weakness and treachery.

Historical & Cultural Context

The Last Supper was a Passover Seder, a meal rich with symbolic meaning for first-century Jews. The Passover commemorated God's deliverance of Israel from slavery in Egypt, marked by the blood of a lamb on the doorposts, which averted the angel of death (Exodus 12:1-14). The meal traditionally involved multiple cups of wine, each with specific significance. By taking the third cup, known as the "Cup of Redemption," and reinterpreting it as His "blood of the new covenant," Jesus was deliberately re-contextualizing a deeply significant Jewish ritual. He was not abolishing the Passover but fulfilling and transforming its meaning, shifting the focus from a historical deliverance of Israel to a spiritual deliverance for all humanity through His own sacrifice.

Key Themes

Luke 22:20 powerfully articulates several key themes central to the Gospel of Luke and the broader biblical narrative. Foremost is the theme of the New Covenant, prophesied in Jeremiah 31:31-34, which Jesus now inaugurates through His blood. This signifies a radical departure from the Old Covenant, which was based on the Mosaic Law and animal sacrifices, to a new relationship with God founded on grace and Christ's perfect, once-for-all sacrifice. Another crucial theme is Sacrificial Atonement, as the phrase "shed for you" underscores the substitutionary nature of Jesus' death—His life given as a ransom for many (Mark 10:45). Finally, the Personal Application of salvation is emphasized by the phrase "for you," highlighting that Christ's redemptive work is not a general act but one specifically for the benefit of each individual who believes, offering forgiveness and reconciliation with God.

Exposition and Analysis

Key Word Analysis

new kainós' G2537

This word signifies "new" in terms of freshness, quality, and being unprecedented, rather than merely new in age (which would be neos). Here, it emphasizes that the covenant Jesus institutes is qualitatively different and superior to the Old Covenant. It is a fresh, never-before-seen arrangement with God, marked by an internal transformation rather than external law.

testament diathḗkē' G1242

While often translated "testament" (implying a will), the primary meaning here is "covenant" or "agreement." It refers to a solemn, binding pact or disposition established by God. This choice of word highlights the divine initiation and unbreakable nature of this new relationship, a unilateral promise from God to His people, sealed by His Son's sacrifice.

blood haîma' G129

In biblical thought, blood is intrinsically linked to life and atonement. It is the life-giving fluid, and in the Old Testament, the shedding of blood was required for the remission of sins, signifying a life given in place of another (Leviticus 17:11). Here, Jesus' blood is not merely symbolic; it is the very means by which the New Covenant is ratified, providing ultimate cleansing and forgiveness.

shed ekchéō' G1632

This verb means "to pour forth" or "to gush out." Its use here vividly portrays the violent and complete nature of Jesus' sacrifice. It is not just a drop or a small amount, but a full outpouring of His life, indicating the totality and sufficiency of His atoning work. The passive voice ("is shed") emphasizes that this is an act done to Him, yet willingly undertaken for a specific purpose.

Verse Breakdown

"Likewise also the cup after supper, saying,"

This phrase establishes the immediate context within the Last Supper. "Likewise also" connects this action with the previous one of breaking bread, indicating that the cup holds a parallel and equally profound significance. The phrase "after supper" indicates that this was the final, climactic act of the meal, often associated with the third cup of the Passover Seder, the "Cup of Redemption." Jesus' "saying" introduces His authoritative interpretation of the cup's meaning.

"This cup is the new testament in my blood,"

Here, Jesus identifies the cup not merely as wine, but as a representation of the "new testament" or "new covenant." The phrase "in my blood" is crucial, signifying that His very life-blood, soon to be poured out, is the ratification and foundation of this new divine agreement. Unlike the Old Covenant, sealed with animal blood, this covenant is inaugurated by the precious, perfect blood of God's own Son, making it qualitatively superior and eternally effective.

"which is shed for you."

This concluding clause clarifies the purpose and personal application of Jesus' sacrifice. The blood is not shed arbitrarily but "for you," indicating a substitutionary and redemptive act. It is a sacrifice made on behalf of humanity, specifically for the disciples present, and by extension, for all who would believe. This emphasizes the atoning, sin-forgiving nature of His death, providing reconciliation and access to God.

Literary Devices

Luke 22:20 is rich with Symbolism, where the physical elements of the cup and its contents (wine/blood) are imbued with profound spiritual meaning. The Metaphor "This cup is the new testament in my blood" directly equates the cup with the covenant, highlighting that it represents the covenant sealed by His blood, rather than literally being the covenant itself. The phrase "shed for you" employs Substitutionary Language, a theological concept where one's sacrifice stands in place of another's, emphasizing the vicarious nature of Christ's atonement. The setting within the Passover meal also creates a powerful Typology, where the Old Testament Passover lamb and its blood, which delivered Israel from physical slavery and death, serve as a type foreshadowing Jesus, the ultimate Passover Lamb, whose blood delivers humanity from spiritual slavery to sin and eternal death.

Theological and Thematic Connections

Luke 22:20 stands as a foundational text for understanding the New Covenant and the atoning work of Christ. It reveals that God's plan for humanity's redemption culminates not in adherence to a legal code, but in a radical, grace-filled relationship established through the self-giving sacrifice of His Son. This new covenant, sealed by Jesus' blood, offers complete forgiveness of sins, direct access to God, and an inner transformation of the heart, fulfilling ancient prophecies of a new and better way. It underscores the profound truth that salvation is a gift, undeserved and unearned, made possible only by the shedding of innocent blood.

Reflection and Application

Luke 22:20 invites believers to a profound remembrance and participation in the ongoing reality of the New Covenant. When we partake in the Lord's Supper, we are not merely performing a ritual; we are proclaiming the death of Christ until He comes again, remembering the immense cost of our redemption and the depth of God's love. This verse calls us to live in light of this new reality: our sins are forgiven, we are reconciled to God, and we are empowered by His Spirit to live a new life. It challenges us to embrace the freedom and responsibility that come with being covenant partners with God, living lives of gratitude, obedience, and witness, sharing the good news of this new agreement with a world still bound by sin. The "shed for you" reminds us of the intensely personal nature of Christ's sacrifice, urging us to respond with personal devotion and surrender.

Questions for Reflection

  1. How does understanding the "new testament in my blood" deepen your appreciation for the Lord's Supper?
  2. In what ways does the New Covenant, sealed by Christ's blood, transform your daily walk with God?
  3. How does the phrase "shed for you" personally resonate with your understanding of God's love and sacrifice?
  4. What practical steps can you take to live more fully in the reality of the New Covenant?

FAQ

What is the significance of the "new testament" in Jesus' blood?

The "new testament" refers to the New Covenant, a new and superior agreement between God and humanity, prophesied in Jeremiah 31:31-34. Unlike the Old Covenant, which was based on the Mosaic Law and animal sacrifices, this New Covenant is established by Jesus' perfect, once-for-all sacrifice. His blood is the ultimate seal of this covenant, signifying complete forgiveness of sins, direct access to God, and an internal transformation of the heart through the Holy Spirit. It moves from external regulations to an internal relationship, making reconciliation with God possible for all who believe.

Why is blood so central to the concept of the covenant?

In biblical understanding, blood represents life itself (Leviticus 17:11). Throughout the Old Testament, the shedding of blood was essential for atonement and the remission of sins (Hebrews 9:22). Covenants were often ratified with blood, symbolizing the solemnity and binding nature of the agreement, often with the implicit understanding that breaking the covenant could result in the shedding of one's own blood. Jesus' declaration signifies that His own life, represented by His blood, is given as the perfect, ultimate sacrifice to establish this new, eternal covenant, providing complete and final atonement for sin.

Christ-Centered Fulfillment

Luke 22:20 is a profound declaration of Christ's central role in God's redemptive plan, revealing Him as the inaugurator and embodiment of the New Covenant. Jesus, the true Passover Lamb (1 Corinthians 5:7), transforms the ancient Passover meal, fulfilling its typological significance by offering His own life as the ultimate sacrifice. His blood, "shed for you," is the very substance by which this new covenant is ratified, providing a perfect and eternal atonement that animal sacrifices could never achieve (Hebrews 10:1-14). This act foreshadows His crucifixion, where He would fully pour out His life, not just for Israel, but for the sins of the whole world (John 1:29). Through His shed blood, believers are reconciled to God (Romans 5:9-11), cleansed from all unrighteousness (1 John 1:7), and granted access to the very presence of God (Hebrews 10:19-20). Thus, Luke 22:20 is not merely a historical account but a timeless testament to Christ's unparalleled work as the mediator of a better covenant, secured by His precious blood, offering eternal life to all who believe.

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Public-domain commentary

Matthew Henry

From his Commentary on the Whole Bible. Henry comments on passages, not single verses — this entry covers Luke 22:7–20. His two-level outline is real structure in the source text, so it is rendered as structure.

1662–1714 · 14 verses
Passage under commentLuke 22:7–20
I. II. Main points1. 2. Sub-points

What a hopeful prospect had we of Christ's doing a great deal of good by his preaching in the temple during the feast of unleavened bread, which continued seven days, when the people were every morning, and early in the morning, so attentive to hear him! But here is a stop put to it. He must enter upon work of another kind; in this, however, he shall do more good than in the other, for neither Christ's nor his church's suffering days are their idle empty days. Now here we have,

I.The preparation that was made for Christ's eating the passover with his disciples, upon the very day of unleavened bread, when the passover must be killed according to the law, Luk 22:7. Christ was made under the law, and observed the ordinances of it, particularly that of the passover, to teach us in like manner to observe his gospel institutions, particularly that of the Lord's supper, and not to neglect them. It is probable that he went to the temple to preach in the morning, when he sent Peter and John another way into the city to prepare the passover. Those who have attendants about them, to do their secular business for them in a great measure, must not think that this allows them to be idle; it engages them to employ themselves more in spiritual business, or service to the public. He directed those whom he employed whither they should go (Luk 22:9, Luk 22:10): they must follow a man bearing a pitcher of water, and he must be their guide to the house. Christ could have described the house to them; probably it was a house they knew, and he might have said no more than, Go to such a one's house, or to a house in such a street, with such a sign, etc. But he directed them thus, to teach them to depend upon the conduct of Providence, and to follow that, step by step. They went, not knowing whither they went, nor whom they followed. Being come to the house, they must desire the master of the house to show them a room (Luk 22:11), and he will readily do it, Luk 22:12. Whether it was a friend's house or a public house does not appear; but the disciples found their guide, and the house, and the room, just as he had said to them (Luk 22:13); for they need not fear a disappointment who go upon Christ's word; according to the orders given them, they got every thing in readiness for the passover, Luk 22:11.

II.The solemnizing of the passover, according to the law.

When the hour was come that they should go to supper he sat down, probably at the head-end of the table, and the twelve apostles with him, Judas not excepted; for it is possible that those whose hearts are filled with Satan, and all manner of wickedness, may yet continue a plausible profession of religion, and be found in the performance of its external services; and while it is in the heart, and does not break out into any thing scandalous, such cannot be denied the external privileges of their external profession. Though Judas has already been guilty of an overt act of treason, yet, it not being publicly known, Christ admits him to sit down with the rest at the passover. Now observe,

1.How Christ bids this passover welcome, to teach us in like manner to welcome his passover, the Lord's supper, and to come to it with an appetite (Luk 22:15): "With desire I have desired, I have most earnestly desired, to eat this passover with you before I suffer." He knew it was to be the prologue to his sufferings, and therefore he desired it, because it was in order to his Father's glory and man's redemption. He delighted to do even this part of the will of God concerning him as Mediator. Shall we be backward to any service for him who was so forward in the work of our salvation? See the love he had to his disciples; he desired to eat it with them, that he and they might have a little time together, themselves, and none besides, for private conversation, which they could not have in Jerusalem but upon this occasion. He was now about to leave them, but was very desirous to eat this passover with them before he suffered, as if the comfort of that would carry him the more cheerfully through his sufferings, and make them the easier to him. Note, Our gospel passover, eaten by faith with Jesus Christ, will be an excellent preparation for sufferings, and trials, and death itself.

2.How Christ in it takes his leave of all passovers, thereby signifying his abrogating all the ordinances of the ceremonial law, of which that of the passover was one of the earliest and one of the most eminent (Luk 22:16): "I will not any more eat thereof, nor shall it by any more celebrated by my disciples, until it be fulfilled in the kingdom of God." (1.) It was fulfilled when Christ our Passover was sacrificed for us, Co1 5:7. And therefore that type and shadow was laid aside, because now in the kingdom of God the substance was come, which superseded it. (2.) It was fulfilled in the Lord's supper, an ordinance of the gospel kingdom, in which the passover had its accomplishment, and which the disciples, after the pouring out of the Spirit, did frequently celebrate, as we find Act 2:42, Act 2:46. They ate of it, and Christ might be said to eat with them, because of the spiritual communion they had with him in that ordinance. He is said to sup with them and they with him, Rev 3:20. But, (3.) The complete accomplishment of that commemoration of liberty will be in the kingdom of glory, when all God's spiritual Israel shall be released from the bondage of death and sin, and be put in possession of the land of promise. What he had said of his eating of the paschal lamb, he repeats concerning his drinking of the passover wine, the cup of blessing, or of thanksgiving, in which all the company pledged the Master of the feast, at the close of the passover supper. This cup he took, according to the custom, and gave thanks for the deliverance of Israel out of Egypt, and the preservation of their first-born, and then said, Take this, and divide it among yourselves, Luk 22:17. This is not said afterwards of the sacramental cup, which being probably of much more weight and value, being the New Testament in his blood, he might give into every one's hand, to teach them to make a particular application of it to their own souls; but, as for the paschal cup which is to be abolished, it is enough to say, "Take it, and divide it among yourselves, do what you will with it, for we shall have no more occasion for it, Luk 22:18. I will not drink of the fruit of the vine any more, I will not have it any more drank of, till the kingdom of God shall come, till the Spirit be poured out, and then you shall in the Lord's supper commemorate a much more glorious redemption, of which both the deliverance out of Egypt and the passover commemoration of it were types and figures. The kingdom of God is now so near being set up that you will not need to eat or drink any more till it comes." Christ dying next day opened it. As Christ with a great deal of pleasure took leave of all the legal feasts (which fell of course with the passover) for the evangelical ones, both spiritual and sacramental; so may good Christians, when they are called to remove from the church militant to that which is triumphant, cheerfully exchange even their spiritual repasts, much more their sacramental ones, for the eternal feast.

III.The institution of the Lord's supper, Luk 22:19, Luk 22:20.

The passover and the deliverance out of Egypt were typical and prophetic signs of a Christ to come, who should by dying deliver us from sin and death, and the tyranny of Satan; but they shall no more say, The Lord liveth, that brought us up out of the land of Egypt; a much greater deliverance shall eclipse the lustre of that, and therefore the Lord's supper is instituted to be a commemorative sign or memorial of a Christ already come, that has by dying delivered us; and it is his death that is in a special manner set before us in that ordinance.

1.The breaking of Christ's body as a sacrifice for us is here commemorated by the breaking of bread; and the sacrifices under the law were called the bread of our God (Lev 21:6, Lev 21:8, Lev 21:17): This is my body which is given for you. And there is a feast upon that sacrifice instituted, in which we are to apply it to ourselves, and to take the benefit and comfort of it. This bread that was given for us is given to us to be food for our souls, for nothing can be more nourishing and satisfying to our souls than the doctrine of Christ's making atonement for sin, and the assurance of our interest in that atonement; this bread that was broken and given for us, to satisfy for the guilt of our sins, is broken and given to us, to satisfy the desire of our souls. And this we do in remembrance of what he did for us, when he died for us, and for a memorial of what we do, in making ourselves partakers of him, and joining ourselves to him in an everlasting covenant; like the stone Joshua set up for a witness, Jos 24:27.

2.The shedding of Christ's blood, by which the atonement was made (for the blood made atonement for the soul, Lev 17:11), as represented by the wine in the cup; and that cup of wine is a sign and token of the New Testament, or new covenant, made with us. It commemorates the purchase of the covenant by the blood of Christ, and confirms the promises of the covenant, which are all Yea and Amen in him. This will be reviving and refreshing to our souls, as wine that makes glad the heart. In all our commemorations of the shedding of Christ's blood, we must have an eye to it as shed for us; we needed it, we take hold of it, we hope to have benefit by it; who loved me, and gave himself for me. And in all our regards to the New Testament we must have an eye to the blood of Christ, which gave life and being to it, and seals to us all the promises of it. Had it not been for the blood of Christ, we had never had the New Testament; and, had it not been for the New Testament, we had never know the meaning of Christ's blood shed.

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Historical interpretation

Twelve Centuries of Reception

17 surviving comments on this verse. Each one is dated, so this reads as a timeline rather than a list.

17 quotes · AD 100–1274
Ante-NicenePost-NiceneEarly MedievalMedieval
1002003004005006007008009001000110012001300

Select a marker to jump to its quote. Markers stagger vertically where authors wrote within a few decades of each other.

AD 100DidacheAnte-NiceneSourceThe Didache, Chapters 9-10
Now concerning the Thanksgiving (Eucharist), thus give thanks. First, concerning the cup: We thank thee, our Father, for the holy vine of David Thy servant, which Thou madest known to us through Jesus Thy Servant; to Thee be the glory for ever. And concerning the broken bread: We thank Thee, our Father, for the life and knowledge which Thou modest known to us through Jesus Thy Servant; to Thee be the glory for ever. Even as this broken bread was scattered over the hills, and was gathered together and became one, so let Thy Church be gathered together from the ends of the earth into Thy kingdom; for Thine is the glory and the power through Jesus Christ for ever. But let no one eat or drink of your Thanksgiving (Eucharist), but they who have been baptized into the name of the Lord; for concerning this also the Lord hath said, Give not that which is holy to the dogs.

But after ye are filled, thus give thanks: We thank Thee, holy Father, for Thy holy name which Thou didst cause to tabernacle in our hearts, and for the knowledge and faith and immortality, which Thou modest known to us through Jesus Thy Servant; to Thee be the glory for ever. Thou, Master almighty, didst create all things for Thy name's sake; Thou gavest food and drink to men for enjoyment, that they might give thanks to Thee; but to us Thou didst freely give spiritual food and drink and life eternal through Thy Servant. Before all things we thank Thee that Thou art mighty; to Thee be the glory for ever. Remember, Lord, Thy Church, to deliver it from all evil and to make it perfect in Thy love, and gather it from the four winds, sanctified for Thy kingdom which Thou hast prepared for it; for Thine is the power and the glory for ever. Let grace come, and let this world pass away. Hosanna to the God (Son) of David! If any one is holy, let him come; if any one is not so, let him repent. Maran atha. Amen. But permit the prophets to make Thanksgiving as much as they desire.
AD 220TertullianAnte-NiceneSourceAgainst Marcion Book IV
He likewise, when mentioning the cup and making the new testament to be sealed "in His blood," affirms the reality of His body.
AD 220TertullianAnte-NiceneSourceOn Fasting
Plainly we do, if we are observers of Jewish ceremonies, of legal solemnities: for those the apostle unteaches, suppressing the continuance of the Old Testament which has been buried in Christ, and establishing that of the New. But if there is a new creation in Christ, our solemnities too will be bound to be new: else, if the apostle has erased all devotion absolutely "of seasons, and days, and months, and years," why do we celebrate the passover by an annual rotation in the first month? Why in the fifty ensuing days do we spend our time in all exultation? Why do we devote to Stations the fourth and sixth days of the week, and to fasts the "preparation-day? " Anyhow, you sometimes continue your Station even over the Sabbath,-a day never to be kept as a fast except at the passover season, according to a reason elsewhere given.
AD 379Basil of Caesareaas quoted by Aquinas, AD 1274Post-NiceneSourceCatena Aurea by Aquinas
(Moral. Reg. 21. c. 3. Reg. Brev. ad int. 172.) Learn then in what manner you ought to eat the Body of Christ, namely, in remembrance of Christ's obedience even unto death, that they who live may no more live in themselves, but in Him who died for them, and rose again. (2 Cor. 5:15.)
Being mindful, therefore, of those things that He endured for our sakes, we give You thanks, O God Almighty, not in such a manner as we ought, but as we are able, and fulfil His constitution: "For in the same night that He was betrayed, He took bread" [1 Corinthians 11:23] in His holy and undefiled hands, and, looking up to You His God and Father, "He broke it, and gave it to His disciples, saying, This is the mystery of the new covenant: take of it, and eat. This is my body, which is broken for many, for the remission of sins." In like manner also "He took the cup," and mixed it of wine and water, and sanctified it, and delivered it to them, saying: "Drink all of this; for this is my blood which is shed for many, for the remission of sins: do this in remembrance of me. For as often as you eat this bread and drink this cup, you do show forth my death until I come." Being mindful, therefore, of His passion, and death, and resurrection from the dead, and return into the heavens, and His future second appearing, wherein He is to come with glory and power to judge the quick and the dead, and to recompense to every one according to his works, we offer to You, our King and our God, according to His constitution, this bread and this cup, giving You thanks, through Him, that You have thought us worthy to stand before You, and to sacrifice to You; and we beseech You that You will mercifully look down upon these gifts which are here set before You, O God, who standest in need of none of our offerings. And accept them, to the honour of Your Christ, and send down upon this sacrifice Your Holy Spirit, the Witness of the Lord Jesus' sufferings, that He may show this bread to be the body of Your Christ, and the cup to be the blood of Your Christ, that those who are partakers thereof may be strengthened for piety, may obtain the remission of their sins, may be delivered from the devil and his deceit, may be filled with the Holy Ghost, may be made worthy of Your Christ, and may obtain eternal life upon Your reconciliation to them, O Lord Almighty.
AD 395Gregory of Nyssaas quoted by Aquinas, AD 1274Post-NiceneSourceCatena Aurea by Aquinas
(Orat. de Bapt. Christ.) For the bread before the consecration is common bread, but when the mystery has consecrated it, it is, and it is called, the Body of Christ.
AD 407John Chrysostomas quoted by Aquinas, AD 1274Post-NiceneSourceCatena Aurea by Aquinas
(Hom. 46. in Joan.) Christ did this to bring us to a closer bond of friendship, and to betoken His love toward us, giving Himself to those who desire Him, not only to behold Him, but also to handle Him, to eat Him, to embrace Him with the fulness of their whole heart. Therefore as lions breathing fire do we depart from that table, rendered objects of terror to the devil.

(Hom. 46. in Joan.) For this Blood moulds in us a royal image, it suffers not our nobleness of soul to waste away, moreover it refreshes the soul, and inspires it with great virtue. This Blood puts to flight the devils, summons angels, and the Lord of angels. This Blood poured forth washed the world, and made heaven open. They that partake of it are built up with heavenly virtues, and arrayed in the royal robes of Christ; yea rather clothed upon by the King Himself. And since if thou comest clean, thou comest healthfully; so if polluted by an evil conscience, thou comest to thy own destruction, to pain and torment. For if they who defile the imperial purple are smitten with the same punishment as those who tear it asunder, it is not unreasonable that they who with an unclean heart receive Christ should be beaten with the same stripes as they were who pierced Him with nails.
AD 430Augustine of HippoPost-NiceneSourceSERMON 227
You hold the sacraments in their order. First, after the prayer, you are admonished to lift up your hearts; this befits the members of Christ. For if you have become members of Christ, where is your head? Members have a head. If the head had not gone before, the members would not follow. Where did our head go? What did you recite in the Creed? On the third day, He rose again from the dead, He ascended into heaven, He sits at the right hand of the Father. Therefore, our head is in Heaven. Thus when it is said: Lift up your hearts, you answer: We have them with the Lord. And so that you do not attribute the fact that you have your hearts with the Lord to your own strengths, merits, or labors—for it is a gift of God to have your heart lifted up to Him—the bishop or the priest who offers the sacrifice continues and says—when the people respond: We have them with the Lord—: Let us give thanks to the Lord our God, because we have our hearts with the Lord. Let us give thanks because if he did not give it, we would have our hearts on earth. And you attest by saying: It is right and just, that we should give thanks to Him who made us have our hearts lifted up to our head. Then, after the sanctification of God's sacrifice, because he willed that we ourselves should be his sacrifice—this was shown when the first sacrifice of God was laid down and we—meaning the sign of the reality—which we are; behold where the sanctification has been accomplished, we say the Lord’s Prayer, which you have received and rendered. After it has been said: Peace be with you, and the Christians give each other a holy kiss. It is a sign of peace: as the lips show, let it be done in conscience, that is, just as your lips approach your brother’s lips, let your heart not depart from his heart. Great indeed are the sacraments and very great indeed. Do you wish to know how they are commended? The Apostle says: Whosoever shall eat of the body of Christ or drink of the cup of the Lord unworthily, shall be guilty of the body and blood of the Lord. What does it mean to receive unworthily? To receive it contemptuously, to receive it scoffingly. Do not make it seem cheap to you, because you see it. What you see passes away, but what is signified, the invisible, does not pass, but remains. Behold, it is received, eaten, consumed. Does the body of Christ perish? Does the Church of Christ perish? Do the members of Christ perish? By no means. Here they are cleansed, there they are crowned. Therefore, what is signified remains, even though that which signifies might seem to pass away.
AD 430Augustine of Hippoas quoted by Aquinas, AD 1274Post-NiceneSourceCatena Aurea by Aquinas
(de Con. Ev. lib. iii. c. 1.) Or because Luke has twice mentioned the cup, first before Christ gave the bread, then after He had given it, on the first occasion he has anticipated, as he frequently does, but on the second that which he has placed in its natural order, he had made no mention of before. But both joined together make the same sense which we find in the others, that is, Matthew and Mark.
AD 444Cyril of AlexandriaPost-NiceneSourceCOMMENTARY ON LUKE, HOMILY 142
It was suitable for him to be in us divinely by the Holy Spirit. It was also suitable for him to be mingled with our bodies by his holy flesh and precious blood, which we possess as a life-giving Eucharist, in the form of bread and wine. God feared that seeing actual flesh and blood placed on the holy tables of our churches would terrify us. Humbling himself to our infirmities, God infuses into the things set before us the power of life. He transforms them into the effectiveness of his flesh, that we may have them for a life-giving participation, that the body of life thus might be found in us as a life-producing seed. Do not doubt that this is true. Christ plainly says, “This is my body. This is my blood.” In faith, receive the Savior’s word. Since he is the truth, he cannot lie. You will honor him. The wise John says, “He that receives his witness has set his seal that God is true. For he whom God sent speaks the words of God.” The words of God, of course, are true. In no way whatsoever can they be false. Although we cannot understand how God does that, yet he himself knows the way of his works.
AD 444Cyril of AlexandriaPost-NiceneSourceCOMMENTARY ON LUKE, HOMILY 142
By uniting flesh that was subject to death to himself, the Word being God and life drove corruption away from it. Christ also made it to be the source of life. The body of him who is the life must be this.Do not doubt what I have said but rather accept the word in faith, having gathered proofs from a few examples. When you place a piece of bread into wine, oil, or any other liquid, you find that it becomes charged with the quality of that particular thing. When iron is brought into contact with fire, it becomes full of its activity. While it is by nature iron, it exerts the power of fire. The life-giving Word of God, having united himself to his own flesh in a way known to himself, likewise endowed it with the power of giving life.… When we eat the holy flesh of Christ, the Savior of us all, and drink his precious blood, we have life in us. We are made one with him, abide in him, and possess him in us.
AD 444Cyril of Alexandriaas quoted by Aquinas, AD 1274Post-NiceneSourceCatena Aurea by Aquinas
(in Luc.) Nor doubt that this is true; for He plainly says, This is my body; but rather receive the words of thy Saviour in faith. For since He is the Truth, He lies not. (Ep. ad Calosyr.). a They rave foolishly then who say that the mystical blessing loses its power of sanctifying, if any remains are left till the following day. For the most holy Body of Christ will not be changed, but the power of blessing and the life-giving grace is ever abiding in it. (in Luc. ut sup.). For the life-giving power of God the Father is the only-begotten Word, which was made flesh not ceasing to be the Word, but making the flesh life-giving. What then? since we have in us the life of God, the Word of God dwelling in us, will our body be life-giving? But it is one thing for us by the habit of participation to have in ourselves the Son of God, another for Himself to have been made flesh, that is, to have made the body which He took from the pure Virgin His own Body. He must needs then be in a certain manner united to our bodies by His holy Body and precious Blood, which we have received for a life-giving blessing in the bread and wine. For lest we should be shocked, seeing the Flesh and Blood placed on the holy altars, God, in compassion to our infirmities, pours into the offerings the power of life, changing them into the reality of His own flesh, that the body of life may be found in us, as it were a certain life-giving seed. He adds. Do this in commemoration of me.
Daniel the disciple of Arsenius used to talk also about a hermit in Scetis, saying that he was a great man but simple in the faith, and in his ignorance he thought and said that the bread which we receive is not in very truth the Body of Christ, but a symbol of His Body. Two of the monks heard what he said but because they knew of his sublime works and labours, they imagined that he had said it in innocence and simple-mindedness; and so they came to him and said unto him, ‘Abba, someone told us something that we do not believe; he said that this bread that we receive is not in very truth the Body of Christ, but a mere symbol.’ He said to them, ‘I said that.’ They begged him, saying, ‘You mustn’t say that, abba; according to what the Catholic Church has handed down to us, even so do we believe, that is to say, this bread is the Body of Christ in very truth, and is not a mere symbol. It is the same as when God took dust from the earth, and made man in His image; just as no one can say that he is not the image of God, so also with the bread of which He said, “This is My Body” is not to be regarded as a merely commemorative thing; we believe that it is indeed the Body of Christ.’ The hermit said, ‘Unless I can be convinced by the thing itself I will not listen to this.’ Then the monks said to him, ‘Let us pray to God all week about this mystery, and we believe that He will reveal the truth to us.’ The hermit agreed to this with great joy, and each went to his cell. Then the hermit prayed, saying, ‘O Lord, you know that it is not out of wickedness that I do not believe, so in order that I may not go astray through ignorance, reveal to me, Lord Jesus Christ, the truth of this mystery.’ The other two brothers prayed to God and said, ‘Lord Jesus Christ, give this hermit understanding about this mystery, and we believe that he will not be lost.’ God heard the prayer of the two monks. When the week was over they came to the church, and the three of them sat down by themselves on one seat, the hermit between the other two. The eyes of their understanding were opened, and when the time of the mysteries arrived, and the bread was laid upon the holy table, there appeared to the three of them as it were a child on the table. Then the priest stretched out his hand to break the bread, and behold the angel of the Lord came down from heaven with a knife in his hand, and he killed the child and pressed out his blood into the cup. When the priest broke off from the bread small pieces, the hermit went forward to receive communion and a piece of living flesh smeared and dripping with blood was given to him. Now when he saw this he was afraid and he cried out loudly, saying, ‘Lord, I believe that the bread is Your Body, and that the cup is Your Blood.’ At once the flesh that was in his hand became bread, and he took it and gave thanks to God. The brothers said to him, ‘God knows the nature of men, and that we are unable to eat living flesh, and so He turneth His Body into bread, and His Blood into wine for those who receive Him in faith.’ Then they gave thanks to God for the hermit, because He had not let Satan destroy him, and the three of them went back to their cells joyfully.
AD 735Bedeas quoted by Aquinas, AD 1274Early MedievalSourceCatena Aurea by Aquinas
Having finished the rites of the old Passover, He passes on to the new, which He desires the Church to celebrate in memory of His redemption, substituting for the flesh and blood of the lamb, the Sacrament of His own Flesh and Blood in the figure of the bread and wine, being made a Priest for ever after the order of Melchisedech. (Ps. 110:4.) Hence it is said, And he took bread, and gave thanks, (Heb. 7:21.) as also He had given thanks upon finishing the old feast, leaving us an example to glorify God at the beginning and end of every good work. It follows, And brake it. He Himself breaks the bread which He holds forth, to show that the breaking of His Body, that is, His Passion, will not be without His will. And gave unto them, saying, This is my body which is given for you.

He gave to them, is here understood to complete the sentence.

Because the bread strengthens, and the wine produces blood in the flesh, the former is ascribed to the Body of Christ, the latter to His Blood. But because both we ought to abide in Christ, and Christ in us, the wine of the Lord's cup is mixed with water, for John bears witness, The people are many waters. (Rev. 17:15.)

For this reason then the Apostles communicated after supper, because it was necessary that the typical passover should be first completed, and then they should pass on to the Sacrament of the true Passover. But now in honour of so great a Sacrament, the masters of the Church think right that we should first be refreshed with the spiritual banquet, and afterward with the earthly.
AD 735BedeEarly MedievalSourceOn the Gospel of Luke
Similarly also the cup, after he had supped, saying: This cup is the new testament in my blood, which shall be shed for you. What he says: Similarly also the cup, it is understood to be given in common (ἀπὸ κοινοῦ), as the full sentence: Similarly also the cup, after he had supped, he gave to them. Therefore, because bread strengthens the body and wine works blood in the body, this refers mystically to the body of Christ, that to the blood. But because it is necessary that both we in Christ, and Christ in us remain, the wine of the Lord’s cup is mixed with water. For as John testifies, the waters are peoples (Rev. 15). And it is not permitted to offer water alone, nor wine alone, just as neither is it permitted to offer wheat grain alone without mixing and processing it into bread, lest such offering would signify as if the head is to be separated from the members, and either that Christ could suffer without the love of our redemption, or that we could be saved without Christ's passion, and be offered to the Father; if anyone is moved that when the Savior had supped with the apostles, he handed over his body and blood, why then are we taught by the universal Church’s custom of fasting to receive the same sacraments? Let him briefly hear that therefore the apostles then, having supped, communicated, because it was necessary for that typical Passover to be consummated first, and so to move on to the sacraments of the true Passover. Now, in honor of such a great and so terrible sacrament, it pleased the teachers of the Church that we first be strengthened by the participation in the Lord’s passion, first to be sanctified by spiritual feasts inwardly and outwardly, and thereafter the body to be refreshed by earthly banquets and common foods. And what he says: This is the cup of the new testament in my blood, refers to the distinction of the old Testament, which was dedicated with the blood of goats and calves, as the legislator said while sprinkling: This is the blood of the testament which God has commanded unto you (Heb. 9). For it is necessary indeed that the examples of heavenly things be purified with these, but the heavenly things themselves with better sacrifices than these, according to what the Apostle throughout the whole Epistle to the Hebrews distinguishes between the law and the Gospel, with very beautiful exposition and complete reasoning declares.
AD 1107Theophylact of Ohridas quoted by Aquinas, AD 1274MedievalSourceCatena Aurea by Aquinas
Now Luke mentions two cups; of the one we spoke above, Take this, and divide it among yourselves, which we may say is a type of the Old Testament; but the other after the breaking and giving of bread, He Himself imparts to His disciples. Hence it is added, Likewise also the cup after supper.

Our Lord calls the cup the New Testament, as it follows, This cup is the New Testament in my blood, which shall be shed for you, signifying that the New Testament has its beginning in His blood. For in the Old Testament the blood of animals was present when the law was given, but now the blood of the Word of God signifies to us the New Testament. But when He says, for you, He does not mean that for the Apostles only was His Body given, and His Blood poured out, but for the sake of all mankind. And the old Passover was ordained to remove the slavery of Egypt; but the blood of the lamb to protect the first-born. The new Passover was ordained to the remission of sins; but the Blood of Christ to preserve those who are dedicated to God.

But first the bread is given, next the cup. For in spiritual things labour and action come first, that is, the bread, not only because it is toiled for by the sweat of the brow, but also because while being eaten it is not easy to swallow. Then after labour follows the rejoicing of Divine grace, which is the cup.
AD 1274Ancient Greek Expositoras quoted by Aquinas, AD 1274MedievalSourceCatena Aurea by Aquinas
(Eutychius Patriarch.) He that communicates receives the whole Body and Blood of our Lord, even though he receive but a part of the Mysteries. For as one seal imparts the whole of its device to different substances, and yet remains entire after distribution, and as one word penetrates to the hearing of many, so there is no doubt that the Body and Blood of our Lord is received whole in all. But the breaking of the sacred bread signifies the Passion.
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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