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Translation
King James Version
But there shall not an hair of your head perish.
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KJV (with Strong's)
But G2532 there shall not G3364 an hair G2359 of G1537 your G5216 head G2776 perish G622.
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Complete Jewish Bible
But not a hair of your head will be lost.
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Berean Standard Bible
Yet not even a hair of your head will perish.
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American Standard Version
And not a hair of your head shall perish.
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World English Bible Messianic
And not a hair of your head will perish.
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Geneva Bible (1599)
Yet there shall not one heare of your heads perish.
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Young's Literal Translation
and a hair out of your head shall not perish;
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In the KJVVerse 25,845 of 31,102

Study This Verse

SUMMARY

Luke 21:18 delivers a profound promise of divine preservation amidst dire warnings of persecution, assuring Jesus's disciples that despite the intense suffering and even martyrdom some may face for their faith, their ultimate well-being and eternal destiny are immutably secure under God's sovereign care. This idiomatic expression conveys an absolute guarantee that nothing of true significance to the believer will be lost or destroyed.

CONTEXT

  • Literary Context: This verse is embedded within Jesus's Olivet Discourse, a significant prophetic teaching delivered on the Mount of Olives. Preceding Luke 21:18, Jesus has just detailed the severe tribulations awaiting His followers, including betrayal by family members, hatred from all nations, and being brought before rulers and kings for His name's sake (Luke 21:12-17). He explicitly states that "some of you shall they cause to be put to death" (Luke 21:16). Therefore, Luke 21:18 stands as a powerful, almost paradoxical, assurance of ultimate safety immediately following the grim prediction of physical death, setting up a crucial tension between temporal suffering and eternal security. The subsequent verse, Luke 21:19, then calls for patient endurance, clarifying the means by which this preservation is realized.
  • Historical & Cultural Context: The Olivet Discourse, delivered shortly before Jesus's crucifixion, anticipates the destruction of the Jerusalem Temple in A.D. 70 and the subsequent persecution of early Christians. The disciples lived in a volatile political and religious climate, where adherence to a new, counter-cultural faith could lead to ostracism, legal charges, and even execution, as seen in the early church's history (e.g., the martyrdom of Stephen in Acts 7 or James in Acts 12). The idiom "not a hair of your head perish" was a common expression in the ancient Near East and Hellenistic world, signifying complete safety and preservation, often used in contexts of war or imminent danger (e.g., 1 Samuel 14:45 or 2 Samuel 14:11). Jesus's use of this familiar phrase would have immediately conveyed a strong sense of absolute, divine protection to His listeners.
  • Key Themes: This verse contributes significantly to several overarching themes in Luke's Gospel and biblical theology. It underscores the theme of Divine Providence and Sovereignty, asserting God's absolute control over the ultimate fate of His children, even in the face of human malice and persecution. It highlights God's Meticulous Care for His People, emphasizing that His concern extends to the smallest details of their lives, as also seen in Jesus's teaching that the very hairs of your head are all numbered. This promise provides a foundational Assurance in Persecution, offering comfort and strength to those who suffer for Christ's name, reminding them that their true life and spiritual well-being are eternally secure, regardless of physical harm. Finally, it speaks to the theme of Ultimate Preservation, distinguishing between temporal suffering and eternal destruction, implying that while the body may perish, the soul and one's eternal destiny in Christ are inviolable.

EXPOSITION AND ANALYSIS

Key Word Analysis

  • hair (Greek, thríx', G2359): This word refers to a single strand of hair. In this idiomatic expression, it represents the smallest, most insignificant part of a person. The use of "hair" here emphasizes the meticulous and comprehensive nature of the promised preservation, suggesting that not even the most minor detail of the believer's life or being will be lost without God's ultimate purpose.
  • not (Greek, _ou _mḗ'__, G3364): This is a double negative in Greek, combining ou (an objective negation) and (a subjective or conditional negation). Together, ou mē creates the strongest possible denial, signifying "never," "not at all," or "by no means." Its inclusion here emphatically reinforces the absolute certainty of the promise: there is no possibility, under any circumstances, that a hair of their head will perish in the ultimate sense.
  • perish (Greek, apóllymi', G622): Derived from apó (from) and óllymi (to destroy), this verb means "to destroy fully," "to lose," or "to ruin." While it can refer to physical death, in the context of this idiom and in contrast to the preceding verse where some will be "put to death," apóllymi here carries a deeper theological meaning of ultimate, irrecoverable destruction or eternal ruin. It signifies that despite physical suffering or even martyrdom, the believer's true life, their soul, and their eternal standing with God will not be ultimately lost or destroyed.

Verse Breakdown

  • "But there shall not an hair": This opening phrase, introduced by "But" (G2532 kaí - often translated as "and" or "but" depending on context, here indicating a strong contrast), immediately shifts the focus from the preceding warnings of persecution and death to an absolute assurance. The "not an hair" (G2359 thríx) uses a common idiom to signify the smallest, most insignificant part, emphasizing the meticulous nature of the divine protection.
  • "of your head": This specifies the source of the "hair," reinforcing the personal and comprehensive nature of the promise. It refers to the entirety of the person, indicating that every aspect of their being is under God's watchful eye.
  • "perish": This final word (G622 apóllymi) is the core of the promise. Given the preceding context of physical death, "perish" here must be understood not as a denial of physical harm or even martyrdom, but as a guarantee against ultimate, spiritual, or eternal destruction. It assures that the believer's soul, their relationship with God, and their eternal destiny are secure and cannot be truly lost or ruined by any earthly tribulation.

Literary Devices

Luke 21:18 employs several powerful literary devices to convey its message of assurance. Idiom is central, as "not an hair of your head perish" is a well-established phrase in ancient literature, universally understood to mean complete safety and preservation, even in dire circumstances. This idiom functions as a form of Hyperbole, using an exaggerated statement (the inability to lose even a single hair) to emphasize the absolute certainty and meticulousness of God's protection. The verse also utilizes Contrast, standing in stark opposition to the preceding verses that detail intense persecution and physical death, thereby highlighting the spiritual and eternal nature of the promised preservation. Finally, the verse serves as a Divine Promise, offering a declarative statement of future certainty from Jesus, designed to instill hope and courage in His disciples facing impending trials.

THEOLOGICAL AND THEMATIC CONNECTIONS

Luke 21:18 is a profound declaration of God's unwavering sovereignty and meticulous care over His elect. It underscores the theological truth that while believers may experience temporal suffering, physical harm, and even martyrdom, their ultimate spiritual reality and eternal destiny are held securely in God's hands. This promise does not negate the reality of earthly trials but redefines their ultimate impact, asserting that no earthly power or tribulation can sever the believer from God's redemptive plan or cause them to "perish" in an eternal sense. It points to a deeper, spiritual preservation that transcends physical existence, rooted in God's faithfulness and His ultimate control over life and death.

REFLECTION AND APPLICATION

This verse offers immense comfort and profound strength to believers navigating a world often hostile to faith. In an age where Christians may face various forms of opposition, from social ostracism to severe persecution, Luke 21:18 serves as an anchor for the soul. It reminds us that our true security is not found in the absence of trouble, but in the unwavering presence and power of God. While we are not promised immunity from physical suffering or even death, we are guaranteed that nothing can ultimately destroy our spiritual life, our relationship with Christ, or our eternal inheritance. This truth empowers us to face trials with courage, to stand firm in our convictions, and to endure hardship with a perspective rooted in eternity. It calls us to trust that God's plan for our lives, even through suffering, is ultimately for our good and His glory, and that He will preserve us for His eternal purposes.

Questions for Reflection

  • How does the promise of ultimate preservation in Luke 21:18 comfort you when facing personal challenges or societal pressures against your faith?
  • In what ways might understanding the difference between temporal suffering and eternal "perishing" change your perspective on hardship?
  • How does this verse encourage you to live boldly for Christ, even when it might lead to difficult consequences?

FAQ

Does "not an hair of your head perish" mean that believers will not experience physical harm or death?

Answer: No, this idiom does not promise immunity from physical harm, suffering, or even martyrdom. In fact, the verses immediately preceding Luke 21:18 explicitly state that some disciples "shall they cause to be put to death" (Luke 21:16). The phrase "not an hair of your head perish" is an idiom signifying ultimate, complete preservation, not of the physical body from all harm, but of the true self and eternal destiny. It assures that nothing of ultimate value to the believer—their soul, their faith, their relationship with God—will be lost or destroyed in an eternal sense. It emphasizes God's sovereign protection over their spiritual well-being, even when their physical lives are taken.

CHRIST-CENTERED FULFILLMENT

Luke 21:18 finds its ultimate fulfillment and profound meaning in the person and work of Jesus Christ. The promise that "not an hair of your head perish" is not a generic assurance but is rooted in Christ's victory over sin, death, and the grave. Believers are preserved because they are "in Christ," united with Him through faith. His resurrection from the dead (Luke 24:1-12) is the ultimate guarantee that death has lost its sting and that those who belong to Him will not "perish" eternally (1 Corinthians 15:54-57). Jesus Himself endured the ultimate "perishing" on the cross, taking upon Himself the full wrath of God for sin, so that those who trust in Him might have eternal life and never truly perish (John 3:16). Therefore, the preservation promised in Luke 21:18 is a direct consequence of Christ's finished work, His ongoing intercession (Romans 8:34), and His promise to raise His people on the last day (John 6:40). Our ultimate security is found not in our own strength or circumstances, but in the unbreakable bond we share with the resurrected and reigning Christ, who is our life and our eternal hope (Colossians 3:3-4).

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Commentary on Luke 21 verses 5–19

I. II. Main points1. 2. Sub-points(1.) (2.) Details[1.] [2.] Fine details

See here, I. With what admiration some spoke of the external pomp and magnificence of the temple, and they were some of Christ's own disciples too; and they took notice of it to him how it was adorned with goodly stones and gifts, Luk 21:5. The outside was built up with goodly stones, and within it was beautified and enriched with the presents that were offered up for that purpose, and were hung up in it. They thought their Master should be as much affected with those things as they were, and should as much regret the destruction of them as they did. When we speak of the temple, it should be of the presence of God in it, and of the ordinances of God administered in it, and the communion which his people there have with him. It is a poor thing, when we speak of the church, to let our discourse dwell upon its pomps and revenues, and the dignities and powers of its officers and rulers; for the king's daughter is all glorious within.

II. With what contempt Christ spoke of them, and with what assurance of their being all made desolate very shortly (Luk 21:6): "As for those things which you behold, those dear things which you are so much in love with, behold, the days will come, and some now living may live to see them, in which there shall not be left one stone upon another. This building, which seems so beautiful that one would think none could, for pity, pull it down, and which seems so strong that one would think none would be able to pull it down, shall yet be utterly ruined; and this shall be done as soon as ever the spiritual temple of the gospel church (the substance of that shadow) begins to flourish in the world." Did we by faith foresee the blasting and withering of all external glory, we should not set our hearts upon it as those do that cannot see, or will not look, so far before them.

III. With what curiosity those about him enquire concerning the time when this great desolation should be: Master, when shall these things be? Luk 21:7. It is natural to us to covet to know future things and the time of them, which it is not for us to know, when we are more concerned to ask what is our duty in the prospect of these things, and how we may prepare for them, which it is for us to know. They enquire what sign there shall be when these things shall come to pass. They ask not for a present sign, to confirm the prediction itself, and to induce them to believe it (Christ's word was enough for that), but what the future signs will be of the approaching accomplishment of the prediction, by which they may be put in mind of it. These signs of the times Christ had taught them to observe.

IV. With what clearness and fulness Christ answers their enquiries, as far as was necessary to direct them in their duty; for all knowledge is desirable as far as it is in order to practice.

1.They must expect to hear of false Christs and false prophets appearing, and false prophecies given out (Luk 21:8): Many shall come in my name; he does not mean in the name of Jesus, though there were some deceivers who pretended commissions from him (as Act 19:13), but usurping the title and character of the Messiah. Many pretended to be the deliverers of the Jewish church and nation from the Romans, and to fix the time when the deliverance should be wrought, by which multitudes were drawn into a snare, to their ruin. They shall say, hoti egō eimi - I am he, or I am, as if they would assume that incommunicable name of God, by which he made himself known when he came to deliver Israel out of Egypt, I am; and, to encourage people to follow them, they added, "The time draws near when the kingdom shall be restored to Israel, and all who will follow me shall share in it." Now as to this, he gives them a needful caution (1.) "Take heed that you be not deceived; do not imagine that I shall myself come again in external glory, to take possession of the throne of kingdoms. No, you must not expect any such thing, for my kingdom is not of this world." When they asked solicitously and eagerly, Master, when shall these things be? the first word Christ said was, Take heed that you be not deceived. Note, Those that are most inquisitive in the things of God (though it is very good to be so) are in most danger of being imposed upon, and have most need to be upon their guard. (2.) "Go you not after them. You know the Messiah is come, and you are not to look for any other; and therefore do not so much as hearken to them, nor have any thing to do with them." If we are sure that Jesus is the Christ, and his doctrine is the gospel, of God, we must be deaf to all intimations of another Christ and another gospel.

2.They must expect to hear of great commotions in the nations, and many terrible judgments inflicted upon the Jews and their neighbours. (1.) There shall be bloody wars (Luk 21:10): Nation shall rise against nation, one part of the Jewish nation against another, or rather the whole against the Romans. Encouraged by the false Christs, they shall wickedly endeavour to throw off the Roman yoke, by taking up arms against the Roman powers; when they had rejected the liberty with which Christ would have made them free they were left to themselves, to grasp at their civil liberty in ways that were sinful, and therefore could not be successful. (2.) There shall be earthquakes, great earthquakes, in divers places, which shall not only frighten people, but destroy towns and houses, and bury many in the ruins of them. (3.) There shall be famines and pestilences, the common effects of war, which destroys the fruits of the earth, and, by exposing men to ill weather and reducing them to ill diet, occasions infectious diseases. God has various ways of punishing a provoking people. The four sorts of judgments which the Old Testament prophets so often speak of are threatened by the New Testament prophets too; for, though spiritual judgments are more commonly inflicted in gospel times, yet God makes use of temporal judgments also. (4.) There shall be fearful sights and great signs from heaven, uncommon appearances in the clouds, comets and blazing stars, which frighten the ordinary sort of beholders, and have always been looked upon as ominous, and portending something bad. Now, as to these, the caution he gives them is, "Be not terrified. Others will be frightened at them, but be not you frightened, Luk 21:2. As to the fearful sights, let them not be fearful to you, who look above the visible heavens to the throne of God's government in the highest heavens. Be not dismayed at the signs of heaven, for the heathen are dismayed at them, Jer 10:2. And, as to the famines and pestilences, you fall into the hands of God, who has promised to those who are his that in the days of famine they shall be satisfied, and that he will keep them from the noisome pestilence; trust therefore in him, and be not afraid. Nay, when you hear of wars, when without are fightings and within are fears, yet then be not you terrified; you know the worst that any of these judgments can do to you, and therefore be not afraid of them; for," [1.] "It is your interest to make the best of that which is, for all your fears cannot alter it: these things must first come to pass; there is no remedy; it will be your wisdom to make yourselves easy by accommodating yourselves to them." [2.] "There is worse behind; flatter not yourselves with a fancy that you will soon see an end of these troubles, no, not so soon as you think of: the end is not by and by, not suddenly. Be not terrified, for, if you begin so quickly to be discouraged, how will you bear up under what is yet before you?"

3.They must expect to be themselves for signs and wonders in Israel; their being persecuted would be a prognostic of the destruction of the city and temple, which he had now foretold. Nay, this would be the first sign of their ruin coming: "Before all these, they shall lay their hands on you. The judgment shall begin at the house of God; you must smart first, for warning to them, that, if they have any consideration, they may consider, If this be done to the green tree, what shall be done to the dry? See Pe1 4:17, Pe1 4:18. But this is not all; this must be considered not only as the suffering of the persecuted, but as the sin of the persecutors. Before God's judgments are brought upon them, they shall fill up the measure of their iniquity by laying their hands on you." Note, The ruin of a people is always introduced by their sin; and nothing introduces a surer or sorer ruin than the sin of persecution. This is a sign that God's wrath is coming upon a people to the uttermost when their wrath against the servants of God comes to the uttermost. Now as to this,

(1.)Christ tells them what hard things they should suffer for his name's sake, much to the same purport with what he had told them when he first called them to follow him, Mt. 10: They should know the wages of it, that they might sit down and count the cost. St. Paul, who was the greatest labourer and sufferer of them all, not being now among them, was told by Christ himself what great things he should suffer for his name's sake (Act 9:16), so necessary is it that all who will live godly in Christ Jesus should count upon persecution. The Christians, having themselves been originally Jews, and still retaining an equal veneration with them for the Old Testament and all the essentials of their religion, and differing only in ceremony, might expect fair quarter with them; but Christ bids them not expect it: "No, they shall be the most forward to persecute you." [1.] "They shall use their own church-power against you: They shall deliver you up to the synagogues to be scourged there, and stigmatized with their anathemas." [2.] "They shall incense the magistrates against you: they shall deliver you into prisons, that you may be brought before kings and rulers for my name's sake, and be punished by them." [2.] "Your own relations will betray you (Luk 21:16), your parents, brethren, and kinsfolks, and friends; so that you will not know whom to put a confidence in, or where to be safe." [4.] "Your religion will be made a capital crime, and you will be called to resist unto blood. Some of you shall they cause to be put to death; so far must you be from expecting honour and wealth that you must expect nothing but death in its most frightful shapes, death in all its dreadful pomp. Nay." [5.] "You shall be hated of all men for my name's sake." This is worse than death itself, and was fulfilled when the apostles were not only appointed to death, but made a spectacle to the world, and counted as the filth of the world, and the offscouring of all things, which every body loathes, Co1 4:9, Co1 4:13. They were hated of all men, that is, of all bad men, who could not bear the light of the gospel (because it discovered their evil deeds), and therefore hated those who brought in that light, flew in their faces, and would have pulled them to pieces. The wicked world, which hated to be reformed, hated Christ the great Reformer, and all that were his, for his sake. The rulers of the Jewish church, knowing very well that if the gospel obtained among the Jews their usurped abused power was at an end, raised all their forces against it, put it into an ill name, filled people's minds with prejudices against it, and so made the preachers and professors of it odious to the mob.

(2.)He encourages them to bear up under their trials, and to go on in their work, notwithstanding the opposition they would meet with.

[1.]God will bring glory both to himself and them out of their sufferings: "It shall turn to you for a testimony, Luk 21:13. Your being set up thus for a mark, and publicly persecuted, will make you the more taken notice of and your doctrine and miracles the more enquired into; your being brought before kings and rulers will give you an opportunity of preaching the gospel to them, who otherwise would never have come within hearing of it; your suffering such severe things, and being so hated by the worst of men, men of the most vicious lives, will be a testimony that you are good, else you would not have such bad men for your enemies; your courage, and cheerfulness, and constancy under your sufferings will be a testimony for you, that you believe what you preach, that you are supported by a divine power, and that the Spirit of God and glory rests upon you."

[2.]"God will stand by you, and own you, and assist you, in your trials; you are his advocates, and you shall be well furnished with instructions, Luk 21:14, Luk 21:15. Instead of setting your hearts on work to contrive an answer to informations, indictments, articles, accusations, and interrogatories, that will be exhibited against you in the ecclesiastical and civil courts, on the contrary, settle it in your hearts, impress it upon them, take pains with them to persuade them not to meditate before what you shall answer; do not depend upon your own wit and ingenuity, your own prudence and policy, and do not distrust or despair of the immediate and extraordinary aids of the divine grace. Think not to bring yourselves off in the cause of Christ as you would in a cause of your own, by your own parts and application, with the common assistance of divine Providence, but promise yourselves, for I promise you, the special assistance of divine grace: I will give you a mouth and wisdom." This proves Christ to be God; for it is God's prerogative to give wisdom, and he it is that made man's mouth. Note, First, A mouth and wisdom together completely fit a man both for services and sufferings; wisdom to know what to say, and a mouth wherewith to say it as it should be said. It is a great happiness to have both matter and words wherewith to honour God and do good; to have in the mind a storehouse well furnished with things new and old, and a door of utterance by which to bring them forth. Secondly, Those that plead Christ's cause may depend upon him to give them a mouth and wisdom, which way soever they are called to plead it, especially when they are brought before magistrates for his name's sake. It is not said that he will send an angel from heaven to answer for them, though he could do this, but that he will give them a mouth and wisdom to enable them to answer for themselves, which puts a greater honour upon them, which requires them to use the gifts and graces Christ furnishes them with, and redounds the more to the glory of God, who stills the enemy and the avenger out of the mouths of babes and sucklings. Thirdly, When Christ gives to his witnesses a mouth and wisdom, they are enabled to say that both for him and themselves which all their adversaries are not able to gainsay or resist, so that they are silenced, and put to confusion. This was remarkably fulfilled presently after the pouring out of the Spirit, by whom Christ gave his disciples this mouth and wisdom, when the apostles were brought before the priest sand rulers, and answered them so as to make them ashamed, Acts 4, 5, and Act 6:1-15.

[3.]"You shall suffer no real damage by all the hardships they shall put upon you (Luk 21:18): There shall not a hair of your head perish." Shall some of them lose their heads, and yet not lose a hair? It is a proverbial expression, denoting the greatest indemnity and security imaginable; it is frequently used both in the Old Testament and New, in that sense. Some think that it refers to the preservation of the lives of all the Christians that were among the Jews when they were cut off by the Romans; historians tell us that not one Christian perished in that desolation. Others reconcile it with the deaths of multitudes in the cause of Christ, and take it figuratively in the same sense that Christ saith, He that loseth his life for my sake shall find it. "Not a hair of your head shall perish but," First, "I will take cognizance of it." To this end he had said (Mat 10:30), The hairs of your head are all numbered; and an account is kept of them, so that none of them shall perish but he will miss it. Secondly, "It shall be upon a valuable consideration." We do not reckon that lost or perishing which is laid out for good purposes, and will turn to a good account. If we drop the body itself for Christ's name's sake, it does not perish, but is well bestowed. Thirdly, "It shall be abundantly recompensed; when you come to balance profit and loss, you will find that nothing has perished, but, on the contrary, that you have great gain in present comforts, especially in the joys of a life eternal;" so that though we may be losers for Christ we shall not, we cannot, be losers by him in the end.

[4.]"It is therefore your duty and interest, in the midst of your own sufferings and those of the nation, to maintain a holy sincerity and serenity of mind, which will keep you always easy (Luk 21:19): In your patience possess ye your souls; get and keep possession of your souls." Some read it as a promise, "You may or shall possess your souls." It comes all to one. Note, First, It is our duty and interest at all times, especially in perilous trying times, to secure the possession of our own souls; not only that they be not destroyed and lost for ever, but that they be not distempered now, nor our possession of them disturbed and interrupted. "Possess your souls, be your own men, keep up the authority and dominion of reason, and keep under the tumults of passion, that neither grief nor fear may tyrannize over you, nor turn you out of the possession and enjoyment of yourselves." In difficult times, when we can keep possession of nothing else, then let us make that sure which may be made sure, and keep possession of our souls. Secondly, It is by patience, Christian patience, that we keep possession of our own souls. "In suffering times, set patience upon the guard for the preserving of your souls; by it keep your souls composed and in a good frame, and keep out all those impressions which would ruffle you and put you out of temper."

Matthew Henry (1662–1714) — Commentary on the Whole Bible. This section covers verses 5–19. Public domain.
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Hippolytus of RomeAD 235
Hippolytus Dogmatical and Historical Fragments
These things, then, being to come to pass, beloved, and the one week being divided into two parts, and the abomination of desolation being manifested then, and the two prophets and forerunners of the Lord having finished their course, and the whole world finally approaching the consummation, what remains but the coming of our Lord and Saviour Jesus Christ from heaven, for whom we have looked in hope? who shall bring the conflagration and just judgment upon all who have refused to believe on Him. For the Lord says, "And when these things begin to come to pass, then look up, and lift up your heads; for your redemption draweth nigh." "And there shall not a hair of your head perish." "For as the lightning cometh out of the east, and shineth even unto the west, so shall also the coming of the Son of man be. For wheresoever the carcase is, there will the eagles be gathered together." Now the fall took place in paradise; for Adam fell there. And He says again, "Then shall the Son of man send His angels, and they shall gather together His elect from the four winds of heaven." And David also, in announcing prophetically the judgment and coming of the Lord, says, "His going forth is from the end of the heaven, and His circuit unto the end of the heaven: and there is no one hid from the heat thereof." By the heat he means the conflagration. And Esaias speaks thus: "Come, my people, enter thou into thy chamber, (and) shut thy door: hide thyself as it were for a little moment, until the indignation of the Lord be overpast." And Paul in like manner: "For the wrath of God is revealed from heaven against all ungodliness and unrighteousness of men, who hold the truth of God in unrighteousness."
Apostolic ConstitutionsAD 380
Apostolic Constitutions (Book V)
For the Almighty God Himself will raise us up through our Lord Jesus Christ, according to His infallible promise, and grant us a resurrection with all those that have slept from the beginning of the world; and we shall then be such as we now are in our present form, without any defect or corruption. For we shall rise incorruptible: whether we die at sea, or are scattered on the earth, or are torn to pieces by wild beasts and birds, He will raise us by His own power; for the whole world is held together by the hand of God. Now He says: "An hair of your head shall not perish." [Luke 21:18] Wherefore He exhorts us, saying: "In your patience you possess your souls." [Luke 21:19]
Gregory of Nyssa (as quoted by Aquinas, AD 1274)AD 395
Catena Aurea by Aquinas
But let us consider the state of things at that time. While all men were suspected, kinsfolk were divided against one another, each differing from the other in religion; the gentile son stood up the betrayer of his believing parents, and of his believing son the unbelieving father became the determined accuser; no age was spared in the persecution of the faith; women were unprotected even by the natural weakness of their sex.
Ambrose of Milan (as quoted by Aquinas, AD 1274)AD 397
Catena Aurea by Aquinas
There are also other wars which the Christian wages, the struggles of different lusts, and the conflicts of the will; and domestic foes are far more dangerous than foreign.

Now in one place Christ speaks in His disciples, as here; in another, the Father; (Mat. 16:17) in another the Spirit of the Father speaketh. (Mat. 10:20.) These do not differ but agree together, In that one speaketh, three speak, for the voice of the Trinity is one.
Augustine of HippoAD 430
SERMON 273.1
Death comes to either the soul or the body. The soul cannot die, and yet it can die. It cannot die, because its consciousness is never lost. It can die, if it loses God. You see, just as the soul itself is the life of the body, so in the same way God is the life of the soul. As the body dies when the soul that is its life abandons it, in the same way when God abandons the soul, it dies. To make sure, however, that God does not abandon the soul, it must always have enough faith not to fear death for God's sake. Then God does not abandon it, and it does not die.It remains that the death that is feared is feared for the body. Even on this point, the Lord Christ reassured his martyrs. After all, how could they be unsure of the integrity of their bodies, when they had been reassured about the number of their hairs? "He said that your hairs have all been counted." In another place he says even more plainly, "For I tell you, that not a hair of your head shall perish." Truth speaks. Does weakness hesitate?
Augustine of HippoAD 430
SERMON 214.11-12
We should have no doubt that our mortal flesh also will rise again at the end of the world.… This is the Christian faith. This is the Catholic faith. This is the apostolic faith. Believe Christ when he says, "Not a hair of your head shall perish." Putting aside all unbelief, consider how valuable you are. How can our Redeemer despise any person when he cannot despise a hair of that person's head? How are we going to doubt that he intends to give eternal life to our soul and body? He took on a soul and body in which to die for us, which he laid down for us when he died and which he took up again that we might not fear death.
Cyril of AlexandriaAD 444
COMMENTARY ON LUKE, HOMILY 139
Jesus gives them clear and evident signs of the time when the consummation of the world draws near. He says that there will be wars, turmoil, famines and epidemics everywhere. There will be terrors from heaven and great signs. As another Evangelist says, “All the stars shall fall, and the heaven be rolled up like a scroll, and its powers will be shaken.”In the middle of this, the Savior places what refers to the capture of Jerusalem. He mixes the accounts together in both parts of the narrative. Before all these things, he says, “They will lay their hands on you and persecute you, delivering you up to synagogues and to prisons and bringing you before kings and rulers for my name’s sake. This will be a witness to you.” Before the times of consummation, the land of the Jews was taken captive, and the Roman armies overran it. They burned the temple, overthrew their national government, and stopped the means for legal worship. They no longer had sacrifices, now that the temple was destroyed. The country of the Jews together with Jerusalem itself was totally laid waste. Before these things happened, they persecuted the blessed disciples. They imprisoned them and had a part in unendurable trials. They brought the disciples before judges and sent them to kings. Paul was sent to Rome to Caesar.…
Christ promises, however, that he will deliver them certainly and completely. He says that a hair of your head will not perish.
Cyril of Alexandria (as quoted by Aquinas, AD 1274)AD 444
Catena Aurea by Aquinas
Or He says this, because before that Jerusalem should be taken by the Romans, the disciples, having suffered persecution from the Jews, were imprisoned and brought before rulers; Paul was sent to Rome to Cæsar, and stood before Festus and Agrippa.
It follows, And it shall turn to you for a testimony. In the Greek it is εἰς μαρτύριον, that is, for the glory of martyrdom.
Gregory the Dialogist (as quoted by Aquinas, AD 1274)AD 604
Catena Aurea by Aquinas
(Hom. 35. in Evang.) Because the things which have been prophesied of arise not from the injustice of the inflictor of them, but from the deserts of the world which suffers them, the deeds or wicked men are foretold; as it is said, But before all these things, they shall lay their hands upon you: as if He says, First the hearts of men, afterwards the elements, shall be disturbed, that when the order of things is thrown into confusion, it may be plain from what retribution it arises. For although the end of the world depends upon its own appointed course, yet finding some more corrupt than others who shall rightly be overwhelmed in its fall, our Lord makes them known.

(ut sup.) Or, for a testimony, that is, against those who by persecuting you bring death upon themselves, or living do not imitate you, or themselves becoming hardened perish without excuse, from whom the elect take example that they may live. But as hearing so many terrible things the hearts of men may be troubled, He therefore adds for their consolation, Settle it therefore in your hearts, &c.

(ut sup.) As if the Lord said to His disciples, "Be not afraid, go forward to the battle, it is I that fight; you utter the words, I am He that speaketh."

(ut sup.) We are the more galled by the persecutions we suffer from those of whose dispositions we made sure, because together with the bodily pain, we are tormented by the bitter pangs of lost affection.

(ut sup.) But because of the hard things foretold concerning the affliction of death, there immediately follows a consolation, concerning the joy of the resurrection, when it is said, But there shall not an hair of your head perish. As though He said to the martyrs, Why fear ye for the perishing of that which when cut, pains, when that can not perish in you, which when cut gives no pain?

(Mor. 5. c. 16.) He who preserves patience in adversity, is thereby rendered proof against all affliction, and so by conquering himself, he gains the government of himself; as it follows, In your patience shall ye possess your souls. For what is it to possess your souls, but to live perfectly in all things, and sitting as it were upon the citadel of virtue to hold in subjection every motion of the mind?

(Hom. 35. in Ev.) By patience then we possess our souls, because when we are said to govern ourselves, we begin to possess that very thing which we are. But for this reason, the possession of the soul is laid in the virtue of patience, because patience is the root and guardian of all virtues. Now patience is to endure calmly the evils which are inflicted by others, and also to have no feeling of indignation against him who inflicts them.
Gregory the DialogistAD 604
Forty Gospel Homilies, Homily 35
But because the things foretold concerning the affliction of death are harsh, consolation is immediately added concerning the joy of the resurrection, when it is said: "Not a hair of your head shall perish." We know, brothers, that flesh when cut feels pain, but hair when cut does not feel pain. Therefore He says to His martyrs: "Not a hair of your head shall perish," clearly saying: Why do you fear that what feels pain when cut may perish, when even that which does not feel pain when cut cannot perish in you?
Bede (as quoted by Aquinas, AD 1274)AD 735
Catena Aurea by Aquinas
Or else, There shall not perish a hair of the head of our Lord's Apostles, because not only the noble deeds and words of the Saints, but even the slightest thought shall meet with its deserving reward.
BedeAD 735
On the Gospel of Luke
And not a hair of your head will perish. We know that flesh cut feels pain, hair cut does not feel pain. Therefore, he says to his martyrs: Not a hair of your head will perish, evidently saying openly: Why do you fear lest what is cut and feels pain will perish, when even that in you which is cut and feels no pain cannot perish? In another sense: Not a hair of the head of the disciples of the Lord will perish, because not only the strong deeds or words of saints, of which it is said: The Lord preserves all their bones (Psalm 33), but also the volatile (so to speak) and most delicate surface of the thoughts of the faithful, which emerges from the hidden root of the heart, as hair from the brain, will be preserved with due reward by the just judge. Hence rightly the Prophet, to show how much the merits of even good thoughts are accepted by the Lord, says: And the leftovers of thoughts will feast for you (Psalm 76). Hence the Nazarenes in the law, during the time of consecration, are commanded to nurture their hair, and it is said that a razor did not come upon the head of Samuel. Conversely, the captive woman in order to marry an Israelite man, cleansed from leprosy to be worthy to communicate with the Church, is commanded to shave all the hair of her body, because evidently every thought of the wise, which is good, pleasing, and perfect, is saved forever, and its reward is with the Lord. But the thought of the foolish and wicked, as an unworthy root before the sight of God, must be cut off through repentance.
Theophylact of Ohrid (as quoted by Aquinas, AD 1274)AD 1107
Catena Aurea by Aquinas
For because they were foolish and inexperienced, the Lord tells them this, that they might not be confounded when about to give account to the wise. And He adds the cause, For I will give you a mouth and wisdom, which all your adversaries shall not be able to gainsay or resist. As if He said, Ye shall forthwith receive of me eloquence and wisdom, so that all your adversaries, were they gathered together in one, shall not be able to resist you, neither in wisdom, that is, the power of the understanding, nor in eloquence, that is, excellence of speech, for many men have often wisdom in their mind, but being easily provoked to their great disturbance, mar the whole when their time of speaking comes, But not such were the Apostles, for in both these gifts they were highly favoured.

Having in what has gone before dispelled the fear of inexperience, He goes on to warn them of another very certain event, which might agitate their minds, lest falling suddenly upon them, it should dismay them; for it follows, And ye shall be betrayed both by parents, and brethren, and kinsfolk, and some of you shall they cause to be put to death.

To all this He adds the hatred which they shall meet with from all men.
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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