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Translation
King James Version
Then said Mary unto the angel, How shall this be, seeing I know not a man?
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KJV (with Strong's)
Then G1161 said G2036 Mary G3137 unto G4314 the angel G32, How G4459 shall G2071 this G5124 be G2071, seeing G1893 I know G1097 not G3756 a man G435?
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Complete Jewish Bible
"How can this be," asked Miryam of the angel, "since I am a virgin?"
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Berean Standard Bible
“How can this be,” Mary asked the angel, “since I am a virgin?”
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American Standard Version
And Mary said unto the angel, How shall this be, seeing I know not a man?
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World English Bible Messianic
Miriam said to the angel, “How can this be, seeing I am a virgin?”
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Geneva Bible (1599)
Then sayde Marie vnto the Angel, How shall this be, seeing I knowe not man?
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Young's Literal Translation
And Mary said unto the messenger, `How shall this be, seeing a husband I do not know?'
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In the KJVVerse 24,928 of 31,102

Study This Verse

SUMMARY

Mary's profound question marks a pivotal moment in the annunciation narrative, revealing her humble yet logical human inquiry into the mechanics of a divine promise. Faced with the angel Gabriel's declaration that she, a virgin, would conceive and bear the Son of God, Mary seeks understanding regarding the physical impossibility of such an event given her marital status, setting the stage for one of Scripture's clearest affirmations of the miraculous virgin birth.

CONTEXT

  • Literary Context: This verse immediately follows the angel Gabriel's astonishing announcement to Mary in Luke 1:26-33, where he declares that she will conceive a son by the Holy Spirit, name him Jesus, and that he will be the Son of the Most High, reigning over the house of Jacob forever. Mary's question arises as a direct, natural response to this supernatural declaration, highlighting the biological paradox presented by Gabriel's words. Her inquiry contrasts sharply with the initial disbelief and subsequent muteness of Zechariah, John the Baptist's father, when he received a similar miraculous promise in Luke 1:18-20. Mary's question is not born of doubt, but of a sincere desire for clarification regarding the "how" of God's plan.
  • Historical & Cultural Context: In first-century Jewish society, virginity before marriage was strictly guarded and highly valued. A betrothal, though not yet a legal marriage, was a binding commitment, making any premarital sexual activity a grave offense. Mary's statement, "seeing I know not a man," underscores her status as a virgin who had not yet consummated her betrothal to Joseph. This cultural reality makes Gabriel's prophecy even more astounding and Mary's question entirely understandable. Furthermore, the setting in Nazareth, a small, unassuming Galilean town, adds to the unexpected nature of God's choice, highlighting His tendency to work through the humble and overlooked, a theme found throughout biblical history.
  • Key Themes: Mary's question contributes significantly to several key themes in Luke's Gospel and the broader biblical narrative. It directly introduces the theme of the Virgin Birth, a foundational doctrine of Christian faith, emphasizing the unique, supernatural origin of Jesus Christ. It also highlights the Clash of Human Logic and Divine Power, demonstrating that God's plans often transcend human understanding and natural laws. Mary's response exemplifies Humble Inquiry versus Doubt, portraying her as a thoughtful, receptive servant rather than a skeptic, setting the stage for her faithful submission in Luke 1:38. This moment underscores God's Sovereignty and Faithfulness in fulfilling His promises, even through seemingly impossible means, a concept echoed in Jeremiah 32:27.

EXPOSITION AND ANALYSIS

Key Word Analysis

  • know (Greek, ginṓskō', G1097): This verb, G1097, signifies to "know" in a deep, intimate, and experiential sense, not merely intellectual acquaintance. In biblical Hebrew and Greek idiom, "to know" a person, especially in the context of marriage or procreation (as seen in Genesis 4:1), refers to sexual intercourse. Mary's use of this word emphatically declares her virginity and the absence of any sexual relations.
  • man (Greek, anḗr', G435): This noun, G435, specifically refers to an individual male, a husband, or a fellow, distinguishing it from the more general term for human being (anthrōpos). Mary's choice of "man" confirms she is speaking about a male partner in a conjugal sense, reinforcing the biological impossibility of the angel's announcement from a human perspective.

Verse Breakdown

  • "Then said Mary unto the angel,": This opening clause establishes Mary's direct and immediate engagement with Gabriel's message. Her response is not one of shock-induced silence or outright rejection, but a measured and respectful address to the divine messenger, indicating a readiness to understand.
  • "How shall this be,": This is the core of Mary's inquiry. The interrogative "How" (Greek, pōs' - G4459) seeks an explanation for the mechanism of conception. It is a logical question from a human perspective, acknowledging the miraculous nature of the promise while seeking to reconcile it with her physical reality. It sets up the angel's subsequent explanation of divine intervention.
  • "seeing I know not a man?": This phrase provides the crucial context for Mary's "how." The Greek particle epeí (G1893), translated as "seeing," introduces the reason or cause for her question. Her declaration "I know not a man" (Greek, ou ginṓskō anḗr - G3756, G1097, G435) is a clear and unambiguous statement of her virginity, making the angel's prophecy of conception utterly impossible by natural means.

Literary Devices

Luke employs several literary devices to convey the significance of this moment. The most prominent is Dialogue, which provides a direct and intimate exchange between the divine messenger and the human recipient, allowing the reader to witness Mary's genuine reaction and humble inquiry. Mary's question, "How shall this be...?" functions as a Rhetorical Question, not necessarily seeking a simple factual answer, but expressing the profound human incomprehension in the face of a divine miracle. It highlights the vast chasm between human capability and God's omnipotence. Furthermore, the phrase "I know not a man" serves as a Euphemism for sexual intimacy, a common biblical idiom that delicately yet unequivocally communicates Mary's virgin status without explicit language, underscoring the purity and sanctity of her condition.

THEOLOGICAL AND THEMATIC CONNECTIONS

Mary's question and the subsequent divine explanation lay the theological groundwork for understanding the unique person of Jesus Christ. Her virginity, explicitly stated, is not merely a biological detail but a theological necessity, affirming that Jesus' conception was a direct, supernatural act of God, ensuring His sinless nature and divine Sonship. This event demonstrates God's power to transcend natural laws, fulfilling His redemptive plan through miraculous means. It underscores the truth that salvation is entirely a work of God, not dependent on human agency or natural processes, thus magnifying His grace and sovereignty. Mary's humble inquiry, rather than doubt, models a faith that seeks understanding while remaining open to the impossible.

REFLECTION AND APPLICATION

Mary's response to Gabriel offers profound lessons for contemporary believers. When confronted with God's seemingly impossible commands or promises, it is natural to question "how." However, Mary's inquiry is not rooted in skepticism or a refusal to believe, but in a sincere desire for understanding and a humble recognition of her own limitations. Her question, "How shall this be?" invites divine explanation, rather than shutting down the possibility. This teaches us that genuine faith is not blind; it can ask questions, wrestle with paradoxes, and seek clarity, all while maintaining an open heart to God's supernatural power. In our own lives, when God calls us to tasks that seem beyond our natural abilities or understanding, we are encouraged to bring our "hows" to Him in prayer, trusting that His power is limitless and that He will provide the means, often through the empowering work of the Holy Spirit, to accomplish His divine will. This verse reminds us that God's ways are indeed higher than our ways, and His wisdom surpasses all human comprehension.

Questions for Reflection

  • How do I typically react when God's will or promises seem impossible or contrary to my understanding?
  • Am I willing to ask "how" with a heart of humble inquiry, or does my questioning often stem from doubt or resistance?
  • What "impossible" situations in my life might God be calling me to trust Him with, even when the "how" is unclear?
  • In what ways can I cultivate a deeper trust in God's supernatural power to accomplish what is humanly impossible?

FAQ

Was Mary expressing doubt or disbelief in the angel's message?

Answer: No, Mary was not expressing doubt or disbelief. Her question, "How shall this be, seeing I know not a man?" is a logical inquiry stemming from her physical reality as a virgin. Unlike Zechariah, who doubted the angel's message due to his and Elizabeth's old age in Luke 1:18, Mary's question seeks understanding regarding the mechanism of conception, not the veracity of the promise itself. Her subsequent response in Luke 1:38 – "Behold the handmaid of the Lord; be it unto me according to thy word" – clearly demonstrates her profound faith and submission to God's will.

What does "I know not a man" mean in this context?

Answer: The phrase "I know not a man" is a common biblical idiom for sexual intimacy or conjugal relations. In both Hebrew and Greek cultures, "to know" someone in this context implies a deep, personal, and physical relationship, specifically sexual intercourse. Mary's statement unequivocally affirms her virginity and the absence of any sexual experience, underscoring the miraculous nature of the angel's prophecy that she would conceive a son. This usage is consistent with other biblical passages, such as Genesis 4:1, where Adam "knew" Eve.

Why is the virgin birth of Jesus so important theologically?

Answer: The virgin birth is a cornerstone of Christian theology because it affirms Jesus' unique identity as both fully human and fully divine. It signifies that Jesus' origin was not through natural human procreation but by a direct, supernatural act of God the Holy Spirit (Luke 1:35). This miraculous conception ensures Jesus' sinlessness, as He did not inherit the fallen nature passed down through human lineage (Hebrews 4:15). It also fulfills Old Testament prophecies, such as Isaiah 7:14, and underscores that salvation is entirely a divine initiative, not dependent on human effort or natural processes.

CHRIST-CENTERED FULFILLMENT

Mary's profound question in Luke 1:34 sets the stage for the ultimate revelation of Christ's unique identity. Her declaration of virginity ("I know not a man") directly necessitates the divine intervention described by Gabriel in Luke 1:35, where the Holy Spirit's overshadowing power enables the conception. This miraculous birth is foundational to Christology, establishing Jesus' status as the Son of God in a unique sense, not merely as a prophet or a king, but as the incarnate Word (John 1:14). Because He was conceived by the Holy Spirit and not through natural human means, Jesus entered humanity without the stain of inherited sin, making Him the perfect, spotless Lamb of God capable of bearing the sins of the world (John 1:29). His virgin birth is thus inextricably linked to His sinless life, His atoning death, and His role as the perfect mediator between God and humanity (1 Timothy 2:5). Mary's humble inquiry ultimately points to the incomprehensible wisdom and power of God, who, in Christ, bridges the infinite gap between the divine and the human, offering salvation to all who believe.

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Commentary on Luke 1 verses 26–38

I. II. Main points1. 2. Sub-points(1.) (2.) Details

We have here notice given us of all that it was fit we should know concerning the incarnation and conception of our blessed Saviour, six months after the conception of John. The same angel, Gabriel, that was employed in making known to Zacharias God's purpose concerning his son, is employed in this also; for in this, the same glorious work of redemption, which was begun in that, is carried on. As bad angels are none of the redeemed, so good angels are none of the redeemers; yet they are employed by the Redeemer as his messengers, and they go cheerfully on his errands, because they are his Father's humble servants, and his children's hearty friends and well-wishers.

I. We have here an account given of the mother of our Lord, of whom he was to be born, whom, though we are not to pray to, yet we ought to praise God for.

1.Her name was Mary, the same name with Miriam, the sister of Moses and Aaron; the name signifies exalted, and a great elevation it was to her indeed to be thus favoured above all the daughters of the house of David.

2.She was a daughter of the royal family, lineally descended from David, and she herself and all her friends knew it, for she went under the title and character of the house of David, though she was poor and low in the world; and she was enabled by God's providence, and the care of the Jews, to preserve their genealogies, to make it out, and as long as the promise of the Messiah was to be fulfilled it was worth keeping; but for those now, who are brought low in the world, to have descended from persons of honour, is not worth mentioning.

3.She was a virgin, a pure unspotted one, but espoused to one of the same royal stock, like her, however, of low estate; so that upon both accounts there was (as it was fit there should be) an equality between them; his name was Joseph; he also was of the house of David, Mat 1:20. Christ's mother was a virgin, because he was not to be born by ordinary generation, but miraculously; it was necessary that he should be so, that, though he must partake of the nature of man, yet not of the corruption of that nature: but he was born of a virgin espoused, made up to be married, and contracted, to put honour upon the married state, that that might not be brought into contempt (which was an ordinance in innocency) by the Redeemer's being born of a virgin.

4.She lived in Nazareth, a city of Galilee, a remote corner of the country, and in no reputation for religion or learning, but which bordered upon the heathen, and therefore was called Galilee of the Gentiles. Christ's having his relations resident there intimates favour in reserve for the Gentile world. And Dr. Lightfoot observes that Jonah was by birth a Galilean, and Elijah and Elisha very much conversant in Galilee, who were all famous prophets of the Gentiles. The angel was sent to her from Nazareth. Note, No distance or disadvantage of place shall be a prejudice to those for whom God has favours in store. The angel Gabriel carries his message as cheerfully to Mary and Nazareth in Galilee as to Zacharias in the temple at Jerusalem.

II. The address of the angel to her, Luk 1:28. We are not told what she was doing, or how employed, when the angel came unto her; but he surprised her with this salutation, Hail, thou art highly favoured. This was intended to raise in her, 1. A value for herself; and, though it is very rare that any need to have any sparks struck into their breast with such design, yet in some, who like Mary pore only on their low estate, there is occasion for it. 2. An expectation of great news, not from abroad, but from above. Heaven designs, no doubt, uncommon favours for one whom an angel makes court to with such respect, Hail thou, chaire - rejoice thou; it was the usual form of salutation; it expresses an esteem of her, and good-will to her and her prosperity.

(1.)She is dignified: "Thou art highly favoured. God, in his choice of thee to be the mother of the Messiah, has put an honour upon thee peculiar to thyself, above that of Eve, who was the mother of all living." The vulgar Latin translates this grati plena - full of grace, and thence gathers that she had more of the inherent graces of the Spirit than ever any had; whereas it is certain that this bespeaks no other than the singular favour done her in preferring her to conceive and bear our blessed Lord, an honour which, since he was to be the seed of the woman, some woman must have, not for personal merit, but purely for the sake of free grace, and she is pitched upon. Even so, Father, because it seemed good unto thee.

(2.)She has the presence of God with her: "The Lord is with thee, though poor and mean, and perhaps now forecasting how to get a livelihood and maintain a family in the married state." The angel with this word raised the faith of Gideon (Jdg 6:12): The Lord is with thee. Nothing is to be despaired of, not the performance of any service, not the obtaining of any favour, though ever so great, if we have God with us. This word might put her in mind of the Immanuel, God with us, which a virgin shall conceive and bear (Isa 7:14), and why not she?

(3.)She has the blessing of God upon her: "Blessed art thou among women; not only thou shalt be accounted so by men, but thou shalt be so. Thou that art so highly favoured in this instance mayest expect in other things to be blessed." She explains this herself (Luk 1:48), All generations shall call me blessed. Compare it with that which Deborah saith of Jael, another that was the glory of her sex (Jdg 5:24), Blessed shall she be above women in the tent.

III. The consternation she was in, upon this address (Luk 1:29). When she saw him, and the glories with which he was surrounded, she was troubled at the sight of him, and much more at his saying. Had she been a proud ambitious young woman, that aimed high, and flattered herself with the expectation of great things in the world, she would have been pleased at his saying, would have been puffed up with it, and (as we have reason to think she was a young woman of very good sense) would have had an answer ready, signifying so much: but, instead of that, she is confounded at it, as not conscious to herself of any thing that either merited or promised such great things; and she cast in her mind what manner of salutation this should be. Was it from heaven or of men? Was it to amuse her? was it to ensnare her? was it to banter her? or was there something substantial and weighty in it? But, of all the thoughts she had as to what manner of salutation it should be, I believe she had not the least idea of its being ever intended or used for a prayer, as it is, and has been, for many ages, by the corrupt, degenerate, and anti-christian ages of the church, and to be ten times repeated for the Lord's prayer once; so it is in the church of Rome. But her thoughtfulness upon this occasion gives a very useful intimation to young people of her sex, when addresses are made to them, to consider and cast in their minds what manner of salutations they are, whence they come, and what their tendency is, that they may receive them accordingly, and may always stand on their guard.

IV. The message itself which the angel had to deliver to her. Some time the angel gives her to pause; but, observing that this did but increase her perplexity, he went on with his errand, Luk 1:30. To what he had said she made no reply; he therefore confirms it: "Fear not, Mary, I have no other design than to assure thee that thou hast found favour with God more than thou thinkest of, as there are many who think they are more favoured with God than they really are." Note, Those that have found favour with God should not give way to disquieting distrustful fears. Doth God favour thee? Fear not, though the world frown upon thee. Is he for thee? No matter who is against thee.

1.Though she is a virgin, she shall have the honour of being a mother: "Thou shalt conceive in thy womb, and bring forth a son, and thou shalt have the naming of him; thou shalt call his name Jesus," Luk 1:31. It was the sentence upon Eve, that, though she should have the honour to be the mother of all living, yet this mortification shall be an allay to that honour, that her desire shall be to her husband, and he shall rule over her, Gen 3:16. But Mary has the honour without the allay.

2.Though she lives in poverty and obscurity, yet she shall have the honour to be the mother of the Messiah; her son shall be named Jesus - a Saviour, such a one as the world needs, rather than such one as the Jews expect.

(1.)He will be very nearly allied to the upper world. He shall be great, truly great, incontestably great; for he shall be called the Son of the Highest, the Son of God who is the Highest; of the same nature, as the son is of the same nature with the father; and very dear to him, as the son is to the father. He shall be called, and not miscalled, the Son of the Highest; for he is himself God over all, blessed for evermore, Rom 9:5. Note, Those who are the children of God, though but by adoption and regeneration, are truly great, and therefore are concerned to be very good, Jo1 3:1, Jo1 3:2.

(2.)He will be very highly preferred in the lower world; for, though born under the most disadvantageous circumstances possible, and appearing in the form of a servant, yet the Lord God shall give unto him the throne of his father David, Luk 1:32. He puts her in mind that she was of the house of David; and that therefore, since neither the Salique law, nor the right of primogeniture, took place in the entail of his throne, it was not impossible but that she might bring forth an heir to it, and therefore might the more easily believe it when she was told by an angel from heaven that she should do so, that after the sceptre had been long departed from that ancient and honourable family it should now at length return to it again, to remain in it, not by succession, but in the same hand to eternity. His people will not give him that throne, will not acknowledge his right to rule them; but the Lord God shall give him a right to rule them, and set him as his king upon the holy hill of Zion. He assures her, [1.] That his kingdom shall be spiritual: he shall reign over the house of Jacob, not Israel according to the flesh, for they neither came into his interests nor did they continue long a people; it must therefore be a spiritual kingdom, the house of Israel according to the promise, that he must rule over. [2.] That it shall be eternal: he shall reign for ever, and of his kingdom there shall be no end, as there had been long since of the temporal reign of David's house, and would shortly be of the state of Israel. Other crowns endure not to every generation, but Christ's doth, Pro 27:24. The gospel is the last dispensation, we are to look for no other.

V. The further information given her, upon her enquiry concerning the birth of this prince.

1.It is a just enquiry which she makes: "How shall this be? Luk 1:34. How can I now presently conceive a child" (for so the angel meant) "when I know not a man; must it therefore be otherwise than by ordinary generation? If so, let me now how?" She knew that the Messiah must be born of a virgin; and, if she must be his mother, she desires to know how. This was not the language of her distrust, or any doubt of what the angel said, but of a desire to be further instructed.

2.It is a satisfactory answer that is given to it, Luk 1:35. (1.) She shall conceive by the power of the Holy Ghost, whose proper work and office is to sanctify, and therefore to sanctify the virgin for this purpose. The Holy Ghost is called the power of the Highest. Doth she ask how this shall be? This is enough to help her over all the difficulty there appears in it; a divine power will undertake it, not the power of an angel employed in it, as in other works of wonder, but the power of the Holy Ghost himself.

(2.)She must ask no questions concerning the way and manner how it shall be wrought; for the Holy Ghost, as the power of the Highest, shall overshadow her, as the cloud covered the tabernacle when the glory of God took possession of it, to conceal it from those that would too curiously observe the motions of it, and pry into the mystery of it. The formation of every babe in the womb, and the entrance of the spirit of life into it, is a mystery in nature; none knows the way of the spirit, nor how the bones are formed in the womb of her that is with child, Ecc 11:5. We were made in secret, Psa 139:15, Psa 139:16. Much more was the formation of the child Jesus a mystery; without controversy, great was the mystery of godliness, God manifest in the flesh, Ti1 3:16. It is a new thing created in the earth (Jer 31:22), concerning which we must not covet to be wise above what is written.

(3.)The child she shall conceive is a holy thing, and therefore must not be conceived by ordinary generation, because he must not share in the common corruption and pollution of the human nature. He is spoken of emphatically, That Holy Thing, such as never was; and he shall be called the Son of God, as the Son of the Father by eternal generation, as an indication of which he shall now be formed by the Holy Ghost in the present conception. His human nature must be so produced, as it was fit that should be which was to be taken into union with the divine nature.

3.It was a further encouragement to her faith to be told that her cousin Elisabeth, though stricken in years, was with child, Luk 1:36. Here is an age of wonders beginning, and therefore be not surprised: here is one among thy own relations truly great, though not altogether so great as this; it is usual with God to advance in working wonders. Greater works than these shall ye do. Though Elisabeth was, on the father's side, of the daughters of Aaron (Luk 1:5), yet on the mother's side she might be of the house of David, for those two families often intermarried, as an earnest of the uniting of the royalty and the priesthood of the Messiah. This is the sixth month with her that was called barren. This intimates, as Dr. Lightfoot thinks, that all the instances in the Old Testament of those having children that had been long barren, which was above nature, were designed to prepare the world for the belief of a virgin's bearing a son, which was against nature. And therefore, even in the birth of Isaac, Abraham saw Christ's day, foresaw such a miracle in the birth of Christ. The angel assures Mary of this, to encourage her faith, and concludes with that great truth, of undoubted certainty and universal use, For with God nothing shall be impossible (Luk 1:37), and, if nothing, then not this. Abraham therefore staggered not at the belief of the divine promise, because he was strong in his belief of the divine power, Rom 4:20, Rom 4:21. No word of God must be incredible to us, as long as no work of God is impossible to him.

VI. Her acquiescence in the will of God concerning her, Luk 1:38. She owns herself, 1. A believing subject to the divine authority: "Behold, the handmaid of the Lord. Lord, I am at thy service, at thy disposal, to do what thou commandest me." She objects not the danger of spoiling her marriage, and blemishing her reputation, but leaves the issue with God, and submits entirely to his will. 2. A believing expectant of the divine favour. She is not only content that it should be so, but humbly desires that it may be so: Be it unto me according to thy word. Such a favour as this it was not for her to slight, or be indifferent to; and for what God has promised he will be sought unto; by prayer we must put our amen, or so be it, to the promise. Remember, and perform thy word unto thy servant, upon which thou has caused me to hope. We must, as Mary here, guide our desires by the word of God, and ground our hopes upon it. Be it unto me according to thy word; just so, and no otherwise.

Hereupon, the angel departed from her; having completed the errand he was sent upon, he returned, to give an account of it, and receive new instructions. Converse with angels was always a transient thing, and soon over; it will be constant and permanent in the future state. It is generally supposed that just at this instant the virgin conceived, by the overshadowing power of the Holy Ghost: but, the scripture being decently silent concerning it, it doth not become us to be inquisitive, much less positive.

Matthew Henry (1662–1714) — Commentary on the Whole Bible. This section covers verses 26–38. Public domain.
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Justin MartyrAD 165
The First Apology, Chapter XXXIII
And hear again how Isaiah in express words foretold that He should be born of a virgin; for he spoke thus: "Behold, a virgin shall conceive, and bring forth a son, and they shall say for His name, `God with us.'" For things which were incredible and seemed impossible with men, these God predicted by the Spirit of prophecy as about to come to pass, in order that, when they came to pass, there might be no unbelief, but faith, because of their prediction. But lest some, not understanding the prophecy now cited, should charge us with the very things we have been laying to the charge of the poets who say that Jupiter went in to women through lust, let us try to explain the words. This, then, "Behold, a virgin shall conceive," signifies that a virgin should conceive without intercourse. For if she had had intercourse with any one whatever, she was no longer a virgin; but the power of God having come upon the virgin, overshadowed her, and caused her while yet a virgin to conceive. And the angel of God who was sent to the same virgin at that time brought her good news, saying, "Behold, thou shalt conceive of the Holy Ghost, and shalt bear a Son, and He shall be called the Son of the Highest, and thou shalt call His name Jesus; for He shall save His people from their sins," -as they who have recorded all that concerns our Saviour Jesus Christ have taught, whom we believed, since by Isaiah also, whom we have now adduced, the Spirit of prophecy declared that He should be born as we intimated before. It is wrong, therefore, to understand the Spirit and the power of God as anything else than the Word, who is also the first-born of God, as the foresaid prophet Moses declared; and it was this which, when it came upon the virgin and overshadowed her, caused her to conceive, not by intercourse, but by power. And the name Jesus in the Hebrew language means Σωτήρ (Saviour) in the Greek tongue. Wherefore, too, the angel said to the virgin, "Thou shalt call His name Jesus, for He shall save His people from their sins." And that the prophets are inspired by no other than the Divine Word, even you, as I fancy, will grant.
Gregory of NeocaesareaAD 270
Twelve Topics on the Faith, Topic 4
If any one affirms that Christ was born of the seed of man by the Virgin, in the same manner as all men are born, and refuses to acknowledge that He was made flesh by the Holy Spirit and the holy Virgin Mary, mad became man of the seed of David, even as it is written, let him be anathema.

Explication: How could one say that Christ was born of the seed of man by the Virgin, when the holy Gospel and the angel, in proclaiming the good tidings, testify of Mary the Virgin that she said, "How shall this be, seeing I know not a man? " [Luke 1:34] Wherefore he says, "The Holy Ghost shall come upon you, and the power of the highest shall overshadow you: therefore also that holy thing which shall be born of you shall be called the Son of the Highest." [Luke 1:35] And to Joseph he says, "Fear not to take unto you Mary your wife: for that which is conceived in her is of the Holy Ghost. And she shall bring forth a son, and they shall call His name Jesus: for He shall save His people from their sins." [Matthew 1:20-21]
Athanasius of Alexandria (as quoted by Aquinas, AD 1274)AD 373
Catena Aurea by Aquinas
(Ep. ad Epictetum.) For we confess that which then was taken up from Mary to be of the nature of man and a most real body, the very same also according to nature with our own body. For Mary is our sister, seeing we have all descended from Adam.
Ephrem the SyrianAD 373
COMMENTARY ON TATIAN’S DIATESSARON 1.25
It was fitting that the Architect of the works of creation should come and raise up the house that had fallen and that the hovering Spirit should sanctify the buildings that were unclean. Thus, if the Progenitor entrusted the judgment that is to come to his Son, it is clear that he accomplished the creation of humanity and its restoration through him as well. He was the live coal, which had come to kindle the briars and thorns. He dwelt in the womb and cleansed it and sanctified the place of the birth pangs and the curses. The flame, which Moses saw, was moistening the bush and distilling the fat lest it be inflamed. The likeness of refined gold could be seen in the bush, entering into the fire but without being consumed. This happened so that it might make known that living fire which was to come at the end, watering and moistening the womb of the Virgin and clothing it like the fire that enveloped the bush.
Basil of Caesarea (as quoted by Aquinas, AD 1274)AD 379
Catena Aurea by Aquinas
(235. Ep. Amph.) Knowledge is spoken of in various ways. The wisdom of our Creator is called knowledge, and an acquaintance with His mighty works, the keeping also of His commandments, and the constant drawing near to Him; and besides these the marriage union is called knowledge, as it is here.

(Lib. de Spirit. Sanct. c. v.) Hence also, St. Paul says, God sent forth his Son, born not (through a woman) but of a woman. For the words through a woman might convey only a notion of birth as a passing through, but when it is said, of a woman, (Gal. 4:4.) there is openly declared a communion of nature between the son and the parent.
Gregory of NyssaAD 395
Oration on the Savior’s Nativity (Greek)
Then the virgin was initiated into the mystery by Gabriel. The words of the mystagogy were a blessing. “Hail,” he says, “blessed woman, the Lord is with you.” [...] He says, “You will conceive in your womb and will bear a son and you shall call his name ‘Jesus’.” [Luke 1:31, Protevangelium of James 11.3] And what did Mary do? Listen to the pure virgin’s utterance. The angel declared the birth, and she clings to her virginity, judging incorruption to be nobler than the angelic appearance and could neither disbelieve the angel nor abandon her judgments. She says, I have no experience of intercourse with a husband: “How will this happen to me, since I have not known a husband?” [Luke 1:34] Mary’s very utterance is proof of what is narrated in the apocryphal book [the Protevangelium of James]. For if she had been taken by Joseph for marriage, how could she be totally astonished at the one who announced the birth to her if she was quite favorably disposed to becoming a mother according to the law of nature? But since the flesh that had been consecrated to God had to be kept inviolate like one of the holy dedicated things, this is why she says, “Even if you are an angel, even if you have come from heaven, even if the appearance was beyond humanity, still for a husband to know me is not possible. How will I become a mother without a husband? I know Joseph as a fiancé, but I have not known a husband.” And what did Gabriel (the bridal escort) do? What sort of bridal chamber did he announce for the pure and undefiled marriage? “The Holy Spirit,” he says, “will come upon you and the power of the Most High will overshadow you.” [Luke 1:35, Protevangelium of James 11.3]
Gregory of Nyssa (as quoted by Aquinas, AD 1274)AD 395
Catena Aurea by Aquinas
(Orat. in Diem Nat. Christi.) Hear the chaste words of the Virgin. The Angel tells her she shall bear a son, but she rests upon her virginity, deeming her inviolability a more precious thing than the Angel's declaration. Hence she says, Seeing that I know not a man.

(sup.) These words of Mary are a token of what she was pondering in the secrets of her heart; for if for the sake of the marriage union she had wished to be espoused to Joseph, why was she seized with astonishment when the conception was made known unto her? seeing in truth she might herself be expecting at the time to become a mother according to the law of nature. But because it was meet that her body being presented to God as an holy offering-should be kept inviolate, therefore she says, Seeing that I know not a man. As if she said, Notwithstanding that thou who speakest art an Angel, yet that I should know a man is plainly an impossible thing. How then can I be a mother, having no husband? For Joseph I have acknowledged as my betrothed.

(Orat. in Diem Nat.) O blessed is that womb which because of the overflowing purity of the Virgin Mary has drawn to itself the gift of life! For in others scarcely indeed shall a pure soul obtain the presence of the Holy Spirit, but in her the flesh is made the receptacle of the Spirit.

(Lib. de Vita Moysis.) For the tables of our nature which guilt had broken, the true Lawgiver has formed anew to Himself from our dust without cohabitation, creating a body capable of taking His divinity, which the finger of God hath carved, that is to say, the Spirit coming upon the Virgin.

(in Diem Natal.) Moreover, the power of the Highest shall overshadow thee. Christ is the power of the most high King, who by the coming of the Holy Spirit is formed in the Virgin.

(Orat. in Diem Nat.) Or he says, overshadow thee, because as a shadow takes its shape from the character of those bodies which go before it, so the signs of the Son's Deity will appear from the power of the Father. (non occ. in Greg. Nyss.). For as in us a certain life-giving power is seen in the material substance, by which man is formed; so in the Virgin, has the power of the Highest in like manner, by the life-giving Spirit, taken from the Virgin's body a fleshly substance inherent in the body to form a new man. Hence it follows, Therefore also that holy thing which shall be born of thee.
Ambrose of MilanAD 397
EXPOSITION OF THE GOSPEL OF LUKE 2.14
It seems that Mary did not believe here, unless you pay careful attention; for it is not right for the chosen one to be seen as unbelieving in conceiving the only-begotten Son of God. But in what way could it happen (although the prerogative of the mother is preserved, to whom it certainly had to be deferred to a greater extent: but as a greater prerogative, a greater faith should also have been reserved for her), therefore in what way could it happen, that Zacharias, who did not believe, was condemned to silence: but Mary, if she had not believed, would be exalted by the infusion of the Holy Spirit? But Mary neither should not believe, nor should she rashly usurp: not believe the angel, usurp divine things. For it was not easy to know the mystery hidden in God from the ages, which even the higher Powers could not know. And yet she did not refuse faith, did not reject the duty: but she adjusted her emotions, promised obedience. For when she says: How will this be done? she did not doubt the outcome, but sought the quality of the effect itself.
Ambrose of Milan (as quoted by Aquinas, AD 1274)AD 397
Catena Aurea by Aquinas
It was Mary's part neither to refuse belief in the Angel, nor too hastily take unto herself the divine message. How subdued her answer is, compared with the words of the Priest. Then said Mary to the Angel, How shall this be? She says, How shall this be? He answers, Whereby shall I know this? He refuses to believe that which he says he does not know, and seeks as it were still further authority for belief. She avows herself willing to do that which she doubts not will be done, but how, she is anxious to know. Mary had read, Behold, she shall conceive and bear a son. (Is. 7:14.) She believed therefore that it should be, but how it was to take place she had never read, for even to so great a prophet this had not been revealed. So great a mystery was not to be divulged by the mouth of man, but of an Angel.
John Chrysostom (as quoted by Aquinas, AD 1274)AD 407
Catena Aurea by Aquinas
(Hom. 49 in Gen.) As if he said, Look not for the order of nature in things which transcend and overpower nature. Dost thou say, How shall this be, seeing I know not a man? Nay rather, shall it happen to thee for this very reason, that thou hast never known a husband. For if thou hadst, thou wouldest not have been thought worthy of the mystery, not that marriage is unholy, but virginity more excellent. It became the common Lord of all both to take part with us, and to differ with us in His nativity; for the being born from the womb, He shared in common with us, but in that He was born without cohabitation, He was exalted far above us.
PrudentiusAD 410
SCENES FROM SACRED HISTORY 25
When God’s coming draws near, the angel Gabriel advances
From the Father’s high throne and enters the house of the Virgin.
“Mary,” he says, “the Holy Spirit will render you fruitful,
And you shall give birth to the Christ, O glorious Virgin.”
PrudentiusAD 410
AGAINST SYMMACHUS 2.265-69
He had to be redeemed: my Spirit came down
And impregnated flesh made from the dust
With the divine nature; God has assumed
Humanity, joining it with divinity,
And kindled in men’s hearts new love of me.
Augustine of HippoAD 430
Sermon 153.14
The first sinner, the first transgressor, begot sinners liable to death. To heal them, the Savior came from the Virgin; because he didn’t come to you the way you came, seeing that he did not originate from the sexual appetite of male and female, not from that chain of lust. The Holy Spirit, it says, will come upon you. That was said to the Virgin glowing with faith, not seething with carnal lust. The Holy Spirit will come upon you, and the power of the Most High will overshadow you [Luke 1:35]. Being overshadowed like that, how could she be seething with the heat of sexual desire? So, because he didn’t come to you the way you came, he sets you free.
Augustine of HippoAD 430
Of Holy Virginity, Section 4
Her virginity also itself was on this account more pleasing and accepted, in that it was not that Christ being conceived in her, rescued it beforehand from a husband who would violate it, Himself to preserve it; but, before He was conceived, chose it, already dedicated to God, as that from which to be born. This is shown by the words which Mary spoke in answer to the Angel announcing to her her conception; "How," says she, "shall this be, seeing I know not a man?" Which assuredly she would not say, unless she had before vowed herself unto God as a virgin. But, because the habits of the Israelites as yet refused this, she was espoused to a just man, who would not take from her by violence, but rather guard against violent persons, what she had already vowed. Although, even if she had said this only, "How shall this take place?" and had not added, "seeing I know not a man," certainly she would not have asked, how, being a female, she should give birth to her promised Son, if she had married with purpose of sexual intercourse. She might have been bidden also to continue a virgin, that in her by fitting miracle the Son of God should receive the form of a servant, but, being to be a pattern to holy virgins, lest it should be thought that she alone needed to be a virgin, who had obtained to conceive a child even without sexual intercourse, she dedicated her virginity to God, when as yet she knew not what she should conceive, in order that the imitation of a heavenly life in an earthly and mortal body should take place of vow, not of command; through love of choosing, not through necessity of doing service. Thus Christ by being born of a virgin, who, before she knew Who was to be born of her, had determined to continue a virgin, chose rather to approve, than to command, holy virginity. And thus, even in the female herself, in whom He took the form of a servant, He willed that virginity should be free.
Leo the GreatAD 461
SERMON 30.4.2
But the birth of our Lord Jesus Christ exceeds all understanding and goes beyond any precedent.
Leo the GreatAD 461
SERMON 24.3
Each one is a partaker of this spiritual origin in regeneration. To every one, when he is reborn, the water of baptism is like the Virgin’s womb, for the same Holy Spirit fills the font, who filled the Virgin, that the sin, which that sacred conception overthrew, may be taken away by this mystical washing.
Leo the GreatAD 461
Sermon 24, Section III
In this nativity also, Isaiah's saying is fulfilled, "let the earth produce and bring forth salvation, and let righteousness spring up together." [Isaiah 45:8] For the earth of human flesh, which in the first transgressor, was cursed, in this Offspring of the Blessed Virgin only produced a seed that was blessed and free from the fault of its stock. And each one is a partaker of this spiritual origin in regeneration; and to every one when he is re-born, the water of baptism is like the Virgin's womb; for the same Holy Spirit fills the font, Who filled the Virgin, that the sin, which that sacred conception overthrew, may be taken away by this mystical washing.
Gregory the Dialogist (as quoted by Aquinas, AD 1274)AD 604
Catena Aurea by Aquinas
(18 Moral. c. 20. super Job 27:21.) By the term overshadowing, both natures of the Incarnate God are signified. For shadow is formed by light and matter. But the Lord by His Divine nature is light. Because then immaterial light was to be embodied in the Virgin's womb, it is well said unto her, The power of the Highest shall overshadow thee, that is, the human body in thee shall receive an immaterial light of divinity. For this is said to Mary for the heavenly refreshing of her soul.

(18 Moral. c. 52. super Job 28:19.) To distinguish His holiness from ours, Jesus is stated in an especial manner to be born holy. For we although indeed made holy, are not born so, for we are constrained by the very condition of our corruptible nature to cry out with the Prophet, Behold, I was conceived in iniquity. (Ps. 51:5.) But He alone is in truth holy, who was not conceived by the cementing of a fleshly union, nor as the heretics rave, one person in His human nature, another in His divine; not conceived and brought forth a mere man, and afterwards by his merits, obtained that He should be God, but the Angel announcing and the Spirit coming, first the Word in the womb, afterwards within the womb the Word made flesh. Whence it follows, Shall be called the Son of God.
Bede (as quoted by Aquinas, AD 1274)AD 735
Catena Aurea by Aquinas
Let Nestorius then cease to say that the Virgin's Son is only man, and to deny that He is taken up by the Word of God into the unity of the Person. For the Angel when he says that the very same has David for His father whom he declares is called the Son of the Highest, demonstrates the one Person of Christ in two natures. The Angel uses the future tense  (vocabitur, regnabit) not because, as the Heretics say, Christ was not before Mary, but because in the same person, man with God shares the same name of Son.

Thou shalt conceive then not by the seed of man whom thou knowest not, but by the operation of the Holy Spirit, with which thou art filled. There shall be no flame of desire in thee when the Holy Spirit shall overshadow thee.
BedeAD 735
On the Gospel of Luke
But Mary said to the angel: How will this be, since I do not know a man? She reverently expressed the purpose of her mind, that is, that she had decided to lead a virginal life. Because she was the first among women to devote herself to such great virtue, she rightfully deserved, by unique merit, to excel in blessedness above other women. How, she said, will this be? She did not say: How will I know this; but, How will this be, she said, since I do not know a man. She inquired about the order of obedience to which she should submit, not asking for a sign to believe. For it did not befit the virgin chosen to bear God to exist in doubtful mistrust but in cautious prudence, since man could not easily know the mystery that was hidden in God through the ages. Therefore, because she had read, Behold a virgin shall conceive, and bear a son, but had not read how it could happen, rightfully believing in what she had read, she asked the angel about what she did not find in the prophet (Isaiah VII).
Theophanes of NicaeaAD 845
Canon of Annunciation
Theotokos: Make plain to me, how I, a virgin, shall bear him?

The angel: You seek to know from me the manner of your conceiving, Virgin, but this is beyond all interpretation! The Holy Spirit will overshadow you in his creative power and shall make this come to pass!

Theotokos: When she accepted the suggestion of the serpent, my mother Eve was banished from divine delight. Therefore I fear your strange greeting, for I take care that I not slip.

The angel: I am sent as God’s messenger to disclose the divine will to you. Why are you afraid of me, undefiled one? I rather am afraid of you! Why do you stand in awe of me, O lady, who stand in reverent awe of you?

[...]

The angel: Rejoice, lady; rejoice, most pure virgin! Rejoice, God-containing vessel! Rejoice, candlestick of the light, the restoration of Adam and the deliverance of Eve! Rejoice, holy mountain, shining sanctuary! Rejoice, bridal chamber of immortality!

Theotokos: The descent of the Holy Spirit has purified my soul; it has sanctified my body; it has made me a temple containing God, a divinely adorned tabernacle, a living sanctuary and the pure mother of life.

The angel: I see you as a lamp with many lights; a bridal chamber made by God! Spotless maiden, as an ark of gold, receive now the giver of the law, who through you has been pleased to deliver humankind’s corrupted nature!
Bernard of ClairvauxAD 1153
Sermons, On The "Missus Est", Homily IV
Thus animated to cast out fear by a spirit of faith, she said to the angel: "How shall this be done, for I know not man?" She doubts not the fact, but only inquires about the manner of its accomplishment. She says not "Will it be done?" but "How will this be done?" As if she would say: "Since my Lord knows, and my conscience bears me witness, that His handmaid has made a vow to know no man, by what law shall it please Him to work this wonder? If I must break my vow that I may bring forth such a Son, I rejoice on account of the Son, but I grieve because of my vow. Nevertheless, His will be done. If, however, as a Virgin I may bring forth this Son and it is not impossible if He so will it then I shall know that He hath had regard to the humility of His handmaid. How, then, shall this be done, for I know not man?"
Ancient Greek Expositor (as quoted by Aquinas, AD 1274)AD 1274
Catena Aurea by Aquinas
(Geometer.) But mark, how the Angel solves the Virgin's doubts, and shows to her the unstained marriage and the unspeakable birth. And the Angel answered, and said unto her, The Holy Spirit shall come upon thee.

(Victor Presbyter.) But observe, how the Angel has declared the whole Trinity to the Virgin, making mention of the Holy Spirit, the Power, and the Most High, for the Trinity is indivisible.c
Thomas AquinasAD 1274
Summa Theologiae, Third Part, Question 28, Article 4
Article 4. Whether the Mother of God took a vow of virginity?

Objection 1. It would seem that the Mother of God did not take a vow of virginity. For it is written (Deuteronomy 7:14): "No one shall be barren among you of either sex." But sterility is a consequence of virginity. Therefore the keeping of virginity was contrary to the commandment of the Old Law. But before Christ was born the old law was still in force. Therefore at that time the Blessed Virgin could not lawfully take a vow of virginity.

Objection 2. Further, the Apostle says (1 Corinthians 7:25): "Concerning virgins I have no commandment of the Lord; but I give counsel." But the perfection of the counsels was to take its beginning from Christ, who is the "end of the Law," as the Apostle says (Romans 10:4). It was not therefore becoming that the Virgin should take a vow of virginity.

Objection 3. Further, the gloss of Jerome says on 1 Timothy 5:12, that "for those who are vowed to virginity, it is reprehensible not only to marry, but also to desire to be married." But the Mother of Christ committed no sin for which she could be reprehended, as stated above (III:27:4). Since therefore she was "espoused," as related by Luke 1:27 it seems that she did not take a vow of virginity.

On the contrary, Augustine says (De Sanct. Virg. iv): "Mary answered the announcing angel: 'How shall this be done, because I know not man?' [Luke 1:34] She would not have said this unless she had already vowed her virginity to God."

I answer that, As we have stated in the II-II:88:6, works of perfection are more praiseworthy when performed in fulfilment of a vow. Now it is clear that for reasons already given virginity had a special place in the Mother of God. It was therefore fitting that her virginity should be consecrated to God by vow. Nevertheless because, while the Law was in force both men and women were bound to attend to the duty of begetting, since the worship of God was spread according to carnal origin, until Christ was born of that people; the Mother of God is not believed to have taken an absolute vow of virginity, before being espoused to Joseph, although she desired to do so, yet yielding her own will to God's judgment. Afterwards, however, having taken a husband, according as the custom of the time required, together with him she took a vow of virginity.

Reply to Objection 1. Because it seemed to be forbidden by the law not to take the necessary steps for leaving a posterity on earth, therefore the Mother of God did not vow virginity absolutely, but under the condition that it were pleasing to God. When, however, she knew that it was acceptable to God, she made the vow absolute, before the angel's Annunciation.

Reply to Objection 2. Just as the fulness of grace was in Christ perfectly, yet some beginning of the fulness preceded in His Mother; so also the observance of the counsels, which is an effect of God's grace, began its perfection in Christ, but was begun after a fashion in His Virgin Mother.

Reply to Objection 3. These words of the Apostle are to be understood of those who vow chastity absolutely. Christ's Mother did not do this until she was espoused to Joseph. After her espousals, however, by their common consent she took a vow of virginity together with her spouse.
CS LewisAD 1963
Miracles, from God in the Dock
There is an activity of God displayed throughout creation, a wholesale activity let us say which men refuse to recognize. The miracles done by God incarnate, living as a man in Palestine, perform the very same things as this wholesale activity, but at a different speed and on a smaller scale. One of their chief purposes is that men, having seen a thing done by personal power on the small scale, may recognize, when they see the same thing done on the large scale, that the power behind it is also personal – is indeed the very same person who lived among us two thousand years ago. The miracles in fact are a retelling in small letters of the very same story which is written across the whole world in letters too large for some of us to see...

I can understand the man who denies the miraculous altogether; but what is one to make of the people who admit some miracles but deny the Virgin Birth? Is it that for all their lip service to the laws of Nature there is only one law of Nature that they really believe? Or is it that they see in this miracle a slur upon sexual intercourse which is rapidly becoming the one thing venerated in a world without veneration? No miracle is in fact more significant. What happens in ordinary generation? What is a father’s function in the act of begetting? A microscopic particle of matter from his body fertilizes the female: and with that microscopic particle passes, it may be, the color of his hair and his great grandfather’s hanging lip, and the human form in all its complexity of bones, liver, sinews, heart, and limbs, and pre-human form which the embryo will recapitulate in the womb. Behind every spermatozoon lies the whole history of the universe: locked within it is no small part of the world’s future. That is God’s normal way of making a man – a process that takes centuries, beginning with the creation of matter itself, and narrowing to one second and one particle at the moment of begetting. And once again men will mistake the sense impressions which this creative act throws off for the act itself or else refer it to some infinite being such as Genius. Once, therefore, God does it directly, instantaneously; without a spermatozoon, without the millenniums of organic history behind the spermatozoon. There was of course another reason. This time He was creating not simply a man, but the man who was to be Himself: the only true Man. The process which leads to the spermatozoon has carried down with it through the centuries much undesirable silt; the life which reaches us by that normal route is tainted. To avoid that taint, to give humanity a fresh start, he once short-circuited the process. There is a vulgar anti-God paper which some anonymous donor sends me every week. In it recently I saw the taunt that we Christians believe in a God who committed adultery with the wife of a Jewish carpenter. The answer to that is that if you describe the action of God in fertilizing Mary as “adultery” then, in that sense, God would have committed adultery with every woman who ever had a baby. For what He did once without a human father, He does always even when He uses a human father as His instrument. For the human father in ordinary generation is only a carrier, sometimes an unwilling carrier, always the last in a long line of carriers, of life that comes from the supreme life. Thus the filth that our poor, muddled, sincere, resentful enemies fling at the Holy One, either does not stick, or, sticking, turns into glory.
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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