Found 5 Strong's definitions.
patronymically from חוּפָם; a Chuphamite or descendant of Chupham; Huphamites.
from the same as חוֹף; protection; Chupham, an Israelite; Hupham.
from שָׁפָה (compare שִׁפְחָה); a family, i.e. circle of relatives; figuratively, a class (of persons), a species (of animals) or sort (of things); by extension a tribe or people; family, kind(-red).
patronymic from שְׁפוּפָם; a Shuphamite (collectively) or descendants of Shephupham; Shuphamite.
or שְׁפוּפָן; from the same as שְׁפִיפֹן; serpent-like; Shephupham or Shephuphan, an Israelite; Shephuphan, Shupham.
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