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Translation
King James Version
For the Son of man is come to save that which was lost.
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KJV (with Strong's)
For G1063 the Son G5207 of man G444 is come G2064 to save G4982 that which G3588 was lost G622.
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Complete Jewish Bible
For the Son of Man came to save the lost.
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Berean Standard Bible
Not present in the manuscripts this translation follows.
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American Standard Version
Not present in the manuscripts this translation follows.
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World English Bible Messianic
For the Son of Man came to save that which was lost.
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Geneva Bible (1599)
For the Sonne of man is come to saue that which was lost.
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Young's Literal Translation
for the Son of Man did come to save the lost.
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In the KJVVerse 23,739 of 31,102

Study This Verse

SUMMARY

Matthew 18:11, though sometimes bracketed in certain textual traditions, encapsulates the very essence of Jesus Christ's redemptive mission: His divine purpose in coming to earth was to actively seek out and rescue humanity from its lost and perishing state. This profound declaration serves as a foundational theological statement, underscoring God's compassionate initiative to restore those alienated by sin, setting the stage for the subsequent Parable of the Lost Sheep and revealing the immense value God places on every individual soul.

CONTEXT

  • Literary Context: This verse is strategically placed within a significant discourse by Jesus concerning the nature of the Kingdom of Heaven, humility, and the value of "little ones" (likely referring to believers, especially new or vulnerable disciples). It immediately follows Jesus' teaching on the severe consequences of causing a "little one" to stumble and precedes the well-known Parable of the Lost Sheep. In this parable, a shepherd leaves the ninety-nine sheep to search for the one that has strayed, emphasizing God's relentless pursuit and immense care for each individual who is lost. Thus, Matthew 18:11 functions as a theological underpinning or a summary statement for the divine compassion illustrated in the parable, revealing the ultimate purpose behind God's active seeking.
  • Historical & Cultural Context: The concept of "lostness" would have resonated deeply with a Jewish audience familiar with Old Testament themes of Israel straying from God's covenant and needing to be gathered. Shepherds were common figures in ancient Israel, and their diligence in caring for their flock was a well-understood metaphor for leadership and divine care. The "Son of Man" title, frequently used by Jesus, carries significant weight, drawing from Daniel 7:13-14 where a human-like figure is given eternal dominion and authority. This title simultaneously emphasizes Jesus' humanity and His divine, authoritative role as the promised Messiah, who comes not to be served, but to serve and to give His life as a ransom for many (Mark 10:45).
  • Key Themes: Matthew 18:11 powerfully articulates several core theological themes. Firstly, it highlights The Mission of the Son of Man, clearly stating Jesus' primary purpose for incarnation: to "save that which was lost." This is not a secondary objective but the very heart of His earthly ministry. Secondly, it addresses The State of Humanity, portraying mankind as "lost"—a condition implying spiritual alienation, separation from God, and an inability to find the way back independently. This lostness is a direct result of sin, as seen in passages like Romans 3:23. Thirdly, the verse beautifully illustrates Divine Initiative and Compassion. God does not passively wait for humanity to find Him; instead, He actively "comes" in the person of Jesus to seek and rescue. This theme of God's proactive love is central to the Gospel, echoed by Jesus Himself in Luke 19:10, where He declares, "For the Son of Man has come to seek and to save that which was lost." Finally, the verse points to Salvation as the ultimate outcome of Christ's mission—deliverance from the power and penalty of sin, reconciliation with God, and the promise of eternal life.

EXPOSITION AND ANALYSIS

Key Word Analysis

  • For (Greek, gár, G1063): This particle serves to assign a reason or provide an explanation for the preceding statement. In this context, it introduces the foundational theological truth that justifies and explains Jesus' concern for the "little ones" and His subsequent teaching on the lost sheep. It signifies that His mission to save the lost is the underlying principle for His entire ministry.
  • is come (Greek, érchomai, G2064): This verb signifies a purposeful arrival or movement. Here, it denotes Jesus' intentional incarnation and presence on earth. It emphasizes that His coming was not accidental or coincidental, but a deliberate act of God, fulfilling divine prophecy and initiating the plan of salvation.
  • lost (Greek, apóllymi, G622): While this word can mean "to destroy fully" or "to perish," in this context, it refers to a state of being astray, wandering, or in spiritual peril. It describes humanity's condition apart from God—alienated, without direction, and facing ruin unless rescued. It implies a dire need for intervention, aligning with the imagery of a sheep that has wandered away from the safety of the flock.

Verse Breakdown

  • "For the Son of man is come": This clause identifies the agent and the action. "The Son of man" is Jesus' self-designation, emphasizing both His true humanity and His unique, divinely appointed authority as the Messiah. His "coming" signifies His incarnation, His deliberate entry into human history, not as an observer, but as an active participant with a specific purpose.
  • "to save that which was lost": This clause states the explicit purpose of Jesus' coming. The infinitive "to save" (Greek: sṓzō) indicates the goal of His mission: to deliver, heal, preserve, and make whole. "That which was lost" refers to humanity in its fallen, sinful, and alienated state—those who are spiritually adrift, separated from God, and unable to find their way back on their own. This phrase encompasses all individuals in need of redemption.

Literary Devices

The verse employs several significant literary devices. Identification is central, as Jesus explicitly identifies Himself as "the Son of Man," a title rich with Old Testament prophetic Allusion (especially to Daniel 7:13) that underscores His unique authority and messianic role. The phrase "to save that which was lost" uses Metaphor and Synecdoche. "Lost" functions metaphorically to describe humanity's spiritual condition of being astray from God, akin to a wandering sheep. "That which was lost" is also a form of synecdoche, where a part (the lost individual) stands for the whole (all humanity in need of salvation). The entire verse functions as a concise Thesis Statement, encapsulating the overarching purpose of Jesus' earthly ministry and providing the theological framework for the subsequent Parable of the Lost Sheep.

THEOLOGICAL AND THEMATIC CONNECTIONS

Matthew 18:11 serves as a concise yet profound summary of God's redemptive heart, revealing that His ultimate desire is not judgment but salvation. It underscores the divine initiative in seeking out humanity, which is inherently lost due to sin, and highlights the unparalleled compassion of God embodied in Jesus Christ. This verse is a testament to the Gospel's core message: God's love is so great that He sent His Son to bridge the chasm created by sin, offering rescue and restoration to all who believe. It sets the stage for understanding the depth of God's pursuit of every individual soul, emphasizing that each life holds immeasurable value in His eyes.

REFLECTION AND APPLICATION

Matthew 18:11 offers profound comfort and a clear call to action for every believer. For those who feel adrift, burdened by past mistakes, or separated from God, this verse is a beacon of hope, assuring them that Jesus' primary purpose was to find and save them. It reminds us that no one is too far gone, too broken, or too lost for His redemptive reach. His mission was not to condemn, but to restore. For believers, this verse serves as a powerful reminder of the immense value God places on every individual. Just as Jesus actively sought the lost, so too are His followers called to embody His heart, extending compassion, grace, and the message of salvation to those around them who are spiritually lost. It fuels our passion for evangelism and mission, compelling us to participate in the divine work of seeking and saving, mirroring the Good Shepherd's love for His flock.

Questions for Reflection

  • In what ways do I recognize my own "lostness" and ongoing need for Christ's saving work in my life?
  • How does the truth that Jesus came to save the lost impact my view of those who are far from God?
  • What practical steps can I take this week to participate in Christ's mission of seeking and saving the lost in my sphere of influence?

FAQ

Why is Matthew 18:11 sometimes bracketed or omitted in certain Bible translations?

Answer: The bracketing or omission of Matthew 18:11 in some modern translations, particularly those based on critical Greek texts (like the NIV, ESV, NASB), stems from textual criticism. This verse is present in the Textus Receptus (the Greek text underlying the King James Version) but is absent from some of the earliest and most reliable Greek manuscripts, such as Codex Sinaiticus and Codex Vaticanus. Scholars believe it was likely a marginal note or an interpolation from Luke 19:10 that found its way into later manuscripts. Despite its textual uncertainty in Matthew, the theological truth it expresses is undeniably affirmed elsewhere in Scripture, particularly in Luke's Gospel, making its message consistent with the broader biblical narrative of Jesus' mission.

CHRIST-CENTERED FULFILLMENT

Matthew 18:11 stands as a profound declaration of Christ's redemptive purpose, revealing the very heart of God's plan for humanity. Jesus, as the "Son of Man," embodies the divine initiative to seek and save those who are spiritually lost. This mission finds its ultimate fulfillment in His sacrificial death and resurrection. He did not merely come to identify the lost, but to pay the ultimate price for their redemption, becoming the Lamb of God who takes away the sin of the world. Through His atoning work on the cross, Jesus provides the means by which humanity, alienated by sin, can be reconciled to God (2 Corinthians 5:19). His resurrection demonstrates His victory over sin and death, offering new life and eternal salvation to all who believe (Romans 6:4). Thus, Matthew 18:11 is not just a statement of intent, but a prophecy of the glorious work Christ would accomplish, culminating in the establishment of His church, which continues His mission of seeking and saving the lost until His return (Matthew 28:19-20).

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Commentary on Matthew 18 verses 1–35

I. II. Main points1. 2. Sub-points(1.) (2.) Details[1.] [2.] Fine details

As there never was a greater pattern of humility, so there never was a greater preacher of it, than Christ; he took all occasions to command it, to commend it, to his disciples and followers.

I. The occasion of this discourse concerning humility was an unbecoming contest among the disciples for precedency; they came to him, saying, among themselves (for they were ashamed to ask him, Mar 9:34), Who is the greatest in the kingdom of heaven? They mean not, who by character (then the question had been good, that they might know what graces and duties to excel in), but who by name. They had heard much, and preached much, of the kingdom of heaven, the kingdom of the Messiah, his church in this world; but ass yet they were so far from having any clear notion of it, that they dreamt of a temporal kingdom, and the external pomp and power of it. Christ had lately foretold his sufferings, and the glory that should follow, that he should rise again, from whence they expected his kingdom would commence; and now they thought it was time to put in for their places in it; it is good, in such cases, to speak early. Upon other discourses of Christ to that purport, debates of this kind arose (Mat 20:19, Mat 20:20; Luk 22:22, Luk 22:24); he spoke many words of his sufferings, but only one of his glory; yet they fasten upon that, and overlook the other; and, instead of asking how they might have strength and grace to suffer with him, they ask him, "Who shall be highest in reigning with him." Note, Many love to hear and speak of privileges and glory, who are willing to pass by the thoughts of work and trouble. They look so much at the crown, that they forget the yoke and the cross. So the disciples here did, when they asked, Who is the greatest in the kingdom of heaven?

1.They suppose that all who have a place in that kingdom are great, for it is a kingdom of priests. Note, Those are truly great who are truly good; and they will appear so at last, when Christ shall own them as his, though ever so mean and poor in the world.

2.They suppose that there are degrees in this greatness. All the saints are honourable, but not all alike so; one star differs from another star in glory. All David's officers were not worthies, nor all his worthies of the first three.

3.They suppose it must be some of them, that must be prime ministers of state. To whom should King Jesus delight to do honour, but to them who had left all for him, and were now his companions in patience and tribulation?

4.They strive who it should be, each having some pretence or other to it. Peter was always the chief speaker, and already had the keys given him; he expects to be lord-chancellor, or lord-chamberlain of the household, and so to be the greatest. Judas had the bag, and therefore he expects to be lord-treasurer, which, though now he come last, he hopes, will then denominate him the greatest. Simon and Jude are nearly related to Christ, and they hope to take place of all the great officers of state, as princes of the blood. John is the beloved disciple, the favourite of the Prince, and therefore hopes to be the greatest. Andrew was first called, and why should not he be first preferred? Note, We are very apt to amuse and humour ourselves with foolish fancies of things that will never be.

II. The discourse itself, which is a just rebuke to the question, Who shall be greatest? We have abundant reason to think, that if Christ ever intended that Peter and his successors at Rome should be heads of the church, and his chief vicars on earth, having so fair an occasion given him, he would now have let his disciples know it; but so far is he from this, that his answer disallows and condemns the thing itself. Christ will not lodge such an authority or supremacy any where in his church; whoever pretend to it are usurpers; instead of settling any of the disciples in this dignity, he warns them all not to put in for it.

Christ here teacheth them to be humble,

1.By a sign (Mat 18:2); He called a little child to him, and set him in the midst of them. Christ often taught by signs or sensible representations (comparisons to the eye), as the prophets of old. Note, Humility is a lesson so hardly learned, that we have need by all ways and means to be taught it. When we look upon a little child, we should be put in mind of the use Christ made of this child. Sensible things must be improved to spiritual purposes. He set him in the midst of them; not that they might play with him, but that they might learn by him. Grown men, and great men, should not disdain the company of little children, or think it below them to take notice of them. They may either speak to them, and give instruction to them; or look upon them, and receive instruction from them. Christ himself, when a child, was in the midst of the doctors, Luk 2:46.

2.By as sermon upon this sign; in which he shows them and us,

(1.)The necessity of humility, Mat 18:3. His preface is solemn, and commands both attention and assent; Verily I say unto you, I, the Amen, the faithful Witness, say it, Except ye be converted, and become as little children, ye shall not enter into the kingdom of heaven. Here observe,

[1.]What it is that he requires and insists upon.

First, "You must be converted, you must be of another mind, and in another frame and temper, must have other thoughts, both of yourselves and of the kingdom of heaven, before you be fit for a place in it. The pride, ambition, and affectation of honour and dominion, which appear in you, must be repented of, mortified, and reformed, and you must come to yourselves." Note, Besides the first conversion of a soul from a state of nature to a state of grace, there are after-conversions from particular paths of backsliding, which are equally necessary to salvation. Every step out of the way by sin, must be a step into it again by repentance. When Peter repented of his denying his Master, he was converted. Secondly, You must become as little children. Note, Converting grace makes us like little children, not foolish as children (Co1 14:20), nor fickle (Eph 4:14), nor playful (Mat 11:16); but, as children, we must desire the sincere milk of the word (Pe1 2:2); as children, we must be careful for nothing, but leave it to our heavenly Father to care for us (Mat 6:31); we must, as children, be harmless and inoffensive, and void of malice (Co1 14:20), governable, and under command (Gal 4:2); and (which is here chiefly intended) we must be humble as little children, who do not take state upon them, nor stand upon the punctilios of honour; the child of a gentleman will play with the child of a beggar (Rom 12:16), the child in rags, if it have the breast, is well enough pleased, and envies not the gaiety of the child in silk; little children have no great aims at great places, or projects to raise themselves in the world; they exercise not themselves in things too high for them; and we should in like manner behave, and quiet ourselves, Psa 131:1, Psa 131:2. As children are little in body and low in stature, so we must be little and low in spirit, and in our thoughts of ourselves. This is a temper which leads to other good dispositions; the age of childhood is the learning age.

[2.]What stress he lays upon this; Without this, you shall not enter into the kingdom of heaven. Note, Disciples of Christ have need to be kept in awe by threatenings, that they may fear lest they seem to come short, Heb 4:1. The disciples, when they put that question (Mat 18:1), thought themselves sure of the kingdom of heaven; but Christ awakens them to be jealous of themselves. They were ambitious of being greatest in the kingdom of heaven; Christ tells them, that, except they came to a better temper, they should never come thither. Note, many that set up for great ones in the church, prove not only little, but nothing, and are found to have no part or lot in the matter. Our Lord designs here to show the great danger of pride and ambition; whatever profession men make, if they allow themselves in this sin, they will be rejected both from God's tabernacle and from his holy hill. Pride threw the angels that sinned out of heaven, and will keep us out, if we be not converted from it. They that are lifted up with pride, fall into the condemnation of the devil; to prevent this, we must become as little children, and, in order to do that, must be born again, must put on the new man, must be like the holy child Jesus; so he is called, even after his ascension, Act 4:27.

(2.)He shows the honour and advancement that attend humility (Mat 18:4), thus furnishing a direct but surprising answer to their question. He that humbles himself as a little child, though he may fear that hereby he will render himself contemptible, as men of timid minds, who thereby throw themselves out of the way of preferment, yet the same is greatest in the kingdom of heaven. Note, The humblest Christians are the best Christians, and most like to Christ, and highest in his favour; are best disposed for the communications of divine grace, and fittest to serve God in this world, and enjoy him in another. They are great, for God overlooks heaven and earth, to look on such; and certainly those are to be most respected and honoured in the church that are most humble and self-denying; for, though they least seek it, they best deserve it.

(3.)The special care Christ takes for those that are humble; he espouses their cause, protects them, interests himself in their concerns, and will see that they are not wronged, without being righted.

Those that thus humble themselves will be afraid,

[1.]That nobody will receive them; but (Mat 18:5), Whoso shall receive one such little child in my name, receiveth me. Whatever kindnesses are done to such, Christ takes as done to himself. Whoso entertains a meek and humble Christian, keeps him in countenance, will not let him lose by his modesty, takes him into his love and friendship, and society and care, and studies to do him a kindness; and doth this in Christ's name, for his sake, because he bears the image of Christ, serves Christ, and because Christ has received him; this shall be accepted and recompensed as an acceptable piece of respect to Christ. Observe, Though it be but one such little child that is received in Christ's name, it shall be accepted. Note, The tender regard Christ has to his church extends itself to every particular member, even the meanest; not only to the whole family, but to every child of the family; the less they are in themselves, to whom we show kindness, the more there is of good will in it to Christ; the less it is for their sakes, the more it is for his; and he takes it accordingly. If Christ were personally among us, we think we should never do enough to welcome him; the poor, the poor in spirit, we have always with us, and they are his receivers. See Mat 25:35-40.

[2.]They will be afraid that every body will abuse them; the basest men delight to trample upon the humble; Vexat censura columbas - Censure pounces on doves. This objection he obviates (Mat 18:6), where he warns all people, as they will answer it at their utmost peril, not to offer any injury to one of Christ's little ones. This word makes a wall of fire about them; he that touches them, touches the apple of God's eye.

Observe, First, The crime supposed; offending one of these little ones that believe in Christ. Their believing in Christ, though they be little ones, unites them to him, and interests him in their cause, so that, as they partake of the benefit of his sufferings, he also partakes in the wrong of theirs. Even the little ones that believe have the same privileges with the great ones, for they have all obtained like precious faith. There are those that offend these little ones, by drawing them to sin (Co1 8:10, Co1 8:11), grieving and vexing their righteous souls, discouraging them, taking occasion from their mildness to make a prey of them in their persons, families, goods, or good name. Thus the best men have often met with the worst treatment in this world.

Secondly, The punishment of this crime; intimated in that word, Better for him that he were drowned in the depth of the sea. The sin is so heinous, and the ruin proportionably so great, that he had better undergo the sorest punishments inflicted on the worst of malefactors, which can only kill the body. Note, 1. Hell is worse than the depth of the sea; for it is a bottomless pit, and it is a burning lake. The depth of the sea is only killing, but hell is tormenting. We meet with one that had comfort in the depth of the sea, it was Jonah (Jon 2:2, Jon 2:4, Jon 2:9); but never any had the least grain or glimpse of comfort in hell, nor will have to eternity. 2. The irresistible irrevocable doom of the great Judge will sink sooner and surer, and bind faster, than a mill-stone hanged about the neck. It fixes a great gulf, which can never be broken through, Luk 16:26. Offending Christ's little ones, though by omission, is assigned as the reason of that dreadful sentence, Go ye cursed, which will at last be the doom of proud persecutors.

Matthew Henry (1662–1714) — Commentary on the Whole Bible. This section covers verses 1–35. Public domain.
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TertullianAD 220
On Modesty
Wherefore, if the image of a "son" is not entirely suitable to a Jew either, our interpretation shall be simply governed with an eye to the object the Lord had in view. The Lord had come, of course, to save that which "had perished; " "a Physician.
Hilary of Poitiers (as quoted by Aquinas, AD 1274)AD 367
Catena Aurea by Aquinas
The Angels offer daily to God the prayers of those that are to be saved by Christ; it is therefore perilous to despise him whose desires and requests are conveyed to the eternal and invisible God, by the service and ministry of Angels.

But by the one sheep is to be understood one man, and under this one man is comprehended the whole human race. He that seeks man is Christ, and the ninety and nine are the host of the heavenly glory which He left.
John Chrysostom (as quoted by Aquinas, AD 1274)AD 407
Catena Aurea by Aquinas
Or otherwise; As to shun the evil, so to honour the good, has great recompense. Above then He had bid them to cut off the friendships of those that gave offence, here He teaches them to show honour and service to the saints.

Or because the perfect are esteemed of many as little ones, as poor, namely, and despicable.

Here He is speaking not of any Angels, but of the higher sort; for when He says, Behold the face of my Father, He shows that their presence before God is free and open, and their honour great.

He gives yet another reason weightier than the foregoing, why the little ones are not to be despised, For the Son of Man is come to save that which was lost.

And to this reasoning He adds a parable, in which He sets forth the Father as seeking the salvation of men, and saying, What think you, If a man have a hundred sheep.
John ChrysostomAD 407
Homily on the Gospel of Matthew 59
"Take heed that ye despise not one of these little ones; for I say unto you, that their angels do always behold the face of my Father which is in Heaven."

He calleth little ones not them that are really little, but them that are so esteemed by the multitude, the poor, the objects of contempt, the unknown (for how should he be little who is equal in value to the whole world; how should he be little, who is dear to God?); but them who in the imagination of the multitude are so esteemed.

And He speaks not of many only, but even of one, even by this again warding off the hurt of the many offenses. For even as to flee the wicked, so also to honor the good, hath very great gain, and would be a twofold security to him who gives heed, the one by rooting out the friendships with them that offend, the other from regarding these saints with respect and honor.

Then in another way also He makes them objects of reverence, saying, "That their angels do always behold the face of my Father which is in Heaven."

Hence it is evident, that the saints have angels, or even all men. For the apostle too saith of the woman, "That she ought to have power on her head because of the angels." And Moses, "He set the bounds of the nations according to the number of the angels of God."

But here He is discoursing not of angels only, but rather of angels that are greater than others. But when He saith, "The face of my Father," He means nothing else than their fuller confidence, and their great honor.

"For the Son of Man is come to save that which was lost."

Again, He is putting another reason stronger than the former, and connects with it a parable, by which He brings in the Father also as desiring these things. "For how think ye?" saith He; "If a man have an hundred sheep, and one of them be gone astray, doth he not leave the ninety and nine, and goeth into the mountains, and seeketh that which is gone astray? And if so be that he find it, he rejoiceth over it more than over the ninety and nine, which went not astray. Even so it is not will before your Father, that one of these little ones should perish."

Seest thou by how many things He is urging to the care of our mean brethren. Say not then, "Such a one is a blacksmith, a shoemaker, he is a ploughman, he is a fool," and so despise him. For in order that thou shouldest not feel this, see by how many motives He persuades thee to practise moderation, and presses thee into a care for these. He set a little child, and saith, "Be ye as little children." And, "Whosoever receiveth such a little child receiveth me;" and, "Whosoever shall offend," shall suffer the utmost penalties. And He was not even satisfied with the comparison of the "millstone," but added also His "woe," and commanded us to cut off such, though they be in the place of hands and eyes to us. And by the angels again that are entrusted with these same mean brethren, He makes them objects of veneration, and from His own will and passion (for when He said, "The Son of Man is come to save that which was lost," He signifies even the cross, like as Paul saith, speaking of a brother, "For whom Christ died"); and from the Father, for that neither to Him doth it seem good that one should perish; and from common custom, because the shepherd leaves them that are safe, and seeks what is lost; and when he hath found what was gone astray, he is greatly delighted at the finding and the saving of this.

If then God thus rejoices over the little one that is found, how dost thou despise them that are the objects of God's earnest care, when one ought to give up even one's very life for one of these little ones? But is he weak and mean? Therefore for this very cause most of all, one ought to do everything in order to preserve him. For even He Himself left the ninety and nine sheep, and went after this, and the safety of so many availed not to throw into the shade the loss of one. But Luke saith, that He even brought it on his shoulders, and that "There was greater joy over one sinner that repenteth, than over ninety and nine just persons" And from His forsaking those that were saved for it, and from His taking more pleasure in this one, He showed His earnestness about it to be great.

Let us not then be careless about such souls as these. For all these things are said for this object. For by threatening, that he who has not become a little child should not so much as at all set foot in the Heavens, and speaking of "the millstone," He hath brought down the haughtiness of the boastful; for nothing is so hostile to love as pride; and by saying, "It must needs be that offenses come," He made them to be wakeful; and by adding, "Woe unto him by whom the offense cometh," He hath caused each to endeavor that it be not by him. And while by commanding to cut off them that offend He made salvation easy; by enjoining not to despise them, and not merely enjoining, but with earnestness (for "take heed," saith He, "that ye despise not one of these little ones"), and by saying, "Their angels behold the face of my Father," and, "For this end am I come," and "my Father willeth this," He hath made those who should take care of them more diligent.

Seest thou what a wall He hath set around them, and what earnest care He taketh of them that are contemptible and perishing, at once threatening incurable ills to them that make them fall, and promising great blessings to them that wait upon them, and take care of them, and bringing an example from Himself again and from the Father?

Him let us also imitate, refusing none of the tasks that seem lowly and troublesome for our brethren's sake; but though we have to do service, though he be small, though he be mean for whom this is done, though the work be laborious, though we must pass over mountains and precipices, let all things be held endurable for the salvation of our brother. For a soul is an object of such earnest care to God, that "He spared not His own Son."
JeromeAD 420
Commentary on Matthew
(Verses 10, 11.) See that you do not despise one of these little ones. For I tell you that their angels in heaven always see the face of my Father who is in heaven. The Son of Man came to save what was lost. Above, he had said that all close relationships and connections that could cause scandal should be cut off by hand, foot, or eye. Therefore, he tempers the severity of the sentence with a subordinate command, saying: See that you do not despise one of these little ones. Thus, he said, I command severity, so that I may teach the mixing of mercy. As much as is in you, do not despise, but seek the health even of those. But if you see them persevering in sins, and serving vices, it is better for you to be saved alone than to perish with many. For their angels in heaven always see the face of the Father. Great is the dignity of souls, so that each one has been assigned a guardian angel from birth to watch over them. Where do we read in the Apocalypse of John: 'To the angel of the church in Ephesus, write...' (Rev. 2:1). The apostle also commands women to cover their heads in the churches, because of the angels (1 Cor. 11).
Jerome (as quoted by Aquinas, AD 1274)AD 420
Catena Aurea by Aquinas
The Lord had said, under the type of hand, foot, and eye, that all kin and connection which could afford scandal must be cut off. The harshness of this declaration He accordingly tempers with the following precept, saying, Take heed that ye despise not one of these little ones; i. e. As far as you may avoid despising them, but next to your own salvation seek also to heal them. But if ye see that they hold to their sins, it is better that ye be saved, than that ye perish in much company.

High dignity of souls, that each from its birth has an Angel set in charge over it!

Others think that by the ninety and nine sheep are understood the number of the righteous, and by the one sheep the sinners, according to that said in another place, I am not come to call the righteous but sinners to repentance. (Matt. 9:13.)

What follows, Even so it is not the will, &c. is to be referred to what was said above, Take heed that ye despise not one of these little ones; and so He shows that this parable was set forth to enforce that same saying. Also in saying, It is not the will of my Father which is in heaven that one of these little ones should perish, He shows that so oft as one of these little ones does perish, it is not by the Father's will that it perishes.
Remigius of Rheims (as quoted by Aquinas, AD 1274)AD 533
Catena Aurea by Aquinas
As much as to say, Despise not little ones, for I also for men condescended to become man. By that which was lost, understand the human race; for all the elements have kept their place, but man was lost, because he has broken his ordained place.
Gregory the Dialogist (as quoted by Aquinas, AD 1274)AD 604
Catena Aurea by Aquinas
(Hom. in Ev. 34. 12) But Dionysius says, that it is from the ranks of the lesser Angels that these are sent to perform this ministry, either visibly or invisibly, for that those higher ranks have not the employment of an outward ministry.

(Mor. ii. 3.) And therefore the Angels always behold the face of the Father, and yet they come to us, for by a spiritual presence they come forth to us, and yet by internal contemplation keep themselves there whence they come forth; for they come not so forth from the divine vision, as to hinder the joys of inward contemplation.

(Hom. in Ev. xxxiv. 3.) This refers to the Creator of man Himself; for a hundred is a perfect number, and He had a hundred sheep when He created the substance of Angels and men.

(ubi sup.) The Evangelist says they were left on the mountains, to signify that the sheep which were not lost abode on high.

(ubi sup.) We must consider whence it is that the Lord declares that He has joy rather over the converted sinners, than over the righteous that stand. Because these last are often slothful and slack to practise the greater good works, as being very secure within themselves, for that they have committed none of the heavier sins. While on the other hand those who have their wicked deeds to remember, do often through the compunction of sorrow glow with the more heat in their love of God, and when they think how they have strayed from Him, they replace their former losses by gains following. So the general in a battle loves best that soldier who turns in his flight and courageously presses the enemy, than him who never turned his back, yet never did any valorous deed. Yet there be some righteous over whom is joy so great, that no penitent can be preferred before them, those, who though not conscious to themselves of sins, yet reject things lawful, and humble themselves in all things. How great is the joy when the righteous mourns, and humbles himself, if there be joy when the unrighteous condemns himself wherein he has done amiss?
Bede (as quoted by Aquinas, AD 1274)AD 735
Catena Aurea by Aquinas
(ap. Anselm.) The Lord found the sheep when He restored man, and over that sheep that is found there is more joy in heaven than over the ninety and nine, because there is a greater matter for thanksgiving to God in the restoration of man than in the creation of the Angels. Wonderfully are the Angels made, but more wonderfully man restored.

(ap. Anselm.)f; Or, By the ninety-nine sheep, which He left on the mountains, are signified the proud to whom a unit is still wanting for perfection. When then He has found the sinner, He rejoices over him, that is, He makes his own to rejoice over him, rather than over the false righteous.
Rabanus Maurus (as quoted by Aquinas, AD 1274)AD 856
Catena Aurea by Aquinas
Note, that nine wants only one to make it ten, and ninety and nine the same to be a hundred. Thus members which want one only to be perfect, may be larger or smaller, but yet the unit remaining invariable, when it is added makes the rest perfect. And that the number of sheep might be made up perfect in heaven, lost man was sought on earth.
Theophylact of OhridAD 1107
He commands them not to disdain those thought to be of little importance, that is, those poor in spirit who are great in God’s eyes. They are so greatly loved by God, He says, that they have angels watching over them so that they may not be harmed by the demons. Every believer, and indeed, every one of us human beings, has a guardian angel. The angels of those who are little and humble in Christ are so intimate with God that they always stand before Him and behold His face. From this it is apparent that although we all have angels, the angels of us sinners are ashamed on account of our lack of boldness, and neither do they have boldness to behold the face of God and perhaps even to pray for us. But the angels of those who are humble minded behold the face of God because of the boldness with which they can approach Him. And, the Lord goes on to say, "Why should I say merely that such ones as these have angels? I Myself have come for this very reason, to save that which was lost, and to make those who are thought by many to be of no account My intimate friends."
Glossa Ordinaria (as quoted by Aquinas, AD 1274)AD 1274
Catena Aurea by Aquinas
(ap. Anselm.) Or otherwise; Because so great evils come of brethren being scandalized, Take heed that ye despise not one of these little ones.

(ap. Anselm.) Therefore are they not to be despised for that they are so dear to God, that Angels are deputed to be their guardians; For I say unto you, that in heaven their Angels do always behold the face of my Father which is in heaven.
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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