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Translation
King James Version
Then one said unto him, Behold, thy mother and thy brethren stand without, desiring to speak with thee.
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KJV (with Strong's)
Then G1161 one G5100 said G2036 unto him G846, Behold G2400, thy G4675 mother G3384 and G2532 thy G4675 brethren G80 stand G2476 without G1854, desiring G2212 to speak G2980 with thee G4671.
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Complete Jewish Bible
Not present in the manuscripts this translation follows.
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Berean Standard Bible
Someone told Him, “Look, Your mother and brothers are standing outside, wanting to speak to You.”
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American Standard Version
And one said unto him, Behold, thy mother and thy brethren stand without, seeking to speak to thee.
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World English Bible Messianic
One said to him, “Behold, your mother and your brothers stand outside, seeking to speak to you.”
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Geneva Bible (1599)
Then one said vnto him, Beholde, thy mother and thy brethren stand without, desiring to speake with thee.
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Young's Literal Translation
and one said to him, `Lo, thy mother and thy brethren do stand without, seeking to speak to thee.'
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In the KJVVerse 23,537 of 31,102

Study This Verse

SUMMARY

Matthew 12:47 presents a pivotal moment in Jesus' ministry, where the arrival of His earthly mother and brothers interrupts His teaching, setting the stage for a profound redefinition of true kinship. This seemingly simple announcement serves as a narrative pivot, shifting the focus from the escalating conflict with religious authorities to the nature of spiritual family, highlighting Jesus' unwavering commitment to His divine mission and the preeminence of obedience to God's will over biological ties.

CONTEXT

  • Literary Context: Matthew 12:47 is situated within a highly charged section of Matthew's Gospel, immediately following Jesus' powerful discourse on the nature of spiritual authority and the unpardonable sin. Prior to this verse, Jesus has just healed a demon-possessed man, prompting the Pharisees to accuse Him of casting out demons by Beelzebul, the prince of demons (Matthew 12:22-24). Jesus refutes their baseless claims, warns against blasphemy against the Holy Spirit, and emphasizes that a tree is known by its fruit, concluding with a stark warning about the judgment for idle words (Matthew 12:25-37). He then addresses the crowd's demand for a sign, offering only the "sign of Jonah" (Matthew 12:38-42). The verse directly preceding Matthew 12:47 describes Jesus teaching about the return of an unclean spirit, illustrating the perilous state of those who reject God's truth (Matthew 12:43-45). It is precisely at this moment, while Jesus is still speaking to the multitudes, that the announcement of His family's arrival is made, serving as an immediate catalyst for His subsequent teaching on spiritual family in Matthew 12:48-50).
  • Historical & Cultural Context: In ancient Jewish society, family ties were paramount. Lineage, clan, and household were fundamental to identity, social standing, and economic security. The concept of "family" (oikos) extended beyond the nuclear unit to include extended relatives, servants, and even close associates, forming a primary social and economic network. For Jesus' family to seek Him out in public, especially during a teaching session, suggests a matter of some urgency or concern, perhaps even an attempt to persuade Him to return home or temper His public ministry, as hinted at in Mark 3:21). The crowd gathered around Jesus would have been a common sight for a popular rabbi or teacher, and the public nature of the announcement underscores the interruption. The reference to "mother and brethren" indicates Mary and Jesus' half-brothers, children born to Mary and Joseph after Jesus, as confirmed by other New Testament passages (Mark 6:3).
  • Key Themes: This verse contributes significantly to several overarching themes within Matthew's Gospel. Firstly, it highlights the tension between earthly relationships and divine calling. Jesus' ministry consistently demonstrates His prioritization of God's will over conventional societal expectations, including familial obligations. Secondly, it foreshadows and directly introduces the theme of redefining family based on spiritual allegiance. The physical presence of His blood relatives prompts Jesus to articulate a radical new understanding of kinship, where obedience to God's will transcends biological ties, establishing a spiritual family of disciples (Matthew 12:49-50). Thirdly, it underscores Jesus' unwavering focus on His mission. Despite the personal nature of the interruption, Jesus does not immediately dismiss the crowd or attend to His family but uses the moment as a teaching opportunity, demonstrating His commitment to proclaiming the kingdom of God. This moment also subtly contributes to the theme of Jesus' authority, as He, not His family, dictates the terms of engagement and the nature of His true relationships.

EXPOSITION AND ANALYSIS

Key Word Analysis

  • said (Greek, épō', G2036): This verb (G2036) indicates the act of uttering words or speaking. In this context, it signifies a direct verbal communication from someone in the crowd to Jesus, conveying the message about His family's arrival. It's a straightforward report, setting the scene for Jesus' response.
  • Behold (Greek, idoú', G2400): As an imperative (G2400), "behold" serves as an interjection, drawing immediate attention to what follows. It's a dramatic particle, often used in the New Testament to introduce something significant or surprising, compelling the listener to observe or consider the stated fact. Here, it emphasizes the presence of Jesus' family as a notable event.
  • desiring (Greek, zētéō', G2212): This verb (G2212) means "to seek" or "to desire." It implies a purposeful intent on the part of Jesus' mother and brothers to engage with Him. While the specific nature of their desire is not stated, the word suggests an active pursuit, indicating they had a specific reason for wanting to speak with Him, rather than a casual visit.

Verse Breakdown

  • "Then one said unto him": This phrase indicates an immediate report from an unnamed individual within the crowd to Jesus. The "Then" (G1161, ) links this event directly to Jesus' preceding discourse, signifying a continuation of the narrative flow but also a shift in focus. The "one" (G5100, tìs) is an indefinite pronoun, highlighting that the messenger is not a significant character in themselves, but merely the conveyer of information.
  • "Behold, thy mother and thy brethren stand without": The messenger uses the attention-grabbing interjection "Behold" (G2400, idoú) to emphasize the presence of Jesus' family. "Thy mother and thy brethren" explicitly identifies Mary and Jesus' biological half-brothers. The phrase "stand without" (G1854, éxō, and G2476, hístēmi) indicates they are physically outside the immediate vicinity where Jesus is teaching, unable or unwilling to enter the crowded space, perhaps respecting the public nature of His teaching or due to the sheer number of people.
  • "desiring to speak with thee": This final clause clarifies the purpose of their presence. "Desiring" (G2212, zētéō) implies a strong intention or wish, and "to speak with thee" (G2980, laléō, and G4671, soí) indicates their aim to have a personal conversation with Jesus. The text does not specify their reason, leaving it open to interpretation, but it sets up the contrast between earthly and spiritual priorities.

Literary Devices

The verse primarily employs Narrative Interruption as a key literary device. The announcement about Jesus' family breaks into His ongoing teaching, creating a sudden shift in focus for both Jesus and the reader. This interruption is not merely a plot device but serves a theological purpose, setting the stage for Jesus' profound redefinition of family. The use of Direct Speech ("Behold, thy mother and thy brethren stand without, desiring to speak with thee") adds immediacy and authenticity to the scene, allowing the reader to experience the announcement as it happens. Furthermore, the unnamed "one" who speaks functions as a Foil or a Catalyst, whose simple message unexpectedly precipitates a deeper theological teaching from Jesus, highlighting how seemingly mundane events can become opportunities for divine revelation.

THEOLOGICAL AND THEMATIC CONNECTIONS

Matthew 12:47, while brief, is theologically rich as it directly precedes Jesus' groundbreaking teaching on the nature of true family. It underscores the tension between biological kinship and spiritual allegiance, a theme that resonates throughout the New Testament. Jesus' response in the subsequent verses elevates obedience to God's will above all other relationships, establishing a new covenant community defined not by bloodline but by shared faith and commitment to the Father's purpose. This passage challenges the conventional understanding of family, asserting that spiritual connection to Christ, demonstrated through active discipleship, forms the deepest and most enduring bond.

REFLECTION AND APPLICATION

Matthew 12:47 invites us to critically examine our own priorities and allegiances. In a world that often prioritizes blood ties, social networks, or personal comfort, Jesus' response to this interruption challenges us to consider what truly defines our identity and our deepest connections. It prompts us to ask whether our primary allegiance lies with earthly relationships and expectations, or with the divine will of God. True belonging, according to Jesus, is not merely inherited or assumed; it is forged through active obedience and a shared commitment to the Father's purposes. This passage encourages believers to live with a kingdom-first mindset, understanding that spiritual kinship with Christ and fellow believers, established through doing God's will, is a relationship of eternal significance that transcends all earthly bonds. It calls us to embody a radical discipleship where Christ's mission and God's word take precedence in our lives, shaping our choices, our relationships, and our very identity.

Questions for Reflection

  • How do I prioritize my earthly relationships versus my spiritual relationship with Christ and His body?
  • In what ways might my family or social expectations sometimes conflict with my commitment to doing God's will?
  • What does it practically mean to be part of Jesus' spiritual family, and how does that influence my daily life and decisions?
  • Am I willing to allow God's will to redefine my understanding of what is truly important, even if it challenges my preconceived notions of family or belonging?

FAQ

Why did Jesus' mother and brothers want to speak with Him?

Answer: The Gospel of Matthew does not explicitly state their reason for wanting to speak with Jesus. However, the parallel account in Mark 3:21 suggests that His family believed He was "out of his mind" and sought to "lay hold of Him," possibly to bring Him home or to restrain Him from His intense public ministry, which they might have perceived as jeopardizing His safety or reputation. Their desire "to speak with thee" (Matthew 12:47) could imply a personal intervention or an urgent private matter, rather than a supportive visit.

CHRIST-CENTERED FULFILLMENT

Matthew 12:47, though a simple narrative interjection, finds its profound Christ-centered fulfillment in Jesus' subsequent redefinition of family. This moment is not merely about Jesus prioritizing His ministry; it reveals the very essence of the new covenant community He came to establish. Jesus, the Son of God, came not to abolish the law but to fulfill it, including the law of love and relationship. By declaring that those who "do the will of my Father who is in heaven" are His "brother and sister and mother" (Matthew 12:50), Jesus inaugurates a spiritual family, a new humanity united by faith and obedience to God, rather than by bloodline or ethnicity. This new family, the Church, is born out of His redemptive work, a community where believers are adopted as children of God through Christ (Romans 8:15), made fellow heirs with Him (Romans 8:17), and united as one body in Him (1 Corinthians 12:13). Jesus' words here foreshadow the inclusive nature of the gospel, breaking down barriers of race, social status, and even family ties, to create a universal family of believers centered on Him as Lord and Savior, whose ultimate bond is the shared Fatherhood of God and obedience to His divine will, made possible through the Spirit He provides (Galatians 3:28).

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Commentary on Matthew 12 verses 46–50

I. II. Main points1. 2. Sub-points(1.) (2.) Details

Many excellent, useful sayings came from the mouth of our Lord Jesus upon particular occasions; even his digressions were instructive, as well as his set discourses: as here,

Observe, I. How Christ was interrupted in his preaching by his mother and his brethren, that stood without, desiring to speak with him (Mat 12:40, Mat 12:47); which desire of theirs was conveyed to him through the crowd. It is needless to enquire which of his brethren they were that came along with his mother (perhaps they were those who did not believe in him, Joh 7:5); or what their business was; perhaps it was only designed to oblige him to break off, for fear he should fatigue himself, or to caution him to take heed of giving offence by his discourse to the Pharisees, and or involving himself in a difficulty; as if they could teach him wisdom.

1.He was as yet talking to the people. Note, Christ's preaching was talking; it was plain, easy, and familiar, and suited to their capacity and case. What Christ had delivered had been cavilled at, and yet he went on. Note, The opposition we meet with in our work, must not drive us from it. He left off talking with the Pharisees, for he saw he could do no good with them; but continued to talk to the common people, who, not having such a conceit of their knowledge as the Pharisees had, were willing to learn.

2.His mother and brethren stood without, desiring to speak with him, when they should have been standing within, desiring to hear him. They had the advantage of his daily converse in private, and therefore were less mindful to attend upon his public preaching. Note, Frequently those who are nearest to the means of knowledge and grace, are most negligent. Familiarity and easiness of access breed some degree of contempt. We are apt to neglect that this day, which we think we may have any day, forgetting that it is only the present time we can be sure of; tomorrow is none of ours. There is too much truth in that common proverb, "The nearer the church, the further from God;" it is pity it should be so.

3.They not only would not hear him themselves, but they interrupted others that heard him gladly. The devil was a sworn enemy to our Saviour's preaching. He had sought to baffle his discourse by the unreasonable cavils of the scribes and Pharisees, and when he could not gain his point that way, he endeavoured to break it off by the unseasonable visits of relations. Note, We often meet with hindrances and obstructions in our work, by our friends that are about us, and are taken off by civil respects from our spiritual concerns. Those who really wish well to us and to our work, may sometimes, by their indiscretion, prove our back-friends, and impediments to us in our duty; as Peter was offensive to Christ, with his, "Master, spare thyself," when he thought himself very officious. The mother of our Lord desired to speak with him; it seemed she had not then learned to command her Son, as the iniquity and idolatry of the church of Rome has since pretended to teach her: nor was she so free from fault and folly as they would make her. It was Christ's prerogative, and not his mother's, to do every thing wisely, and well, and in its season. Christ once said to his mother, How is it that ye sought me? Wist he not, that I must be about my Father's business? And it was then said, she laid up that saying in her heart (Luk 2:49); but if she had remembered it now, she would not have given him this interruption when he was about his Father's business. Note, There is many a good truth that we thought was well laid up when we heard it, which yet is out of the way when we have occasion to use it.

II. How he resented this interruption, Mat 12:48-50.

1.He would not hearken to it; he was so intent upon his work, that no natural or civil respects should take him off from it. Who is my mother and who are my brethren? Not that natural affection is to be put off, or that, under pretence of religion, we may be disrespectful to parents, or unkind to other relations; but every thing is beautiful in its season, and the less duty must stand by, while the greater is done. When our regard to our relations comes in competition with the service of God, and the improving of an opportunity to do good, in such a case, we must say to our Father, I have not seen him, as Levi did, Deu 33:9. The nearest relations must be comparatively hated, that is, we must love them less than Christ (Luk 14:26), and our duty to God must have the preference. This Christ has here given us an example of; the zeal of God's house did so far eat him up, that it made him not only forget himself, but forget his dearest relations. And we must not take it ill of our friends, nor put it upon the score of their wickedness, if they prefer the pleasing of God before the pleasing of us; but we must readily forgive those neglects which may be easily imputed to a pious zeal for God's glory and others' good. Nay, we must deny ourselves and our own satisfaction, rather than do that which may any way divert our friends fRom. or distract them in, their duty to God.

2.He took that occasion to prefer his disciples, who were his spiritual kindred, before his natural relations as such: which was a good reason why he would not leave preaching to speak with his brethren. He would rather be profiting his disciples, than pleasing his relations. Observe,

(1.)The description of Christ's disciples. They are such as do the will of his Father; not only hear it, and know it, and talk of it, but do it; for doing the will of God is the best preparative for discipleship (Joh 7:17), and the best proof of it (Mat 7:21); that denominates us his disciples indeed. Christ does not say, "Whosoever shall do my will," for he came not to seek or do his own will distinct from his Father's: his will and his Father's are the same; but he refers us to his Father's will, because now in his present state and work he referred himself to it, Joh 6:38.

(2.)The dignity of Christ's disciples: The same is my brother, and sister, and mother. His disciples, that had left all to follow him, and embraced his doctrine, were dearer to him than any that were akin to him according to the flesh. They had preferred Christ before their relations; they left their father (Mat 4:22; Mat 10:37); and now to make them amends, and to show that there was no love lost, he preferred them before his relations. Did not they hereby receive, in point of honour, a hundred fold? Mat 19:29. It was very endearing and very encouraging for Christ to say, Behold my mother and my brethren; yet it was not their privilege alone, this honour have all the saints. Note, All obedient believers are near akin to Jesus Christ. They wear his name, bear his image, have his nature, are of his family. He loves them, converses freely with them as his relations. He bids them welcome to his table, takes care of them, provides for them, sees that they want nothing that is fit for them: when he died he left them rich legacies, now he is in heaven he keeps up a correspondence with them, and will have them all with him at last, and will in nothing fail to do the kinsman's part (Rut 3:13), nor will ever be ashamed of his poor relations, but will confess them before men, before the angels, and before his Father.

Matthew Henry (1662–1714) — Commentary on the Whole Bible. This section covers verses 46–50. Public domain.
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Hilary of Poitiers (as quoted by Aquinas, AD 1274)AD 367
Catena Aurea by Aquinas
Because He had spoken all the aforesaid things in the power of His Father's majesty, therefore the Evangelist proceeds to tell what answer He made to one that told Him that His mother and His brethren waited for Him without; While he yet spake unto the people, his mother and his brethren stood without desiring to see him.

And He cannot be held to have thought meanly of His mother, seeing that in His passion He evinced the most extreme carefulness for her.

Although they had like the rest power to come in, yet they abstain from all approach to Him, for he came unto his own, and his own received him not. (John 1:11.)
Apollinaris of LaodiceaAD 382
FRAGMENT 75
That “his brothers” did not yet believe in him we learn from John, while from Mark we have also heard something else: for his own family tried to lay hands on him, as though he were beside himself. On account of their frame of mind, the Lord does not often mention them as his own family. He points instead to those who are obedient. To believers he applies all the terms of family relationship, those, namely, who had been joined to him in the kindred fellowship of obedience. Even if temporarily he had a quarrel with Mary, as Simeon had foretold when he had said “a sword shall pierce through your own soul,” she overcame these things, as was fitting, and the Lord graciously made mention of her at his passion and entrusted her to the beloved disciple.
Ambrose of Milan (as quoted by Aquinas, AD 1274)AD 397
Catena Aurea by Aquinas
(in Luc. 8:21.) Nor does He overthrow the duty of filial submission, which is conveyed in the command, Honour thy father and thy mother, (Ex. 20:12.) but shows that He owes more to the mysteries and relationship of His Father, than of His mother; as it follows, And stretching out his hand to his disciples, he said, Behold my mother and my brethren.
John Chrysostom (as quoted by Aquinas, AD 1274)AD 407
Catena Aurea by Aquinas
(Hom. xliv.) But mart the loftiness of His brethrena; when they should have come in and heartened with the crowd, or if they would not this, to have waited the end of His speech, and then to have approached Him—they on the contrary call Him out to them, and do this before the multitude, therein showing their superabundant love of honour, and also, that with all authority they lay their commands upon Christ. This the Evangelist covertly hints when he says, While he yet spake; as much as to say, Was there no other time? But what did they seek to say? Was it aught of the dogmas of truth? then should they have brought it forth before all, that all might profit thereby. But if of other things that concerned themselves alone, they should not have called Him in such haste, whence it is plain that they did this out of vain glory.

For He said not, Go and say unto her, She is not My mother, but continues His discourse to him that had brought Him word; as it follows; But he answered and said unto him that told him, Who is my mother? and who are my brethren?

But had He desired to disown His mother, He would have done it at the time when the Jews cast His birth in His teeth.

And besides what has been said, He taught also somewhat more, namely, that we should not neglect virtue relying on any kindred. For if it profited His mother nothing that she was such, if she had not had virtue, who is there that shall be saved by his kindred? For there is one only nobility, to do the will of God, and therefore it follows, Whoso shall do the will of my Father which is in heaven, the same is my brother, and sister, and mother. Many women have blessed that holy Virgin and her womb, and have desired to be made such mothers. What is it then that hinders? Behold, He hath set before you a broad way, and not women only, but men likewise, may become the mother of God.
John ChrysostomAD 407
Homily on the Gospel of Matthew 44
That which I was lately saying, that when virtue is wanting all things are vain, this is now also pointed out very abundantly. For I indeed was saying, that age and nature, and to dwell in the wilderness, and all such things, are alike unprofitable, where there is not a good mind; but to-day we learn in addition another thing, that even to have borne Christ in the womb, and to have brought forth that marvellous birth, hath no profit, if there be not virtue.

And this is hence especially manifest. "For while He yet talked to the people," it is said, "one told Him, Thy mother and Thy brethren seek Thee. But He saith, who is my mother, and who are my brethren?" And this He said, not as being ashamed of His mother, nor denying her that bare Him; for if He had been ashamed of her, He would not have passed through that womb; but as declaring that she hath no advantage from this, unless she do all that is required to be done. For in fact that which she had essayed to do, was of superfluous vanity; in that she wanted to show the people that she hath power and authority over her Son, imagining not as yet anything great concerning Him; whence also her unseasonable approach. See at all events both her self-confidence and theirs. Since when they ought to have gone in, and listened with the multitude; or if they were not so minded, to have waited for His bringing His discourse to an end, and then to have come near; they call Him out, and do this before all, evincing a superfluous vanity, and wishing to make it appear, that with much authority they enjoin Him. And this too the evangelist shows that he is blaming, for with this very allusion did he thus express himself, "While He yet talked to the people;" as if he should say, What? was there no other opportunity? Why, was it not possible to speak with Him in private?

And what was it they wished to say? For if it were touching the doctrines of the truth, they ought to have propounded these things publicly, and stated them before all, that the rest also might have the benefit: but if about other matters that concerned themselves, they ought not to have been so urgent. For if He suffered not the burial of a father, lest the attendance on Him should be interrupted, much less ought they to have stopped His discourse to the people, for things that were of no importance. Whence it is clear, that nothing but vainglory led them to do this; which John too declares, by saying, "Neither did His brethren believe on Him;" and some sayings too of theirs he reports, full of great folly; telling us that they were for dragging Him to Jerusalem, for no other purpose, but that they themselves might reap glory from His miracles. "For if thou do these things," it is said, "show Thyself to the world. For there is no man that doeth anything in secret, and seeketh himself to be manifest;" when also He Himself rebuked them, attributing it to their carnal mind. That is, because the Jews were reproaching Him, and saying, "Is not this the carpenter's son, whose father and mother we know? and His brethren, are not they with us?" they, willing to throw off the disparagement caused by His birth, were calling Him to the display of His miracles.

For this cause He quite repels them, being minded to heal their infirmity; since surely, had it been His will to deny His mother, He would have denied her then, when the Jews were reproaching Him. But as it is, we see that He takes so great care of her, as even at the very cross to commit her to the disciple whom He loved most of all, and to give him a great charge concerning her.

But now He doth not so, out of care for her, and for His brethren. I mean, because their regard for Him was as towards a mere man, and they were vainglorious, He casts out the disease, not insulting, but correcting them.

But do thou, I pray, examine not the words only, which contain a moderate reproof, but also the unbecoming conduct of His brethren, and the boldness wherewith they had been bold and who was the person reproving it, no mere man, but the only-begotten Son of God; and with what purpose He reproved; that it was not with intent to drive them to perplexity, but to deliver them from the most tyrannical passion and to lead them on by little and little to the right idea concerning Himself, and to convince her that He was not her Son only, but also her Lord: so wilt thou perceive that the reproof is in the highest degree both becoming Him and profitable to her, and withal having in it much gentleness. For He said not, "Go thy way, tell my mother, thou art not my mother," but He addresses Himself to the person that told Him; saying, "Who is my mother?" together with the things that have been mentioned providing for another object also. What then is that? That neither they nor others confiding in their kindred, should neglect virtue. For if she is nothing profited by being His mother, were it not for that quality in her, hardly will any one else be saved by his kindred. For there is one only nobleness, to do the will of God. This kind of noble birth is better than the other, and more real.
Jerome (as quoted by Aquinas, AD 1274)AD 420
Catena Aurea by Aquinas
(cont. Helvid. 14, et seq.) From this is taken one of Helvidius's propositions, on the ground that mention is made in the Gospel of the brethren of the Lord. How, says he, are they called brethren of the Lord, if they were not his brethren? But now it should be known that in divine Scripture men are said to be brethren in four different ways, by nature, by nation, by kindred, and by affection. By nature, as Esau and Jacob. By nation, as all Jews are called brethren, as in Deuteronomy, Thou shalt not set over thee a foreigner who is not thy brother. (Deut. 17:15) They are called brethren by kindred who are of one family, as in Genesis, Abraham said unto Lot, Let there not be strife between thee and me, for we are brethren. (Gen. 13:8) Also men are called brethren by affection, which is of two kinds, special and general. Special, as all Christians are called brethren, as the Saviour says, Go tell my brethren. General, inasmuch as all men are born of one father, we are bound together by a tie of consanguinity, as in that, Say unto them that hate you, Ye are our brethren. (Is. 66:5 sec. LXX.) I ask then, after which manner these are called the Lord's brethren in the Gospel? According to nature? But Scripture saith not, neither calling them sons of Mary nor of Joseph. By nation? But it is absurd that some few out of all the Jews should be called brethren, seeing that all the Jews who were there might have thus been called brethren. By affection, either of a human sort, or of the Spirit? If that be true, yet how were they more His brethren than the Apostles, whom He instructed in the inmost mysteries. Or if because they were men, and all men are brethren, it was foolish to say of them in particular, Behold, thy brethren seek thee. It only remains then that they should be His brethren by kindred, not by affection, not by privilege of nation, not by nature.

(in loc.) But some suspect the brethren of the Lord to be sons of Joseph by another wife, following the idle fancies of apocryphal writers, who have coined a certain woman called E sea. But we understand by the brethren of the Lord, not the sons of Joseph, but cousins of the Saviour, sons of a sister of Mary, an aunt of Our Lord, who is said to be the mother of James the Less, and Joseph, and Jude, whom in another place of the Gospel we find called the brethren of the Lord. (Mark 6:3) And that cousins are called brethren, appears from every part of Scripture.

He that delivers this message, seems to me not to do it casually and without meaning, but as setting a snare for Him, whether He would prefer flesh and blood to the spiritual work; and thus the Lord refused to go out, not because He disowned His mother and His brethren, but that He might confound him that had laid this snare for Him.

He did not then, as Marcion and Manichæus say, disown His mother, so as to be thought to be born of a phantasm, but He preferred His Apostles to His kindred, that we also in a comparison of our affections should set the spirit before the flesh.

Let us also expound in another way. The Saviour is speaking to the multitude—that is, He teaches the Gentiles the inward mysteries; His mother and His brethren, that is the synagogue and the Jewish people, stand without.

And when they shall have asked and enquired, and sent a messenger, they shall receive for answer, that their will is free, and that they can enter in, if they will believe.
JeromeAD 420
Commentary on Matthew
(Verse 46 and following) While he was still speaking to the crowds, behold his mother and brothers stood outside seeking to speak to him. But someone said to him: Look, your mother and brothers stand outside seeking you. But he answered the one who told him, saying: Who is my mother, and who are my brothers? And stretching out his hand towards his disciples, he said. The Lord was occupied with the work of speaking, teaching the people, and fulfilling the duty of preaching, while his mother and brothers came and stood outside, desiring to speak to him. Then someone announces to the Savior that his mother and brothers are standing outside, seeking him. It seems to me that this person who announces it is not doing so by chance and simply: but is setting a trap for the Savior, whether he prefers spiritual work over flesh and blood. Therefore, the Lord, not because he denied his mother and brothers, ignored their request to go out; but because he responded to the one laying a trap, extending his hand towards his disciples, he said:
Augustine of Hippo (as quoted by Aquinas, AD 1274)AD 430
Catena Aurea by Aquinas
(De Nat. et Grat. 36.) But whatever may be decided concerning these brethren, yet concerning the holy Virgin Mary, (for the honour of Christ,) when sin in her is in question, I would not have it brought into doubt. For from this only we might know that more abundant grace was conferred upon her that she should overcome sin on all sides, because she merited to conceive and bring forth Him Who it is clear had no sin. It follows; Then said one unto him, Behold, thy mother and thy brethren stand without seeking thee.
Gregory the Dialogist (as quoted by Aquinas, AD 1274)AD 604
Catena Aurea by Aquinas
(Mor. vii. 17.) For it often happens that the soul in the commencement of its progress is lifted up, and prides itself on its virtues, that it opens an entrance to the adversary who is raging against it, and who shows himself the more violent in breaking into it, by how much he was grieved at being cast out, though but for a short space.

(Hom. in Ev. iii. 2.) The Lord deigned to call faithful disciples His brethren, saying, Go, tell my brethren. Since then a man may be made a brother of the Lord by coming to the faith, it should be enquired how one may become also His mother. Be it known by us then, that he that by believing is made brother or sister of Christ, becomes His mother by preaching; for in pouring Him into the heart of the hearer, he may be said to beget the Lord; and he is made the Lord's mother, when by his word love of the Lord is begotten in the mind of his neighbour.

(ubi sup.) Thus also His mother is declared to stand without, as though she was not acknowledged, because the synagogue is therefore not acknowledged by its Author, because it held to the observance of the Law, and having lost the spiritual discernment thereof, kept itself without to guard the letter.
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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