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Translation
King James Version
For thus saith the LORD that created the heavens; God himself that formed the earth and made it; he hath established it, he created it not in vain, he formed it to be inhabited: I am the LORD; and there is none else.
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KJV (with Strong's)
For thus saith H559 the LORD H3068 that created H1254 the heavens H8064; God H430 himself that formed H3335 the earth H776 and made H6213 it; he hath established H3559 it, he created H1254 it not in vain H8414, he formed H3335 it to be inhabited H3427: I am the LORD H3068; and there is none else.
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Complete Jewish Bible
For thus says ADONAI, who created the heavens, God, who shaped and made the earth, who established and created it not to be chaos, but formed it to be lived in: "I am ADONAI; there is no other.
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Berean Standard Bible
For thus says the LORD, who created the heavens—He is God; He formed the earth and fashioned it; He established it; He did not create it to be empty, but formed it to be inhabited: “I am the LORD, and there is no other.
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American Standard Version
For thus saith Jehovah that created the heavens, the God that formed the earth and made it, that established it and created it not a waste, that formed it to be inhabited: I am Jehovah; and there is none else.
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World English Bible Messianic
For thus says the LORD who created the heavens, the God who formed the earth and made it, who established it and didn’t create it a waste, who formed it to be inhabited: “I am the LORD; and there is no other.
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Geneva Bible (1599)
For thus saith the Lord (that created heauen, God himselfe, that formed the earth, and made it: he that prepared it, he created it not in vaine: he formed it to be inhabited) I am the Lord, and there is none other.
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Young's Literal Translation
For thus said Jehovah, Creator of heaven, He is God, Former of earth, and its Maker, He established it--not empty He prepared it, For inhabiting He formed it: `I am Jehovah, and there is none else.
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Study This Verse

SUMMARY

Isaiah 45:18 powerfully declares the LORD's singular identity as the sovereign Creator of the cosmos. It asserts that God, in His infinite wisdom and power, formed the earth with deliberate intention and purpose, specifically to be inhabited, rather than leaving it as a desolate void. This verse profoundly reaffirms the foundational truth of biblical monotheism: Yahweh is the one true God, and there is none other, challenging all competing claims to deity and underscoring His unique authority, purposeful design, and unwavering faithfulness.

CONTEXT

  • Literary Context: Isaiah 45:18 is situated within the "Book of Comfort" (Isaiah 40-55), a pivotal section of the prophecy primarily addressed to the Jewish exiles in Babylon. This portion of Isaiah serves to reassure a dispirited people of God's unparalleled power and unwavering commitment to His covenant promises, particularly His ability to deliver them from exile and restore them to their homeland. Chapters 40-48 are especially focused on establishing God's absolute omnipotence and unique status as the only God, contrasting Him sharply with the impotent idols of Babylon and the false gods worshipped by the surrounding nations. Specifically, chapter 45 highlights God's sovereign control over all nations and even over pagan rulers like Cyrus, whom He raises up as His instrument to fulfill His redemptive purposes. This demonstrates that God is the orchestrator of history, not merely a tribal deity, and that His plan for Israel's restoration is part of a larger, cosmic design. Within this grand narrative of divine intervention and redemption, Isaiah 45:18 serves as a theological anchor, reinforcing the Creator's purposeful design and His singular authority as the foundation for all His redemptive acts.
  • Historical & Cultural Context: The Jewish exiles in Babylon were immersed in a profoundly polytheistic society, surrounded by magnificent temples dedicated to a vast pantheon of gods and goddesses, such as Marduk (the chief god of Babylon), Ishtar (goddess of love and war), and Nabu (god of wisdom). These deities were often associated with specific natural phenomena, celestial bodies, or cities, and their worship involved elaborate rituals, idol processions, and mythological narratives. The prevailing Babylonian creation myths, most notably the Enuma Elish, depicted creation as a violent, chaotic struggle among warring deities, resulting in a world that was often seen as an accidental byproduct of divine conflict. In this religiously pluralistic and often overwhelming environment, Isaiah's message was revolutionary and counter-cultural. He declared that Israel's God, Yahweh, was not merely one god among many, nor was His creation accidental or haphazard. Instead, He was the sole, purposeful Creator, utterly distinct from and superior to all pagan deities. This powerful monotheistic declaration provided immense comfort, hope, and a compelling call to exclusive worship for a people tempted to assimilate into Babylonian culture or despair in their foreign captivity.
  • Key Themes: This verse powerfully articulates several core themes prevalent throughout Isaiah and the broader biblical narrative. Firstly, it underscores Divine Creation and Purpose, asserting that God's creative act was not arbitrary or without design, but profoundly intentional, forming the earth specifically "to be inhabited." This contrasts sharply with the "formless and empty" state described in Genesis 1:2 before God brought order and life, emphasizing that chaos was not God's final intent. Secondly, it champions God's Absolute Sovereignty and Uniqueness, culminating in the emphatic declaration, "I am the LORD; and there is none else." This monotheistic assertion is a recurring refrain in Isaiah, challenging the prevalent polytheism of the ancient Near East and asserting Yahweh's singular claim to deity (e.g., Isaiah 44:6 and Isaiah 46:9). Finally, it speaks to Order and Stability in Creation, emphasizing that God "hath established it," signifying His ongoing maintenance, providential care, and the inherent order He instilled in the world He has made, ensuring its suitability for life and purpose.

EXPOSITION AND ANALYSIS

Key Word Analysis

  • LORD (Hebrew, Yᵉhôvâh', H3068): This is the sacred Tetragrammaton, YHWH (יהוה), God's covenant name, consistently rendered as "LORD" in all capital letters in the KJV. As defined by H3068, it signifies "the self-Existent or Eternal; Jehovah, Jewish national name of God." In Isaiah 45:18, its use emphasizes God's eternal, unchanging, and personal nature, distinguishing Him as the one true God who reveals Himself and enters into covenant relationship with His people. This name stands in stark contrast to the transient and fabricated deities of the nations, highlighting Yahweh's unique and ultimate authority.
  • created (Hebrew, bârâʼ', H1254): This primitive root (H1254) specifically denotes creation ex nihilo (out of nothing) or the bringing into existence of something new and unique, often with divine agency. Unlike other Hebrew verbs for "making" or "forming," bârâʼ is almost exclusively used with God as the subject, highlighting His unparalleled power to originate and bring into being that which did not previously exist. Here, it applies to both the "heavens" and the earth, underscoring the absolute, foundational, and effortless nature of God's creative act.
  • to be inhabited (Hebrew, yâshab', H3427): While primarily meaning "to sit down," "to dwell," or "to remain" (H3427), in this context, yâshab conveys the divine purpose behind creation. God did not create the earth as a desolate wasteland ("not in vain"), but specifically designed it to be a dwelling place for living beings, especially humanity. This word emphasizes God's intentionality, foresight, and benevolent design in preparing a suitable, sustainable, and flourishing environment for life, reflecting His desire for relationship and order within His creation.

Verse Breakdown

  • "For thus saith the LORD that created the heavens; God himself that formed the earth and made it; he hath established it": This opening clause establishes God's unique identity and multifaceted role in creation. "The LORD" (Yahweh) is identified as the one who "created the heavens," emphasizing His cosmic sovereignty and the absolute nature of His power. The parallel phrases "God himself that formed the earth and made it" utilize different verbs (formed/yatsar, made/asah) to describe the intricate work of shaping and bringing the earth into existence, highlighting both the initial act of creation and the detailed craftsmanship involved in its design. The declaration "he hath established it" speaks to God's ongoing work of bringing order, stability, and permanence to His creation, ensuring its foundational integrity and continued existence.
  • "he created it not in vain, he formed it to be inhabited": This pivotal clause clarifies the divine purpose behind creation, directly refuting any notion of randomness or futility. The phrase "not in vain" translates the Hebrew tôhûw (H8414), which often denotes emptiness, chaos, or desolation (as in Genesis 1:2). Here, however, it is negated, asserting that God's creation was not meant to remain a meaningless void or an accidental byproduct. Instead, He "formed it to be inhabited," explicitly stating that the earth's ultimate design and destiny was to support life and be a dwelling place for humanity, underscoring God's intentionality and benevolent design for a thriving cosmos.
  • "I am the LORD; and there is none else.": This concluding declaration serves as a powerful summary and theological punchline, encapsulating the essence of biblical monotheism. It reaffirms God's absolute uniqueness and His exclusive claim to deity. This is a direct and uncompromising challenge to the polytheistic beliefs of the surrounding nations and a profound statement of Yahweh's incomparable nature. This assertion underscores His singular authority, omnipotent power, and sole worthiness of worship, leaving no room for rival gods or competing claims to ultimate reality.

Literary Devices

Isaiah 45:18 employs several powerful literary devices to convey its profound theological message with emphasis and clarity. Parallelism is prominently featured in the repeated structure of divine action and description: "created the heavens," "formed the earth and made it," and "created it not in vain, he formed it to be inhabited." This technique, common in Hebrew poetry, uses repetition with variation to emphasize the comprehensive nature of God's creative work and His multifaceted involvement. The use of Antithesis is particularly striking in the phrase "created it not in vain, he formed it to be inhabited," where the negative "not in vain" (implying chaos or emptiness) is immediately contrasted with the positive, purposeful "to be inhabited," highlighting God's deliberate and ordered design over any state of desolation. The verse also features powerful Declarative Statements, especially the concluding "I am the LORD; and there is none else," which functions as a definitive and unchallengeable assertion of God's unique identity and sovereignty, characteristic of prophetic pronouncements that demand recognition and allegiance. This strong Monotheistic Affirmation serves as a theological climax, leaving no ambiguity about the singular nature of the God of Israel.

THEOLOGICAL AND THEMATIC CONNECTIONS

Isaiah 45:18 serves as a foundational text for understanding God's nature as both the transcendent Creator and the immanent Sustainer, emphasizing His purposeful design for the entire created order. It directly counters any notion of an accidental, chaotic, or meaningless universe, asserting divine intentionality in establishing an ordered cosmos fit for life. This truth underpins humanity's unique place within creation, implying a profound responsibility for stewardship and a recognition of God's ultimate authority over all things. The verse's emphatic declaration of "none else" reinforces the core tenet of biblical monotheism, calling believers to exclusive worship, unwavering trust, and undivided allegiance to the one true God amidst a world of competing ideologies, false deities, and secular philosophies. It grounds our hope and security not in human endeavors, fleeting powers, or material possessions, but in the unchanging character of the sovereign LORD who created, sustains, and purposefully directs all things.

REFLECTION AND APPLICATION

Isaiah 45:18 offers a profound anchor for our faith and worldview in a world often characterized by randomness, despair, or competing claims to ultimate truth. Recognizing God as the sole Creator who purposefully formed the earth "not in vain" and "to be inhabited" instills a deep sense of meaning, security, and inherent value in all creation. It reminds us that our existence, and the existence of the world around us, is not a cosmic accident or a product of blind chance, but the result of a benevolent, intelligent, and intentional design. This understanding calls us to live with a profound sense of purpose, acknowledging that if God has such meticulous plans for the physical world, He undoubtedly has a purposeful design for our individual lives and for humanity as a whole. It challenges us to reject anything that attempts to usurp God's unique position as ultimate authority and to live in faithful stewardship of the world He has entrusted to us, finding our ultimate identity, hope, and meaning in Him alone, the purposeful Creator and only LORD.

Questions for Reflection

  • How does the truth that God created the earth "not in vain" and "to be inhabited" shape your view of the world's inherent value and your place within God's grand design?
  • In what specific ways might the declaration "I am the LORD; and there is none else" challenge or comfort you in your daily life, especially when faced with societal pressures, competing ideologies, or personal anxieties?
  • What practical implications does God's purposeful creation have for how you approach environmental stewardship, engage with issues of human flourishing, or pursue your own life's calling?

FAQ

What does "created it not in vain" mean in Isaiah 45:18?

Answer: The phrase "created it not in vain" (Hebrew: lo' tôhûw) directly contrasts with the concept of tôhûw (chaos, emptiness, waste, futility) found in Genesis 1:2. While Genesis 1:2 describes the earth as "formless and empty" before God brought order, light, and life, Isaiah 45:18 asserts that God's ultimate purpose in creation was not for it to remain in such a state of desolation. Rather, He specifically "formed it to be inhabited." This means God's creation was purposeful, intentional, and designed for life and flourishing, not for emptiness, waste, or futility. It underscores His deliberate design, benevolent plan, and the inherent order He established for the cosmos and humanity within it, ensuring a suitable dwelling place for His image-bearers.

CHRIST-CENTERED FULFILLMENT

Isaiah 45:18, with its profound declaration of God as the sole, purposeful Creator who formed the earth "to be inhabited," finds its ultimate fulfillment and deepest meaning in the person and work of Jesus Christ. The New Testament unequivocally reveals that Jesus is not merely a participant in creation but the very divine agent through whom all things were made. John 1:3 states, "All things were made through him, and without him was not anything made that was made." Similarly, Colossians 1:16 declares that "by him all things were created, in heaven and on earth, visible and invisible... all things were created through him and for him." This establishes Jesus as the divine "LORD" (Yahweh) of Isaiah 45:18, the one who "created the heavens" and "formed the earth." Furthermore, the divine purpose of creation—"to be inhabited"—points to Christ as the one who redeems and restores fallen humanity, making it possible for us to truly "inhabit" God's good creation in fellowship with Him. The "vain" or chaotic state that God did not intend for creation ultimately entered through sin, but Christ, through His atoning sacrifice and resurrection, brings order out of spiritual chaos, making "all things new" (Revelation 21:5). Thus, the purposeful creation of Isaiah 45:18 is not only initiated by the pre-incarnate Christ but also ultimately redeemed and brought to its intended glorious completion by Him, ensuring that God's purpose for a world "to be inhabited" by His image-bearers in restored fellowship with Him is fully realized.

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Commentary on Isaiah 45 verses 11–19

I. II. Main points1. 2. Sub-points

The people of God in captivity, who reconciled themselves to the will of God in their affliction and were content to wait his time for their deliverance, are here assured that they should not wait in vain.

I. They are invited to enquire concerning the issue of their troubles, Isa 45:11. The Holy One of Israel, and his Maker, though he does not allow them to strive with him, yet encourages them, 1. To consult his word: "Ask of me things to come; have recourse to the prophets and their prophecies, and see what they say concerning these things. Ask the watchmen, What of the night? Ask them, How long?" Things to come, as far as they are revealed, belong to us and to our children, and we must not be strangers to them. 2. To seek unto him by prayer: "Concerning my sons and concerning the work of my hands, which as becomes them submit to the will of their Father, the will of their potter, command you me, not by way of prescription, but by way of petition. Be earnest in your requests, and confident in your expectations, as far as both are guided by and grounded upon the promise." We may not strive with our Maker by passionate complaints, but we may wrestle with him by faithful and fervent prayer. My sons, and the work of my hands, commend to me (so some read it), bring them to me and leave them with me. See the power of prayer, and its prevalency with God: Thou shalt cry, and he shall say, Here I am; what would you that I should do unto you? Some read it with an interrogation, as carrying on the reproof (Isa 45:9, Isa 45:10): Do you question me concerning things to come? and am I bound to give you an account? And concerning my children, even concerning the work of my hands, will you command me, or prescribe to me? Dare you do so? Shall any teach God knowledge, or give law to him? Those that complain of God do in effect assume an authority over him.

II. They are encouraged to depend upon the power of God when they are brought very low and are utterly incapable of helping themselves, Isa 45:12. Their help stands in the name of the Lord, who made heaven and earth, which he mentions here, not only for his own glory, but for their comfort. The heavens and earth shall contribute, if he please, to the deliverance of the church (Isa 45:8), for he created both, and therefore has both at command. 1. He made the earth, and created man upon it, for it was intended to be a habitation for man, Psa 115:16. He has therefore not only authority, but wisdom and power sufficient to govern man here on this earth and to make what use he pleases of him. 2. His hands have stretched out the heavens, and all their hosts he commanded into being at first, and therefore still governs all their motions and influences. It is good news to God's Israel that their God is the creator and governor of the world.

III. They are particularly told what God would do for them, that they might know what to depend upon; and this shall lead them to expect a more glorious Redeemer and redemption, of whom, and of which, Cyrus and their deliverance by him were types and figures.

1.Liberty shall be proclaimed to them, Isa 45:13. Cyrus is the man that shall proclaim it; and, in order hereunto, God will put power into his hands: I have raised him up in righteousness, that is, in pursuance and performance of my promises and to plead my people's just but injured cause. He will give him success in all his enterprises, particularly that against Babylon: I will direct all his ways; and then it follows that he will prosper him, for those must needs speed well that are under a divine direction. God will make plain the way of those whom he designs to employ for him. Two things Cyrus must do for God: - (1.) Jerusalem is God's city, but it is now in ruins, and he must rebuild it, that is, he must give orders for the rebuilding of it, and give wherewithal to do it. (2.) Israel is God's people, but they are now captives, and he must release them freely and generously, not demanding any ransom, nor compounding with them for price or reward. And Christ is anointed to do that for poor captive souls which Cyrus was to do for the captive Jews, to proclaim the opening of the prison to those that were bound (Isa 61:1), enlargement from a worse bondage than that in Babylon.

2.Provision shall be made for them. They went out poor, and unable to bear the expenses of their return and re-establishment; and therefore it is promised that the labour of Egypt and other nations should come over to them and be theirs, Isa 45:14. Cyrus, having conquered those countries, out of their spoils provided for the returning Jews; and he ordered his subjects to furnish them with necessaries (Ezr 1:4), so that they did not go out empty from Babylon any more than from Egypt. Those that are redeemed by Christ shall be not only provided for, but enriched. Those whose spirits God stirs up to go to the heavenly Zion may depend upon him to bear their charges. The world is theirs as far as is good for them.

3.Proselytes shall be brought over to them: Men of stature shall come after thee in chains; they shall fall down to thee, saying, Surely God is in thee. This was in part fulfilled when many of the people of the land became Jews (Est 8:17), and said, We will go with you, humbly begging leave to do so, for we have heard that God is with you, Zac 8:23. The restoration would be a means of the conviction of many and the conversion of some. Perhaps many of the Chaldeans who were now themselves conquered by Cyrus, when they saw the Jews going back in triumph, came and begged pardon for the affronts and abuses they had given them, owned that God was among them and that he was God alone, and therefore desired to join themselves to them. But this promise was to have its full accomplishment in the gospel church, - when the Gentiles shall become obedient by word and deed to the faith of Christ (Rom 15:18), as willing captives to the church (Psa 110:3), glad to wear her chains, - when an infidel, beholding the public worship of Christians, shall own himself convinced that God is with them of a truth (Co1 14:24, Co1 14:25) and shall assay to join himself to them, - and when those that had been of the synagogue of Satan shall come and worship before the church's feet, and be made to know that God has loved her (Rev 3:9), and the kings of the earth and the nations shall bring their glory into the gospel Jerusalem, Rev 21:24. Note, It is good to be with those, though it be in chains, that have God with them.

IV. They are taught to trust God further than they can see him. The prophet puts this word into their mouths, and goes before them in saying it (Isa 45:15): Verily, thou art a God that hidest thyself. 1. God hid himself when he brought them into the trouble, hid himself and was wroth, Isa 57:17. Note, Though God be his people's God and Saviour, yet sometimes, when they provoke him, he hides himself from them in displeasure, suspends his favours, and lays them under his frowns: but let them wait upon the Lord that hides his face, Isa 8:17. 2. He hid himself when he was bringing them out of the trouble. Note, When God is acting as Israel's God and Saviour commonly his way is in the sea, Psa 77:19. The salvation of the church is carried on in a mysterious way, by the Spirit of the Lord of hosts working on men's spirits (Zac 4:6), by weak and unlikely instruments, small and accidental occurrences, and not wrought till the last extremity; but this is our comfort, though God hide himself, we are sure he is the God of Israel, the Saviour. See Job 35:14.

V. They are instructed to triumph over idolaters and all the worshippers of other gods (Isa 45:16): Those who are makers of idols, not only who frame them, but who make gods of them by praying to them, shall be ashamed and confounded, when they shall be convinced of their mistakes and shall be forced to acknowledged that the God of Israel is the only true God, and when they shall be disappointed in their expectations from their idols, under whose protection they had put themselves. They shall go to confusion when they shall find that they can neither excuse the sin nor escape the punishment of it, Psa 97:7. It is not here and there one more timorous than the rest that shall thus shrink, and give up the cause, but all of them; nay, though they appear in a body, though hand join in hand, and they do all they can to keep one another in countenance, yet they shall go to confusion together. Bind them in bundles, to burn them.

VI. They are assured that those who trust in God shall never be made ashamed of their confidence in him, Isa 45:17. Now that God was about to deliver them out of Babylon he directed them by his prophet, 1. To look up to him as the author of their salvation: Israel shall be saved in the Lord. Not only their salvation shall be wrought out by his power, but it shall be treasured up for them in his grace and promise, and so secured to them. They shall be saved in him; for his name shall be their strong tower, into which they shall run, and in which they shall be safe. 2. To look beyond this temporal deliverance to that which is spiritual and has reference to another world, to think of that salvation by the Messiah which is an everlasting salvation, the salvation of the soul, a rescue from everlasting misery and a restoration to everlasting bliss. "Give diligence to make that sure, for it may be made sure, so sure that you shall not be ashamed nor confounded world with out end. You shall not only be delivered from the everlasting shame and contempt which will be the portion of idolaters (Dan 12:2), but you shall have everlasting honour and glory." [1.] There is a world without end; and it will be well or ill with us according as it will be with us in that world. [2.] Those who are saved with the everlasting salvation shall never be ashamed of what they did or suffered in the hopes of it; for it will so far outdo their expectations as to be a more abundant reimbursement. The returning captives owned that to them did belong confusion of face (Dan 9:7, Dan 9:8); yet God tells them that they shall not be confounded, but shall have assurance for ever. Those who are confounded as penitents for their own sin shall not be confounded as believers in God's promise and power.

VII. They are engaged for ever to cleave to God, and never to desert him, never to distrust him. What had been often inculcated before is here again repeated, for the encouragement of his people to continue faithful to him, and to hope that he would be so to them: I am the Lord, and there is none else. That the Lord we serve and trust in is God alone appears by the two great lights, that of nature and that of revelation.

1.It appears by the light of nature; for he made the world, and therefore may justly demand its homage (Isa 45:18): "Thus saith the Lord, that created the heavens and formed the earth, I am the Lord, the sovereign Lord of all, and there is none else." The gods of the heathen did not do this, nay, they did not pretend to do it. He here mentions the creation of the heavens, but enlarges more upon that of the earth, because that is the part of the creation which we have the nearest view of and are most conversant with. It is here observed, (1.) That he formed it. It is not a rude and indigested chaos, but cast into the most proper shape and size by Infinite Wisdom. (2.) That he fixed it. When he had made it he established it, founded it on the seas, (Psa 24:2), hung it on nothing (Job 26:7) as at first he made it of nothing, and yet made it substantial an hung it fast, ponderibus librata suis - poised by its own weight. (3.) That he fitted it for use, and for the service of man, to whom he designed to give it. He created it not in vain, merely to be a proof of his power; but he formed it to be inhabited by the children of men, and for that end he drew the waters off from it, with which it was at first covered, and made the dry land appear, Psa 104:6, Psa 104:7. Be it observed here, to the honour of God's wisdom, that he made nothing in vain, but intended every thing for some end and fitted it to answer the intention. If any man prove to have been made in vain, it is his own fault. It should also be observed, to the honour of God's goodness and his favour to man, that he reckoned that not made in vain which serves for his use and benefit, to be a habitation and maintenance for him.

2.It appears by the light of revelation. As the works of God abundantly prove that he is God alone, so does his word, and the discovery he has made of himself and of his mind and will by it. His oracles far exceed those of the Pagan deities, as well as his operations, Isa 45:19. The preference is here placed in three things: - All that God has said is plain, satisfactory, and just. (1.) In the manner of the delivery of it it is plain and open: I have not spoken in secret, in a dark place of the earth. The Pagan deities delivered their oracles out of dens and caverns, with a low and hollow voice, and in ambiguous expressions; those that had familiar spirits whispered and muttered (Isa 8:19); but God delivered his law from the top of Mount Sinai before all the thousands of Israel, in distinct, audible, and intelligible sounds. Wisdom cries in the chief places of concourse, Pro 1:20, Pro 1:21; Pro 8:1-3. The vision is written, and made plain, so that he who runs may read it; if he be obscure to any, they may thank themselves. Christ pleaded in his own defence what God says here, In secret have I said nothing, Joh 18:20. (2.) In the use and benefit of it it was highly satisfactory: I said not unto the seed of Jacob, who consulted these oracles and governed themselves by them, Seek you me in vain, as the false gods did to their worshippers, who sought for the living to the dead, Isa 8:19. This includes all the gracious answers that God gave both to those who consulted him (his word is to them a faithful guide) and to those that prayed to him. The seed of Jacob are a praying people; it is the generation of those that seek him, Psa 24:6. And, as he has in his word invited them to seek him, so he never denied their believing prayers nor disappointed their believing expectations. He said not to them, to any of them, Seek you me in vain; for, if he did not think fit to give them the particular thing they prayed for, yet he gave them such a sufficiency of grace and such comfort and satisfaction of soul as were equivalent. What we say of winter is true of prayer, It never rots in the skies. God not only gives a gracious answer to those that diligently seek him, but will be their bountiful rewarder. (3.) In the matter of it it was incontestably just, and there was no iniquity in it: I the Lord speak righteousness, I declare things that are right, and consonant to the eternal rules and reasons of good and evil. The heathen deities dictated those things to their worshippers which were the reproach of human nature and tended to the extirpation of virtue; but God speaks righteousness, dictates that which is right in itself and tends to make men righteous; and therefore he is God, and there is none else.

Matthew Henry (1662–1714) — Commentary on the Whole Bible. This section covers verses 11–19. Public domain.
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Methodius of OlympusAD 311
ON THE RESURRECTION 1:8
For in reality God did not establish the universe in vain or to no purpose but destruction, as those weak-minded people say, but to exist and be inhabited and continue. Therefore the earth and the heaven must exist again after the conflagration and shaking of all things.
JeromeAD 420
Commentary on Isaiah
(Vers. 18 seqq.) Because this is what the Lord says, the one who created the heavens, the one who formed the earth and made it, the one who established it; he did not create it in vain, but formed it to be inhabited. I am the Lord, and there is no other. I did not speak in secret, in a dark place on the earth. I did not say to the offspring of Jacob, 'Seek me in vain.' I am the Lord, speaking truth, declaring what is right. Gather together and come, draw near, you who have been saved from the nations. They have no knowledge, those who carry about their wooden idols and pray to a god who cannot save. Announce, and come, and counsel together: Who has declared this from the beginning, and from then on predicted it? Is it not I, the Lord? There is no other God besides me, a righteous God and a Savior; there is none besides me. Turn to me and be saved, all the ends of the earth; for I am God, and there is no other. By myself I have sworn, from my mouth has gone forth in righteousness a word that shall not return: 'To me every knee shall bow, every tongue shall swear allegiance.' Therefore, in the Lord, it is said: My justice and power belong to me; they will come to him, and all who oppose him will be put to shame. In the Lord, all the descendants of Israel will be justified and praised. LXX: Thus says the Lord who made the heavens: this is the God who revealed the earth and made it, he prepared it: he did not make it empty, but formed it to be inhabited. I am the Lord, and there is no other. I have not spoken in secret, nor in a dark place on the earth. I have not spoken in secret, in a place of a land of darkness: I have not said to the seed of Jacob: Seek me in vain. I am the Lord that speak justice, that declare right things. Assemble yourselves, and come, and draw near together, ye that are saved of the Gentiles: they have no knowledge that set up the wood of their graven work, and pray to a god that cannot save. Tell ye, and come, and consult together: who hath declared this from the beginning, who hath foretold this from that time? Have not I the Lord, and there is no God else besides me? A just God and a saviour, there is none besides me. Turn to me and you will be saved from the ends of the earth. I am God, and there is no other. By myself I swear: righteousness will go out of my mouth, my words will not be turned away, for every knee will bow to me, and every tongue will swear and confess to God, saying: Righteousness and glory will come to him, and all who separate themselves from the Lord will be put to shame. Every descendant of Israel will be justified and glorified in God. He calls Egypt, and Ethiopia, and the Sabaeans with their exalted men, through whom the salvation of all barbarian nations and the conversion of the whole world to God is shown, God shows His justice; so that the Lord is not only of the Jews, but also of the Gentiles. For He is the maker of heaven and earth equally the God of all, and He created the earth for no other reason than that it should be the habitation of mankind who would worship and understand their Creator, and despise all idols. For on Mount Sinai, from its lofty summit, he spoke these words to the listening people: You shall have no other gods before me, nor shall you make for yourself an idol (Exod. XX, 3, 4). But it is better to believe this saying about the preaching of the Gospel: For Moses spoke to the people in the hidden solitude alone. But the sound of the Apostles went forth into the whole world, and their words reached to the ends of the earth (Psal. XVIII). I did not say, he said, that I am seeking the seed of Jacob in vain. For I have promised them the kingdom of heaven, and I spoke first to them: I have come only for the lost sheep of the house of Israel (Matth. XXV, 24). And for this reason I spoke of justice and proclaimed what is right, or the truth, so that, with the images of the Law and the ceremonies set aside, they would follow the truth of the Gospel. But because they did not want to believe and judged themselves unworthy of salvation, therefore I say to the Gentiles: Gather from all over the world; and come and join me, all of you who have been saved from the Gentiles. By which he shows that not all nations will believe immediately, but gradually and in part. Finally, he rebukes those who remained in their former error, saying: They did not know those who lift up the wood of their carved image, and they pray to a God who does not save. And the meaning is: They did not understand my words, burdened by the weight of their idols, and hoping in them, in which there is no salvation. Therefore, the Apostles are commanded to proclaim the truth opportune and importune (2 Timothy 4), and to devise a plan for the salvation of the nations. But, that is, in order that many might be saved, God spoke from the beginning that they should be gathered and come from the nations, and the mouths of all the prophets proclaimed those who spoke the word of the Lord, except for whom there is no other. For the Son is not without Him, but in Him is God. And elegantly He joins together: God is just, not of one nation alone, but of the whole world, to whom He speaks: Turn to me and you shall be saved, all the ends of the earth; this having been fulfilled which the Father promised to the Son: Ask of me, and I will give you the nations as your inheritance, and the ends of the earth as your possession (Psalm 2:8). And He swore by Himself, since His word and judgment are unchangeable, that the declaration which He uttered once concerning the salvation of the nations might not in any way be voided, but that His promise might be fulfilled by His work, saying above: Turn to Me, and you will be saved, all the ends of the earth. He also swore by the Apostle (Heb. 6) that through two unchangeable things, in which it is impossible for God to lie, we may have strong consolation; and He also swore that every knee should bow to Him, heavenly, earthly, and infernal, and every tongue should swear by Him among mortal men (Phil. 2). In which it is clearly stated that the Christian people are signified. It is the custom of the Church to bow the knee to Christ: which the Jews, demonstrating the pride of their minds, absolutely do not do. But also every tongue of all barbarian nations, not in synagogues but in the Churches of Christ, confesses God. Moreover, every tongue confessing Christ will speak in the Lord, and will say: 'Mine are righteousness and mine is dominion, not the people of the Jews.' To him all nations will come, and those who previously resisted his Gospel will be put to shame; and all the descendants of Israel will be justified and praised, whose preaching and most fruitful sowing has brought abundant fruit throughout the whole world. Whether according to the Seventy or in every language, swearing and confessing God, it will be said that the righteousness and glory of the whole world come to him, and the Jews who separate themselves from him will be confounded. But those who are descended from the children of Israel and have sprung from the seed of the Apostles, and have believed in Christ, may they have eternal righteousness and glory.
Cyril of AlexandriaAD 444
COMMENTARY ON ISAIAH 4:3.45:18-19
For it says, “thus says the Lord” and not simply an earthly “lord,” for there are many in heaven and earth that ruin this name [the Lord] by overusing it. But he is the one who by nature and in truth is just—he is what he is said to be and derives no false glory from what he has ordained.… For if he who made heaven and earth did not make it in vain but to be inhabited, … then who else other than him can be considered God?
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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