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Translation
King James Version
And this is the writing that was written, MENE, MENE, TEKEL, UPHARSIN.
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KJV (with Strong's)
And this H1836 is the writing H3792 that was written H7560, MENE H4484, MENE H4484, TEKEL H8625, UPHARSIN H6537.
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Complete Jewish Bible
and the inscription says, 'M'ne! M'ne! T'kel ufarsin.'
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Berean Standard Bible
Now this is the inscription that was written: MENE, MENE, TEKEL, PARSIN.
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American Standard Version
And this is the writing that was inscribed: MENE, MENE, TEKEL, UPHARSIN.
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World English Bible Messianic
This is the writing that was inscribed: MENE, MENE, TEKEL, UPHARSIN.
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Geneva Bible (1599)
And this is the writing that he hath written, MENE, MENE, TEKEL UPHARSIN.
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Young's Literal Translation
and this is the writing that is noted down: Numbered, Numbered, Weighed, and Divided.
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In the KJVVerse 21,900 of 31,102

Study This Verse

SUMMARY

Daniel 5:25 records the mysterious, divinely inscribed words "MENE, MENE, TEKEL, UPHARSIN" that appeared supernaturally on the palace wall during King Belshazzar's sacrilegious feast. This enigmatic message, incomprehensible to Babylon's wise men, served as an immediate and terrifying divine judgment against Belshazzar for his profound pride and blasphemous desecration of the sacred temple vessels from Jerusalem. The words themselves, seemingly simple Aramaic terms related to weights and currency, held a profound prophetic significance that only Daniel, empowered by God, was able to unveil, sealing the imminent downfall of the Babylonian Empire.

CONTEXT

  • Literary Context: The narrative of Daniel 5 commences with King Belshazzar's opulent and audacious feast, a scene of revelry marked by blatant defiance against the God of Israel. In a climactic act of sacrilege, Belshazzar commands that the gold and silver vessels plundered from the temple in Jerusalem by his predecessor, Nebuchadnezzar, be brought out for his nobles, wives, and concubines to drink from while praising their pagan gods (Daniel 5:1-4). This profound act of disrespect immediately precipitates the supernatural event described in Daniel 5:5, where a disembodied hand appears and inscribes mysterious words on the palace wall. The terrifying sight causes Belshazzar to tremble with fear, and his wise men are utterly unable to read or interpret the writing, intensifying the king's distress (Daniel 5:6-9). It is at this critical juncture that the queen mother suggests calling for Daniel, renowned for his wisdom and ability to interpret divine mysteries (Daniel 5:10-12). Before revealing the meaning of the words, Daniel delivers a powerful, convicting rebuke to Belshazzar, reminding him of Nebuchadnezzar's humbling experience and Belshazzar's willful failure to learn from it (Daniel 5:18-23). Verse 25 then presents the exact, uninterpreted words that were written, setting the stage for Daniel's divinely inspired revelation in the subsequent verses.

  • Historical & Cultural Context: The dramatic events of Daniel 5 unfold in 539 BC, on the very eve of Babylon's fall to the formidable Medo-Persian Empire. Babylon, once the dominant world power under Nebuchadnezzar, was by Belshazzar's time (who served as co-regent with his father Nabonidus) in decline and under siege. The use of the sacred temple vessels from Jerusalem was far more than mere revelry; it was a profound cultural and religious insult. In the ancient Near East, the defeat of a nation often signified the defeat of its gods, and the plundering of temple artifacts was a symbolic act of subjugation. Belshazzar's act, however, went beyond triumphalism; it was a direct and deliberate blasphemy, a defiant taunt against the God of Israel, whose power Nebuchadnezzar himself had once been forced to acknowledge (Daniel 4:34-37). The appearance of a divine omen, particularly a mysterious writing, would have been deeply unsettling in a culture that placed immense stock in omens, diviners, and astrologers. The abject failure of Belshazzar's own wise men to interpret the message underscored the unique, transcendent nature of the God of Daniel, whose communication bypassed human wisdom and required divine insight.

  • Key Themes: The narrative of Daniel 5, culminating in the words of verse 25, powerfully illustrates several core themes found throughout the book of Daniel. Foremost is Divine Sovereignty, demonstrating God's absolute and unchallengeable control over human history, the rise and fall of kingdoms, and the fate of rulers. He is the one who "changes times and seasons; he removes kings and sets up kings" (Daniel 2:21). Closely related is the theme of Divine Judgment, where God directly intervenes to hold powerful rulers accountable for their actions, particularly their egregious pride and blasphemy. Belshazzar's swift and terrifying fate serves as a stark warning against Human Pride and Arrogance, contrasting sharply with Nebuchadnezzar's eventual humility and repentance. The story also highlights Accountability, emphasizing that despite worldly power and perceived invincibility, all individuals, especially those in positions of authority, are ultimately answerable to God. Finally, the event underscores the Supremacy of God's Revelation over human wisdom, as only Daniel, empowered by the Spirit of God, could understand the divine message, reinforcing the theme that true wisdom and understanding come from God alone (Daniel 2:20-23).

EXPOSITION AND ANALYSIS

Key Word Analysis

  • MENE (Aramaic, mᵉnêʼ', H4484): From the passive participle of מְנָא, meaning "numbered" or "counted." Its repetition in the inscription underscores the divine certainty and finality of God's accounting of Belshazzar's reign and the Babylonian kingdom, indicating that their allotted time had definitively run out. This word signifies a completed divine audit, leaving no room for negotiation or extension.
  • TEKEL (Aramaic, tᵉqal', H8625): Corresponding to שָׁקַל, meaning "to balance" or "be weighed." This term signifies a divine assessment or evaluation, implying that Belshazzar's character, actions, and reign had been placed on God's perfect scales of justice and found to be utterly insufficient or "wanting." He failed to meet the divine standard of righteousness and reverence.
  • UPHARSIN (Aramaic, pᵉraç', H6537): The plural form of "Peres," derived from a root meaning "to split up" or "to divide." The prefixed "U" means "and." This word carries a profound double meaning: it literally declares the kingdom's imminent division and points phonetically to the "Persians" (Pâras) and the "Medes," the very powers destined to conquer Babylon, thus revealing the instruments of God's judgment and the precise manner of the kingdom's downfall.

Verse Breakdown

  • "And this [is] the writing that was written": This opening clause immediately establishes the supernatural origin and divine authority of the message. The phrase "this [is] the writing" points to the visible, tangible inscription, while "that was written" (passive voice, Aramaic rᵉsham) subtly indicates an unseen, non-human agent—the finger of God—was responsible for its manifestation. This sets a tone of awe and dread, signaling that the following words are not merely human script but a direct, unalterable divine decree intended for King Belshazzar.
  • "MENE, MENE, TEKEL, UPHARSIN": These four enigmatic Aramaic words form the core of the divine message. Their literal meanings as units of weight (mina, shekel, half-mina) veiled their deeper prophetic significance, which only Daniel, empowered by divine wisdom, could unravel. The repetition of "MENE" emphasizes the absolute certainty and completion of the divine counting, signifying the end of Babylon's dominion. "TEKEL" highlights the divine assessment and finding of utter deficiency in Belshazzar. "UPHARSIN" not only declares the kingdom's imminent division but also cleverly alludes to the specific conquering powers, the Medes and Persians, making the divine judgment both precise and terrifyingly immediate.

Literary Devices

The inscription in Daniel 5:25 is rich with literary devices that amplify its dramatic impact and theological significance. The most prominent is Wordplay (or pun), a sophisticated literary technique where the Aramaic words for units of weight or currency (mina, shekel, half-mina) are ingeniously used to convey prophetic messages through their phonetic similarity to other Aramaic verbs. "Mene" sounds like "numbered," "Tekel" like "weighed," and "Upharsin" (the plural of "Peres") like "divided," while also phonetically resembling "Persia" and the "Medes." This clever double entendre allows the divine message to be both mysterious and profoundly precise once interpreted by Daniel. The Repetition of "MENE, MENE" serves as an emphatic device, underscoring the absolute certainty and finality of God's judgment—the counting of Belshazzar's kingdom is not merely happening; it is definitively complete and irreversible. Furthermore, the entire scene functions as potent Symbolism: the disembodied hand symbolizes the unseen, irresistible power and direct intervention of God; the writing itself symbolizes divine judgment and an unalterable decree; and Belshazzar's feast, with its audacious sacrilege, symbolizes the ultimate hubris and rebellion that inevitably invite divine wrath.

THEOLOGICAL AND THEMATIC CONNECTIONS

Daniel 5:25 serves as a potent theological statement about God's active and sovereign involvement in human affairs, particularly His absolute authority over nations and their rulers. It underscores that no earthly power, however mighty or self-assured, operates outside of God's ultimate jurisdiction. The "writing on the wall" is a vivid and undeniable demonstration of divine judgment, a direct consequence of Belshazzar's blasphemous pride and his willful failure to acknowledge the true God, even after having witnessed Nebuchadnezzar's humbling. This event highlights that God keeps meticulous accounts, weighing the actions and character of individuals and nations, and that His patience, while vast, has limits, leading to inevitable accountability. It is a powerful reminder that human history is not random but unfolds according to God's predetermined plan, and He often uses seemingly small, enigmatic signs to communicate monumental shifts in power and destiny, revealing His unparalleled wisdom and control.

REFLECTION AND APPLICATION

The chilling account of the writing on the wall in Daniel 5:25 transcends its ancient setting to offer timeless and profound lessons for all generations. It serves as a stark reminder that our lives, our actions, and our stewardship of any power, influence, or resources we possess are constantly observed and weighed by a holy and righteous God. Belshazzar's fatal error was not merely his revelry, but his defiant sacrilege and his willful ignorance of God's power, despite having witnessed the humbling of his predecessor. This narrative calls us to a posture of profound humility and reverence, recognizing that true authority belongs to God alone and that all earthly power is ultimately delegated and temporary. It challenges us to examine our own hearts: are we living in a way that honors God, or are we, like Belshazzar, indulging in pride, self-sufficiency, or a casual disregard for spiritual truths and the sacred? The swift and decisive judgment upon Babylon underscores the seriousness with which God views impiety and arrogance, urging us to live with a keen awareness of our accountability to Him in every facet of our existence.

Questions for Reflection

  • In what areas of my life might I be acting with a "Belshazzar-like" pride or a disregard for God's holiness and sovereignty?
  • How does the swiftness and certainty of God's judgment in this passage challenge or deepen my understanding of His patience and justice?
  • What "sacred vessels" (e.g., time, talents, resources, relationships, the church) has God entrusted to me, and am I using them for His glory or for my own indulgence and self-aggrandizement?
  • How can I cultivate a greater sense of accountability to God in my daily decisions, interactions, and the exercise of any influence I may possess?

FAQ

What do the words "MENE, MENE, TEKEL, UPHARSIN" mean?

Answer: While the words themselves are Aramaic terms related to units of weight or currency (mina, shekel, half-mina), Daniel's inspired interpretation reveals their profound prophetic meaning through a clever wordplay. "MENE" (repeated for emphasis) means "numbered," signifying that God had numbered and brought to an end Belshazzar's kingdom and his reign. "TEKEL" means "weighed," indicating that Belshazzar had been weighed in God's balances and found deficient or "wanting" in character and righteousness. "UPHARSIN" (the plural of "Peres") means "divided," foretelling that the kingdom would be divided and given to the Medes and Persians. It also phonetically alludes to "Persia" and "Medes," the conquering powers, making the prophecy remarkably specific.

Why did God choose to write on the wall rather than speak directly or send a prophet initially?

Answer: God chose this dramatic and undeniable method to communicate His judgment for several compelling reasons. Firstly, it was a public, undeniable spectacle that directly confronted Belshazzar in the midst of his blasphemous feast, leaving no room for doubt about its divine origin. A disembodied hand writing on the wall was an unprecedented and terrifying sign, designed to shatter the king's arrogance and instill immediate fear. Secondly, the enigmatic nature of the writing, unreadable by the Babylonian wise men, served to highlight the unique wisdom and power of Daniel's God, setting Him apart from the pagan deities and their impotent diviners. It underscored that only through divine revelation could the true meaning of God's actions be understood, preparing the way for Daniel's powerful rebuke and interpretation, thereby exalting the God of Israel.

What was the immediate consequence of this divine message for Belshazzar and Babylon?

Answer: The consequence was swift and absolute, demonstrating God's immediate and decisive judgment. As Daniel concluded his interpretation, the prophecy of "UPHARSIN" was immediately fulfilled. That very night, Belshazzar was slain, and the Babylonian Empire fell to the Medes and Persians, led by Darius the Mede (Daniel 5:30-31). This rapid fulfillment underscored the certainty and immediacy of God's judgment when His patience is exhausted, demonstrating His ultimate sovereignty over all earthly kingdoms and His unwavering commitment to justice.

CHRIST-CENTERED FULFILLMENT

The dramatic scene of the writing on the wall in Daniel 5:25, with its pronouncement of divine judgment and the sudden fall of a great kingdom, finds profound Christ-centered fulfillment in the New Testament. Belshazzar's being "weighed in the balances and found wanting" foreshadows the universal truth that all humanity, apart from Christ, stands condemned before God's perfect standard of righteousness. Just as God's hand wrote the judgment against Babylon, so too does He hold all creation accountable, but now, all judgment has been entrusted to the Son (John 5:22). The fall of Babylon, a powerful symbol of worldly power, rebellion against God, and spiritual corruption, points forward to the ultimate downfall of all earthly kingdoms and the establishment of Christ's eternal, unshakeable kingdom (Revelation 19:16). While Belshazzar was found deficient, Christ alone lived a perfect, sinless life, fulfilling all righteousness, and through His atoning sacrifice, He provides the perfect righteousness that we desperately lack, imputed to all who believe (2 Corinthians 5:21). The "division" of Belshazzar's kingdom ultimately gives way to the unified, everlasting reign of Christ, in whom all things hold together and find their purpose (Colossians 1:16-17). Thus, Daniel 5:25 not only declares God's sovereignty in judgment but also implicitly points to the necessity of Christ as the one who perfectly fulfills God's righteous demands and establishes a kingdom that will never be weighed and found wanting.

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Commentary on Daniel 5 verses 10–29

I. II. Main points1. 2. Sub-points(1.) (2.) Details

Here is, I. The information given to the king, by the queen-mother, concerning Daniel, how fit he was to be consulted in this difficult case. It is supposed that this queen was the widow of Evil-Merodach, and was that famous Nitocris whom Herodotus mentions as a woman of extraordinary prudence. She was not present at the feast, as the king's wives and concubines were (Dan 5:2); it was not agreeable to her age and gravity to keep a merry night. But, tidings of the fright which the king and his lords were put into being brought to her apartment, she came herself to the banqueting-house, to recommend to the king a physician for his melancholy. She entreated him not to be discouraged by the insufficiency of his wise men to solve this riddle, for that there was a man in his kingdom that had more than once helped his grandfather at such a dead lift, and, no doubt, could help him, Dan 5:11, Dan 5:12. She could not undertake to read the writing herself, but directed him to one that could; let Daniel be called now, who should have been called first. Now observe, 1. The high character she gives of Daniel: He is a man in whom is the spirit of the holy gods, who has something in him more than human, not only the spirit of a man, which, in all, is the candle of the Lord, but a divine spirit. According to the language of her country and religion, she could not give a higher encomium of any man; she speaks honourably of him as a man that had, (1.) An admirably good head: Light, and understanding, and wisdom, like the wisdom of the gods, were found in him. Such an insight had he into things secret, and such a foresight of things to come, that it was evident he was divinely inspired; he had knowledge and understanding beyond all the other wise men for interpreting dreams, explaining enigmas or hard sentences, untying knots, and resolving doubts. Solomon had a wonderful sagacity of this kind; but it should seem that in these things Daniel had more of an immediate divine direction. Behold, a greater than Solomon himself is here. Yet what was the wisdom of them both compared with the treasures of wisdom hidden in Christ? (2.) He had an admirably good heart: An excellent spirit was found in him, which was a great ornament to his wisdom and knowledge, and qualified him to receive that gift; for God gives to a man that is good in his sight wisdom, and knowledge, and joy. He was of a humble, holy, heavenly spirit, had a devout and gracious spirit, a spirit of zeal for the glory of God and the good of men. This was indeed an excellent spirit. 2. The account she gives of the respect that Nebuchadnezzar had for him; he was much in his favour, and was preferred by him: "The king thy father" (that is, thy grandfather, but even to many generations Nebuchadnezzar might well be called the father of that royal family, for he it was that raised it to such a pitch of grandeur), "the king, I say, thy father, made him master of the magicians." Perhaps Belshazzar had sometimes, in his pride, spoken slightly of Nebuchadnezzar, and his politics, and the methods of his government, and the ministers he employed, and thought himself wiser than he; and therefore his mother harps upon that. "The king, I say, thy father, to whose good management all thou hast owing, he pronounced him chief of, and gave him dominion over, all the wise men of Babylon, and named him Belteshazzar, according to the name of his god, thinking thereby to put honour upon him;" but Daniel, by constantly making use of his Jewish name himself (which he resolved to keep, in token of his faithful adherence to his religion), had worn out that name; only the queen-dowager remembered it, otherwise he was generally called Daniel. Note, It is a very good office to revive the remembrance of the good services of worthy men, who are themselves modest, and willing that they should be forgotten. 3. The motion she makes concerning him: Let Daniel be called, and he will show the interpretation. By this it appears that Daniel was now forgotten at court. Belshazzar was a stranger to him, knew not that he had such a jewel in his kingdom. With the new king there came in a new ministry, and the old one was laid aside. Note, There are a great many valuable men, and such as might be made very useful, that lie long buried in obscurity, and some that have done eminent services that live to be overlooked and taken no notice of; but, whatever men are, God is not unrighteous to forget the services done to his kingdom. Daniel, being turned out of his place, lived privately, and sought not any opportunity to come into notice again; yet he lived near the court and within call, though Babylon was now besieged, that he might be ready, if there were occasion, to do any good office, by what interest he had among the great ones, for the children of his people. But Providence so ordered it that now, just at the fall of that monarchy, he should by the queen's means be brought to court again, that he might lie there ready for preferment in the ensuing government. Thus do the righteous shine forth out of obscurity, and before honour is humility.

II. The introducing of Daniel to the king, and his request to him to read and expound the writing. Daniel was brought in before the king, Dan 5:13. He was now nearly ninety years of age, so that his years, and honours, and former preferments, might have entitled him to a free admission into the king's presence; yet he was willing to be conducted in, as a stranger, by the master of the ceremonies. Note, 1. The king asks, with an air of haughtiness: Art thou that Daniel who art of the children of the captivity? Being a Jew, and a captive, he was loth to be beholden to him if he could help it. 2. He tells him what an encomium he had heard of him (Dan 5:14), that the spirit of the gods was in him; and he had sent for him to try whether he deserved so high a character or no. 3. He acknowledges that all the wise men of Babylon were baffled; they could not read this writing, nor show the interpretation, Dan 5:16. But, 4. He promises him the same rewards that he had promised them if he would do it, Dan 5:16. It was strange that the magicians, when now, and in Nebuchadnezzar's time, once and again, they were nonplussed, did not attempt something to save their credit; if they had with a good assurance said, "This is the meaning of such a dream, such a writing," who could disprove them? But God so ordered it that they had nothing at all to say, as, when Christ was born, the heathen oracles were struck dumb.

III. The interpretation which Daniel gave of these mystic characters, which was so far from easing the king of his fears that we may suppose it increased them rather. Daniel was now in years, and Belshazzar was young; and therefore he seems to take a greater liberty of dealing plainly and roundly with him than he had done upon the like occasions with Nebuchadnezzar. In reproving any man, especially great men, there is need of wisdom to consider all circumstances; for they are the reproofs of instruction that are the way of life. In Daniel's discourse here,

1.He undertakes to read the writing which gave them this alarm, and to show them the interpretation of it, Dan 5:17. He slights the offer he made him of rewards, is not pleased that it was mentioned, for he is not one of those that divine for money; what gratuities Nebuchadnezzar gave him afterwards he gladly accepted, but he scorned to bargain for them, or to read the writing to the king for and in consideration of such and such honours promised him. No: "Let thy gifts be to thyself, for they will not be long thine, and give thy fee to another, to any of the wise men whom thou wouldst have most wished to earn it; I value it not." Daniel sees his kingdom now at its last gasp, and therefore looks with contempt upon his gifts and rewards. And thus should we despise all the gifts and rewards that this world can give did we see, as we may by faith, its final period hastening on. Let it give its perishing gifts to another; there are better gifts which we have our eyes and hearts upon; but let us do our duty in the world, do it all the real service we can, read God's writing to it in a profession of religion, and by an agreeable conversation make known the interpretation of it, and then trust God for his gifts, his rewards, in comparison with which all the world can give is mere trash and trifles.

2.He largely recounts to the king God's dealings with his father Nebuchadnezzar, which were intended for instruction and warning to him, Dan 5:18, Dan 5:21. This is not intended for a flourish or an amusement, but is a necessary preliminary to the interpretation of the writing. Note, That we may understand aright what God is doing with us, it is of use to us to review what he has done with others.

(1.)He describes the great dignity and power to which the divine Providence had advanced Nebuchadnezzar, Dan 5:18, Dan 5:19. He had a kingdom, and majesty, and glory, and honour, for aught we know, above what any heathen prince ever had before him; he thought that he got his glory by his own extraordinary conduct and courage, and ascribed his successes to a projecting active genius of his own; but Daniel tells him who now enjoyed what he had laboured for that it was the most high God, the God of gods and Lord of kings (as Nebuchadnezzar himself had called him), that gave him that kingdom, that vast dominion, that majesty wherewith he presided in the affairs of it, and that glory and honour which by his prosperous management he acquired. Note, Whatever degree of outward prosperity any arrive at, they must own that it is of God's giving, not their own getting. Let it never be said, My might, and the power of my hand, have gotten me this wealth, this preferment; but let it always be remembered that it is God that gives men power to get wealth, and gives success to their endeavours. Now the power which God gave to Nebuchadnezzar is here described to be very great in respect both of ability and of authority. [1.] His ability was so strong that it was irresistible; such was the majesty that God gave him, so numerous were the forces he had at command, and such an admirable dexterity he had at commanding them, that, which way soever his sword turned, it prospered. He could captivate and subdue nations by threatening them, without striking a stroke, for all people trembled and feared before him, and would compound with him for their lives upon any terms. See what force is, and what the fear of it does. It is that by which the brutal part of the world, even of the world of mankind, both governs and is governed. [2.] His authority was so absolute that it was uncontrollable. The power which was allowed him, which descended upon him, or which, at least, he assumed, was without contradiction, was absolute and despotic, none shared with him either in the legislative or in the executive part of it. In dispensing punishments he condemned or acquitted at pleasure: Whom he would he slew, and whom he would he saved alive, though both were equally innocent or equally guilty. The jus vitae et necis - the power of life and death was entirely in his hand. In dispensing rewards he granted or denied preferment at pleasure: Whom he would he set up, and whom he would he put down, merely for a humour, and without giving a reason so much as to himself; but it is all ex mero motu - of his own good pleasure, and stat pro ratione voluntas - his will stands for a reason. Such was the constitution of the eastern monarchies, such the manner of their kings.

(2.)He sets before him the sins which Nebuchadnezzar had been guilty of, whereby he had provoked God against him. [1.] He behaved insultingly towards those that were under him, and grew tyrannical and oppressive. The description given of his power intimates his abuse of his power, and that he was directed in what he did by humour and passion, not by reason and equity; so that he often condemned the innocent and acquitted the guilty, both which are an abomination to the Lord. He deposed men of merit and preferred unworthy men, to the great detriment of the public, and for this he was accountable to the most high God, that gave him his power. Note, It is a very hard and rare thing for men to have an absolute arbitrary power, and not to make an ill use of it. Camden has a distich of Giraldus, wherein he speaks of it as a rare instance, concerning our king Henry II of England, that never any man had so much power and did so little hurt with it.

Glorior hoc uno, quod nunquam vidimus unum,

Nec potuisse magis, nec nocuisse minus -

Of him I can say, exulting, that with the same power

to do harm no one was ever more inoffensive.

But that was not all. [2.] He behaved insolently towards the God above him, and grew proud and haughty (Dan 5:20): His heart was lifted up, and there his sin and ruin began; his mind was hardened in pride, hardened against the commands of God and his judgments; he was willful and obstinate, and neither the word of God nor his rod made any lasting impression upon him. Note, Pride is a sin that hardens the heart in all other sin and renders the means of repentance and reformation ineffectual.

(3.)He reminds him of the judgments of God that were brought upon him for his pride and obstinacy, how he was deprived of his reason, and so deposed from his kingly throne (Dan 5:20), driven from among men, to dwell with the wild asses, Dan 5:21. He that would not govern his subjects by rules of reason had not reason sufficient for the government himself. Note, Justly does God deprive men of their reason when they become unreasonable and will not use it, and of their power when they become oppressive and use it ill. He continued like a brute till he knew and embraced that first principle of religion, That the most high God rules. And it is rather by religion than reason that man is distinguished from, and dignified above, the beasts; and it is more his honour to be a subject to the supreme Creator than to be lord of the inferior creatures. Note, Kings must know, or shall be made to know, that the most high God rules in their kingdoms (that is an imperium in imperio - an empire within an empire, not to be excepted against), and that he appoints over them whomsoever he will. As he makes heirs, so he makes princes.

3.In God's name, he exhibits articles of impeachment against Belshazzar. Before he reads him his doom, from the hand-writing on the wall, he shows him his crime, that God may be justified when he speaks, and clear when he judges. Now that which he lays to his charge is, (1.) That he had not taken warning by the judgments of God upon his father (Dan 5:22): Thou his son, O Belshazzar! hast not humbled thy heart, though thou knewest all this. Note, It is a great offence to God if our hearts be not humbled before him to comply both with his precepts and with his providences, humbled by repentance, obedience, and patience; nay, he expects from the greatest of men that their hearts should be humbled before him, by an acknowledgment that, great as they are, to him they are accountable. And it is a great aggravation of the unhumbledness of our hearts when we know enough to humble them but do not consider and improve it, particularly when we know how others have been broken that would not bend, how others have fallen that would not stoop, and yet we continue stiff and inflexible. It makes the sin of children the more heinous if they tread in the steps of their parents' wickedness, though they have seen how dearly it has cost them, and how pernicious the consequences of it have been. Do we know this, do we know all this, and yet are we not humbled? (2.) That he had affronted God more impudently than Nebuchadnezzar himself had done, witness the revels of this very night, in the midst of which he was seized with this horror (Dan 5:23): "Thou hast lifted up thyself against the Lord of heaven, hast swelled with rage against him, and taken up arms against his crown and dignity, in this particular instance, that thou hast profaned the vessels of his house, and made the utensils of his sanctuary instruments of thy iniquity, and, in an actual designed contempt of him, hast praised the gods of silver and gold, which see not, nor hear, nor know anything, as if they were to be preferred before the God that sees, and hears, and knows every thing." Sinners that are resolved to go on in sin are well enough pleased with gods that neither see, nor hear, nor know, for then they may sin securely; but they will find, to their confusion, that though those are the gods they choose those are not the gods they must be judged by, but one to whom all things are naked and open. (3.) That he had not answered the end of his creation and maintenance: The God in whose hand thy breath is, and whose are all thy ways, hast thou not glorified. This is a general charge, which stands good against us all; let us consider how we shall answer it. Observe, [1.] Our dependence upon God as our creator, preserver, benefactor, owner, and ruler; not only from his hand our breath was at first, but in his hand our breath is still; it is he that holds our souls in life, and, if he take away our breath, we die. Our times being in his hand, so is our breath, by which our times are measured. In him we live, and move, and have our being; we live by him, live upon him, and cannot live without him. The way of man is not in himself, not at his own command, at his own disposal, but his are all our ways; for our hearts are in his hand, and so are the hearts of all men, even of kings, who seem to act most as free-agents. [2.] Our duty to God, in consideration of this dependence; we ought to glorify him, to devote ourselves to his honour and employ ourselves in his service, to make it our care to please him and our business to praise him. [3.] Our default in this duty, notwithstanding that dependence; we have not done it; for we have all sinned, and come short of the glory of God. This is the indictment against Belshazzar; there needs no proof, it is made good by the notorious evidence of the fact, and his own conscience cannot but plead guilty to it. And therefore,

4.He now proceeds to read the sentence, as he found it written upon the wall: "Then" (says Daniel) "when thou hast come to such a height of impiety as thus to trample upon the most sacred things, then when thou wast in the midst of thy sacrilegious idolatrous feast, then was the part of the hand, the writing fingers, sent from him, from that God whom thou didst so daringly affront, and who had borne so long with thee, but would bear no longer; he sent them, and this writing, thou now seest, was written, Dan 5:24. It is he that now writes bitter things against thee, and makes thee to possess thy iniquities," Job 13:26. Note, As the sin of sinners is written in the book of God's omniscience, so the doom of sinners is written in the book of God's law; and the day is coming when those books shall be opened, and they shall be judged by them. Now the writing was, Mene, Mene, Tekel, Upharsin, Dan 5:25. It is well that we have an authentic exposition of these words annexed, else we could make little of them, so concise are they; the signification of them is, He has numbered, he has weighed, and they divide. The Chaldean wise men, because they knew not that there is but one God only, could not understand who this He should be, and for that reason (some think) the writing puzzled them. (1.) Mene; that is repeated, for the thing is certain - Mene, mene; that signifies, both in Hebrew and Chaldee, He has numbered and finished, which Daniel explains thus (Dan 5:26): "God has numbered thy kingdom, the years and days of the continuance of it; these were numbered in the counsel of God, and now they are finished; the term has expired for and during which thou wast to hold it, and now it must be surrendered. Here is an end of thy kingdom." (2.) Tekel; that signifies, in Chaldee, Thou art weighed, and, in Hebrew, Thou art too light. So Dr. Lightfoot. For this king and his actions are weighed in the just and unerring balances of divine equity. God does as perfectly know his true character as the goldsmith knows the weight of that which he has weighed in the nicest scales. God does not give judgment against him till he has first pondered his actions, and considered the merits of his case. "But thou art found wanting, unworthy to have such a trust lodged in thee, a vain, light, empty man, a man of no weight or consideration." (3.) Upharsin, which should be rendered, and Pharsin, or Peres. Parsin, in Hebrew, signifies the Persians; Paresin, in Chaldee, signifies dividing; Daniel puts both together (Dan 5:28): "Thy kingdom is divided, is rent from thee, and given to the Medes and Persians, as a prey to be divided among them." Now this may, without any force, be applied to the doom of sinners. Mene, Tekel, Peres, may easily be made to signify death, judgment, and hell. At death, the sinner's days are numbered and finished; after death the judgment, when he will be weighed in the balance and found wanting; and after judgment the sinner will be cut asunder, and given as a prey to the devil and his angels. Daniel does not here give Belshazzar such advice and encouragement to repent as he had given Nebuchadnezzar, because he saw the decree had gone forth and he would not be allowed any space to repent.

One would have thought that Belshazzar would be exasperated against Daniel, and, seeing his own case desperate, would be in a rage against him. But he was so far convicted by his own conscience of the reasonableness of all he said that he objected nothing against it; but, on the contrary, gave Daniel the reward he promised him, put on him the scarlet gown and the gold chain, and proclaimed him the third ruler in the kingdom (Dan 5:29), because he would be as good as his word, and because it was not Daniel's fault if the exposition of the hand-writing was not such as he desired. Note, Many show great respect to God's prophets who yet have no regard to his word. Daniel did not value these titles and ensigns of honour, yet would not refuse them, because they were tokens of his prince's good-will: but we have reason to think that he received them with a smile, foreseeing how soon they would all wither with him that bestowed them. They were like Jonah's gourd, which came up in a night and perished in a night, and therefore it was folly for him to be exceedingly glad of them.

Matthew Henry (1662–1714) — Commentary on the Whole Bible. This section covers verses 10–29. Public domain.
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JeromeAD 420
St. Jerome, Commentary on Daniel, CHAPTER FIVE
Verses 25-28. "This is the inscription which has been set up: MANE, THECEL, PHARES. And this is the interpretation of the sentence: 'MANE' means that God has numbered thy kingdom and brought it to an end. 'THECEL' means it has been weighed in the scales and has been found deficient (Vulg.: thou hast been weighed and hast been found...). 'PHARES' means that thy kingdom has been removed and given to the Medes and Persians." The inscription of these three words on the wall simply meant: "Mane, Thecel, Phares"; the first of which sounds forth the idea of "number," and the second "a weighing out," and the third "removal." And so there was a need not only for reading the inscription but also for interpreting what had been read, in order that it might be understood what these words were announcing. That is to say, that God had numbered his kingdom and brought it to an end, and that He had seized hold upon him to weigh him in His judgment-scales, and the sword would slay him before he should meet a natural death; and that his empire would be divided among the Medes and Persians. For Cyrus, the king of the Persians, as we have already mentioned, overthrew the Chaldean Empire in alliance with Darius, his maternal uncle.
Source: Quotations drawn from early Church Fathers and historical Christian theologians (AD 100–1500). Some quotes address the surrounding passage context rather than this verse alone.
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